LOCUS       NM_001323368            3198 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens ST3 beta-galactoside alpha-2,3-sialyltransferase 6
            (ST3GAL6), transcript variant 9, mRNA.
ACCESSION   NM_001323368 XM_005247070
VERSION     NM_001323368.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3198)
  AUTHORS   Shen,Y., Feng,Y., Li,F., Jia,Y., Peng,Y., Zhao,W., Hu,J. and He,A.
  TITLE     lncRNA ST3GAL6-AS1 promotes invasion by inhibiting
            hnRNPA2B1-mediated ST3GAL6 expression in multiple myeloma
  JOURNAL   Int J Oncol 58 (4) (2021)
   PUBMED   33649796
  REMARK    GeneRIF: lncRNA ST3GAL6AS1 promotes invasion by inhibiting
            hnRNPA2B1mediated ST3GAL6 expression in multiple myeloma.
REFERENCE   2  (bases 1 to 3198)
  AUTHORS   Qi,F., Isaji,T., Duan,C., Yang,J., Wang,Y., Fukuda,T. and Gu,J.
  TITLE     ST3GAL3, ST3GAL4, and ST3GAL6 differ in their regulation of
            biological functions via the specificities for the
            alpha2,3-sialylation of target proteins
  JOURNAL   FASEB J 34 (1), 881-897 (2020)
   PUBMED   31914669
  REMARK    GeneRIF: a cross-restoration of each of the three genes in ST3GAL6
            KO cells showed that overexpression of ST3GAL6 sufficiently rescued
            the total alpha2,3-sialylation levels, cell morphology, and
            alpha2,3-sialylation of EGFR, whereas the alpha2,3-sialylation
            levels of beta1 were greatly enhanced by an overexpression of
            ST3GAL4
REFERENCE   3  (bases 1 to 3198)
  AUTHORS   Glavey,S.V., Manier,S., Natoni,A., Sacco,A., Moschetta,M.,
            Reagan,M.R., Murillo,L.S., Sahin,I., Wu,P., Mishima,Y., Zhang,Y.,
            Zhang,W., Zhang,Y., Morgan,G., Joshi,L., Roccaro,A.M.,
            Ghobrial,I.M. and O'Dwyer,M.E.
  TITLE     The sialyltransferase ST3GAL6 influences homing and survival in
            multiple myeloma
  JOURNAL   Blood 124 (11), 1765-1776 (2014)
   PUBMED   25061176
  REMARK    GeneRIF: The sialyltransferase ST3GAL6 influences homing and
            survival in multiple myeloma.
REFERENCE   4  (bases 1 to 3198)
  AUTHORS   Yang,W.H., Nussbaum,C., Grewal,P.K., Marth,J.D. and Sperandio,M.
  TITLE     Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in
            the synthesis of selectin ligands
  JOURNAL   Blood 120 (5), 1015-1026 (2012)
   PUBMED   22700726
REFERENCE   5  (bases 1 to 3198)
  AUTHORS   Verbeek,E.C., Bakker,I.M., Bevova,M.R., Bochdanovits,Z., Rizzu,P.,
            Sondervan,D., Willemsen,G., de Geus,E.J., Smit,J.H., Penninx,B.W.,
            Boomsma,D.I., Hoogendijk,W.J. and Heutink,P.
  TITLE     A fine-mapping study of 7 top scoring genes from a GWAS for major
            depressive disorder
  JOURNAL   PLoS One 7 (5), e37384 (2012)
   PUBMED   22649524
REFERENCE   6  (bases 1 to 3198)
  AUTHORS   Kawamura,Y.I., Toyota,M., Kawashima,R., Hagiwara,T., Suzuki,H.,
            Imai,K., Shinomura,Y., Tokino,T., Kannagi,R. and Dohi,T.
  TITLE     DNA hypermethylation contributes to incomplete synthesis of
            carbohydrate determinants in gastrointestinal cancer
  JOURNAL   Gastroenterology 135 (1), 142-151 (2008)
   PUBMED   18485915
  REMARK    GeneRIF: Epigenetic changes in a group of glycosyltransferases
            including B4GALNT2 and ST3GAL6 represent a malignant phenotype of
            gastric cancer caused by silencing of the activity of these enzymes
REFERENCE   7  (bases 1 to 3198)
  AUTHORS   Groux-Degroote,S., Krzewinski-Recchi,M.A., Cazet,A., Vincent,A.,
            Lehoux,S., Lafitte,J.J., Van Seuningen,I. and Delannoy,P.
