LOCUS       NM_001254757            1810 bp    mRNA    linear   PRI 26-FEB-2025
DEFINITION  Homo sapiens ST3 beta-galactoside alpha-2,3-sialyltransferase 4
            (ST3GAL4), transcript variant 2, mRNA.
ACCESSION   NM_001254757
VERSION     NM_001254757.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1810)
  AUTHORS   Chen,X., Su,W., Chen,J., Ouyang,P. and Gong,J.
  TITLE     ST3GAL4 promotes tumorigenesis in breast cancer by enhancing
            aerobic glycolysis
  JOURNAL   Hum Cell 38 (1), 1 (2024)
   PUBMED   39422756
  REMARK    GeneRIF: ST3GAL4 promotes tumorigenesis in breast cancer by
            enhancing aerobic glycolysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1810)
  AUTHORS   Costa,A.F., Senra,E., Faria-Ramos,I., Teixeira,A., Morais,J.,
            Pacheco,M., Reis,C.A. and Gomes,C.
  TITLE     ST3GalIV drives SLeX biosynthesis in gastrointestinal cancer cells
            and associates with cancer cell motility
  JOURNAL   Glycoconj J 40 (4), 421-433 (2023)
   PUBMED   37074623
  REMARK    GeneRIF: ST3GalIV drives SLeX biosynthesis in gastrointestinal
            cancer cells and associates with cancer cell motility.
REFERENCE   3  (bases 1 to 1810)
  AUTHORS   Singh,P., Joon,A., Kumari,M., Singh,T., Bal,A., Maan,P. and
            Ghosh,S.
  TITLE     Role of a Disease-associated ST3Gal-4 in Non-small Cell Lung Cancer
  JOURNAL   Cell Biochem Biophys 80 (4), 781-793 (2022)
   PUBMED   36083411
  REMARK    GeneRIF: Role of a Disease-associated ST3Gal-4 in Non-small Cell
            Lung Cancer.
REFERENCE   4  (bases 1 to 1810)
  AUTHORS   Kitano,M., Kizuka,Y., Sobajima,T., Nakano,M., Nakajima,K.,
            Misaki,R., Itoyama,S., Harada,Y., Harada,A., Miyoshi,E. and
            Taniguchi,N.
  TITLE     Rab11-mediated post-Golgi transport of the sialyltransferase
            ST3GAL4 suggests a new mechanism for regulating glycosylation
  JOURNAL   J Biol Chem 296, 100354 (2021)
   PUBMED   33524390
  REMARK    GeneRIF: Rab11-mediated post-Golgi transport of the
            sialyltransferase ST3GAL4 suggests a new mechanism for regulating
            glycosylation.
REFERENCE   5  (bases 1 to 1810)
  AUTHORS   Wang,T., Hao,Z., Liu,C., Yuan,L., Li,L., Yin,M., Li,Q., Qi,Z. and
            Wang,Z.
  TITLE     MiR-193b modulates osteoarthritis progression through targeting
            ST3GAL4 via sialylation of CD44 and NF-small ka, CyrillicB pathway
  JOURNAL   Cell Signal 76, 109814 (2020)
   PUBMED   33080315
  REMARK    GeneRIF: MiR-193b modulates osteoarthritis progression through
            targeting ST3GAL4 via sialylation of CD44 and NF-small ka,
            CyrillicB pathway.
REFERENCE   6  (bases 1 to 1810)
  AUTHORS   Kitagawa,H., Mattei,M.G. and Paulson,J.C.
  TITLE     Genomic organization and chromosomal mapping of the Gal beta
            1,3GalNAc/Gal beta 1,4GlcNAc alpha 2,3-sialyltransferase
  JOURNAL   J Biol Chem 271 (2), 931-938 (1996)
   PUBMED   8557707
REFERENCE   7  (bases 1 to 1810)
  AUTHORS   Munro,S.
