LOCUS       NM_001199760            2268 bp    mRNA    linear   PRI 15-FEB-2024
DEFINITION  Homo sapiens ST20-MTHFS readthrough (ST20-MTHFS), mRNA.
ACCESSION   NM_001199760
VERSION     NM_001199760.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2268)
  AUTHORS   Teumer,A., Holtfreter,B., Volker,U., Petersmann,A., Nauck,M.,
            Biffar,R., Volzke,H., Kroemer,H.K., Meisel,P., Homuth,G. and
            Kocher,T.
  TITLE     Genome-wide association study of chronic periodontitis in a general
            German population
  JOURNAL   J Clin Periodontol 40 (11), 977-985 (2013)
   PUBMED   24024966
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK002935.1 and AC021483.11.
            
            On Aug 13, 2020 this sequence version replaced NM_001199760.1.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring suppressor of tumorigenicity
            20 and 5,10-methenyltetrahydrofolate synthetase
            (5-formyltetrahydrofolate cyclo-ligase) genes on chromosome 15. The
            read-through transcript produces a fusion protein that shares
            sequence identity with each individual gene product. [provided by
            RefSeq, Dec 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK002935.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2142348,
                                           SAMEA2145245 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 10588, 400410
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 CK002935.1         18-26
            10-484              CK002935.1         28-502
            485-2268            AC021483.11        135089-136872       c
FEATURES             Location/Qualifiers
     source          1..2268
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.1"
     gene            1..2268
                     /gene="ST20-MTHFS"
                     /gene_synonym="MTHFS"
                     /note="ST20-MTHFS readthrough"
                     /db_xref="GeneID:100528021"
                     /db_xref="HGNC:HGNC:44655"
     exon            1..54
                     /gene="ST20-MTHFS"
                     /gene_synonym="MTHFS"
                     /inference="alignment:Splign:2.1.0"
     exon            55..110
                     /gene="ST20-MTHFS"
                     /gene_synonym="MTHFS"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..605
                     /gene="ST20-MTHFS"
                     /gene_synonym="MTHFS"
                     /EC_number="6.3.3.2"
                     /note="5-formyltetrahydrofolate cyclo-ligase;
                     5,10-methenyl-tetrahydrofolate synthetase; Methenyl-THF
                     synthetase"
                     /codon_start=1
                     /product="ST20-MTHFS protein"
                     /protein_id="NP_001186689.1"
                     /db_xref="GeneID:100528021"
                     /db_xref="HGNC:HGNC:44655"
                     /translation="MARSRLTATSVSQVQVIAHSEYQKSKRISIFLSMQDEIETEEII
                     KDIFQRGKICFIPRYRFQSNHMDMVRIESPEEISLLPKTSWNIPQPGEGDVREEALST
                     GGLDLIFMPGLGFDKHGNRLGRGKGYYDAYLKRCLQHQEVKPYTLALAFKEQICLQVP
                     VNENDMKVDEVLYEDSSTA"
     exon            111..372
                     /gene="ST20-MTHFS"
                     /gene_synonym="MTHFS"
                     /inference="alignment:Splign:2.1.0"
     exon            373..2268
                     /gene="ST20-MTHFS"
                     /gene_synonym="MTHFS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      752..757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST20-MTHFS"
                     /gene_synonym="MTHFS"
