LOCUS       NM_001352845            6067 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens ST18 C2H2C-type zinc finger transcription factor
            (ST18), transcript variant 21, mRNA.
ACCESSION   NM_001352845 XM_011517636
VERSION     NM_001352845.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6067)
  AUTHORS   Assaf,S., Vodo,D., Malovitski,K., Mohamad,J., Bergson,S.,
            Feller,Y., Malki,L., Sarig,O. and Sprecher,E.
  TITLE     Up-regulation of ST18 in pemphigus vulgaris drives a
            self-amplifying p53-dependent pathomechanism resulting in decreased
            desmoglein 3 expression
  JOURNAL   Sci Rep 12 (1), 5958 (2022)
   PUBMED   35396567
  REMARK    GeneRIF: Up-regulation of ST18 in pemphigus vulgaris drives a
            self-amplifying p53-dependent pathomechanism resulting in decreased
            desmoglein 3 expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6067)
  AUTHORS   Skou,A.S., Juul-Dam,K.L., Hansen,M., Lausen,B., Stratmann,S.,
            Holmfeldt,L., Aggerholm,A., Nyvold,C.G., Ommen,H.B. and Hasle,H.
  TITLE     Measurable Residual Disease Monitoring of SPAG6, ST18, PRAME, and
            XAGE1A Expression in Peripheral Blood May Detect Imminent Relapse
            in Childhood Acute Myeloid Leukemia
  JOURNAL   J Mol Diagn 23 (12), 1787-1799 (2021)
   PUBMED   34600138
  REMARK    GeneRIF: Measurable Residual Disease Monitoring of SPAG6, ST18,
            PRAME, and XAGE1A Expression in Peripheral Blood May Detect
            Imminent Relapse in Childhood Acute Myeloid Leukemia.
REFERENCE   3  (bases 1 to 6067)
  AUTHORS   Kim,B.H., Nho,K. and Lee,J.M.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     Genome-wide association study identifies susceptibility loci of
            brain atrophy to NFIA and ST18 in Alzheimer's disease
  JOURNAL   Neurobiol Aging 102, 200 (2021)
   PUBMED   33640202
  REMARK    GeneRIF: Genome-wide association study identifies susceptibility
            loci of brain atrophy to NFIA and ST18 in Alzheimer's disease.
REFERENCE   4  (bases 1 to 6067)
  AUTHORS   Assaf,S., Malki,L., Mayer,T., Mohamad,J., Peled,A., Pavlovsky,M.,
            Malovitski,K., Sarig,O., Vodo,D. and Sprecher,E.
  TITLE     ST18 affects cell-cell adhesion in pemphigus vulgaris in a tumour
            necrosis factor-alpha-dependent fashion
  JOURNAL   Br J Dermatol 184 (6), 1153-1160 (2021)
   PUBMED   33205400
  REMARK    GeneRIF: ST18 affects cell-cell adhesion in pemphigus vulgaris in a
            tumour necrosis factor-alpha-dependent fashion.
REFERENCE   5  (bases 1 to 6067)
  AUTHORS   Radeva,M.Y., Walter,E., Stach,R.A., Yazdi,A.S., Schlegel,N.,
            Sarig,O., Sprecher,E. and Waschke,J.
  TITLE     ST18 Enhances PV-IgG-Induced Loss of Keratinocyte Cohesion in
            Parallel to Increased ERK Activation
  JOURNAL   Front Immunol 10, 770 (2019)
   PUBMED   31057535
  REMARK    GeneRIF: ST18 Enhances PV-IgG-Induced Loss of Keratinocyte Cohesion
            in Parallel to Increased ERK Activation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6067)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 6067)
  AUTHORS   Yang,J., Siqueira,M.F., Behl,Y., Alikhani,M. and Graves,D.T.
  TITLE     The transcription factor ST18 regulates proapoptotic and
            proinflammatory gene expression in fibroblasts
  JOURNAL   FASEB J 22 (11), 3956-3967 (2008)
   PUBMED   18676404
  REMARK    GeneRIF: Fibroblasts that overexpress ST18 by transient
            transfection exhibit significantly increased apoptosis and
            increased expression of TNF-alpha, interleukin (IL) -1alpha, and
            IL-6.
REFERENCE   8  (bases 1 to 6067)
  AUTHORS   Jandrig,B., Seitz,S., Hinzmann,B., Arnold,W., Micheel,B.,
            Koelble,K., Siebert,R., Schwartz,A., Ruecker,K., Schlag,P.M.,
            Scherneck,S. and Rosenthal,A.