  TITLE     An investigation of the role of transmembrane domains in Golgi
            protein retention
  JOURNAL   EMBO J 14 (19), 4695-4704 (1995)
   PUBMED   7588599
REFERENCE   8  (bases 1 to 1810)
  AUTHORS   Chang,M.L., Eddy,R.L., Shows,T.B. and Lau,J.T.
  TITLE     Three genes that encode human beta-galactoside alpha
            2,3-sialyltransferases. Structural analysis and chromosomal mapping
            studies
  JOURNAL   Glycobiology 5 (3), 319-325 (1995)
   PUBMED   7655169
REFERENCE   9  (bases 1 to 1810)
  AUTHORS   Kitagawa,H. and Paulson,J.C.
  TITLE     Cloning of a novel alpha 2,3-sialyltransferase that sialylates
            glycoprotein and glycolipid carbohydrate groups
  JOURNAL   J Biol Chem 269 (2), 1394-1401 (1994)
   PUBMED   8288606
REFERENCE   10 (bases 1 to 1810)
  AUTHORS   Sasaki,K., Watanabe,E., Kawashima,K., Sekine,S., Dohi,T.,
            Oshima,M., Hanai,N., Nishi,T. and Hasegawa,M.
  TITLE     Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha
            2,3-sialyltransferase using lectin resistance selection
  JOURNAL   J Biol Chem 268 (30), 22782-22787 (1993)
   PUBMED   7901202
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI259855.1, AL520639.3,
            AL529887.3, AP000806.4 and BP320415.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001254757.1.
            
            Summary: This gene encodes a member of the glycosyltransferase 29
            family, a group of enzymes involved in protein glycosylation. The
            encoded protein is targeted to Golgi membranes but may be
            proteolytically processed and secreted. The gene product may also
            be involved in the increased expression of sialyl Lewis X antigen
            seen in inflammatory responses. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Dec 2011].
            
            Transcript Variant: This variant (2), as well as variants 3 and 8,
            encodes isoform 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.669020.1,
                                           SRR3476690.985822.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000444328.7/ ENSP00000394354.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-723               BI259855.1         10-732
            724-880             AL520639.3         723-879
            881-893             AL529887.3         796-808
            894-894             AP000806.4         24983-24983
            895-1024            AL529887.3         810-939
            1025-1104           BP320415.1         503-582
            1105-1132           AP000806.4         29287-29314
            1133-1810           AP000806.4         29627-30304
FEATURES             Location/Qualifiers
     source          1..1810
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..1810
                     /gene="ST3GAL4"
                     /gene_synonym="CGS23; gal-NAc6S; NANTA3; SAT3; SIAT4;
                     SIAT4C; ST-4; ST3GalA.2; ST3GalIV; STZ"
                     /note="ST3 beta-galactoside alpha-2,3-sialyltransferase 4"
                     /db_xref="GeneID:6484"
                     /db_xref="HGNC:HGNC:10864"
                     /db_xref="MIM:104240"
     exon            1..157
                     /gene="ST3GAL4"
                     /gene_synonym="CGS23; gal-NAc6S; NANTA3; SAT3; SIAT4;
                     SIAT4C; ST-4; ST3GalA.2; ST3GalIV; STZ"
                     /inference="alignment:Splign:2.1.0"
     exon            158..233
                     /gene="ST3GAL4"
                     /gene_synonym="CGS23; gal-NAc6S; NANTA3; SAT3; SIAT4;