  TITLE     IL-6 and IL-8 increase the expression of glycosyltransferases and
            sulfotransferases involved in the biosynthesis of sialylated and/or
            sulfated Lewisx epitopes in the human bronchial mucosa
  JOURNAL   Biochem J 410 (1), 213-223 (2008)
   PUBMED   17944600
REFERENCE   8  (bases 1 to 3198)
  AUTHORS   Hemmoranta,H., Satomaa,T., Blomqvist,M., Heiskanen,A., Aitio,O.,
            Saarinen,J., Natunen,J., Partanen,J., Laine,J. and Jaatinen,T.
  TITLE     N-glycan structures and associated gene expression reflect the
            characteristic N-glycosylation pattern of human hematopoietic stem
            and progenitor cells
  JOURNAL   Exp Hematol 35 (8), 1279-1292 (2007)
   PUBMED   17662891
REFERENCE   9  (bases 1 to 3198)
  AUTHORS   Taniguchi,A., Kaneta,R., Morishita,K. and Matsumoto,K.
  TITLE     Gene structure and transcriptional regulation of human Gal
            beta1,4(3) GlcNAc alpha2,3-sialyltransferase VI (hST3Gal VI) gene
            in prostate cancer cell line
  JOURNAL   Biochem Biophys Res Commun 287 (5), 1148-1156 (2001)
   PUBMED   11587543
REFERENCE   10 (bases 1 to 3198)
  AUTHORS   Okajima,T., Fukumoto,S., Miyazaki,H., Ishida,H., Kiso,M.,
            Furukawa,K., Urano,T. and Furukawa,K.
  TITLE     Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal VI)
            that sialylates type II lactosamine structures on glycoproteins and
            glycolipids
  JOURNAL   J Biol Chem 274 (17), 11479-11486 (1999)
   PUBMED   10206952
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC106728.6.
            
            On Aug 13, 2020 this sequence version replaced NM_001323368.1.
            
            Summary: The protein encoded by this gene is a member of the
            sialyltransferase family. Members of this family are enzymes that
            transfer sialic acid from the activated cytidine
            5'-monophospho-N-acetylneuraminic acid to terminal positions on
            sialylated glycolipids (gangliosides) or to the N- or O-linked
            sugar chains of glycoproteins. This protein has high specificity
            for neolactotetraosylceramide and neolactohexaosylceramide as
            glycolipid substrates and may contribute to the formation of
            selectin ligands and sialyl Lewis X, a carbohydrate important for
            cell-to-cell recognition and a blood group antigen. [provided by
            RefSeq, Apr 2016].
            
            Transcript Variant: Variants 1, 4, 7, 8 and 9 encode the same
            isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1688333.1,
                                           SRR14038194.3920513.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000483910.6/ ENSP00000417376.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AC106728.6         132593-132692       c
            101-200             AC106728.6         127503-127602       c
            201-278             AC106728.6         125076-125153       c
            279-382             AC106728.6         123116-123219       c
            383-446             AC106728.6         122049-122112       c
            447-542             AC106728.6         110992-111087       c
            543-729             AC106728.6         107810-107996       c
            730-867             AC106728.6         107569-107706       c
            868-1020            AC106728.6         104039-104191       c
            1021-3198           AC106728.6         100180-102357       c
FEATURES             Location/Qualifiers
     source          1..3198
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q12.1"
     gene            1..3198
                     /gene="ST3GAL6"
                     /gene_synonym="SIAT10; ST3GALVI"
                     /note="ST3 beta-galactoside alpha-2,3-sialyltransferase 6"
                     /db_xref="GeneID:10402"
                     /db_xref="HGNC:HGNC:18080"
                     /db_xref="MIM:607156"
     exon            1..100
                     /gene="ST3GAL6"
                     /gene_synonym="SIAT10; ST3GALVI"
                     /inference="alignment:Splign:2.1.0"
     exon            101..200
                     /gene="ST3GAL6"
