LOCUS       NM_001352841            6031 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens ST18 C2H2C-type zinc finger transcription factor
            (ST18), transcript variant 17, mRNA.
ACCESSION   NM_001352841 XM_017014068
VERSION     NM_001352841.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6031)
  AUTHORS   Assaf,S., Vodo,D., Malovitski,K., Mohamad,J., Bergson,S.,
            Feller,Y., Malki,L., Sarig,O. and Sprecher,E.
  TITLE     Up-regulation of ST18 in pemphigus vulgaris drives a
            self-amplifying p53-dependent pathomechanism resulting in decreased
            desmoglein 3 expression
  JOURNAL   Sci Rep 12 (1), 5958 (2022)
   PUBMED   35396567
  REMARK    GeneRIF: Up-regulation of ST18 in pemphigus vulgaris drives a
            self-amplifying p53-dependent pathomechanism resulting in decreased
            desmoglein 3 expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6031)
  AUTHORS   Skou,A.S., Juul-Dam,K.L., Hansen,M., Lausen,B., Stratmann,S.,
            Holmfeldt,L., Aggerholm,A., Nyvold,C.G., Ommen,H.B. and Hasle,H.
  TITLE     Measurable Residual Disease Monitoring of SPAG6, ST18, PRAME, and
            XAGE1A Expression in Peripheral Blood May Detect Imminent Relapse
            in Childhood Acute Myeloid Leukemia
  JOURNAL   J Mol Diagn 23 (12), 1787-1799 (2021)
   PUBMED   34600138
  REMARK    GeneRIF: Measurable Residual Disease Monitoring of SPAG6, ST18,
            PRAME, and XAGE1A Expression in Peripheral Blood May Detect
            Imminent Relapse in Childhood Acute Myeloid Leukemia.
REFERENCE   3  (bases 1 to 6031)
  AUTHORS   Kim,B.H., Nho,K. and Lee,J.M.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     Genome-wide association study identifies susceptibility loci of
            brain atrophy to NFIA and ST18 in Alzheimer's disease
  JOURNAL   Neurobiol Aging 102, 200 (2021)
   PUBMED   33640202
  REMARK    GeneRIF: Genome-wide association study identifies susceptibility
            loci of brain atrophy to NFIA and ST18 in Alzheimer's disease.
REFERENCE   4  (bases 1 to 6031)
  AUTHORS   Assaf,S., Malki,L., Mayer,T., Mohamad,J., Peled,A., Pavlovsky,M.,
            Malovitski,K., Sarig,O., Vodo,D. and Sprecher,E.
  TITLE     ST18 affects cell-cell adhesion in pemphigus vulgaris in a tumour
            necrosis factor-alpha-dependent fashion
  JOURNAL   Br J Dermatol 184 (6), 1153-1160 (2021)
   PUBMED   33205400
  REMARK    GeneRIF: ST18 affects cell-cell adhesion in pemphigus vulgaris in a
            tumour necrosis factor-alpha-dependent fashion.
REFERENCE   5  (bases 1 to 6031)
  AUTHORS   Radeva,M.Y., Walter,E., Stach,R.A., Yazdi,A.S., Schlegel,N.,
            Sarig,O., Sprecher,E. and Waschke,J.
  TITLE     ST18 Enhances PV-IgG-Induced Loss of Keratinocyte Cohesion in
            Parallel to Increased ERK Activation
  JOURNAL   Front Immunol 10, 770 (2019)
   PUBMED   31057535
  REMARK    GeneRIF: ST18 Enhances PV-IgG-Induced Loss of Keratinocyte Cohesion
            in Parallel to Increased ERK Activation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6031)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 6031)
  AUTHORS   Yang,J., Siqueira,M.F., Behl,Y., Alikhani,M. and Graves,D.T.
  TITLE     The transcription factor ST18 regulates proapoptotic and
            proinflammatory gene expression in fibroblasts
  JOURNAL   FASEB J 22 (11), 3956-3967 (2008)
   PUBMED   18676404
  REMARK    GeneRIF: Fibroblasts that overexpress ST18 by transient
            transfection exhibit significantly increased apoptosis and
            increased expression of TNF-alpha, interleukin (IL) -1alpha, and
            IL-6.
REFERENCE   8  (bases 1 to 6031)
  AUTHORS   Jandrig,B., Seitz,S., Hinzmann,B., Arnold,W., Micheel,B.,
            Koelble,K., Siebert,R., Schwartz,A., Ruecker,K., Schlag,P.M.,
            Scherneck,S. and Rosenthal,A.
