LOCUS       NM_001352831            6385 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens ST18 C2H2C-type zinc finger transcription factor
            (ST18), transcript variant 7, mRNA.
ACCESSION   NM_001352831 XM_017014052
VERSION     NM_001352831.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6385)
  AUTHORS   Assaf,S., Vodo,D., Malovitski,K., Mohamad,J., Bergson,S.,
            Feller,Y., Malki,L., Sarig,O. and Sprecher,E.
  TITLE     Up-regulation of ST18 in pemphigus vulgaris drives a
            self-amplifying p53-dependent pathomechanism resulting in decreased
            desmoglein 3 expression
  JOURNAL   Sci Rep 12 (1), 5958 (2022)
   PUBMED   35396567
  REMARK    GeneRIF: Up-regulation of ST18 in pemphigus vulgaris drives a
            self-amplifying p53-dependent pathomechanism resulting in decreased
            desmoglein 3 expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6385)
  AUTHORS   Skou,A.S., Juul-Dam,K.L., Hansen,M., Lausen,B., Stratmann,S.,
            Holmfeldt,L., Aggerholm,A., Nyvold,C.G., Ommen,H.B. and Hasle,H.
  TITLE     Measurable Residual Disease Monitoring of SPAG6, ST18, PRAME, and
            XAGE1A Expression in Peripheral Blood May Detect Imminent Relapse
            in Childhood Acute Myeloid Leukemia
  JOURNAL   J Mol Diagn 23 (12), 1787-1799 (2021)
   PUBMED   34600138
  REMARK    GeneRIF: Measurable Residual Disease Monitoring of SPAG6, ST18,
            PRAME, and XAGE1A Expression in Peripheral Blood May Detect
            Imminent Relapse in Childhood Acute Myeloid Leukemia.
REFERENCE   3  (bases 1 to 6385)
  AUTHORS   Kim,B.H., Nho,K. and Lee,J.M.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     Genome-wide association study identifies susceptibility loci of
            brain atrophy to NFIA and ST18 in Alzheimer's disease
  JOURNAL   Neurobiol Aging 102, 200 (2021)
   PUBMED   33640202
  REMARK    GeneRIF: Genome-wide association study identifies susceptibility
            loci of brain atrophy to NFIA and ST18 in Alzheimer's disease.
REFERENCE   4  (bases 1 to 6385)
  AUTHORS   Assaf,S., Malki,L., Mayer,T., Mohamad,J., Peled,A., Pavlovsky,M.,
            Malovitski,K., Sarig,O., Vodo,D. and Sprecher,E.
  TITLE     ST18 affects cell-cell adhesion in pemphigus vulgaris in a tumour
            necrosis factor-alpha-dependent fashion
  JOURNAL   Br J Dermatol 184 (6), 1153-1160 (2021)
   PUBMED   33205400
  REMARK    GeneRIF: ST18 affects cell-cell adhesion in pemphigus vulgaris in a
            tumour necrosis factor-alpha-dependent fashion.
REFERENCE   5  (bases 1 to 6385)
  AUTHORS   Radeva,M.Y., Walter,E., Stach,R.A., Yazdi,A.S., Schlegel,N.,
            Sarig,O., Sprecher,E. and Waschke,J.
  TITLE     ST18 Enhances PV-IgG-Induced Loss of Keratinocyte Cohesion in
            Parallel to Increased ERK Activation
  JOURNAL   Front Immunol 10, 770 (2019)
   PUBMED   31057535
  REMARK    GeneRIF: ST18 Enhances PV-IgG-Induced Loss of Keratinocyte Cohesion
            in Parallel to Increased ERK Activation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6385)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 6385)
  AUTHORS   Yang,J., Siqueira,M.F., Behl,Y., Alikhani,M. and Graves,D.T.
  TITLE     The transcription factor ST18 regulates proapoptotic and
            proinflammatory gene expression in fibroblasts
  JOURNAL   FASEB J 22 (11), 3956-3967 (2008)
   PUBMED   18676404
  REMARK    GeneRIF: Fibroblasts that overexpress ST18 by transient
            transfection exhibit significantly increased apoptosis and
            increased expression of TNF-alpha, interleukin (IL) -1alpha, and
            IL-6.
REFERENCE   8  (bases 1 to 6385)
  AUTHORS   Jandrig,B., Seitz,S., Hinzmann,B., Arnold,W., Micheel,B.,
            Koelble,K., Siebert,R., Schwartz,A., Ruecker,K., Schlag,P.M.,
            Scherneck,S. and Rosenthal,A.
