LOCUS       NM_173216               4604 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens ST6 beta-galactoside alpha-2,6-sialyltransferase 1
            (ST6GAL1), transcript variant 1, mRNA.
ACCESSION   NM_173216
VERSION     NM_173216.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4604)
  AUTHORS   Zhou,Y., Wu,Y., Shen,D., Wang,Q., Thomas,A.M., Li,S., Shi,F.,
            Lam,E.W. and Qin,H.
  TITLE     Evaluation of ST6Gal1 expression and clinicopathological
            significance in human glioma
  JOURNAL   Clin Neuropathol 43 (4), 113-126 (2024)
   PUBMED   39120072
  REMARK    GeneRIF: Evaluation of ST6Gal1 expression and clinicopathological
            significance in human glioma.
REFERENCE   2  (bases 1 to 4604)
  AUTHORS   Liu,J., Dong,X., Xie,R., Tang,Y., Thomas,A.M., Li,S., Liu,S., Yu,M.
            and Qin,H.
  TITLE     N-linked alpha2,6-sialylation of integrin beta1 by the
            sialyltransferase ST6Gal1 promotes cell proliferation and stemness
            in gestational trophoblastic disease
  JOURNAL   Placenta 149, 18-28 (2024)
   PUBMED   38490094
  REMARK    GeneRIF: N-linked alpha2,6-sialylation of integrin beta1 by the
            sialyltransferase ST6Gal1 promotes cell proliferation and stemness
            in gestational trophoblastic disease.
REFERENCE   3  (bases 1 to 4604)
  AUTHORS   Gunjaca,I., Benzon,B., Pleic,N., Babic Leko,M., Pesutic Pisac,V.,
            Baric,A., Kalicanin,D., Punda,A., Polasek,O., Vukojevic,K. and
            Zemunik,T.
  TITLE     Role of ST6GAL1 in Thyroid Cancers: Insights from Tissue Analysis
            and Genomic Datasets
  JOURNAL   Int J Mol Sci 24 (22), 16334 (2023)
   PUBMED   38003522
  REMARK    GeneRIF: Role of ST6GAL1 in Thyroid Cancers: Insights from Tissue
            Analysis and Genomic Datasets.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4604)
  AUTHORS   Bhalerao,N., Chakraborty,A., Marciel,M.P., Hwang,J., Britain,C.M.,
            Silva,A.D., Eltoum,I.E., Jones,R.B., Alexander,K.L., Smythies,L.E.,
            Smith,P.D., Crossman,D.K., Crowley,M.R., Shin,B., Harrington,L.E.,
            Yan,Z., Bethea,M.M., Hunter,C.S., Klug,C.A., Buchsbaum,D.J. and
            Bellis,S.L.
  TITLE     ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and
            pancreatic cancer progression
  JOURNAL   JCI Insight 8 (19), e161563 (2023)
   PUBMED   37643018
  REMARK    GeneRIF: ST6GAL1 sialyltransferase promotes acinar to ductal
            metaplasia and pancreatic cancer progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4604)
  AUTHORS   Ankenbauer,K.E., Rao,T.C., Mattheyses,A.L. and Bellis,S.L.
  TITLE     Sialylation of EGFR by ST6GAL1 induces receptor activation and
            modulates trafficking dynamics
  JOURNAL   J Biol Chem 299 (10), 105217 (2023)
   PUBMED   37660914
  REMARK    GeneRIF: Sialylation of EGFR by ST6GAL1 induces receptor activation
            and modulates trafficking dynamics.
REFERENCE   6  (bases 1 to 4604)
  AUTHORS   Lo,N.W. and Lau,J.T.
  TITLE     Transcription of the beta-galactoside alpha 2,6-sialyltransferase
            gene in B lymphocytes is directed by a separate and distinct
            promoter
  JOURNAL   Glycobiology 6 (3), 271-279 (1996)
   PUBMED   8724135
REFERENCE   7  (bases 1 to 4604)
  AUTHORS   Bast,B.J., Zhou,L.J., Freeman,G.J., Colley,K.J., Ernst,T.J.,
            Munro,J.M. and Tedder,T.F.
  TITLE     The HB-6, CDw75, and CD76 differentiation antigens are unique
            cell-surface carbohydrate determinants generated by the
            beta-galactoside alpha 2,6-sialyltransferase
  JOURNAL   J Cell Biol 116 (2), 423-435 (1992)
   PUBMED   1730763
REFERENCE   8  (bases 1 to 4604)
  AUTHORS   Stamenkovic,I., Asheim,H.C., Deggerdal,A., Blomhoff,H.K.,
            Smeland,E.B. and Funderud,S.
  TITLE     The B cell antigen CD75 is a cell surface sialytransferase
  JOURNAL   J Exp Med 172 (2), 641-643 (1990)
   PUBMED   2373995
REFERENCE   9  (bases 1 to 4604)
  AUTHORS   Grundmann,U., Nerlich,C., Rein,T. and Zettlmeissl,G.
