LOCUS       NM_006927               7920 bp    mRNA    linear   PRI 26-FEB-2025
DEFINITION  Homo sapiens ST3 beta-galactoside alpha-2,3-sialyltransferase 2
            (ST3GAL2), mRNA.
ACCESSION   NM_006927 XM_001130512 XM_005256114
VERSION     NM_006927.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7920)
  AUTHORS   Zhang,N., Lin,S., Cui,W. and Newman,P.J.
  TITLE     Overlapping and unique substrate specificities of ST3GAL1 and 2
            during hematopoietic and megakaryocytic differentiation
  JOURNAL   Blood Adv 6 (13), 3945-3955 (2022)
   PUBMED   35507766
  REMARK    GeneRIF: Overlapping and unique substrate specificities of ST3GAL1
            and 2 during hematopoietic and megakaryocytic differentiation.
REFERENCE   2  (bases 1 to 7920)
  AUTHORS   Chumpen Ramirez,S., Ruggiero,F.M., Daniotti,J.L. and Valdez
            Taubas,J.
  TITLE     Ganglioside glycosyltransferases are S-acylated at conserved
            cysteine residues involved in homodimerisation
  JOURNAL   Biochem J 474 (16), 2803-2816 (2017)
   PUBMED   28698248
  REMARK    GeneRIF: Data suggest that ganglioside glycosyltransferases
            ST3GAL5, ST8SIA1, and B4GALNT1 are S-acylated at conserved cysteine
            residues located close to cytoplasmic border of their transmembrane
            domains; ST3Gal-II is acylated at conserved cysteine residue in
            N-terminal cytoplasmic tail; for B4GALNT1 and ST3Gal-II, dimer
            formation controls their S-acylation status.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7920)
  AUTHORS   Ruggiero,F.M., Vilcaes,A.A., Iglesias-Bartolome,R. and
            Daniotti,J.L.
  TITLE     Critical role of evolutionarily conserved glycosylation at Asn211
            in the intracellular trafficking and activity of sialyltransferase
            ST3Gal-II
  JOURNAL   Biochem J 469 (1), 83-95 (2015)
   PUBMED   25916169
  REMARK    GeneRIF: This suggests that the C-terminal domain of ST3Gal-II
            depends on N-glycosylation to attain an optimum conformation for
            proper exit from the endoplasmic reticulum
REFERENCE   4  (bases 1 to 7920)
  AUTHORS   Saito,S., Aoki,H., Ito,A., Ueno,S., Wada,T., Mitsuzuka,K.,
            Satoh,M., Arai,Y. and Miyagi,T.
  TITLE     Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific
            embryonic antigen-4 synthase
  JOURNAL   J Biol Chem 278 (29), 26474-26479 (2003)
   PUBMED   12716912
  REMARK    GeneRIF: ST3Gal II is a MSGb5 (stage-specific embryonic antigen-4)
            synthase and its increased expression level is closely related to
            renal carcinogenesis
REFERENCE   5  (bases 1 to 7920)
  AUTHORS   Taniguchi,A., Morishima,T., Tsujita,Y., Matsumoto,Y. and
            Matsumoto,K.
  TITLE     Genomic structure, expression, and transcriptional regulation of
            human Gal beta 1,3 GalNAc alpha 2,3-sialyltransferase gene
  JOURNAL   Biochem Biophys Res Commun 300 (2), 570-576 (2003)
   PUBMED   12504121
  REMARK    GeneRIF: Genomic structure, expression, and transcriptional
            regulation of ST3GALII.
REFERENCE   6  (bases 1 to 7920)
  AUTHORS   Giordanengo,V., Bannwarth,S., Laffont,C., Van Miegem,V.,
            Harduin-Lepers,A., Delannoy,P. and Lefebvre,J.C.
  TITLE     Cloning and expression of cDNA for a human Gal(beta1-3)GalNAc
            alpha2,3-sialyltransferase from the CEM T-cell line
  JOURNAL   Eur J Biochem 247 (2), 558-566 (1997)
   PUBMED   9266697
REFERENCE   7  (bases 1 to 7920)
  AUTHORS   Kim,Y.J., Kim,K.S., Kim,S.H., Kim,C.H., Ko,J.H., Choe,I.S.,
            Tsuji,S. and Lee,Y.C.
