LOCUS       NM_001352837            6302 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens ST18 C2H2C-type zinc finger transcription factor
            (ST18), transcript variant 13, mRNA.
ACCESSION   NM_001352837 XM_011517634
VERSION     NM_001352837.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6302)
  AUTHORS   Assaf,S., Vodo,D., Malovitski,K., Mohamad,J., Bergson,S.,
            Feller,Y., Malki,L., Sarig,O. and Sprecher,E.
  TITLE     Up-regulation of ST18 in pemphigus vulgaris drives a
            self-amplifying p53-dependent pathomechanism resulting in decreased
            desmoglein 3 expression
  JOURNAL   Sci Rep 12 (1), 5958 (2022)
   PUBMED   35396567
  REMARK    GeneRIF: Up-regulation of ST18 in pemphigus vulgaris drives a
            self-amplifying p53-dependent pathomechanism resulting in decreased
            desmoglein 3 expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6302)
  AUTHORS   Skou,A.S., Juul-Dam,K.L., Hansen,M., Lausen,B., Stratmann,S.,
            Holmfeldt,L., Aggerholm,A., Nyvold,C.G., Ommen,H.B. and Hasle,H.
  TITLE     Measurable Residual Disease Monitoring of SPAG6, ST18, PRAME, and
            XAGE1A Expression in Peripheral Blood May Detect Imminent Relapse
            in Childhood Acute Myeloid Leukemia
  JOURNAL   J Mol Diagn 23 (12), 1787-1799 (2021)
   PUBMED   34600138
  REMARK    GeneRIF: Measurable Residual Disease Monitoring of SPAG6, ST18,
            PRAME, and XAGE1A Expression in Peripheral Blood May Detect
            Imminent Relapse in Childhood Acute Myeloid Leukemia.
REFERENCE   3  (bases 1 to 6302)
  AUTHORS   Kim,B.H., Nho,K. and Lee,J.M.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     Genome-wide association study identifies susceptibility loci of
            brain atrophy to NFIA and ST18 in Alzheimer's disease
  JOURNAL   Neurobiol Aging 102, 200 (2021)
   PUBMED   33640202
  REMARK    GeneRIF: Genome-wide association study identifies susceptibility
            loci of brain atrophy to NFIA and ST18 in Alzheimer's disease.
REFERENCE   4  (bases 1 to 6302)
  AUTHORS   Assaf,S., Malki,L., Mayer,T., Mohamad,J., Peled,A., Pavlovsky,M.,
            Malovitski,K., Sarig,O., Vodo,D. and Sprecher,E.
  TITLE     ST18 affects cell-cell adhesion in pemphigus vulgaris in a tumour
            necrosis factor-alpha-dependent fashion
  JOURNAL   Br J Dermatol 184 (6), 1153-1160 (2021)
   PUBMED   33205400
  REMARK    GeneRIF: ST18 affects cell-cell adhesion in pemphigus vulgaris in a
            tumour necrosis factor-alpha-dependent fashion.
REFERENCE   5  (bases 1 to 6302)
  AUTHORS   Radeva,M.Y., Walter,E., Stach,R.A., Yazdi,A.S., Schlegel,N.,
            Sarig,O., Sprecher,E. and Waschke,J.
  TITLE     ST18 Enhances PV-IgG-Induced Loss of Keratinocyte Cohesion in
            Parallel to Increased ERK Activation
  JOURNAL   Front Immunol 10, 770 (2019)
   PUBMED   31057535
  REMARK    GeneRIF: ST18 Enhances PV-IgG-Induced Loss of Keratinocyte Cohesion
            in Parallel to Increased ERK Activation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6302)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 6302)
  AUTHORS   Yang,J., Siqueira,M.F., Behl,Y., Alikhani,M. and Graves,D.T.
  TITLE     The transcription factor ST18 regulates proapoptotic and
            proinflammatory gene expression in fibroblasts
  JOURNAL   FASEB J 22 (11), 3956-3967 (2008)
   PUBMED   18676404
  REMARK    GeneRIF: Fibroblasts that overexpress ST18 by transient
            transfection exhibit significantly increased apoptosis and
            increased expression of TNF-alpha, interleukin (IL) -1alpha, and
            IL-6.
REFERENCE   8  (bases 1 to 6302)
  AUTHORS   Jandrig,B., Seitz,S., Hinzmann,B., Arnold,W., Micheel,B.,
            Koelble,K., Siebert,R., Schwartz,A., Ruecker,K., Schlag,P.M.,
            Scherneck,S. and Rosenthal,A.