                     /note="hexamer: TATAAA"
     polyA_site      775
                     /gene="ST20-MTHFS"
                     /gene_synonym="MTHFS"
                     /note="major polyA site"
     regulatory      801..806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST20-MTHFS"
                     /gene_synonym="MTHFS"
                     /note="hexamer: ATTAAA"
     polyA_site      839
                     /gene="ST20-MTHFS"
                     /gene_synonym="MTHFS"
     regulatory      2248..2253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST20-MTHFS"
                     /gene_synonym="MTHFS"
                     /note="hexamer: AGTAAA"
     polyA_site      2268
                     /gene="ST20-MTHFS"
                     /gene_synonym="MTHFS"
ORIGIN      
        1 ggacgtcccg gaggatccct ctggtcgggc gcctggcttt gtgtagccag ccaggctgga
       61 gtgcaatggc gcgatctcgg ctcactgcaa cctctgtctc ccaggttcag gtgattgccc
      121 acagtgagta tcaaaagtcc aaaagaattt ccatctttct gagcatgcaa gatgaaattg
      181 agacagaaga gatcatcaag gacattttcc aacgaggcaa aatctgcttc atccctcggt
      241 accggttcca gagcaatcac atggatatgg tgagaataga atcaccagag gaaatttctt
      301 tacttcccaa aacatcctgg aatatccctc agcctggtga gggtgatgtt cgggaggagg
      361 ccttgtccac agggggactt gatctcatct tcatgccagg ccttgggttt gacaaacatg
      421 gcaaccgact ggggaggggc aagggctact atgatgccta tctgaagcgc tgtttgcagc
      481 atcaggaagt gaagccctac accctggcgt tggctttcaa agaacagatt tgcctccagg
      541 tcccagtgaa tgaaaacgac atgaaggtag atgaagtcct ttacgaagac tcgtcaacag
      601 cttaaatctg gattactaca gccaaataat cagtgtttta tatgagagta aagcaaagta
      661 tgtgtatttt tcccttgtca aaaattagtt gaaattgttc attaatgtga atacagactg
      721 cattttaaaa ttgtaattat gaaatacctt atataaaacc atctttaaaa accaatagaa
      781 gtgtgaatag tagaatatta attaaaatgg aggctatcag cctgtgattt tcagcttaac
      841 ttcctggtgt taatgtgaca agttgatctg tctactttgc aatttaagtt aaatatttat
      901 gaggaactgt gctccgactg agtgcgagag gaaggtaaac ttgcgggagt gggcactgta
      961 tttcattacg cctttcatga cctggtctgt cctggcaggc acatggagac ttggggacta
     1021 ttaatttatt tgttggtatt tgctttggat acagaattcc ctaagaatat tatctcactt
     1081 catcatgact tcctttaccc actctagaat tttatgttgg acactttgta gcttttggtg
     1141 gttagtggag ggaaaccttt tatgatttaa atacttttac tccactgatt ggttaccatc
     1201 actgcatgta tcagcccttg atgagtttaa gatctagtat cttataagtt agaaattatt
     1261 tctgtttact catggtttct gctttggaaa tgaaatttgc tgtgagttga aagttggcag
     1321 atggcaacac agctagggag caataatttt gttgtgggga ggatttggtc atctccagaa
     1381 acccgggagt cacgtggctc tcttactcac actccatgtc catcctgtca ccaggtcttg
     1441 ttgattttgc ctctgaaatg cctcttaaat ctattctctc ctttcaattt tcctgtcact
     1501 ccttttgtcc agccttttag catttctaag ctggactagg cgagagtgtc acacctgctt
     1561 cccttggctt ccatcttgcc tcttccagtt tatttctcaa gctgcagtca aactgatctt
     1621 agaaaacacg aatctaatca tgcagcaccc ctgactaagg tcttccggtg gctgttcaga
     1681 gcctcttggg tagcaaacag atggcttctg ttgtatacaa agccccttaa gagaggtctc
     1741 ctcatctact ttttctagcc tcttctctcc caactctgta ttctcctgta acactgactg
     1801 agcactgcag gcttctgccc tttgcacata gtaagcatgc atttctctct gtctgaaatg
     1861 ctctttctgt tgttcatcta gaagactgtt ttcccttgaa gactcagccc tagcatcacc
     1921 tcttctgtga agtcttctgc tactttccca agcagagtga gtgttccttc ccttgtctga
     1981 gtggccttgg ccattgatgt gcttatcatg ttgtcttacg tatcaaatta tttgttgtca
     2041 tatctgtccc cttcaccata ctgtgagctc caaagaaaag aagtgatctt tatacttctt
     2101 atgcttagta cacaactaga catatagtgt gtgtgtgaga gagagaattt tttaatgaaa
     2161 taattgaata cattggaagt gtttcattca aaatactcat ccattattct ttggatagta
     2221 gcataaattt gatgttttat gtacaaaagt aaaaacattt gaaaaata
//