  TITLE     ST18 is a breast cancer tumor suppressor gene at human chromosome
            8q11.2
  JOURNAL   Oncogene 23 (57), 9295-9302 (2004)
   PUBMED   15489893
  REMARK    GeneRIF: ectopic ST18 expression in MCF-7 breast cancer cells
            strongly inhibits colony formation in soft agar and the formation
            of tumors in a xenograft mouse model
REFERENCE   9  (bases 1 to 6385)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol Vis 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 6385)
  AUTHORS   Yee,K.S. and Yu,V.C.
  TITLE     Isolation and characterization of a novel member of the neural zinc
            finger factor/myelin transcription factor family with
            transcriptional repression activity
  JOURNAL   J Biol Chem 273 (9), 5366-5374 (1998)
   PUBMED   9478997
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC103831.4 and AC021915.11.
            
            On Aug 14, 2020 this sequence version replaced NM_001352831.1.
            
            Transcript Variant: This variant (7) encodes isoform a. Variants
            1-33 all encode isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.113729.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AC103831.4         11673-11881
            210-334             AC103831.4         11977-12101
            335-413             AC021915.11        165281-165359       c
            414-459             AC021915.11        148727-148772       c
            460-613             AC021915.11        140335-140488       c
            614-721             AC021915.11        139436-139543       c
            722-881             AC021915.11        136437-136596       c
            882-936             AC021915.11        132898-132952       c
            937-967             AC021915.11        130774-130804       c
            968-1158            AC021915.11        98817-99007         c
            1159-1950           AC021915.11        90487-91278         c
            1951-2085           AC021915.11        85547-85681         c
            2086-2176           AC021915.11        83830-83920         c
            2177-2281           AC021915.11        82681-82785         c
            2282-2475           AC021915.11        80070-80263         c
            2476-2687           AC021915.11        77593-77804         c
            2688-2933           AC021915.11        68427-68672         c
            2934-3049           AC021915.11        61625-61740         c
            3050-3112           AC021915.11        56116-56178         c
            3113-3181           AC021915.11        55285-55353         c
            3182-3244           AC021915.11        51934-51996         c
            3245-3325           AC021915.11        51752-51832         c
            3326-3547           AC021915.11        50653-50874         c
            3548-3636           AC021915.11        44747-44835         c
            3637-3740           AC021915.11        37033-37136         c
            3741-3884           AC021915.11        34970-35113         c
            3885-6385           AC021915.11        29533-32033         c
FEATURES             Location/Qualifiers
     source          1..6385
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q11.23"
     gene            1..6385
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /note="ST18 C2H2C-type zinc finger transcription factor"
                     /db_xref="GeneID:9705"
                     /db_xref="HGNC:HGNC:18695"
                     /db_xref="MIM:617155"
     exon            1..209
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            210..334
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            335..413
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            414..459
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            460..613
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            614..721