  TITLE     ST18 is a breast cancer tumor suppressor gene at human chromosome
            8q11.2
  JOURNAL   Oncogene 23 (57), 9295-9302 (2004)
   PUBMED   15489893
  REMARK    GeneRIF: ectopic ST18 expression in MCF-7 breast cancer cells
            strongly inhibits colony formation in soft agar and the formation
            of tumors in a xenograft mouse model
REFERENCE   9  (bases 1 to 6302)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol Vis 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 6302)
  AUTHORS   Yee,K.S. and Yu,V.C.
  TITLE     Isolation and characterization of a novel member of the neural zinc
            finger factor/myelin transcription factor family with
            transcriptional repression activity
  JOURNAL   J Biol Chem 273 (9), 5366-5374 (1998)
   PUBMED   9478997
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC103831.4 and AC021915.11.
            
            On Aug 14, 2020 this sequence version replaced NM_001352837.1.
            
            Transcript Variant: This variant (13) encodes isoform a. Variants
            1-33 all encode isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.149187.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000689386.1/ ENSP00000509475.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AC103831.4         11673-11881
            210-334             AC103831.4         11977-12101
            335-380             AC021915.11        148727-148772       c
            381-534             AC021915.11        140335-140488       c
            535-642             AC021915.11        139436-139543       c
            643-798             AC021915.11        136441-136596       c
            799-853             AC021915.11        132898-132952       c
            854-884             AC021915.11        130774-130804       c
            885-1075            AC021915.11        98817-99007         c
            1076-1867           AC021915.11        90487-91278         c
            1868-2002           AC021915.11        85547-85681         c
            2003-2093           AC021915.11        83830-83920         c
            2094-2198           AC021915.11        82681-82785         c
            2199-2392           AC021915.11        80070-80263         c
            2393-2604           AC021915.11        77593-77804         c
            2605-2850           AC021915.11        68427-68672         c
            2851-2966           AC021915.11        61625-61740         c
            2967-3029           AC021915.11        56116-56178         c
            3030-3098           AC021915.11        55285-55353         c
            3099-3161           AC021915.11        51934-51996         c
            3162-3242           AC021915.11        51752-51832         c
            3243-3464           AC021915.11        50653-50874         c
            3465-3553           AC021915.11        44747-44835         c
            3554-3657           AC021915.11        37033-37136         c
            3658-3801           AC021915.11        34970-35113         c
            3802-6302           AC021915.11        29533-32033         c
FEATURES             Location/Qualifiers
     source          1..6302
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q11.23"
     gene            1..6302
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /note="ST18 C2H2C-type zinc finger transcription factor"
                     /db_xref="GeneID:9705"
                     /db_xref="HGNC:HGNC:18695"
                     /db_xref="MIM:617155"
     exon            1..209
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            210..334
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            335..380
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            381..534
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            535..642
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            643..798