  TITLE     ST18 is a breast cancer tumor suppressor gene at human chromosome
            8q11.2
  JOURNAL   Oncogene 23 (57), 9295-9302 (2004)
   PUBMED   15489893
  REMARK    GeneRIF: ectopic ST18 expression in MCF-7 breast cancer cells
            strongly inhibits colony formation in soft agar and the formation
            of tumors in a xenograft mouse model
REFERENCE   9  (bases 1 to 6067)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol Vis 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 6067)
  AUTHORS   Yee,K.S. and Yu,V.C.
  TITLE     Isolation and characterization of a novel member of the neural zinc
            finger factor/myelin transcription factor family with
            transcriptional repression activity
  JOURNAL   J Biol Chem 273 (9), 5366-5374 (1998)
   PUBMED   9478997
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC021915.11.
            
            On Aug 13, 2020 this sequence version replaced NM_001352845.1.
            
            Transcript Variant: This variant (21) encodes isoform a. Variants
            1-33 all encode isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.44526.1,
                                           SRR1660809.135158.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AC021915.11        172945-173043       c
            100-145             AC021915.11        148727-148772       c
            146-299             AC021915.11        140335-140488       c
            300-407             AC021915.11        139436-139543       c
            408-563             AC021915.11        136441-136596       c
            564-618             AC021915.11        132898-132952       c
            619-649             AC021915.11        130774-130804       c
            650-840             AC021915.11        98817-99007         c
            841-1632            AC021915.11        90487-91278         c
            1633-1767           AC021915.11        85547-85681         c
            1768-1858           AC021915.11        83830-83920         c
            1859-1963           AC021915.11        82681-82785         c
            1964-2157           AC021915.11        80070-80263         c
            2158-2369           AC021915.11        77593-77804         c
            2370-2615           AC021915.11        68427-68672         c
            2616-2731           AC021915.11        61625-61740         c
            2732-2794           AC021915.11        56116-56178         c
            2795-2863           AC021915.11        55285-55353         c
            2864-2926           AC021915.11        51934-51996         c
            2927-3007           AC021915.11        51752-51832         c
            3008-3229           AC021915.11        50653-50874         c
            3230-3318           AC021915.11        44747-44835         c
            3319-3422           AC021915.11        37033-37136         c
            3423-3566           AC021915.11        34970-35113         c
            3567-6067           AC021915.11        29533-32033         c
FEATURES             Location/Qualifiers
     source          1..6067
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q11.23"
     gene            1..6067
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /note="ST18 C2H2C-type zinc finger transcription factor"
                     /db_xref="GeneID:9705"
                     /db_xref="HGNC:HGNC:18695"
                     /db_xref="MIM:617155"
     exon            1..99
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            100..145
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            146..299
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            300..407
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            408..563
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     CDS             564..3707