  TITLE     Molecular cloning and expression of human Gal beta 1,3GalNAc alpha
            2,3-sialytransferase (hST3Gal II)
  JOURNAL   Biochem Biophys Res Commun 228 (2), 324-327 (1996)
   PUBMED   8920913
REFERENCE   8  (bases 1 to 7920)
  AUTHORS   Chang,M.L., Eddy,R.L., Shows,T.B. and Lau,J.T.
  TITLE     Three genes that encode human beta-galactoside alpha
            2,3-sialyltransferases. Structural analysis and chromosomal mapping
            studies
  JOURNAL   Glycobiology 5 (3), 319-325 (1995)
   PUBMED   7655169
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012184.7, AK127322.1 and
            BC036777.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006927.3.
            
            Summary: The protein encoded by this gene is a type II membrane
            protein that catalyzes the transfer of sialic acid from CMP-sialic
            acid to galactose-containing substrates. The encoded protein is
            normally found in the Golgi but can be proteolytically processed to
            a soluble form. This protein, which is a member of
            glycosyltransferase family 29, can use the same acceptor substrates
            as does sialyltransferase 4A. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.177084.1,
                                           SRR1163658.218064.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342907.3/ ENSP00000345477.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC012184.7         159775-159786       c
            13-152              AC012184.7         159635-159774       c
            153-1819            AK127322.1         1106-2772
            1820-2482           BC036777.1         707-1369
            2483-4462           AC012184.7         100121-102100       c
            4463-7920           AC012184.7         96663-100120        c
FEATURES             Location/Qualifiers
     source          1..7920
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..7920
                     /gene="ST3GAL2"
                     /gene_synonym="Gal-NAc6S; SIAT4B; ST3GalA.2; ST3GALII"
                     /note="ST3 beta-galactoside alpha-2,3-sialyltransferase 2"
                     /db_xref="GeneID:6483"
                     /db_xref="HGNC:HGNC:10863"
                     /db_xref="MIM:607188"
     exon            1..152
                     /gene="ST3GAL2"
                     /gene_synonym="Gal-NAc6S; SIAT4B; ST3GalA.2; ST3GALII"
                     /inference="alignment:Splign:2.1.0"
     exon            153..1494
                     /gene="ST3GAL2"
                     /gene_synonym="Gal-NAc6S; SIAT4B; ST3GalA.2; ST3GALII"
                     /inference="alignment:Splign:2.1.0"
     CDS             1156..2208
                     /gene="ST3GAL2"
                     /gene_synonym="Gal-NAc6S; SIAT4B; ST3GalA.2; ST3GALII"
                     /EC_number="2.4.3.2"
                     /EC_number="2.4.3.4"
                     /note="sialyltransferase 4B (beta-galactosidase
                     alpha-2,3-sialytransferase);
                     Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; SIAT4-B;
                     ST3Gal II; alpha 2,3-ST 2; monosialoganglioside
                     sialyltransferase; beta-galactoside
                     alpha-2,3-sialyltransferase 2"
                     /codon_start=1
