LOCUS       NM_001352881            1882 bp    mRNA    linear   PRI 03-JUN-2024
DEFINITION  Homo sapiens ST18 C2H2C-type zinc finger transcription factor
            (ST18), transcript variant 57, mRNA.
ACCESSION   NM_001352881
VERSION     NM_001352881.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1882)
  AUTHORS   Assaf,S., Vodo,D., Malovitski,K., Mohamad,J., Bergson,S.,
            Feller,Y., Malki,L., Sarig,O. and Sprecher,E.
  TITLE     Up-regulation of ST18 in pemphigus vulgaris drives a
            self-amplifying p53-dependent pathomechanism resulting in decreased
            desmoglein 3 expression
  JOURNAL   Sci Rep 12 (1), 5958 (2022)
   PUBMED   35396567
  REMARK    GeneRIF: Up-regulation of ST18 in pemphigus vulgaris drives a
            self-amplifying p53-dependent pathomechanism resulting in decreased
            desmoglein 3 expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1882)
  AUTHORS   Skou,A.S., Juul-Dam,K.L., Hansen,M., Lausen,B., Stratmann,S.,
            Holmfeldt,L., Aggerholm,A., Nyvold,C.G., Ommen,H.B. and Hasle,H.
  TITLE     Measurable Residual Disease Monitoring of SPAG6, ST18, PRAME, and
            XAGE1A Expression in Peripheral Blood May Detect Imminent Relapse
            in Childhood Acute Myeloid Leukemia
  JOURNAL   J Mol Diagn 23 (12), 1787-1799 (2021)
   PUBMED   34600138
  REMARK    GeneRIF: Measurable Residual Disease Monitoring of SPAG6, ST18,
            PRAME, and XAGE1A Expression in Peripheral Blood May Detect
            Imminent Relapse in Childhood Acute Myeloid Leukemia.
REFERENCE   3  (bases 1 to 1882)
  AUTHORS   Kim,B.H., Nho,K. and Lee,J.M.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     Genome-wide association study identifies susceptibility loci of
            brain atrophy to NFIA and ST18 in Alzheimer's disease
  JOURNAL   Neurobiol Aging 102, 200 (2021)
   PUBMED   33640202
  REMARK    GeneRIF: Genome-wide association study identifies susceptibility
            loci of brain atrophy to NFIA and ST18 in Alzheimer's disease.
REFERENCE   4  (bases 1 to 1882)
  AUTHORS   Assaf,S., Malki,L., Mayer,T., Mohamad,J., Peled,A., Pavlovsky,M.,
            Malovitski,K., Sarig,O., Vodo,D. and Sprecher,E.
  TITLE     ST18 affects cell-cell adhesion in pemphigus vulgaris in a tumour
            necrosis factor-alpha-dependent fashion
  JOURNAL   Br J Dermatol 184 (6), 1153-1160 (2021)
   PUBMED   33205400
  REMARK    GeneRIF: ST18 affects cell-cell adhesion in pemphigus vulgaris in a
            tumour necrosis factor-alpha-dependent fashion.
REFERENCE   5  (bases 1 to 1882)
  AUTHORS   Radeva,M.Y., Walter,E., Stach,R.A., Yazdi,A.S., Schlegel,N.,
            Sarig,O., Sprecher,E. and Waschke,J.
  TITLE     ST18 Enhances PV-IgG-Induced Loss of Keratinocyte Cohesion in
            Parallel to Increased ERK Activation
  JOURNAL   Front Immunol 10, 770 (2019)
   PUBMED   31057535
  REMARK    GeneRIF: ST18 Enhances PV-IgG-Induced Loss of Keratinocyte Cohesion
            in Parallel to Increased ERK Activation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1882)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 1882)
  AUTHORS   Yang,J., Siqueira,M.F., Behl,Y., Alikhani,M. and Graves,D.T.
  TITLE     The transcription factor ST18 regulates proapoptotic and
            proinflammatory gene expression in fibroblasts
  JOURNAL   FASEB J 22 (11), 3956-3967 (2008)
   PUBMED   18676404
  REMARK    GeneRIF: Fibroblasts that overexpress ST18 by transient
            transfection exhibit significantly increased apoptosis and
            increased expression of TNF-alpha, interleukin (IL) -1alpha, and
            IL-6.
REFERENCE   8  (bases 1 to 1882)
  AUTHORS   Jandrig,B., Seitz,S., Hinzmann,B., Arnold,W., Micheel,B.,
            Koelble,K., Siebert,R., Schwartz,A., Ruecker,K., Schlag,P.M.,
            Scherneck,S. and Rosenthal,A.
  TITLE     ST18 is a breast cancer tumor suppressor gene at human chromosome
            8q11.2
  JOURNAL   Oncogene 23 (57), 9295-9302 (2004)
   PUBMED   15489893
  REMARK    GeneRIF: ectopic ST18 expression in MCF-7 breast cancer cells
            strongly inhibits colony formation in soft agar and the formation
            of tumors in a xenograft mouse model
REFERENCE   9  (bases 1 to 1882)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol Vis 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1882)
  AUTHORS   Yee,K.S. and Yu,V.C.