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /note="isoform a is encoded by transcript variant 21; zinc
                     finger protein 387; suppression of tumorigenicity 18
                     (breast carcinoma) (zinc finger protein); suppression of
                     tumorigenicity 18, zinc finger; neural zinc finger
                     transcription factor 3; ST18, C2H2C-type zinc finger;
                     suppression of tumorigenicity 18 protein"
                     /codon_start=1
                     /product="suppression of tumorigenicity 18 protein isoform
                     a"
                     /protein_id="NP_001339774.1"
                     /db_xref="CCDS:CCDS6149.1"
                     /db_xref="GeneID:9705"
                     /db_xref="HGNC:HGNC:18695"
                     /db_xref="MIM:617155"
                     /translation="MDAEAEDKTLRTRSKGTEVPMDSLIQELSVAYDCSMAKKRTAED
                     QALGVPVNKRKSLLMKPRHYSPKADCQEDRSDRTEDDGPLETHGHSTAEEIMIKPMDE
                     SLLSTAQENSSRKEDRYSCYQELMVKSLMHLGKFEKNVSVQTVSENLNDSGIQSLKAE
                     SDEADECFLIHSDDGRDKIDDSQPPFCSSDDNESNSESAENGWDSGSNFSEETKPPRV
                     PKYVLTDHKKDLLEVPEIKTEGDKFIPCENRCDSETERKDPQNALAEPLDGNAQPSFP
                     DVEEEDSESLAVMTEEGSDLEKAKGNLSLLEQAIALQAERGCVFHNTYKELDRFLLEH
                     LAGERRQTKVIDMGGRQIFNNKHSPRPEKRETKCPIPGCDGTGHVTGLYPHHRSLSGC
                     PHKVRVPLEILAMHENVLKCPTPGCTGRGHVNSNRNTHRSLSGCPIAAAEKLAMSQDK
                     NQLDSPQTGQCPDQAHRTSLVKQIEFNFPSQAITSPRATVSKEQEKFGKVPFDYASFD
                     AQVFGKRPLIQTVQGRKTPPFPESKHFPNPVKFPNRLPSAGAHTQSPGRASSYSYGQC
                     SEDTHIAAAAAILNLSTRCREATDILSNKPQSLHAKGAEIEVDENGTLDLSMKKNRIL
                     DKSAPLTSSNTSIPTPSSSPFKTSSILVNAAFYQALCDQEGWDTPINYSKTHGKTEEE
                     KEKDPVSSLENLEEKKFPGEASIPSPKPKLHARDLKKELITCPTPGCDGSGHVTGNYA
                     SHRSVSGCPLADKTLKSLMAANSQELKCPTPGCDGSGHVTGNYASHRSLSGCPRARKG
                     GVKMTPTKEEKEDPELKCPVIGCDGQGHISGKYTSHRTASGCPLAAKRQKENPLNGAS
                     LSWKLNKQELPHCPLPGCNGLGHVNNVFVTHRSLSGCPLNAQVIKKGKVSEELMTIKL
                     KATGGIESDEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENKLIE
                     QNNESLLKELAGLSQALISSLADIQLPQMGPISEQNFEAYVNTLTDMYSNLERDYSPE
                     CKALLESIKQAVKGIHV"
     exon            564..618
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            619..649
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            650..840
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1632
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1767
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1858
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..1963
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2157
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2369
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2615
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..2731
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2794
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..2863
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2864..2926
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2927..3007
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3008..3229
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3230..3318
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3319..3422
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3423..3566
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3567..6067
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6050..6055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /note="hexamer: AATAAA"
     polyA_site      6067
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /note="major polyA site"
ORIGIN      