                     /gene_synonym="SIAT10; ST3GALVI"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1107
                     /gene="ST3GAL6"
                     /gene_synonym="SIAT10; ST3GALVI"
                     /EC_number="2.4.3.6"
                     /note="isoform 1 is encoded by transcript variant 9;
                     sialyltransferase 10 (alpha-2,3-sialyltransferase VI);
                     type 2 lactosamine alpha-2,3-sialyltransferase;
                     CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI;
                     alpha2,3-sialyltransferase ST3Gal VI"
                     /codon_start=1
                     /product="type 2 lactosamine alpha-2,3-sialyltransferase
                     isoform 1"
                     /protein_id="NP_001310297.1"
                     /db_xref="CCDS:CCDS2933.1"
                     /db_xref="GeneID:10402"
                     /db_xref="HGNC:HGNC:18080"
                     /db_xref="MIM:607156"
                     /translation="MRGYLVAIFLSAVFLYYVLHCILWGTNVYWVAPVEMKRRNKIQP
                     CLSKPAFASLLRFHQFHPFLCAADFRKIASLYGSDKFDLPYGMRTSAEYFRLALSKLQ
                     SCDLFDEFDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRR
                     TTFRLFYPESVFSDPIHNDPNTTVILTAFKPHDLRWLLELLMGDKINTNGFWKKPALN
                     LIYKPYQIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFYICHEVHL
                     AGFKYNFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQLFLKDIIEKNLVINLTQD"
     exon            201..278
                     /gene="ST3GAL6"
                     /gene_synonym="SIAT10; ST3GALVI"
                     /inference="alignment:Splign:2.1.0"
     exon            279..382
                     /gene="ST3GAL6"
                     /gene_synonym="SIAT10; ST3GALVI"
                     /inference="alignment:Splign:2.1.0"
     exon            383..446
                     /gene="ST3GAL6"
                     /gene_synonym="SIAT10; ST3GALVI"
                     /inference="alignment:Splign:2.1.0"
     exon            447..542
                     /gene="ST3GAL6"
                     /gene_synonym="SIAT10; ST3GALVI"
                     /inference="alignment:Splign:2.1.0"
     exon            543..729
                     /gene="ST3GAL6"
                     /gene_synonym="SIAT10; ST3GALVI"
                     /inference="alignment:Splign:2.1.0"
     exon            730..867
                     /gene="ST3GAL6"
                     /gene_synonym="SIAT10; ST3GALVI"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1020
                     /gene="ST3GAL6"
                     /gene_synonym="SIAT10; ST3GALVI"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..3198
                     /gene="ST3GAL6"
                     /gene_synonym="SIAT10; ST3GALVI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1287..1292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST3GAL6"
                     /gene_synonym="SIAT10; ST3GALVI"
                     /note="hexamer: AAGAAA"
     polyA_site      1311
                     /gene="ST3GAL6"
                     /gene_synonym="SIAT10; ST3GALVI"
                     /note="major polyA site"
     regulatory      1609..1614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST3GAL6"
                     /gene_synonym="SIAT10; ST3GALVI"
                     /note="hexamer: AATGAA"
     polyA_site      1633
                     /gene="ST3GAL6"
                     /gene_synonym="SIAT10; ST3GALVI"
     regulatory      2576..2581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST3GAL6"
                     /gene_synonym="SIAT10; ST3GALVI"
                     /note="hexamer: AATACA"
     polyA_site      2600
                     /gene="ST3GAL6"
                     /gene_synonym="SIAT10; ST3GALVI"
                     /note="major polyA site"
     regulatory      2925..2930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST3GAL6"
                     /gene_synonym="SIAT10; ST3GALVI"
                     /note="hexamer: AGTAAA"
     polyA_site      2947
                     /gene="ST3GAL6"
                     /gene_synonym="SIAT10; ST3GALVI"
     regulatory      3168..3173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST3GAL6"
                     /gene_synonym="SIAT10; ST3GALVI"