                     /product="CMP-N-acetylneuraminate-beta-galactosamide-
                     alpha-2,3-sialyltransferase 2"
                     /protein_id="NP_008858.1"
                     /db_xref="CCDS:CCDS10890.1"
                     /db_xref="GeneID:6483"
                     /db_xref="HGNC:HGNC:10863"
                     /db_xref="MIM:607188"
                     /translation="MKCSLRVWFLSVAFLLVFIMSLLFTYSHHSMATLPYLDSGALDG
                     THRVKLVPGYAGLQRLSKERLSGKSCACRRCMGDAGASDWFDSHFDGNISPVWTRENM
                     DLPPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRFRDPHQCRRCAVVGNSGN
                     LRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMYPESAKNLPANVSFVLVP
                     FKVLDLLWIASALSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRY
                     PSTGMLVLFFALHVCDEVNVYGFGADSRGNWHHYWENNRYAGEFRKTGVHDADFEAHI
                     IDMLAKASKIEVYRGN"
     exon            1495..1688
                     /gene="ST3GAL2"
                     /gene_synonym="Gal-NAc6S; SIAT4B; ST3GalA.2; ST3GALII"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1868
                     /gene="ST3GAL2"
                     /gene_synonym="Gal-NAc6S; SIAT4B; ST3GalA.2; ST3GALII"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1914
                     /gene="ST3GAL2"
                     /gene_synonym="Gal-NAc6S; SIAT4B; ST3GalA.2; ST3GALII"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2034
                     /gene="ST3GAL2"
                     /gene_synonym="Gal-NAc6S; SIAT4B; ST3GalA.2; ST3GALII"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..7920
                     /gene="ST3GAL2"
                     /gene_synonym="Gal-NAc6S; SIAT4B; ST3GalA.2; ST3GALII"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2429
                     /gene="ST3GAL2"
                     /gene_synonym="Gal-NAc6S; SIAT4B; ST3GalA.2; ST3GALII"
     regulatory      4368..4373
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST3GAL2"
                     /gene_synonym="Gal-NAc6S; SIAT4B; ST3GalA.2; ST3GALII"
                     /note="hexamer: ATTAAA"
     polyA_site      4386
                     /gene="ST3GAL2"
                     /gene_synonym="Gal-NAc6S; SIAT4B; ST3GalA.2; ST3GALII"
                     /note="major polyA site"
     regulatory      7254..7259
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST3GAL2"
                     /gene_synonym="Gal-NAc6S; SIAT4B; ST3GalA.2; ST3GALII"
                     /note="hexamer: AATAAA"
     polyA_site      7281
                     /gene="ST3GAL2"
                     /gene_synonym="Gal-NAc6S; SIAT4B; ST3GalA.2; ST3GALII"
     regulatory      7658..7663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST3GAL2"
                     /gene_synonym="Gal-NAc6S; SIAT4B; ST3GalA.2; ST3GALII"
                     /note="hexamer: CATAAA"
     polyA_site      7681
                     /gene="ST3GAL2"
                     /gene_synonym="Gal-NAc6S; SIAT4B; ST3GalA.2; ST3GALII"
     regulatory      7900..7905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST3GAL2"
                     /gene_synonym="Gal-NAc6S; SIAT4B; ST3GalA.2; ST3GALII"
                     /note="hexamer: AATAAA"
     polyA_site      7920
                     /gene="ST3GAL2"
                     /gene_synonym="Gal-NAc6S; SIAT4B; ST3GalA.2; ST3GALII"