                     SIAT4C; ST-4; ST3GalA.2; ST3GalIV; STZ"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1219
                     /gene="ST3GAL4"
                     /gene_synonym="CGS23; gal-NAc6S; NANTA3; SAT3; SIAT4;
                     SIAT4C; ST-4; ST3GalA.2; ST3GalIV; STZ"
                     /EC_number="2.4.3.6"
                     /EC_number="2.4.3.2"
                     /EC_number="2.4.3.4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     sialyltransferase 4C (beta-galactosidase
                     alpha-2,3-sialytransferase); sialyltransferase 4C
                     (beta-galactoside alpha-2,3-sialytransferase);
                     alpha-3-N-acetylneuraminyltransferase;
                     CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,
                     3-sialyltransferase 4; alpha 2,3-ST 4;
                     gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; alpha
                     2,3-sialyltransferase IV; beta-galactoside
                     alpha-2,3-sialyltransferase 4;
                     gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase;
                     gal-beta-1,4-GlcNAc-alpha-2,3-sialyltransferase;
                     N-acetyllactosaminide alpha-2,3-sialyltransferase"
                     /codon_start=1
                     /product="CMP-N-acetylneuraminate-beta-galactosamide-
                     alpha-2,3-sialyltransferase 4 isoform 2"
                     /protein_id="NP_001241686.1"
                     /db_xref="CCDS:CCDS58193.1"
                     /db_xref="GeneID:6484"
                     /db_xref="HGNC:HGNC:10864"
                     /db_xref="MIM:104240"
                     /translation="MVSKSRWKLLAMLALVLVVMVWYSISREDRYIELFYFPIPEKKE
                     PCLQGEAESKASKLFGNYSRDQPIFLRLEDYFWVKTPSAYELPYGTKGSEDLLLRVLA
                     ITSSSIPKNIQSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVG
                     SKTTMRLFYPESAHFDPKVENNPDTLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQP
                     PLIWDVNPKQIRILNPFFMEIAADKLLSLPMQQPRKIKQKPTTGLLAITLALHLCDLV
                     HIAGFGYPDAYNKKQTIHYYEQITLKSMAGSGHNVSQEALAIKRMLEMGAIKNLTSF"
     exon            234..318
                     /gene="ST3GAL4"
                     /gene_synonym="CGS23; gal-NAc6S; NANTA3; SAT3; SIAT4;
                     SIAT4C; ST-4; ST3GalA.2; ST3GalIV; STZ"
                     /inference="alignment:Splign:2.1.0"
     exon            319..399
                     /gene="ST3GAL4"
                     /gene_synonym="CGS23; gal-NAc6S; NANTA3; SAT3; SIAT4;
                     SIAT4C; ST-4; ST3GalA.2; ST3GalIV; STZ"
                     /inference="alignment:Splign:2.1.0"
     exon            400..497
                     /gene="ST3GAL4"
                     /gene_synonym="CGS23; gal-NAc6S; NANTA3; SAT3; SIAT4;
                     SIAT4C; ST-4; ST3GalA.2; ST3GalIV; STZ"
                     /inference="alignment:Splign:2.1.0"
     exon            498..558
                     /gene="ST3GAL4"
                     /gene_synonym="CGS23; gal-NAc6S; NANTA3; SAT3; SIAT4;
                     SIAT4C; ST-4; ST3GalA.2; ST3GalIV; STZ"
                     /inference="alignment:Splign:2.1.0"
     exon            559..654
                     /gene="ST3GAL4"
                     /gene_synonym="CGS23; gal-NAc6S; NANTA3; SAT3; SIAT4;
                     SIAT4C; ST-4; ST3GalA.2; ST3GalIV; STZ"
                     /inference="alignment:Splign:2.1.0"
     exon            655..844
                     /gene="ST3GAL4"
                     /gene_synonym="CGS23; gal-NAc6S; NANTA3; SAT3; SIAT4;