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     CDS             799..3942
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /note="isoform a is encoded by transcript variant 13; zinc
                     finger protein 387; suppression of tumorigenicity 18
                     (breast carcinoma) (zinc finger protein); suppression of
                     tumorigenicity 18, zinc finger; neural zinc finger
                     transcription factor 3; ST18, C2H2C-type zinc finger;
                     suppression of tumorigenicity 18 protein"
                     /codon_start=1
                     /product="suppression of tumorigenicity 18 protein isoform
                     a"
                     /protein_id="NP_001339766.1"
                     /db_xref="CCDS:CCDS6149.1"
                     /db_xref="GeneID:9705"
                     /db_xref="HGNC:HGNC:18695"
                     /db_xref="MIM:617155"
                     /translation="MDAEAEDKTLRTRSKGTEVPMDSLIQELSVAYDCSMAKKRTAED
                     QALGVPVNKRKSLLMKPRHYSPKADCQEDRSDRTEDDGPLETHGHSTAEEIMIKPMDE
                     SLLSTAQENSSRKEDRYSCYQELMVKSLMHLGKFEKNVSVQTVSENLNDSGIQSLKAE
                     SDEADECFLIHSDDGRDKIDDSQPPFCSSDDNESNSESAENGWDSGSNFSEETKPPRV
                     PKYVLTDHKKDLLEVPEIKTEGDKFIPCENRCDSETERKDPQNALAEPLDGNAQPSFP
                     DVEEEDSESLAVMTEEGSDLEKAKGNLSLLEQAIALQAERGCVFHNTYKELDRFLLEH
                     LAGERRQTKVIDMGGRQIFNNKHSPRPEKRETKCPIPGCDGTGHVTGLYPHHRSLSGC
                     PHKVRVPLEILAMHENVLKCPTPGCTGRGHVNSNRNTHRSLSGCPIAAAEKLAMSQDK
                     NQLDSPQTGQCPDQAHRTSLVKQIEFNFPSQAITSPRATVSKEQEKFGKVPFDYASFD
                     AQVFGKRPLIQTVQGRKTPPFPESKHFPNPVKFPNRLPSAGAHTQSPGRASSYSYGQC
                     SEDTHIAAAAAILNLSTRCREATDILSNKPQSLHAKGAEIEVDENGTLDLSMKKNRIL
                     DKSAPLTSSNTSIPTPSSSPFKTSSILVNAAFYQALCDQEGWDTPINYSKTHGKTEEE
                     KEKDPVSSLENLEEKKFPGEASIPSPKPKLHARDLKKELITCPTPGCDGSGHVTGNYA
                     SHRSVSGCPLADKTLKSLMAANSQELKCPTPGCDGSGHVTGNYASHRSLSGCPRARKG
                     GVKMTPTKEEKEDPELKCPVIGCDGQGHISGKYTSHRTASGCPLAAKRQKENPLNGAS
                     LSWKLNKQELPHCPLPGCNGLGHVNNVFVTHRSLSGCPLNAQVIKKGKVSEELMTIKL
                     KATGGIESDEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENKLIE
                     QNNESLLKELAGLSQALISSLADIQLPQMGPISEQNFEAYVNTLTDMYSNLERDYSPE
                     CKALLESIKQAVKGIHV"
     exon            799..853
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            854..884
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1075
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1867
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2002
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2093
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2198
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2392
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2604
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2850
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..2966
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2967..3029
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3030..3098
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3099..3161
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3162..3242
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3464
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3465..3553
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3554..3657
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3658..3801
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3802..6302
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6285..6290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /note="hexamer: AATAAA"
     polyA_site      6302
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /note="major polyA site"
ORIGIN      
        1 gattctatgg aacctttttg tagggagaag ggcaggatgt ttttaactga atgtgacctc