ORIGIN      
        1 actagcccac ggcgggcgga cgagagagct gcgagctaac gggtccggac gacggcggcg
       61 gcggcggcgg cggcggcgac ggctttctgc gcgggcggcg gcggcggccg gagcggcgag
      121 catggcccgc gcggcgccgg gcgctgactg agggtcgtgc tgcggcagcc tggcgcccga
      181 catgtgaagg ggaacctgcc aggggattac tgtgagctca cagcaggata ggctggcccc
      241 gggggagtgg ggatgggcag aacctgggcc aggagtatta ggaaggagac ctggaccctg
      301 gtagggagct cagcacaagc tcgcctgacc cagatggtat tggacacagt gccccgctga
      361 acagcagctg ttcccagcgc cagaggaccc cacagccaca gtaggagctt tgcgacccct
      421 acgcaactgc agctggggct ggggccacca ggagaaggga ccagcacctc agatgggaag
      481 cagaagggca agacctactg cggaaaggat ctcgatctct gcagcggagt tttcccacac
      541 tcacagagct tcctgttttt gtcctctcag ggttggggtc tggctcccct cctctggcag
      601 aggttttggg ccaggaggtg ggacaacact tgcatggaac ccaagtcccc tgaagcccct
      661 gtgctctctg ttgtgattgg agttctaggg cttccccgct gccgggaacg aggggccgcc
      721 tcattgtctg ctcatgaacc acaaggaccc cgactgctcc agactggatt atttcaagcc
      781 gccaaagagg gggaccccta gagctggcag ccagcaatcc caagggacta gagggctgca
      841 atggactgac ctccccctca ccagggtggc aggagaggca gagcctctgt ggcctagcta
      901 gtgacggaga gacccgatga agccctaagc aggggccccg cctgactcag ggacaggaca
      961 gccactcctg ccaacgtgtg ttctccctac atgagggagg gcgtggcaag ggacccctgc
     1021 cactgtcccc tgctgcagca cgtgccccta tgccctttgc atgtggtgcc agaataggca
     1081 ggctacgccg tggctggccc ctcagcgggc tgggaaaaga gtggccacgg tgaccgtcac
     1141 ccgcctgccg gcaccatgaa gtgctccctg cgggtgtggt tcctctccgt ggccttcctg
     1201 ctggtgttca tcatgtccct gctcttcacc tactcgcacc acagcatggc cacgctcccc
     1261 tacctggact caggggccct ggatgggacg caccgggtga agctggtgcc cggctatgcc
     1321 ggcctgcagc gcctcagcaa ggagaggctc tcgggcaaga gctgtgcctg tcgccgctgc
     1381 atgggcgatg ccggtgcctc cgactggttt gacagccact ttgacggtaa catttccccc
     1441 gtctggaccc gagagaacat ggatcttcca ccggacgtcc agaggtggtg gatgatgctg
     1501 cagccccagt tcaagtcaca caacaccaat gaggtgctgg agaagctgtt ccagatagtg
     1561 cctggcgaga acccctaccg cttccgggac ccccaccagt gccggcgctg tgccgtggtg
     1621 gggaactcgg gcaacctgcg gggctctggc tatgggcagg acgtggacgg gcacaacttc
     1681 atcatgagga tgaatcaggc gccaaccgtg ggctttgagc aggatgttgg cagccgaacc
     1741 acccaccatt tcatgtaccc tgagagtgcc aagaacctgc ccgccaacgt cagcttcgtg
     1801 ctggtgccct tcaaggtcct ggaccttctg tggatcgcca gcgccttgtc cacggggcag
     1861 atccgattca cctacgcccc agtgaagtcc ttccttcgag tggataaaga aaaggtccag
     1921 atctacaacc cagccttctt caagtatatc cacgacaggt ggacagagca tcacgggcgg
     1981 tacccttcca cggggatgct ggtgcttttc tttgccctgc atgtgtgtga tgaggtgaac
     2041 gtgtacgggt tcggggccga cagccggggc aactggcacc actactggga gaacaaccgg
     2101 tacgcgggcg agttccggaa gactggcgtg cacgacgcgg acttcgaggc ccacatcatc
     2161 gacatgctgg ccaaggccag caagatcgaa gtctaccggg gcaactgagc cgggcctcgc
     2221 cgcgaccctt ccggcccatc tatcgggcac cggggctccg gcccgggacc caggaccagc
     2281 aacccgcgac caatcatgct gcagcccagg ggcgtctgct gtgccccgcc aatcacgaga
     2341 ctgggggacc ggccgggcct ggcaccaatc tgcgctgcgg tcgggcggag cttctgtttc
     2401 tcccagccaa tcatgtgact caaggaaaac ttccggcgct gtgtccagtc tcctccaatc
     2461 aatggccttc gggggcgggc cagcggccgc tcaatcccca ctccctcatg ctttgggtta
     2521 gggttttctt tcacgctttc tgaggaggag agcatggcgc gggcctcggc gaagcacttc
     2581 cgtcagcctc gggcggagga tcgtcttagt agctggccag acctggagga gagcgggcgg