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            722..881
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     CDS             882..4025
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /note="isoform a is encoded by transcript variant 7; zinc
                     finger protein 387; suppression of tumorigenicity 18
                     (breast carcinoma) (zinc finger protein); suppression of
                     tumorigenicity 18, zinc finger; neural zinc finger
                     transcription factor 3; ST18, C2H2C-type zinc finger;
                     suppression of tumorigenicity 18 protein"
                     /codon_start=1
                     /product="suppression of tumorigenicity 18 protein isoform
                     a"
                     /protein_id="NP_001339760.1"
                     /db_xref="CCDS:CCDS6149.1"
                     /db_xref="GeneID:9705"
                     /db_xref="HGNC:HGNC:18695"
                     /db_xref="MIM:617155"
                     /translation="MDAEAEDKTLRTRSKGTEVPMDSLIQELSVAYDCSMAKKRTAED
                     QALGVPVNKRKSLLMKPRHYSPKADCQEDRSDRTEDDGPLETHGHSTAEEIMIKPMDE
                     SLLSTAQENSSRKEDRYSCYQELMVKSLMHLGKFEKNVSVQTVSENLNDSGIQSLKAE
                     SDEADECFLIHSDDGRDKIDDSQPPFCSSDDNESNSESAENGWDSGSNFSEETKPPRV
                     PKYVLTDHKKDLLEVPEIKTEGDKFIPCENRCDSETERKDPQNALAEPLDGNAQPSFP
                     DVEEEDSESLAVMTEEGSDLEKAKGNLSLLEQAIALQAERGCVFHNTYKELDRFLLEH
                     LAGERRQTKVIDMGGRQIFNNKHSPRPEKRETKCPIPGCDGTGHVTGLYPHHRSLSGC
                     PHKVRVPLEILAMHENVLKCPTPGCTGRGHVNSNRNTHRSLSGCPIAAAEKLAMSQDK
                     NQLDSPQTGQCPDQAHRTSLVKQIEFNFPSQAITSPRATVSKEQEKFGKVPFDYASFD
                     AQVFGKRPLIQTVQGRKTPPFPESKHFPNPVKFPNRLPSAGAHTQSPGRASSYSYGQC
                     SEDTHIAAAAAILNLSTRCREATDILSNKPQSLHAKGAEIEVDENGTLDLSMKKNRIL
                     DKSAPLTSSNTSIPTPSSSPFKTSSILVNAAFYQALCDQEGWDTPINYSKTHGKTEEE
                     KEKDPVSSLENLEEKKFPGEASIPSPKPKLHARDLKKELITCPTPGCDGSGHVTGNYA
                     SHRSVSGCPLADKTLKSLMAANSQELKCPTPGCDGSGHVTGNYASHRSLSGCPRARKG
                     GVKMTPTKEEKEDPELKCPVIGCDGQGHISGKYTSHRTASGCPLAAKRQKENPLNGAS
                     LSWKLNKQELPHCPLPGCNGLGHVNNVFVTHRSLSGCPLNAQVIKKGKVSEELMTIKL
                     KATGGIESDEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENKLIE
                     QNNESLLKELAGLSQALISSLADIQLPQMGPISEQNFEAYVNTLTDMYSNLERDYSPE
                     CKALLESIKQAVKGIHV"
     exon            882..936
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            937..967
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1158
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1950
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2085
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2176
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2281
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2475
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2687
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2933
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..3049
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3050..3112
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..3181
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3182..3244
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3245..3325
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..3547
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3548..3636
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3637..3740
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3741..3884
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     exon            3885..6385
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6368..6373
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /note="hexamer: AATAAA"
     polyA_site      6385