  TITLE     Complete cDNA sequence encoding human beta-galactoside
            alpha-2,6-sialyltransferase
  JOURNAL   Nucleic Acids Res 18 (3), 667 (1990)
   PUBMED   2408023
REFERENCE   10 (bases 1 to 4604)
  AUTHORS   Lance,P., Lau,K.M. and Lau,J.T.
  TITLE     Isolation and characterization of a partial cDNA for a human
            sialyltransferase
  JOURNAL   Biochem Biophys Res Commun 164 (1), 225-232 (1989)
   PUBMED   2803295
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB152155.1, X17247.1,
            AC007690.12 and AC007488.15.
            
            On Jun 5, 2010 this sequence version replaced NM_173216.1.
            
            Summary: This gene encodes a member of glycosyltransferase family
            29. The encoded protein is a type II membrane protein that
            catalyzes the transfer of sialic acid from CMP-sialic acid to
            galactose-containing substrates. The protein, which is normally
            found in the Golgi but can be proteolytically processed to a
            soluble form, is involved in the generation of the cell-surface
            carbohydrate determinants and differentiation antigens HB-6, CD75,
            and CD76. This gene has been incorrectly referred to as CD75.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.221866.1,
                                           SRR1660805.216305.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000169298.8/ ENSP00000169298.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               DB152155.1         42-242
            202-550             X17247.1           1-349
            551-551             AC007690.12        148297-148297
            552-1990            X17247.1           350-1788
            1991-4604           AC007488.15        95318-97931         c
FEATURES             Location/Qualifiers
     source          1..4604
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.3"
     gene            1..4604
                     /gene="ST6GAL1"
                     /gene_synonym="CDw75; SIAT1; ST6GalI; ST6N"
                     /note="ST6 beta-galactoside alpha-2,6-sialyltransferase 1"
                     /db_xref="GeneID:6480"
                     /db_xref="HGNC:HGNC:10860"
                     /db_xref="MIM:109675"
     exon            1..309
                     /gene="ST6GAL1"
                     /gene_synonym="CDw75; SIAT1; ST6GalI; ST6N"
                     /inference="alignment:Splign:2.1.0"
     exon            310..451
                     /gene="ST6GAL1"
                     /gene_synonym="CDw75; SIAT1; ST6GalI; ST6N"
                     /inference="alignment:Splign:2.1.0"
     exon            452..583
                     /gene="ST6GAL1"
                     /gene_synonym="CDw75; SIAT1; ST6GalI; ST6N"
                     /inference="alignment:Splign:2.1.0"
     exon            584..1240
                     /gene="ST6GAL1"
                     /gene_synonym="CDw75; SIAT1; ST6GalI; ST6N"
                     /inference="alignment:Splign:2.1.0"
     CDS             634..1854
                     /gene="ST6GAL1"
                     /gene_synonym="CDw75; SIAT1; ST6GalI; ST6N"
                     /EC_number="2.4.3.1"
                     /note="isoform a is encoded by transcript variant 1;
                     sialyltransferase 1 (beta-galactoside
                     alpha-2,6-sialyltransferase); CMP-N-acetylneuraminate
                     beta-galactosamide alpha-2,6-sialyltransferase;
                     beta-galactoside alpha-2,6-sialyltransferase 1; alpha
                     2,6-ST 1; B-cell antigen CD75;
                     CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,
                     6-sialyltransferase 1; ST6 beta-galactosamide
                     alpha-2,6-sialyltranferase 1; ST6 N-acetylgalactosaminide
                     alpha-2,6-sialyltransferase 1"
                     /codon_start=1