     2641 tctttgcggg cctcaggaga taggtggccg cccggcccct ttccccgcct gcccggatag
     2701 gtgcgtgcag acccaccaaa gaaaagcggt cgctgcggga cccccagtcc cacctcggcc
     2761 gcgctgtggg atggctgcgc ccccagggct tcctgcgtct ccaggaagcc gggagtggcg
     2821 ccctctgcgg ggtggggtgc tcccgggccg aactccggac aggtggaggg gacagggcag
     2881 agctcgagga agccctgtcc ccttcagtgc aaggtgctgt cactcacgtg tgccctcgac
     2941 cctcccgttc acccgcagcc ttctcagcgc ctctccctgg gccggaggcc tcctcaccag
     3001 cctacctgtt gctctggaaa aaaatcccgt cccccgactc cgtccctacc cccagtcttc
     3061 ggccggctct ggcccctggg gagggggctg cacggcggaa ggaggctggc tatgggcccg
     3121 gctgcccgct gcatgtacct cctcctccac ccatcgcctc ttgcctgggg gtaactttgc
     3181 ctggggctca ttctttggtt aagctgaagc tgccgtgggt ggccaaaccg cagattcttt
     3241 gcaaattctg agctggcaga gctcgcagcc gggagccggc cggggaagag gagacttgcg
     3301 cgccgcaagc cgcctgcctc caccctgctc tccatctccc gctctagaag ggctgggaag
     3361 ctcgcggccg gggttccacc tggaagctgc ttgcatggct gaacccagct taggtccctg
     3421 acggggctgc tggtggaatt ctcccccttc gaagctgggg aggtttagga gggggaaggc
     3481 ttctgtgaag ctctcaaacc actaatagag ccccctcccc aacagtgacg gcgcagatgc
     3541 tccccctttt cttagttgac accaccaggc agcttcctgg ccgttggtag gttcctgcag
     3601 ctggctgagg gaacagggac cggcagggga ctttgttagg ggagggttgg gatgggcagt
     3661 gggcccctga aagttaatat attggaacct agctcgagtg tcgttctttc caattccgaa
     3721 agtagaaaga gtaaaaatag gggtgattgg ggtggggtta gtagaatgcc tctctcaggg
     3781 cgctcccccc tcccccaccg ttttagagag ctaggcctca gccagtcttg ccactcccat
     3841 ctcagtgctt cctgaagagg ctgttttgag tgttgatgaa aagcaatgca attatgccaa
     3901 acagtattga gcagaataat ttatttcttt tttttctttt gctttaaatc atgaatcccg
     3961 ccaggtacgg tggctcacac ctgtcatccc agcactttgg gaggccaagg cgggcggatt
     4021 acttaatact taaggtcagg agttcgagac cagcctggcc aatatggtga aacctcgtct
     4081 ctaccaaaaa aaaaaaaaaa tacaaaaatt agccaggcgc agtggtgcgc acctgtaatc
     4141 ccagctactt ggaaggctga ggcaggagaa tcccttgaac cgaggaggcg aaggttgcag
     4201 tgagccgaga ttgtgccact gcactccagc ctgggcgaca gagcaagacc ctgtctcaaa
     4261 aaaattaaat catgaatccc catcctggaa gaggtaggtc ccagcatcca gccagatttt
     4321 ctgcaatagt aatttaaaca cactttttta tttccttccc tttctgaatt aaaaggaaca
     4381 aaaaactgtc tagtccttca ttgttctgaa atgggcatga tggaagaagg cgggtctggt
     4441 aggatagctg tgactgataa tggctgagaa cgttggggga tatgggaggg gcgagatgac
     4501 tcccagatac cctcccccac ctatacagga ggcacctcat tcctggactc tgcgctccaa
     4561 gacactgaaa tctgagcggg tacaagcatt ttggttaaaa atcagctcgt tgtcgcctct
     4621 tgagtttcct ccaggagagg agttcattgg agaggattcc tggtagcagc tcctcgcagt
     4681 ggctgtcctg taaccacttt ggcctctgtc aacatgatgt ctccaggtat ccatcaggct
     4741 ccgatacatt tgggtggcca caggctgggc tgtccccacc tctcagggaa gtgcatctaa
     4801 gtcaggtttt cccctctggc acagccctgc ctccacagcc caatttccac catgccacag
     4861 gcaacccgca tttttattta tttaatttat ttatttattg agacagagtc ttgttctgtt
     4921 acccaggctg gagtgcaatg gcccgatgtc ggctcatccc aacctccacc tcctgggttc
     4981 aagcgattct tctgcctcag gagagtaggg agtagctggg attacaggca tgcaccacca
     5041 ctcccggata attttatatt tttagtagag acgggttttc tccatgttgg tcaggctagt
     5101 cttgaactcc agacctcagg tgatctgccc gcctcggcct cccaaagtgc tgggattaca
     5161 ggcgtgagcc agtgtgcctg gccgattttt tttttttgag actgattctc actctcgccc
     5221 aggctggagt gcagtggtgg gatctcggct cattgcaagc tccgcctccc gggttcacgc