  TITLE     ST18 is a breast cancer tumor suppressor gene at human chromosome
            8q11.2
  JOURNAL   Oncogene 23 (57), 9295-9302 (2004)
   PUBMED   15489893
  REMARK    GeneRIF: ectopic ST18 expression in MCF-7 breast cancer cells
            strongly inhibits colony formation in soft agar and the formation
            of tumors in a xenograft mouse model
REFERENCE   9  (bases 1 to 6031)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol Vis 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 6031)
  AUTHORS   Yee,K.S. and Yu,V.C.
  TITLE     Isolation and characterization of a novel member of the neural zinc
            finger factor/myelin transcription factor family with
            transcriptional repression activity
  JOURNAL   J Biol Chem 273 (9), 5366-5374 (1998)
   PUBMED   9478997
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC021915.11.
            
            On Aug 13, 2020 this sequence version replaced NM_001352841.1.
            
            Transcript Variant: This variant (17) encodes isoform a. Variants
            1-33 all encode isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.59285.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AC021915.11        172945-173043       c
            100-178             AC021915.11        165281-165359       c
            179-224             AC021915.11        148727-148772       c
            225-265             AC021915.11        143784-143824       c
            266-419             AC021915.11        140335-140488       c
            420-527             AC021915.11        139436-139543       c
            528-582             AC021915.11        132898-132952       c
            583-613             AC021915.11        130774-130804       c
            614-804             AC021915.11        98817-99007         c
            805-1596            AC021915.11        90487-91278         c
            1597-1731           AC021915.11        85547-85681         c
            1732-1822           AC021915.11        83830-83920         c
            1823-1927           AC021915.11        82681-82785         c
            1928-2121           AC021915.11        80070-80263         c
            2122-2333           AC021915.11        77593-77804         c
            2334-2579           AC021915.11        68427-68672         c
            2580-2695           AC021915.11        61625-61740         c
            2696-2758           AC021915.11        56116-56178         c
            2759-2827           AC021915.11        55285-55353         c
            2828-2890           AC021915.11        51934-51996         c
            2891-2971           AC021915.11        51752-51832         c
            2972-3193           AC021915.11        50653-50874         c
            3194-3282           AC021915.11        44747-44835         c
            3283-3386           AC021915.11        37033-37136         c
            3387-3530           AC021915.11        34970-35113         c
            3531-6031           AC021915.11        29533-32033         c
FEATURES             Location/Qualifiers
     source          1..6031
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q11.23"
     gene            1..6031
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /note="ST18 C2H2C-type zinc finger transcription factor"
                     /db_xref="GeneID:9705"
                     /db_xref="HGNC:HGNC:18695"
                     /db_xref="MIM:617155"
     exon            1..99
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            100..178
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            179..224
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            225..265
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            266..419
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            420..527