                     /product="beta-galactoside alpha-2,6-sialyltransferase 1
                     isoform a"
                     /protein_id="NP_775323.1"
                     /db_xref="CCDS:CCDS3285.1"
                     /db_xref="GeneID:6480"
                     /db_xref="HGNC:HGNC:10860"
                     /db_xref="MIM:109675"
                     /translation="MIHTNLKKKFSCCVLVFLLFAVICVWKEKKKGSYYDSFKLQTKE
                     FQVLKSLGKLAMGSDSQSVSSSSTQDPHRGRQTLGSLRGLAKAKPEASFQVWNKDSSS
                     KNLIPRLQKIWKNYLSMNKYKVSYKGPGPGIKFSAEALRCHLRDHVNVSMVEVTDFPF
                     NTSEWEGYLPKESIRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTAN
                     FQQDVGTKTTIRLMNSQLVTTEKRFLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYN
                     FFNNYKTYRKLHPNQPFYILKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTL
                     CDQVDIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPLLYEKNLVKHLNQGTDEDIYL
                     LGKATLPGFRTIHC"
     exon            1241..1338
                     /gene="ST6GAL1"
                     /gene_synonym="CDw75; SIAT1; ST6GalI; ST6N"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1437
                     /gene="ST6GAL1"
                     /gene_synonym="CDw75; SIAT1; ST6GalI; ST6N"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1612
                     /gene="ST6GAL1"
                     /gene_synonym="CDw75; SIAT1; ST6GalI; ST6N"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..4604
                     /gene="ST6GAL1"
                     /gene_synonym="CDw75; SIAT1; ST6GalI; ST6N"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4580..4585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST6GAL1"
                     /gene_synonym="CDw75; SIAT1; ST6GalI; ST6N"
                     /note="hexamer: AATAAA"
     polyA_site      4604
                     /gene="ST6GAL1"
                     /gene_synonym="CDw75; SIAT1; ST6GalI; ST6N"
                     /note="major polyA site"
ORIGIN      
        1 gctcttcttc cttccttctc cagtcccttc cactgtgcgt cttctgtccc ccgttcttcc
       61 ccagcggacc cctctttcga gactccctag tggggtcccc agctcccggg cgatcctgcc
      121 cttgccgagc gcgttttctg gagtcacctg ggggagggga gtcctgggca gggccgggct
      181 ggggaagacg cctggggcac tgcccggcgt taacaaaggg agccgatacc gaccggcgtg
      241 ggcgcggagc gggcggccgc caccgagcgt gctgagcaac cgcagcctcc gcggccgaga
      301 gtgcagcgag caaggggaga gccagttgcg cagagccctg caaccagcag tccagggaga
      361 agtggtgaat gtcatggagc ccagctgaaa tggactggcc cccttgagcc tgtcccaagc
      421 cctggtgcca ggtgtccatc cccgtgctga gatgagtttt gatcatcctg agaaaaatgg
      481 gccttggcct gcagacccaa taaaccttcc ctcccatgga taatagtgct aattcctgag
      541 gacctgaagg gcctgccgcc cctgggggat tagccagaag caggcttgtt ttcctgctca
      601 gaacaaagtg acttccctga acacatcttc attatgattc acaccaacct gaagaaaaag
      661 ttcagctgct gcgtcctggt ctttcttctg tttgcagtca tctgtgtgtg gaaggaaaag
      721 aagaaaggga gttactatga ttcctttaaa ttgcaaacca aggaattcca ggtgttaaag
      781 agtctgggga aattggccat ggggtctgat tcccagtctg tatcctcaag cagcacccag
      841 gacccccaca ggggccgcca gaccctcggc agtctcagag gcctagccaa ggccaaacca
      901 gaggcctcct tccaggtgtg gaacaaggac agctcttcca aaaaccttat ccctaggctg
      961 caaaagatct ggaagaatta cctaagcatg aacaagtaca aagtgtccta caaggggcca
     1021 ggaccaggca tcaagttcag tgcagaggcc ctgcgctgcc acctccggga ccatgtgaat
     1081 gtatccatgg tagaggtcac agattttccc ttcaatacct ctgaatggga gggttatctg
     1141 cccaaggaga gcattaggac caaggctggg ccttggggca ggtgtgctgt tgtgtcgtca
     1201 gcgggatctc tgaagtcctc ccaactaggc agagaaatcg atgatcatga cgcagtcctg
     1261 aggtttaatg gggcacccac agccaacttc caacaagatg tgggcacaaa aactaccatt
     1321 cgcctgatga actctcagtt ggttaccaca gagaagcgct tcctcaaaga cagtttgtac
     1381 aatgaaggaa tcctaattgt atgggaccca tctgtatacc actcagatat cccaaagtgg
     1441 taccagaatc cggattataa tttctttaac aactacaaga cttatcgtaa gctgcacccc