        1 gtcatatcat gggaactacc tttcaaagaa acagctttag tgtttccgtt cagcccacca
       61 gggaggagag aaatataagt tttggaaaca aacaaaaaag agtgatggaa actctccagt
      121 tcagatccag tagcttttag ggaaggaact acagttgctg acttaagttg aagaagcatc
      181 tatttaatgt ctggtcaaat cctacaagaa acacagaaat ctatgattaa aaagctgagc
      241 actttgatat actgcaaagg gtagagaagg caggacggta gaaattttct gcaagaaaga
      301 atgaatttca ggatttatca ctaaataaga caaagtcatt tatttagtcc ccctgacaca
      361 gcagggcaaa ctgagttgac atacaagtta cctggagaaa aagagagcaa ttccaggact
      421 tcctcttcag cctaaaagaa ggtaccagat ctgtgcactg gggcgatgtg gaagagacct
      481 gcttattgcc cctgatgtaa gctccagtaa gaaaagacgt caagtacaag tactaggaaa
      541 tcactttata catctgttta tagatggatg cagaggctga agataaaacg ctgcgtactc
      601 gctctaaagg aaccgaggtg ccaatggatt cactaatcca ggagctcagt gttgcctatg
      661 attgctccat ggcaaagaag agaacagctg aagatcaggc tttgggggtt ccagtcaaca
      721 aaaggaaatc cctgctaatg aagccccgac actacagccc aaaagcagac tgccaagaag
      781 accgcagtga caggacagag gacgatggcc ccttggaaac acatggtcac tctaccgcag
      841 aggaaatcat gataaaacct atggatgaaa gtcttctttc aactgcacaa gaaaactcca
      901 gtaggaagga agacagatac tcttgttatc aagagctcat ggtcaagtct ttaatgcact
      961 tggggaaatt tgaaaaaaat gtatctgttc agactgtaag tgaaaattta aatgacagtg
     1021 gcatccagtc tttaaaagca gagagcgatg aagcagacga gtgctttctg attcattctg
     1081 atgatggaag agacaagatt gatgattctc agccaccctt ctgctcctct gatgacaatg
     1141 aaagtaactc tgaaagtgca gaaaatggct gggacagtgg ctccaacttc tcagaagaaa
     1201 ccaaaccacc tagagtccca aagtatgttt taacagatca taaaaaagac ctattggaag
     1261 ttcctgaaat aaaaactgaa ggtgacaaat ttatcccttg tgagaacagg tgtgattctg
     1321 aaacagaaag gaaagacccg cagaatgctc tcgcagaacc cctggatggc aatgcccagc
     1381 cctcattccc tgacgttgag gaggaagata gcgagagcct ggcagtaatg acggaagagg
     1441 gtagtgacct ggaaaaggcc aaggggaatt taagtttgct ggagcaggca attgctctgc
     1501 aggctgagcg aggttgtgtt ttccataaca cctacaaaga gctggatagg ttcctgctgg
     1561 agcacctagc aggggaaagg aggcaaacca aagttatcga catgggtgga agacaaatct
     1621 ttaacaataa acattcacca aggcctgaaa agagggagac caagtgcccg atccctggat
     1681 gtgatggcac gggacacgtg acagggctct acccgcacca ccgcagcctt tcggggtgcc
     1741 cccacaaagt gcgggttccc ctggaaattc ttgccatgca tgaaaatgtg ctcaagtgtc
     1801 ccacgccggg atgcacagga aggggtcatg tgaacagcaa ccgcaacacc cacaggagtc
     1861 tttctggttg tccaattgct gcagctgaaa aattggcaat gtcccaggat aaaaatcagc
     1921 ttgattctcc ccaaactggg cagtgtcctg accaggccca caggacaagt ttggtgaagc
     1981 aaattgaatt caatttcccg tcacaagcca tcacctctcc cagagccaca gtgtcaaaag
     2041 aacaagagaa gtttggaaaa gtaccatttg attatgccag ttttgatgcc caagttttcg
     2101 gtaaacgccc tctcatacaa acagtgcaag gacgaaaaac accaccattt cctgaatcaa
     2161 agcattttcc aaatccagtg aaatttccta atcgactgcc tagtgcaggc gcccacaccc
     2221 agagccctgg ccgtgccagc tcttatagct acggtcaatg tagtgaagac acccacatag
     2281 cagcagctgc tgccatcctg aacctttcca cccgctgcag ggaagccaca gacatcctct
     2341 ccaacaagcc acagagtctg catgccaagg gagccgaaat agaagtggat gaaaatggca
     2401 cattggactt aagcatgaaa aaaaatcgaa tcctggacaa gtctgcaccc ctaacttcct
     2461 ctaacacttc tattccaact ccttcctctt ccccattcaa aacaagcagc attctggtca
     2521 atgcagcatt ctatcaggct ctttgtgacc aagagggctg ggacactcct atcaactata
     2581 gcaaaactca cgggaagaca gaggaggaga aagagaaaga cccagtgagc tctctagaaa
     2641 atttagagga aaaaaagttt cctggagagg cctctatacc aagccctaaa cccaagcttc
     2701 atgcaagaga tctcaaaaag gaactaatca cctgtccaac accaggatgt gatggaagtg
     2761 gccacgtgac aggaaactat gcatctcatc gcagtgtttc tggatgtcct ttagcagata
     2821 agactctaaa atccctcatg gctgccaact ctcaggagct taagtgtcca accccaggct
     2881 gcgatggctc ggggcacgtg actggaaact atgcttccca cagaagcttg tccggatgcc
     2941 ctcgtgcaag gaaaggtggt gtcaaaatga cccctaccaa ggaagaaaaa gaagaccctg
     3001 aactgaaatg tcctgtgata gggtgtgatg gccaaggtca catatcaggt aaatacacat