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     CDS             528..3671
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /note="isoform a is encoded by transcript variant 17; zinc
                     finger protein 387; suppression of tumorigenicity 18
                     (breast carcinoma) (zinc finger protein); suppression of
                     tumorigenicity 18, zinc finger; neural zinc finger
                     transcription factor 3; ST18, C2H2C-type zinc finger;
                     suppression of tumorigenicity 18 protein"
                     /codon_start=1
                     /product="suppression of tumorigenicity 18 protein isoform
                     a"
                     /protein_id="NP_001339770.1"
                     /db_xref="CCDS:CCDS6149.1"
                     /db_xref="GeneID:9705"
                     /db_xref="HGNC:HGNC:18695"
                     /db_xref="MIM:617155"
                     /translation="MDAEAEDKTLRTRSKGTEVPMDSLIQELSVAYDCSMAKKRTAED
                     QALGVPVNKRKSLLMKPRHYSPKADCQEDRSDRTEDDGPLETHGHSTAEEIMIKPMDE
                     SLLSTAQENSSRKEDRYSCYQELMVKSLMHLGKFEKNVSVQTVSENLNDSGIQSLKAE
                     SDEADECFLIHSDDGRDKIDDSQPPFCSSDDNESNSESAENGWDSGSNFSEETKPPRV
                     PKYVLTDHKKDLLEVPEIKTEGDKFIPCENRCDSETERKDPQNALAEPLDGNAQPSFP
                     DVEEEDSESLAVMTEEGSDLEKAKGNLSLLEQAIALQAERGCVFHNTYKELDRFLLEH
                     LAGERRQTKVIDMGGRQIFNNKHSPRPEKRETKCPIPGCDGTGHVTGLYPHHRSLSGC
                     PHKVRVPLEILAMHENVLKCPTPGCTGRGHVNSNRNTHRSLSGCPIAAAEKLAMSQDK
                     NQLDSPQTGQCPDQAHRTSLVKQIEFNFPSQAITSPRATVSKEQEKFGKVPFDYASFD
                     AQVFGKRPLIQTVQGRKTPPFPESKHFPNPVKFPNRLPSAGAHTQSPGRASSYSYGQC
                     SEDTHIAAAAAILNLSTRCREATDILSNKPQSLHAKGAEIEVDENGTLDLSMKKNRIL
                     DKSAPLTSSNTSIPTPSSSPFKTSSILVNAAFYQALCDQEGWDTPINYSKTHGKTEEE
                     KEKDPVSSLENLEEKKFPGEASIPSPKPKLHARDLKKELITCPTPGCDGSGHVTGNYA
                     SHRSVSGCPLADKTLKSLMAANSQELKCPTPGCDGSGHVTGNYASHRSLSGCPRARKG
                     GVKMTPTKEEKEDPELKCPVIGCDGQGHISGKYTSHRTASGCPLAAKRQKENPLNGAS
                     LSWKLNKQELPHCPLPGCNGLGHVNNVFVTHRSLSGCPLNAQVIKKGKVSEELMTIKL
                     KATGGIESDEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENKLIE
                     QNNESLLKELAGLSQALISSLADIQLPQMGPISEQNFEAYVNTLTDMYSNLERDYSPE
                     CKALLESIKQAVKGIHV"
     exon            528..582
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            583..613
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            614..804
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            805..1596
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1731
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1822
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1927
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2121
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2333
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2579
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2695
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2696..2758
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2827
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..2890
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..2971
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2972..3193
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3194..3282
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..3386
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..3530
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3531..6031
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6014..6019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /note="hexamer: AATAAA"
     polyA_site      6031