     1501 aatcagccct tttacatcct caagccccag atgccttggg agctatggga cattcttcaa
     1561 gaaatctccc cagaagagat tcagccaaac cccccatcct ctgggatgct tggtatcatc
     1621 atcatgatga cgctgtgtga ccaggtggat atttatgagt tcctcccatc caagcgcaag
     1681 actgacgtgt gctactacta ccagaagttc ttcgatagtg cctgcacgat gggtgcctac
     1741 cacccgctgc tctatgagaa gaatttggtg aagcatctca accagggcac agatgaggac
     1801 atctacctgc ttggaaaagc cacactgcct ggcttccgga ccattcactg ctaagcacag
     1861 gctcctcact cttctccatc aggcattaaa tgaatggtct cttggccacc ccagcctggg
     1921 aagaacattt tcctgaacaa ttccagcctg ctccttttac tctaggggcc tctgtcagca
     1981 agaccatggg gacttcaaga gcctgtggtc aggaaatcag gtccagcctt ccctgtagcc
     2041 agacagttta tgagcccaga gcctcctgcc acacacatgc acacatatct agcattcttt
     2101 ccagacagca tcctccccgc cttccacctt ggtagatgca aggtctatct ctcccatcag
     2161 ggctgccaaa gctgggcttt gtttttccca gcagaatgat gccattctca caaaccaatg
     2221 ctctatattg cttgaagtct gcatctaaat attgatttca cgttttaaag aaattctctt
     2281 aaattacaat tgtgcccaat gcagggtggc tctggggggc aagtaggtgg tacaggggat
     2341 tggaaacatg ctccgcgcct ccagagaaaa gttgctcccg aggtccatgc ccctggaacg
     2401 tgttcctatc actctggctg gttgggctgg tccttagact gggtgcttat gattaaaggg
     2461 tcttggttag cccactttcc ctctccatgt ggagatggaa ggtagagaag gatacagtgt
     2521 ctatcctcaa gttgctacgg ttcagtgaga gaggcagaca tctgaacagg caggtaggat
     2581 tcagtgtgct cagtgcactg gggatttgga gagagatggg cttgctctct ctgtgcaccc
     2641 aggagggcca cgcacttaaa actgtgtttg tggatcagag aaggctttat agcacagggg
     2701 gcattcagat gagtcttaga ggaagagaag aaacatggca agcagattac atctgagccg
     2761 tttgaattgt gtttttcttt cttcccatgt ttattttcta agatctacct gaacttagag
     2821 actcaagata tttttttagg aaacctccta cccatgtctg aggtagcaag tgcagcctca
     2881 cgacagatac caggcaatcc agagccacaa aacgtgattc ctccaggctc tgcctggcct
     2941 gaccctgtcc tgtcagctgg gtttacatac cagtcccatt cttccttttc aatacctacc
     3001 cccaaatctt ctcctaacca ccatctgttt ttttttttta aagcattttt tgctttaaaa
     3061 gcatcctgac cccaatttct ttgagctcac gggccttttg ctgaaggtct ctcagggtgt
     3121 agtggtgtgg ctctctggac ttaacgtcac tctcagaggt cagaaccttg gagatcagaa
     3181 ctgattctca ccaggtgtga gaggtgtggt agcagattgc aatgctctgc acctcttcct
     3241 tgcaagtgag caacttcagg ctctctgggc agaggctggc ccactgtagt ttgcagacat
     3301 gctctccaga tggttttact aagtcccctc tccctgatag ggaatcctgc tggaccagcg
     3361 cagccctggt gtggagaggt taaaagactt gcacaggatc accaagtcat gctgtagagc
     3421 caggattcct agacccaggg ctctgcactc tcaaggctgg ccccatgtgc tcaaggggat
     3481 ctaatgtttg ggctccaaac taaccatctc ggagctgggc tcctcattta ctgccaaacc
     3541 ctcagcttat gtagctagaa agggccctgg agtgagaaag cctggatttt caaattgatg
     3601 ctcccctact gactagctgt gccactctgg gcaaatgctc ttccttgagc ctgtttccac
     3661 acctgtaaag tggggatgat gatcctatct cactgctttt gtgaggatta caggaaagca
     3721 cctgtcctgg ctctgtacct ggcacgtagt aggtgctcag ttcatgctgg tttccttcct
     3781 gcctttagta gggacctgct ctgtgctcac acctcggctg catgcaccct gctgtgacgg
     3841 aggctagtgt ggaagaggtc ctgtcctcag ggaattaact gtcttattgg gagacaacaa
     3901 ctgtcctcct tggaacaccc aagaaaccat gcaaagcagt ggacaacaca gaacacgccc
     3961 tcctcctcgc tgcctgcagc tccaatctga ttctgcttgg gaatgggcgg agcacgtggg
     4021 ctgcttaact gctgtatagg acaagcccct tacccctctc tgggcccatg aattcctggc
     4081 ttggtttatg ttctgatttg acacactgat tttaatcttc gaatcatgac actgagtgca
     4141 gaggaggtgg cattccgaca gcaggacata catgttggtg tgaagactgg gacgacactg
     4201 ggtagaatct agtttttaat tattattaat ataaaggatc aaattaattt aaatatgatt
     4261 ctgaagtcta cagaactttt agttctgtgc tgtctatgtg gacactttgg taaaatgcaa
     4321 attatgatat ggacgttatc attggtctgg tgagatgttt catatttgtg acagttaatt
     4381 taaaaattat gagttaatgc tgcctgtgtc tatggggttc tgtcttcttt gatagccatc
     4441 tattcatctg gatcatggga ccctctctaa tccttccacc aatcaaataa gctattgcta
     4501 ttggtttgga gttgagatat cagtctcgga aacttctgaa aaatgctaat aattacccaa
     4561 ggattatgtc aaattttaaa ataaatgtgt gtgtgtttct ttaa
//