                     /gene="ST18"
                     /gene_synonym="NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387"
                     /note="major polyA site"
ORIGIN      
        1 gattctatgg aacctttttg tagggagaag ggcaggatgt ttttaactga atgtgacctc
       61 aggggaatac tagaggtaag gagagaaaaa taattgaggt aactgtgggt gttttacatc
      121 tcggaaacca tggcttttaa taaggccaca tgaagagaga agctggcatc atcccacgca
      181 aaaaccagtg cctggcagag ttgtggaaga aaataataaa atttctgaat ggggcagcgt
      241 ggagaaatcc taagagaaat agcataagag cattttggaa cacatccagg aaaagataac
      301 tttcgacaca cctgtagacg ttcgccaggt aaagagcccc caattttgtg agtgtccctg
      361 aagcattgtg acaattccat tttatgtgtc tgcgtgctca tatcaagact aaggagtgat
      421 ggaaactctc cagttcagat ccagtagctt ttagggaagg aactacagtt gctgacttaa
      481 gttgaagaag catctattta atgtctggtc aaatcctaca agaaacacag aaatctatga
      541 ttaaaaagct gagcactttg atatactgca aagggtagag aaggcaggac ggtagaaatt
      601 ttctgcaaga aagaatgaat ttcaggattt atcactaaat aagacaaagt catttattta
      661 gtccccctga cacagcaggg caaactgagt tgacatacaa gttacctgga gaaaaagaga
      721 gcaattccag gacttcctct tcagcctaaa agaaggtacc agatctgtgc actggggcga
      781 tgtggaagag acctgcttat tgcccctgat gtaagctcca gtaagaaaag acgtcaagta
      841 caagtactag gaaatcactt tatacatctg tttataggtt tatggatgca gaggctgaag
      901 ataaaacgct gcgtactcgc tctaaaggaa ccgaggtgcc aatggattca ctaatccagg
      961 agctcagtgt tgcctatgat tgctccatgg caaagaagag aacagctgaa gatcaggctt
     1021 tgggggttcc agtcaacaaa aggaaatccc tgctaatgaa gccccgacac tacagcccaa
     1081 aagcagactg ccaagaagac cgcagtgaca ggacagagga cgatggcccc ttggaaacac
     1141 atggtcactc taccgcagag gaaatcatga taaaacctat ggatgaaagt cttctttcaa
     1201 ctgcacaaga aaactccagt aggaaggaag acagatactc ttgttatcaa gagctcatgg
     1261 tcaagtcttt aatgcacttg gggaaatttg aaaaaaatgt atctgttcag actgtaagtg
     1321 aaaatttaaa tgacagtggc atccagtctt taaaagcaga gagcgatgaa gcagacgagt
     1381 gctttctgat tcattctgat gatggaagag acaagattga tgattctcag ccacccttct
     1441 gctcctctga tgacaatgaa agtaactctg aaagtgcaga aaatggctgg gacagtggct
     1501 ccaacttctc agaagaaacc aaaccaccta gagtcccaaa gtatgtttta acagatcata
     1561 aaaaagacct attggaagtt cctgaaataa aaactgaagg tgacaaattt atcccttgtg
     1621 agaacaggtg tgattctgaa acagaaagga aagacccgca gaatgctctc gcagaacccc
     1681 tggatggcaa tgcccagccc tcattccctg acgttgagga ggaagatagc gagagcctgg
     1741 cagtaatgac ggaagagggt agtgacctgg aaaaggccaa ggggaattta agtttgctgg
     1801 agcaggcaat tgctctgcag gctgagcgag gttgtgtttt ccataacacc tacaaagagc
     1861 tggataggtt cctgctggag cacctagcag gggaaaggag gcaaaccaaa gttatcgaca
     1921 tgggtggaag acaaatcttt aacaataaac attcaccaag gcctgaaaag agggagacca
     1981 agtgcccgat ccctggatgt gatggcacgg gacacgtgac agggctctac ccgcaccacc
     2041 gcagcctttc ggggtgcccc cacaaagtgc gggttcccct ggaaattctt gccatgcatg
     2101 aaaatgtgct caagtgtccc acgccgggat gcacaggaag gggtcatgtg aacagcaacc
     2161 gcaacaccca caggagtctt tctggttgtc caattgctgc agctgaaaaa ttggcaatgt
     2221 cccaggataa aaatcagctt gattctcccc aaactgggca gtgtcctgac caggcccaca
     2281 ggacaagttt ggtgaagcaa attgaattca atttcccgtc acaagccatc acctctccca
     2341 gagccacagt gtcaaaagaa caagagaagt ttggaaaagt accatttgat tatgccagtt
     2401 ttgatgccca agttttcggt aaacgccctc tcatacaaac agtgcaagga cgaaaaacac
     2461 caccatttcc tgaatcaaag cattttccaa atccagtgaa atttcctaat cgactgccta
     2521 gtgcaggcgc ccacacccag agccctggcc gtgccagctc ttatagctac ggtcaatgta
     2581 gtgaagacac ccacatagca gcagctgctg ccatcctgaa cctttccacc cgctgcaggg
     2641 aagccacaga catcctctcc aacaagccac agagtctgca tgccaaggga gccgaaatag
     2701 aagtggatga aaatggcaca ttggacttaa gcatgaaaaa aaatcgaatc ctggacaagt
     2761 ctgcacccct aacttcctct aacacttcta ttccaactcc ttcctcttcc ccattcaaaa
     2821 caagcagcat tctggtcaat gcagcattct atcaggctct ttgtgaccaa gagggctggg
     2881 acactcctat caactatagc aaaactcacg ggaagacaga ggaggagaaa gagaaagacc