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /note="major polyA site"
ORIGIN      
        1 gtcatatcat gggaactacc tttcaaagaa acagctttag tgtttccgtt cagcccacca
       61 gggaggagag aaatataagt tttggaaaca aacaaaaaaa gcccccaatt ttgtgagtgt
      121 ccctgaagca ttgtgacaat tccattttat gtgtctgcgt gctcatatca agactaagga
      181 gtgatggaaa ctctccagtt cagatccagt agcttttagg gaagggactg gaaggacaaa
      241 tacaaatact gttatgccta ctagtgaact acagttgctg acttaagttg aagaagcatc
      301 tatttaatgt ctggtcaaat cctacaagaa acacagaaat ctatgattaa aaagctgagc
      361 actttgatat actgcaaagg gtagagaagg caggacggta gaaattttct gcaagaaaga
      421 atgaatttca ggatttatca ctaaataaga caaagtcatt tatttagtcc ccctgacaca
      481 gcagggcaaa ctgagttgac atacaagtta cctggagaaa aagagagatg gatgcagagg
      541 ctgaagataa aacgctgcgt actcgctcta aaggaaccga ggtgccaatg gattcactaa
      601 tccaggagct cagtgttgcc tatgattgct ccatggcaaa gaagagaaca gctgaagatc
      661 aggctttggg ggttccagtc aacaaaagga aatccctgct aatgaagccc cgacactaca
      721 gcccaaaagc agactgccaa gaagaccgca gtgacaggac agaggacgat ggccccttgg
      781 aaacacatgg tcactctacc gcagaggaaa tcatgataaa acctatggat gaaagtcttc
      841 tttcaactgc acaagaaaac tccagtagga aggaagacag atactcttgt tatcaagagc
      901 tcatggtcaa gtctttaatg cacttgggga aatttgaaaa aaatgtatct gttcagactg
      961 taagtgaaaa tttaaatgac agtggcatcc agtctttaaa agcagagagc gatgaagcag
     1021 acgagtgctt tctgattcat tctgatgatg gaagagacaa gattgatgat tctcagccac
     1081 ccttctgctc ctctgatgac aatgaaagta actctgaaag tgcagaaaat ggctgggaca
     1141 gtggctccaa cttctcagaa gaaaccaaac cacctagagt cccaaagtat gttttaacag
     1201 atcataaaaa agacctattg gaagttcctg aaataaaaac tgaaggtgac aaatttatcc
     1261 cttgtgagaa caggtgtgat tctgaaacag aaaggaaaga cccgcagaat gctctcgcag
     1321 aacccctgga tggcaatgcc cagccctcat tccctgacgt tgaggaggaa gatagcgaga
     1381 gcctggcagt aatgacggaa gagggtagtg acctggaaaa ggccaagggg aatttaagtt
     1441 tgctggagca ggcaattgct ctgcaggctg agcgaggttg tgttttccat aacacctaca
     1501 aagagctgga taggttcctg ctggagcacc tagcagggga aaggaggcaa accaaagtta
     1561 tcgacatggg tggaagacaa atctttaaca ataaacattc accaaggcct gaaaagaggg
     1621 agaccaagtg cccgatccct ggatgtgatg gcacgggaca cgtgacaggg ctctacccgc
     1681 accaccgcag cctttcgggg tgcccccaca aagtgcgggt tcccctggaa attcttgcca
     1741 tgcatgaaaa tgtgctcaag tgtcccacgc cgggatgcac aggaaggggt catgtgaaca
     1801 gcaaccgcaa cacccacagg agtctttctg gttgtccaat tgctgcagct gaaaaattgg
     1861 caatgtccca ggataaaaat cagcttgatt ctccccaaac tgggcagtgt cctgaccagg
     1921 cccacaggac aagtttggtg aagcaaattg aattcaattt cccgtcacaa gccatcacct
     1981 ctcccagagc cacagtgtca aaagaacaag agaagtttgg aaaagtacca tttgattatg
     2041 ccagttttga tgcccaagtt ttcggtaaac gccctctcat acaaacagtg caaggacgaa
     2101 aaacaccacc atttcctgaa tcaaagcatt ttccaaatcc agtgaaattt cctaatcgac
     2161 tgcctagtgc aggcgcccac acccagagcc ctggccgtgc cagctcttat agctacggtc
     2221 aatgtagtga agacacccac atagcagcag ctgctgccat cctgaacctt tccacccgct
     2281 gcagggaagc cacagacatc ctctccaaca agccacagag tctgcatgcc aagggagccg
     2341 aaatagaagt ggatgaaaat ggcacattgg acttaagcat gaaaaaaaat cgaatcctgg
     2401 acaagtctgc acccctaact tcctctaaca cttctattcc aactccttcc tcttccccat
     2461 tcaaaacaag cagcattctg gtcaatgcag cattctatca ggctctttgt gaccaagagg
     2521 gctgggacac tcctatcaac tatagcaaaa ctcacgggaa gacagaggag gagaaagaga
     2581 aagacccagt gagctctcta gaaaatttag aggaaaaaaa gtttcctgga gaggcctcta
     2641 taccaagccc taaacccaag cttcatgcaa gagatctcaa aaaggaacta atcacctgtc
     2701 caacaccagg atgtgatgga agtggccacg tgacaggaaa ctatgcatct catcgcagtg
     2761 tttctggatg tcctttagca gataagactc taaaatccct catggctgcc aactctcagg
     2821 agcttaagtg tccaacccca ggctgcgatg gctcggggca cgtgactgga aactatgctt
     2881 cccacagaag cttgtccgga tgccctcgtg caaggaaagg tggtgtcaaa atgaccccta
     2941 ccaaggaaga aaaagaagac cctgaactga aatgtcctgt gatagggtgt gatggccaag