     3061 cacaccgcac agcttctggc tgtcctctgg ctgccaagag acagaaggag aatcctctca
     3121 atggagcctc cctctcctgg aaactgaaca aacaagagct accacattgt cccttgccag
     3181 gctgcaatgg gctgggccat gtaaataatg tttttgtcac ccaccgaagc ttatctggat
     3241 gtcctctcaa tgcacaagtt atcaaaaagg gcaaggtttc tgaagaactc atgaccatca
     3301 agctcaaagc aactggggga atagagagtg atgaagaaat taggcatttg gatgaagaaa
     3361 taaaggaact gaatgaatcc aaccttaaaa ttgaagcaga tatgatgaaa cttcagaccc
     3421 agatcacatc tatggagagc aacttaaaga cgatagagga ggagaacaaa ctcatagaac
     3481 agaacaatga aagtctgctg aaagagctgg caggtctaag ccaagctctc atttcaagcc
     3541 ttgctgacat ccagcttcca cagatgggac ctatcagtga gcagaatttt gaagcatatg
     3601 taaatacact cacagatatg tacagcaatc tggaacggga ctattccccg gaatgcaaag
     3661 ctctactgga aagtatcaaa caggcagtga agggtatcca tgtgtaggat cacagcgctg
     3721 ccgggcaaca gaagttacca acagcagtaa actccagatg gatctgttag aggttcatgt
     3781 actgctaagg cgtggaggtt gccgtactgc atttacaatt tgcaacattg cactaatttt
     3841 attttcccca gctgatataa aaaggaaaga aaaactatga tagacttctt ggattaaaag
     3901 caatgcagtc aattattaga tcttatttat tttcatatgt ttttctttta tttcttcatt
     3961 gtactctttt tttttttgta aagtatatgt aaaataaatg tgacattttt ataatttatt
     4021 tattactaat caaagagttt tttatctttt aactgcattt tgaagtctgc cgtattttta
     4081 caagtgtgtt tattaattta ttttccaata ggatttaaat agaaatgcta ttctcaagtc
     4141 atctttcttg ctgggtttta atgaggaaac aggaaagggt gaaggaaatc cttgtctaag
     4201 gactgcacta tagttgagtt tgatttttat tgcacacttc ttcccccacc tttcactgat
     4261 ttttgtattt ataaatgaat ttgcggtaag gtgagctgca cggaaggaat aagaagacaa
     4321 atggcgccca ctagtgggga atccgcactc acaaaagcac aggatgctgg aaaacagcct
     4381 gctcagaatt tgttagcaat aattaaatat agcaatcagc aaagtattcg acttggctgg
     4441 acggttttcg ttaatatgaa ttatttattt gaaatgtttt aaagaaacat aagccttttt
     4501 agtgatgcag atttgtctgt ttgtttttca agtcatatca gatcgttggc aactcgtatc
     4561 ccaagatgaa aaataagact tggtgtgacc agccaggctt tcctgccata tgttggtaca
     4621 atatacaagt gacaatattg gtgtagattt gtacttagca aatacaaaca catccaaatg
     4681 aaaaattttg tagataccat atcccctgaa atagcattta tcttactggg ttgactggaa
     4741 aggaatggaa aatatagtaa cacatgaaaa aatgctactc caatctgaat gattacttca
     4801 aacactggca ccttgggtct cacccaccat aggaaacaag acaacattca atttgataga
     4861 aatcttgcca caaaacttca aatgctacaa aatatacaca cacactcaca cacacaggca
     4921 tactcacaca cagacacaca cacacacaca cacacagact catccacact tcaaattgag
     4981 cccacaatct tgaatttctg aacggatcag agtttcatag tttctatagt aaaggcaatg
     5041 tctatttcag ggattgtaaa gtagttaagc attgtttcaa aagttttttt atatttattt
     5101 tttttaagga aaaggtatag acaaccagct aaactgcctt tttggtgtgc acacacattt
     5161 catgtgcaga cgtgcctctg tgtaaatgta cacatgaact tcatgtgggc ttaattttct
     5221 gtgctataaa caaaagtgtt tattttttat taacctcatg gatatttaga tggaaagtga
     5281 tggcattcac aggcttgatg tattccactg ttattactgt tacctgcaca aatgaaaaac
     5341 aatactcaac agtaattcca ctcccatgaa actttggtca ttgttatgca ttaagtgggg
     5401 cttatctttg gtttggagtt catttgaact cttgaacctt agtttagtga agatgaactg
     5461 tctgttctta ggtagaaacg gtgtttattt aaaaatcagt tttaaaaaat gagctaccat
     5521 atgtgctgtc tattataaat gggacaccaa acaaaatttt ctattacagt tgtgtacttg
     5581 caaacatttt gctatacagt acttcataga tgcatacaaa tgagctcact tattacaaag
     5641 acaaacgttt aatttgctaa atattttaac aagtttgtta tatattttat ttaatttaaa
     5701 agaaatctct taccaaccta catatttatt actataattt gctatgactt caggttaatt
     5761 tatttgtgtt tgcatagttt gagcaggatg ttttgtgaag tatgtttgta tttatttgcc
     5821 tactttgtac ttgatgtgtt ttgtaatgtg cactgaattt gttttctttt caactatgtt
     5881 aatgatcaat actgtaaatt gggtcttttg taaacaaaaa ggcaatgatg tatgcatttt
     5941 ttttaatttg aggtagtttg tttgtatact gtttctccaa acacttaata tttcttacat
     6001 caaagcaaca aaattgtgtt cagtgctgta catttggtgt atggtaggaa ataaaaattg
     6061 ataacga
//