       61 aggggaatac tagaggtaag gagagaaaaa taattgaggt aactgtgggt gttttacatc
      121 tcggaaacca tggcttttaa taaggccaca tgaagagaga agctggcatc atcccacgca
      181 aaaaccagtg cctggcagag ttgtggaaga aaataataaa atttctgaat ggggcagcgt
      241 ggagaaatcc taagagaaat agcataagag cattttggaa cacatccagg aaaagataac
      301 tttcgacaca cctgtagacg ttcgccaggt aaaggagtga tggaaactct ccagttcaga
      361 tccagtagct tttagggaag gaactacagt tgctgactta agttgaagaa gcatctattt
      421 aatgtctggt caaatcctac aagaaacaca gaaatctatg attaaaaagc tgagcacttt
      481 gatatactgc aaagggtaga gaaggcagga cggtagaaat tttctgcaag aaagaatgaa
      541 tttcaggatt tatcactaaa taagacaaag tcatttattt agtccccctg acacagcagg
      601 gcaaactgag ttgacataca agttacctgg agaaaaagag agcaattcca ggacttcctc
      661 ttcagcctaa aagaaggtac cagatctgtg cactggggcg atgtggaaga gacctgctta
      721 ttgcccctga tgtaagctcc agtaagaaaa gacgtcaagt acaagtacta ggaaatcact
      781 ttatacatct gtttatagat ggatgcagag gctgaagata aaacgctgcg tactcgctct
      841 aaaggaaccg aggtgccaat ggattcacta atccaggagc tcagtgttgc ctatgattgc
      901 tccatggcaa agaagagaac agctgaagat caggctttgg gggttccagt caacaaaagg
      961 aaatccctgc taatgaagcc ccgacactac agcccaaaag cagactgcca agaagaccgc
     1021 agtgacagga cagaggacga tggccccttg gaaacacatg gtcactctac cgcagaggaa
     1081 atcatgataa aacctatgga tgaaagtctt ctttcaactg cacaagaaaa ctccagtagg
     1141 aaggaagaca gatactcttg ttatcaagag ctcatggtca agtctttaat gcacttgggg
     1201 aaatttgaaa aaaatgtatc tgttcagact gtaagtgaaa atttaaatga cagtggcatc
     1261 cagtctttaa aagcagagag cgatgaagca gacgagtgct ttctgattca ttctgatgat
     1321 ggaagagaca agattgatga ttctcagcca cccttctgct cctctgatga caatgaaagt
     1381 aactctgaaa gtgcagaaaa tggctgggac agtggctcca acttctcaga agaaaccaaa
     1441 ccacctagag tcccaaagta tgttttaaca gatcataaaa aagacctatt ggaagttcct
     1501 gaaataaaaa ctgaaggtga caaatttatc ccttgtgaga acaggtgtga ttctgaaaca
     1561 gaaaggaaag acccgcagaa tgctctcgca gaacccctgg atggcaatgc ccagccctca
     1621 ttccctgacg ttgaggagga agatagcgag agcctggcag taatgacgga agagggtagt
     1681 gacctggaaa aggccaaggg gaatttaagt ttgctggagc aggcaattgc tctgcaggct
     1741 gagcgaggtt gtgttttcca taacacctac aaagagctgg ataggttcct gctggagcac
     1801 ctagcagggg aaaggaggca aaccaaagtt atcgacatgg gtggaagaca aatctttaac
     1861 aataaacatt caccaaggcc tgaaaagagg gagaccaagt gcccgatccc tggatgtgat
     1921 ggcacgggac acgtgacagg gctctacccg caccaccgca gcctttcggg gtgcccccac
     1981 aaagtgcggg ttcccctgga aattcttgcc atgcatgaaa atgtgctcaa gtgtcccacg
     2041 ccgggatgca caggaagggg tcatgtgaac agcaaccgca acacccacag gagtctttct
     2101 ggttgtccaa ttgctgcagc tgaaaaattg gcaatgtccc aggataaaaa tcagcttgat
     2161 tctccccaaa ctgggcagtg tcctgaccag gcccacagga caagtttggt gaagcaaatt
     2221 gaattcaatt tcccgtcaca agccatcacc tctcccagag ccacagtgtc aaaagaacaa
     2281 gagaagtttg gaaaagtacc atttgattat gccagttttg atgcccaagt tttcggtaaa
     2341 cgccctctca tacaaacagt gcaaggacga aaaacaccac catttcctga atcaaagcat
     2401 tttccaaatc cagtgaaatt tcctaatcga ctgcctagtg caggcgccca cacccagagc
     2461 cctggccgtg ccagctctta tagctacggt caatgtagtg aagacaccca catagcagca
     2521 gctgctgcca tcctgaacct ttccacccgc tgcagggaag ccacagacat cctctccaac
     2581 aagccacaga gtctgcatgc caagggagcc gaaatagaag tggatgaaaa tggcacattg
     2641 gacttaagca tgaaaaaaaa tcgaatcctg gacaagtctg cacccctaac ttcctctaac
     2701 acttctattc caactccttc ctcttcccca ttcaaaacaa gcagcattct ggtcaatgca
     2761 gcattctatc aggctctttg tgaccaagag ggctgggaca ctcctatcaa ctatagcaaa
     2821 actcacggga agacagagga ggagaaagag aaagacccag tgagctctct agaaaattta
     2881 gaggaaaaaa agtttcctgg agaggcctct ataccaagcc ctaaacccaa gcttcatgca
     2941 agagatctca aaaaggaact aatcacctgt ccaacaccag gatgtgatgg aagtggccac
     3001 gtgacaggaa actatgcatc tcatcgcagt gtttctggat gtcctttagc agataagact
     3061 ctaaaatccc tcatggctgc caactctcag gagcttaagt gtccaacccc aggctgcgat
     3121 ggctcggggc acgtgactgg aaactatgct tcccacagaa gcttgtccgg atgccctcgt