     3001 gtcacatatc aggtaaatac acatcacacc gcacagcttc tggctgtcct ctggctgcca
     3061 agagacagaa ggagaatcct ctcaatggag cctccctctc ctggaaactg aacaaacaag
     3121 agctaccaca ttgtcccttg ccaggctgca atgggctggg ccatgtaaat aatgtttttg
     3181 tcacccaccg aagcttatct ggatgtcctc tcaatgcaca agttatcaaa aagggcaagg
     3241 tttctgaaga actcatgacc atcaagctca aagcaactgg gggaatagag agtgatgaag
     3301 aaattaggca tttggatgaa gaaataaagg aactgaatga atccaacctt aaaattgaag
     3361 cagatatgat gaaacttcag acccagatca catctatgga gagcaactta aagacgatag
     3421 aggaggagaa caaactcata gaacagaaca atgaaagtct gctgaaagag ctggcaggtc
     3481 taagccaagc tctcatttca agccttgctg acatccagct tccacagatg ggacctatca
     3541 gtgagcagaa ttttgaagca tatgtaaata cactcacaga tatgtacagc aatctggaac
     3601 gggactattc cccggaatgc aaagctctac tggaaagtat caaacaggca gtgaagggta
     3661 tccatgtgta ggatcacagc gctgccgggc aacagaagtt accaacagca gtaaactcca
     3721 gatggatctg ttagaggttc atgtactgct aaggcgtgga ggttgccgta ctgcatttac
     3781 aatttgcaac attgcactaa ttttattttc cccagctgat ataaaaagga aagaaaaact
     3841 atgatagact tcttggatta aaagcaatgc agtcaattat tagatcttat ttattttcat
     3901 atgtttttct tttatttctt cattgtactc tttttttttt tgtaaagtat atgtaaaata
     3961 aatgtgacat ttttataatt tatttattac taatcaaaga gttttttatc ttttaactgc
     4021 attttgaagt ctgccgtatt tttacaagtg tgtttattaa tttattttcc aataggattt
     4081 aaatagaaat gctattctca agtcatcttt cttgctgggt tttaatgagg aaacaggaaa
     4141 gggtgaagga aatccttgtc taaggactgc actatagttg agtttgattt ttattgcaca
     4201 cttcttcccc cacctttcac tgatttttgt atttataaat gaatttgcgg taaggtgagc
     4261 tgcacggaag gaataagaag acaaatggcg cccactagtg gggaatccgc actcacaaaa
     4321 gcacaggatg ctggaaaaca gcctgctcag aatttgttag caataattaa atatagcaat
     4381 cagcaaagta ttcgacttgg ctggacggtt ttcgttaata tgaattattt atttgaaatg
     4441 ttttaaagaa acataagcct ttttagtgat gcagatttgt ctgtttgttt ttcaagtcat
     4501 atcagatcgt tggcaactcg tatcccaaga tgaaaaataa gacttggtgt gaccagccag
     4561 gctttcctgc catatgttgg tacaatatac aagtgacaat attggtgtag atttgtactt
     4621 agcaaataca aacacatcca aatgaaaaat tttgtagata ccatatcccc tgaaatagca
     4681 tttatcttac tgggttgact ggaaaggaat ggaaaatata gtaacacatg aaaaaatgct
     4741 actccaatct gaatgattac ttcaaacact ggcaccttgg gtctcaccca ccataggaaa
     4801 caagacaaca ttcaatttga tagaaatctt gccacaaaac ttcaaatgct acaaaatata
     4861 cacacacact cacacacaca ggcatactca cacacagaca cacacacaca cacacacaca
     4921 gactcatcca cacttcaaat tgagcccaca atcttgaatt tctgaacgga tcagagtttc
     4981 atagtttcta tagtaaaggc aatgtctatt tcagggattg taaagtagtt aagcattgtt
     5041 tcaaaagttt ttttatattt atttttttta aggaaaaggt atagacaacc agctaaactg
     5101 cctttttggt gtgcacacac atttcatgtg cagacgtgcc tctgtgtaaa tgtacacatg
     5161 aacttcatgt gggcttaatt ttctgtgcta taaacaaaag tgtttatttt ttattaacct
     5221 catggatatt tagatggaaa gtgatggcat tcacaggctt gatgtattcc actgttatta
     5281 ctgttacctg cacaaatgaa aaacaatact caacagtaat tccactccca tgaaactttg
     5341 gtcattgtta tgcattaagt ggggcttatc tttggtttgg agttcatttg aactcttgaa
     5401 ccttagttta gtgaagatga actgtctgtt cttaggtaga aacggtgttt atttaaaaat
     5461 cagttttaaa aaatgagcta ccatatgtgc tgtctattat aaatgggaca ccaaacaaaa
     5521 ttttctatta cagttgtgta cttgcaaaca ttttgctata cagtacttca tagatgcata
     5581 caaatgagct cacttattac aaagacaaac gtttaatttg ctaaatattt taacaagttt
     5641 gttatatatt ttatttaatt taaaagaaat ctcttaccaa cctacatatt tattactata
     5701 atttgctatg acttcaggtt aatttatttg tgtttgcata gtttgagcag gatgttttgt
     5761 gaagtatgtt tgtatttatt tgcctacttt gtacttgatg tgttttgtaa tgtgcactga
     5821 atttgttttc ttttcaacta tgttaatgat caatactgta aattgggtct tttgtaaaca
     5881 aaaaggcaat gatgtatgca ttttttttaa tttgaggtag tttgtttgta tactgtttct
     5941 ccaaacactt aatatttctt acatcaaagc aacaaaattg tgttcagtgc tgtacatttg
     6001 gtgtatggta ggaaataaaa attgataacg a
//