  TITLE     Isolation and characterization of a novel member of the neural zinc
            finger factor/myelin transcription factor family with
            transcriptional repression activity
  JOURNAL   J Biol Chem 273 (9), 5366-5374 (1998)
   PUBMED   9478997
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC103831.4 and AC021915.11.
            
            Transcript Variant: This variant (57) encodes isoform g. Variants
            55-58 all encode isoform g.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.134054.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-198               AC103831.4         11550-11747
            199-323             AC103831.4         11977-12101
            324-1882            AC021915.11        147214-148772       c
FEATURES             Location/Qualifiers
     source          1..1882
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q11.23"
     gene            1..1882
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /note="ST18 C2H2C-type zinc finger transcription factor"
                     /db_xref="GeneID:9705"
                     /db_xref="HGNC:HGNC:18695"
                     /db_xref="MIM:617155"
     exon            1..198
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..288
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /note="isoform g is encoded by transcript variant 57; zinc
                     finger protein 387; suppression of tumorigenicity 18
                     (breast carcinoma) (zinc finger protein); suppression of
                     tumorigenicity 18, zinc finger; neural zinc finger
                     transcription factor 3; ST18, C2H2C-type zinc finger;
                     suppression of tumorigenicity 18 protein"
                     /codon_start=1
                     /product="suppression of tumorigenicity 18 protein isoform
                     g"
                     /protein_id="NP_001339810.1"
                     /db_xref="GeneID:9705"
                     /db_xref="HGNC:HGNC:18695"
                     /db_xref="MIM:617155"
                     /translation="MEPFCREKGRMFLTECDLRGILEKIIKFLNGAAWRNPKRNSIRA
                     FWNTSRKR"
     exon            199..323
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            324..1882
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcttgttcg ctcactctca gtgaaaagag ttttgaaatg agttctgaat agacagcatt
       61 ttctttgtgc ggttggtaaa taacacagag caaagttagc aagttgcagc gcctctgcgt
      121 tctgattcta tggaaccttt ttgtagggag aagggcagga tgtttttaac tgaatgtgac
      181 ctcaggggaa tactagagaa aataataaaa tttctgaatg gggcagcgtg gagaaatcct
      241 aagagaaata gcataagagc attttggaac acatccagga aaagataact ttcgacacac
      301 ctgtagacgt tcgccaggta aaggagtgat ggaaactctc cagttcagat ccagtagctt
      361 ttagggaagg taagtaaaag ctatttaaaa ataaactttt cccccaaaga aaaagaatct
      421 ccaacttttc aacatccatc aaaaacctga gaagttaagg aacttcattt tagaggacca
      481 gaaaagatgc ttgctttggt tattgttggc atcctcatgg taatttgggt tatgttcata
      541 tagatttttg aggagtgttt acacctgttc atcctgattc atgacttcat atgtttgata
      601 ttaggggcat taatatgtaa gacattcaga attaacatgt atgattttaa aatgtggtag
      661 acaggataaa gtacccctcc ccaaaatatc catgaaatct ctgaaatctg tgattatgtt
      721 atcttgcatg acaaaaggga tgtgatttaa tgaagacctt tgagattatc ctatttttct
      781 aaaaaaggcc aactaatcac atggtccttc agaaaaaggc caaagaatga gttagggaga
      841 tgagatgtga gcaggactca acattacccg ccattgctgg tgttgaaaat ggaggaagca
      901 ggccattcac cgaaaaagga gtgggctgtg gaagctggga atggctctca gtttacaacc
      961 tgcaagaaaa cagggacctc agtcctatga cagcaaggaa ctggattcca ccaacagccc
     1021 aatgagtgag gaaatgcatt ctcccttgga gcctccagaa tggaatgtag cttaacttgg
     1081 ttttagtctg gtgagaccgt atcagacttt ggacctccaa aactgtaaga cctttgtgcc
     1141 tttttaagcc atcaaatttg taaaaatttg ttatggcagc aatagaaaac taatacatag
     1201 aataagccca ccaatagatg ggacatattt tgcagctggc agtctgaatc ctatgagtaa
     1261 attcctgtat ttgaatgaag agaaaatgtt cttgagaggc taagactgat agtctgtaag
     1321 aattggaata ttgattttgt tgatccaaat gatagttatt gccaactcag agagttctgt
     1381 tttctacttt gtgacacccc ttcttcatca gaaattcttt atatgatata tttgtaaatg
     1441 caatacctgt gtcactcaag gtacaaatga gtacatgctt tattggactt tttagtgagt
     1501 ccatgtttac ctaagcattg ctgagtggaa tggaacatcg aggggtagaa ggccaggtct
     1561 ctgctgcaga gacctgacag tcaaagaatg ccgagtctag tgtttgaaag cagatggtgg
     1621 ccatgtgaat cctggttcta cctctttcta cctgtgtgaa ccccgggtaa ggtggtgagc
     1681 tcaatttcct tccttttctc atatgtaaca tcaataatac ttccccacag gcatggtaag
     1741 atgactaagt aagatagtac atacaaattc tcacaagagt gcctgccact ctgtgagttt
     1801 ggcaaaggtg aggtgtattt atttagaaac tactgtgccg cctcaccatt ttgattaaaa
     1861 aaataaattg gttttgtctt ta
//