     5281 cattctcctg cctcagtctc ccgagtagct gagactacag gtgaccgcca cgatgcccgg
     5341 cagttttttt gtatttttag tagagacggg gtttcactgt tagccaggat ggtctccatc
     5401 tcctgacctc gtgatctccc cgcctcagcc tcccaaagtg ctgggattac aggcgtgagc
     5461 caccgcgcct ggcttttttt tttttttttt tttgagatgg agtcttgctc tgtcacccag
     5521 gctggagtgc agtggcgcga tcttggctca ctgcaacctc cgcctcccaa gttcacccac
     5581 ctcaacctcc cgagtagctg gaattacagg ggtgtgccac cacacccagc taatttttgt
     5641 atttttagta gagacggggt ttcaccatgt tggccaggct ggtctcgaac tcctgaccac
     5701 aggtcatcca ccccctttgg cctcccaatg tttgaccaca cccagcccat aatagatttt
     5761 taaaactcct ataaatatca ttctacttcc ctttattgct aaaatgggag ctttttcatc
     5821 cagttttttg ggtgtgttcc aaatattttg ttaaatttcc cgtctattgc tgttattgtt
     5881 tccatttatt tgcccatgtg agttgatacc tttttcattc ctttcccata gctttagtga
     5941 cgttgtggga agggaagtta ggtaagtgat gtttcatctt gtacttacta gacacctttt
     6001 tcttccttga tttcctgagt tccctgcctc cacaggtgtg tttcactcct ggttgcttat
     6061 atttttttat ttttgagatg gagttttgct ctgttgacca ggctggagtg cagtggcatg
     6121 atctcggctc actgcaacct gtgcctcctg ggttcaagcg attctcctgc ctcagccacc
     6181 caaatagctg ggattacaga tgcgcaccac catgcccagc taatttttgt atttttagta
     6241 gagacggggt ttcaccatgt tggccaggct ggtcttgaac tcctgacctc gtgatctgcc
     6301 caccttggcc tcccaaggtg ctggcattac aggtgtgagc caccgtgccc ggcctctggt
     6361 tgcttattta acccctttgt cacgatggag gcttttctct tttttttttt tttttttcag
     6421 atggagtctc tctccattgc ccaggctgga atgcagtggt gctatgtccg ctcactgcaa
     6481 gctccgcctc ccgggttcac accattctcc tgtctcagcc tcctgagtag ctgggattac
     6541 aggcatgcac taccacgccc ggctaatttt gtatttttag tagagacggg gtttctccat
     6601 gttggtcagg ctggtcttga actcctgacg tcaggtgatc cgcctgcctt ggcctcccaa
     6661 atggtaggat tacaggcgtg agccaccaga cccttttttt tttttttttt ttttttttaa
     6721 gagacagggt ctcctgtcgc ccagactggt gcagagctca ctgcagcctc aaaaactcct
     6781 ggattcaagt gatcctccca cctcagcctc cagagcagct agagcctagc taaaaaattt
     6841 tttaaaaaca ttttatggcc aggcacggtg gctcatgcct ataatcccag cattttggga
     6901 ggctgaggca ggtgaatcac gaggtcagga gttcaagacc agcctggcca agatggtgaa
     6961 accccgtctc tactaaaaat acaaaaaatt ggccaggctt agtggcagac ggctgtgatc
     7021 ccagctactc gggagaccga ggcagagaat tgcttgaacc tgggaggtgg aagttgtggt
     7081 gagccgagat tgagccactg cactccagcc tgagcgacag agtaagactc cgtctcaaaa
     7141 aaaaaaaagt attttaccca tccacaggca gcagacaagg aagtaccttc tgtgactgtc
     7201 tggcaaggtc agaggcatca gggaaggtaa aatactgaaa ctatattttt aaaaataaaa
     7261 gtattccctt ttgagtgtga attaggaatc aatgcccctt ctcactactt ttgtgaaaaa
     7321 aatcacagct cctgcagcaa gtctatgcct gggtaacaac caacccacaa aatccaagag
     7381 gaggtccccc tctcccgcct ctgtgaggct tgaggagcag tatgtatctg ggccagcctg
     7441 gtcctcagag tgtggaatta acacctttcc tctagcaact gtttgtgctg ctgagaacag
     7501 cacagactct ctggcagcct ggttctctcc agagggaagc ctgtgaagca gaagaaacat
     7561 atggcatctg cactcagggc gcccagttcc atccggcctt gctataaaat gactttgcct
     7621 ttcctttttt aaaattacaa aaataattca accaatacat aaacatatga agtgaatcac
     7681 ggagggcctt cctgcgatat ctttttttgc ctaccatttg tcatggaatg ggtaaagggg
     7741 accacagagg gaagagacgc tgccccttcg cagggccatg gcagtcccct gggctgcgtc
     7801 tccacggtgc ttcctgtgaa acgctgttac cacgggcacc gcactggaga ccatgaaagg
     7861 gaagagtttg acatctcagc tgtctttgct ataaatagaa ataaataaac cttaactaag
//