     3181 gcaaggaaag gtggtgtcaa aatgacccct accaaggaag aaaaagaaga ccctgaactg
     3241 aaatgtcctg tgatagggtg tgatggccaa ggtcacatat caggtaaata cacatcacac
     3301 cgcacagctt ctggctgtcc tctggctgcc aagagacaga aggagaatcc tctcaatgga
     3361 gcctccctct cctggaaact gaacaaacaa gagctaccac attgtccctt gccaggctgc
     3421 aatgggctgg gccatgtaaa taatgttttt gtcacccacc gaagcttatc tggatgtcct
     3481 ctcaatgcac aagttatcaa aaagggcaag gtttctgaag aactcatgac catcaagctc
     3541 aaagcaactg ggggaataga gagtgatgaa gaaattaggc atttggatga agaaataaag
     3601 gaactgaatg aatccaacct taaaattgaa gcagatatga tgaaacttca gacccagatc
     3661 acatctatgg agagcaactt aaagacgata gaggaggaga acaaactcat agaacagaac
     3721 aatgaaagtc tgctgaaaga gctggcaggt ctaagccaag ctctcatttc aagccttgct
     3781 gacatccagc ttccacagat gggacctatc agtgagcaga attttgaagc atatgtaaat
     3841 acactcacag atatgtacag caatctggaa cgggactatt ccccggaatg caaagctcta
     3901 ctggaaagta tcaaacaggc agtgaagggt atccatgtgt aggatcacag cgctgccggg
     3961 caacagaagt taccaacagc agtaaactcc agatggatct gttagaggtt catgtactgc
     4021 taaggcgtgg aggttgccgt actgcattta caatttgcaa cattgcacta attttatttt
     4081 ccccagctga tataaaaagg aaagaaaaac tatgatagac ttcttggatt aaaagcaatg
     4141 cagtcaatta ttagatctta tttattttca tatgtttttc ttttatttct tcattgtact
     4201 cttttttttt ttgtaaagta tatgtaaaat aaatgtgaca tttttataat ttatttatta
     4261 ctaatcaaag agttttttat cttttaactg cattttgaag tctgccgtat ttttacaagt
     4321 gtgtttatta atttattttc caataggatt taaatagaaa tgctattctc aagtcatctt
     4381 tcttgctggg ttttaatgag gaaacaggaa agggtgaagg aaatccttgt ctaaggactg
     4441 cactatagtt gagtttgatt tttattgcac acttcttccc ccacctttca ctgatttttg
     4501 tatttataaa tgaatttgcg gtaaggtgag ctgcacggaa ggaataagaa gacaaatggc
     4561 gcccactagt ggggaatccg cactcacaaa agcacaggat gctggaaaac agcctgctca
     4621 gaatttgtta gcaataatta aatatagcaa tcagcaaagt attcgacttg gctggacggt
     4681 tttcgttaat atgaattatt tatttgaaat gttttaaaga aacataagcc tttttagtga
     4741 tgcagatttg tctgtttgtt tttcaagtca tatcagatcg ttggcaactc gtatcccaag
     4801 atgaaaaata agacttggtg tgaccagcca ggctttcctg ccatatgttg gtacaatata
     4861 caagtgacaa tattggtgta gatttgtact tagcaaatac aaacacatcc aaatgaaaaa
     4921 ttttgtagat accatatccc ctgaaatagc atttatctta ctgggttgac tggaaaggaa
     4981 tggaaaatat agtaacacat gaaaaaatgc tactccaatc tgaatgatta cttcaaacac
     5041 tggcaccttg ggtctcaccc accataggaa acaagacaac attcaatttg atagaaatct
     5101 tgccacaaaa cttcaaatgc tacaaaatat acacacacac tcacacacac aggcatactc
     5161 acacacagac acacacacac acacacacac agactcatcc acacttcaaa ttgagcccac
     5221 aatcttgaat ttctgaacgg atcagagttt catagtttct atagtaaagg caatgtctat
     5281 ttcagggatt gtaaagtagt taagcattgt ttcaaaagtt tttttatatt tatttttttt
     5341 aaggaaaagg tatagacaac cagctaaact gcctttttgg tgtgcacaca catttcatgt
     5401 gcagacgtgc ctctgtgtaa atgtacacat gaacttcatg tgggcttaat tttctgtgct
     5461 ataaacaaaa gtgtttattt tttattaacc tcatggatat ttagatggaa agtgatggca
     5521 ttcacaggct tgatgtattc cactgttatt actgttacct gcacaaatga aaaacaatac
     5581 tcaacagtaa ttccactccc atgaaacttt ggtcattgtt atgcattaag tggggcttat
     5641 ctttggtttg gagttcattt gaactcttga accttagttt agtgaagatg aactgtctgt
     5701 tcttaggtag aaacggtgtt tatttaaaaa tcagttttaa aaaatgagct accatatgtg
     5761 ctgtctatta taaatgggac accaaacaaa attttctatt acagttgtgt acttgcaaac
     5821 attttgctat acagtacttc atagatgcat acaaatgagc tcacttatta caaagacaaa
     5881 cgtttaattt gctaaatatt ttaacaagtt tgttatatat tttatttaat ttaaaagaaa
     5941 tctcttacca acctacatat ttattactat aatttgctat gacttcaggt taatttattt
     6001 gtgtttgcat agtttgagca ggatgttttg tgaagtatgt ttgtatttat ttgcctactt
     6061 tgtacttgat gtgttttgta atgtgcactg aatttgtttt cttttcaact atgttaatga
     6121 tcaatactgt aaattgggtc ttttgtaaac aaaaaggcaa tgatgtatgc atttttttta
     6181 atttgaggta gtttgtttgt atactgtttc tccaaacact taatatttct tacatcaaag
     6241 caacaaaatt gtgttcagtg ctgtacattt ggtgtatggt aggaaataaa aattgataac
     6301 ga
//