                     /note="hexamer: AATAAA"
     polyA_site      3198
                     /gene="ST3GAL6"
                     /gene_synonym="SIAT10; ST3GALVI"
ORIGIN      
        1 agtgtgagct gaagaccagc agagactagg atggatgacg gcctgtccag gggctgaatg
       61 gacacaggtg tcagcagggc cacctggtaa aggtatggag gtgagccagc catgagaggg
      121 tatcttgtgg ccatattcct gagtgctgtc ttcctctatt atgtactgca ttgcatatta
      181 tggggaacga atgtctattg ggtggcacct gtggaaatga aacggagaaa taagatccag
      241 ccttgtttat caaagccagc ttttgcctct ctgctgaggt ttcatcagtt tcaccctttt
      301 ctgtgtgcgg ctgattttag aaagattgct tccttgtatg gtagcgataa gtttgatttg
      361 ccctatggga tgagaacatc agcggaatat tttcgacttg ctctttcaaa actgcagagt
      421 tgtgatctct ttgatgagtt tgacaacata ccctgtaaaa agtgtgtggt ggttggtaat
      481 ggaggagttt tgaagaataa gacattagga gaaaaaatcg actcctatga tgtaataata
      541 agaatgaata atggtcctgt tttaggacat gaagaagaag ttgggagaag gacaaccttc
      601 cgactttttt atccagaatc tgttttttca gatcctattc acaatgaccc taatacgaca
      661 gtgattctca ctgcttttaa gccacatgat ttaaggtggc tgttggaatt gttgatgggt
      721 gacaaaataa acactaatgg tttttggaag aaaccagcct taaacctgat ttataaacct
      781 tatcaaatcc gaatattaga tcctttcatt atcagaacag cagcttatga actgcttcat
      841 tttccaaaag tgtttcccaa aaatcagaaa cctaaacacc caacaacagg aattattgcc
      901 atcacattgg cgttttacat atgtcacgaa gttcacctag ctggttttaa atacaacttt
      961 tctgacctca agagtccttt gcactactat gggaatgcca ccatgtcttt gatgaataag
     1021 aacgcgtatc acaatgtgac tgcagagcag ctctttttga aggacattat agaaaaaaac
     1081 ctcgtaatca acttgactca agattgactc tacagactca gaagatgatg ctaacagtgt
     1141 tagttttatt tttgtactgc aatttttagt ttaaaatatg ttggatgcac tcgtcaaata
     1201 attatgtata ctgtctgttg ctgcctggtg attcataacc accagcttaa tttctgtgaa
     1261 tactgtatat ttaacttatg aaaaccaaga aatgtaaaga taacaggaaa ataagttttg
     1321 attgcattgt ttttaaaata agctagtttt ctgaggtgtt ttcacacgtc tttttatagt
     1381 tacttcatct tagatttttg aagggatatg acttcctact aaggatttag tttaccacaa
     1441 caattctgac tacaataaga cattttgagg aggatatttg gctactgtaa acatggctgg
     1501 tggaaaatca cgattgtggc ttgatgtggc aagccgaaac cacttggctc tggaaatcta
     1561 agttcatact ggtttaatta agctctctcc tgacaacccc cagaattaaa tgaaccatga
     1621 ttgtgaagag taatttggta caatgaaggc agtgtttgtt tttaagttaa aggaaatggg
     1681 ctaaacataa agttcttatt agataagtaa ataactaaag aaagaataca attactaaac
     1741 tctgatggct ttgtattatt ttaaagaaat gaagtttaac tttatacagt gaagctaagc
     1801 taggcaagct caagaaggaa aaaaaaatct tgaacattat ttttttttgc ctgacttact
     1861 tattcattaa attttgaagg ttttccactt gaagtaaatt aggaaaggta aagaagataa
     1921 cagaacaagt aaacacttaa gaaaagtcaa gctgaggccg ggcagggtgg ctcacacctg
     1981 taatcctaac aaacactttg ggaggccgag ggaggcagct ggattgcctg aactcaggag
     2041 ttcaagacca gcctggccaa catggtgaaa cctcatctct actaaaatac aaaataatta
     2101 gctgggcgtg gtggtatgcg ctgtagtccc aggtactcgg gaggctgagg cacgagaatt
     2161 gcttgagccc gggaggcaga ggttgcagtg agccaagatc gcgccactgc acttcagcct
     2221 gggtgacaga gtgaggctgt cttctaaaaa atataaaaag tgaagttggg atttttggat
     2281 ttaaatggta caaaaagaat atctcatttt cccatgatta aagctaatct tcagatggaa
     2341 agcttgcctg gctacctagg gtgcaccaga gaatctgatc caatgcaagc cagtcaatcc
     2401 tacaaatgtg gtgagctagt cttccttcct atattttaat aaatgtaacc aaaggccatc
     2461 tggaggtagg ggaatgagag gtgaagaaac agaaaaatag aggttataag gatggaacta
     2521 aaagttgtca gaagaggtat gagctgaaga aagaattact ctcttttgac caataaatac
     2581 aattgggaaa cactggaaaa ccatggcttg attactgaca accaacctgc ctctctaaag
     2641 agggtgtata aagggtgaaa tacattagat ttggctcaga aacagaatgc ggtacttata
     2701 aagcagaata aaggggagaa cagtagtagt tgatctaacc cagattagac atgaatacca
     2761 gcatatgttt gcagagtccc acagttttga ttcctcttat aactttttga ggtgcaaaag
     2821 gaaggtacca gaactggaat cacatgtaat caatcagtgt gattttcccc tcataccaca
     2881 cagccatagg ctgcagtgtg gctgctgaag ttcaattgat ataaagtaaa tcaggcttca
     2941 aaaagaatgg tgctgtgggt acacaaggac ataaagatgg gaacgataga cactgaggac
     3001 tgcggcgggg ggagcgaggg gagcggggag ggcaagggct gaaagactat gtattgggta
     3061 ctatgctcac aacctggatg atgggatcat tcataccaca aacctcagta tcacacaata
     3121 tacccatgta acaacctgca ctctgcacat gtacccttag aatctaaaat aaaagttgaa
     3181 attatttttt taaaaaaa
//