                     SIAT4C; ST-4; ST3GalA.2; ST3GalIV; STZ"
                     /inference="alignment:Splign:2.1.0"
     exon            845..988
                     /gene="ST3GAL4"
                     /gene_synonym="CGS23; gal-NAc6S; NANTA3; SAT3; SIAT4;
                     SIAT4C; ST-4; ST3GalA.2; ST3GalIV; STZ"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1132
                     /gene="ST3GAL4"
                     /gene_synonym="CGS23; gal-NAc6S; NANTA3; SAT3; SIAT4;
                     SIAT4C; ST-4; ST3GalA.2; ST3GalIV; STZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1810
                     /gene="ST3GAL4"
                     /gene_synonym="CGS23; gal-NAc6S; NANTA3; SAT3; SIAT4;
                     SIAT4C; ST-4; ST3GalA.2; ST3GalIV; STZ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1785..1790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST3GAL4"
                     /gene_synonym="CGS23; gal-NAc6S; NANTA3; SAT3; SIAT4;
                     SIAT4C; ST-4; ST3GalA.2; ST3GalIV; STZ"
                     /note="hexamer: ATTAAA"
     polyA_site      1810
                     /gene="ST3GAL4"
                     /gene_synonym="CGS23; gal-NAc6S; NANTA3; SAT3; SIAT4;
                     SIAT4C; ST-4; ST3GalA.2; ST3GalIV; STZ"
                     /note="major polyA site"
ORIGIN      
        1 gcaggcggac tcgcccgctc ccaggccgga cccgcgcccg ggacagggac ccggccgagt
       61 cgagccgtcg cgccagcgct gcgccgccgg tcggtgcgcc tagcggatcg gagctgcgcg
      121 cggaaccgtg ctgccccgcc ccgctccacc cgtgagggtg gcccgaggca gccgggatga
      181 cagctctccc caggaatcct gctgcctgct gagaaacatg gtcagcaagt cccgctggaa
      241 gctcctggcc atgttggctc tggtcctggt cgtcatggtg tggtattcca tctcccggga
      301 agacaggtac atcgagcttt tttattttcc catcccagag aagaaggagc cgtgcctcca
      361 gggtgaggca gagagcaagg cctctaagct ctttggcaac tactcccggg atcagcccat
      421 cttcctgcgg cttgaggatt atttctgggt caagacgcca tctgcttacg agctgcccta
      481 tgggaccaag gggagtgagg atctgctcct ccgggtgcta gccatcacca gctcctccat
      541 ccccaagaac atccagagcc tcaggtgccg ccgctgtgtg gtcgtgggga acgggcaccg
      601 gctgcggaac agctcactgg gagatgccat caacaagtac gatgtggtca tcagattgaa
      661 caatgcccca gtggctggct atgagggtga cgtgggctcc aagaccacca tgcgtctctt
      721 ctaccctgaa tctgcccact tcgaccccaa agtagaaaac aacccagaca cactcctcgt
      781 cctggtagct ttcaaggcaa tggacttcca ctggattgag accatcctga gtgataagaa
      841 gcgggtgcga aagggtttct ggaaacagcc tcccctcatc tgggatgtca atcctaaaca
      901 gattcggatt ctcaacccct tcttcatgga gattgcagct gacaaactgc tgagcctgcc
      961 aatgcaacag ccacggaaga ttaagcagaa gcccaccacg ggcctgttgg ccatcacgct
     1021 ggccctccac ctctgtgact tggtgcacat tgccggcttt ggctacccag acgcctacaa
     1081 caagaagcag accattcact actatgagca gatcacgctc aagtccatgg cggggtcagg
     1141 ccataatgtc tcccaagagg ccctggccat taagcggatg ctggagatgg gagctatcaa
     1201 gaacctcacg tccttctgac ctgggcaaga gctgtagcct gtcggttgcc tactctgctg
     1261 tctgggtgac ccccatgcgt ggctgtgggg gtggctggtg ccagtatgac ccacttggac
     1321 tcaccccctc ttggggaggg agttctgggc ctggccaggt ctgagatgag gccatgcccc
     1381 tggctgctct tatggagccg agatccagtc agggtggggg cgctggagcc gtgggagccc
     1441 ggccagggca gggggctcgt tgctgtggca ccccctctct gccagcacca agagattatt
     1501 taatgggcta tttaattaag gggtaggaag gtgctgtggg ctggtcccac acatccagga
     1561 aagaggccag tagagaattc tgcccacttt ttataaaaac ttacagcgat ggccccacca
     1621 aggcctagac acggcactgg cctcccagga gggcaggggc attgggaatg ggtgggtgcc
     1681 ctccagagag gggctgctac ctcccagcag gcatgggaag agcactggtg tgggggttcc
     1741 accgagaagg ggacctcatc tagaaaagag gttacaaacc taccattaaa ctatttttcc
     1801 taaaacggaa
//