     2941 cagtgagctc tctagaaaat ttagaggaaa aaaagtttcc tggagaggcc tctataccaa
     3001 gccctaaacc caagcttcat gcaagagatc tcaaaaagga actaatcacc tgtccaacac
     3061 caggatgtga tggaagtggc cacgtgacag gaaactatgc atctcatcgc agtgtttctg
     3121 gatgtccttt agcagataag actctaaaat ccctcatggc tgccaactct caggagctta
     3181 agtgtccaac cccaggctgc gatggctcgg ggcacgtgac tggaaactat gcttcccaca
     3241 gaagcttgtc cggatgccct cgtgcaagga aaggtggtgt caaaatgacc cctaccaagg
     3301 aagaaaaaga agaccctgaa ctgaaatgtc ctgtgatagg gtgtgatggc caaggtcaca
     3361 tatcaggtaa atacacatca caccgcacag cttctggctg tcctctggct gccaagagac
     3421 agaaggagaa tcctctcaat ggagcctccc tctcctggaa actgaacaaa caagagctac
     3481 cacattgtcc cttgccaggc tgcaatgggc tgggccatgt aaataatgtt tttgtcaccc
     3541 accgaagctt atctggatgt cctctcaatg cacaagttat caaaaagggc aaggtttctg
     3601 aagaactcat gaccatcaag ctcaaagcaa ctgggggaat agagagtgat gaagaaatta
     3661 ggcatttgga tgaagaaata aaggaactga atgaatccaa ccttaaaatt gaagcagata
     3721 tgatgaaact tcagacccag atcacatcta tggagagcaa cttaaagacg atagaggagg
     3781 agaacaaact catagaacag aacaatgaaa gtctgctgaa agagctggca ggtctaagcc
     3841 aagctctcat ttcaagcctt gctgacatcc agcttccaca gatgggacct atcagtgagc
     3901 agaattttga agcatatgta aatacactca cagatatgta cagcaatctg gaacgggact
     3961 attccccgga atgcaaagct ctactggaaa gtatcaaaca ggcagtgaag ggtatccatg
     4021 tgtaggatca cagcgctgcc gggcaacaga agttaccaac agcagtaaac tccagatgga
     4081 tctgttagag gttcatgtac tgctaaggcg tggaggttgc cgtactgcat ttacaatttg
     4141 caacattgca ctaattttat tttccccagc tgatataaaa aggaaagaaa aactatgata
     4201 gacttcttgg attaaaagca atgcagtcaa ttattagatc ttatttattt tcatatgttt
     4261 ttcttttatt tcttcattgt actctttttt tttttgtaaa gtatatgtaa aataaatgtg
     4321 acatttttat aatttattta ttactaatca aagagttttt tatcttttaa ctgcattttg
     4381 aagtctgccg tatttttaca agtgtgttta ttaatttatt ttccaatagg atttaaatag
     4441 aaatgctatt ctcaagtcat ctttcttgct gggttttaat gaggaaacag gaaagggtga
     4501 aggaaatcct tgtctaagga ctgcactata gttgagtttg atttttattg cacacttctt
     4561 cccccacctt tcactgattt ttgtatttat aaatgaattt gcggtaaggt gagctgcacg
     4621 gaaggaataa gaagacaaat ggcgcccact agtggggaat ccgcactcac aaaagcacag
     4681 gatgctggaa aacagcctgc tcagaatttg ttagcaataa ttaaatatag caatcagcaa
     4741 agtattcgac ttggctggac ggttttcgtt aatatgaatt atttatttga aatgttttaa
     4801 agaaacataa gcctttttag tgatgcagat ttgtctgttt gtttttcaag tcatatcaga
     4861 tcgttggcaa ctcgtatccc aagatgaaaa ataagacttg gtgtgaccag ccaggctttc
     4921 ctgccatatg ttggtacaat atacaagtga caatattggt gtagatttgt acttagcaaa
     4981 tacaaacaca tccaaatgaa aaattttgta gataccatat cccctgaaat agcatttatc
     5041 ttactgggtt gactggaaag gaatggaaaa tatagtaaca catgaaaaaa tgctactcca
     5101 atctgaatga ttacttcaaa cactggcacc ttgggtctca cccaccatag gaaacaagac
     5161 aacattcaat ttgatagaaa tcttgccaca aaacttcaaa tgctacaaaa tatacacaca
     5221 cactcacaca cacaggcata ctcacacaca gacacacaca cacacacaca cacagactca
     5281 tccacacttc aaattgagcc cacaatcttg aatttctgaa cggatcagag tttcatagtt
     5341 tctatagtaa aggcaatgtc tatttcaggg attgtaaagt agttaagcat tgtttcaaaa
     5401 gtttttttat atttattttt tttaaggaaa aggtatagac aaccagctaa actgcctttt
     5461 tggtgtgcac acacatttca tgtgcagacg tgcctctgtg taaatgtaca catgaacttc
     5521 atgtgggctt aattttctgt gctataaaca aaagtgttta ttttttatta acctcatgga
     5581 tatttagatg gaaagtgatg gcattcacag gcttgatgta ttccactgtt attactgtta
     5641 cctgcacaaa tgaaaaacaa tactcaacag taattccact cccatgaaac tttggtcatt
     5701 gttatgcatt aagtggggct tatctttggt ttggagttca tttgaactct tgaaccttag
     5761 tttagtgaag atgaactgtc tgttcttagg tagaaacggt gtttatttaa aaatcagttt
     5821 taaaaaatga gctaccatat gtgctgtcta ttataaatgg gacaccaaac aaaattttct
     5881 attacagttg tgtacttgca aacattttgc tatacagtac ttcatagatg catacaaatg
     5941 agctcactta ttacaaagac aaacgtttaa tttgctaaat attttaacaa gtttgttata
     6001 tattttattt aatttaaaag aaatctctta ccaacctaca tatttattac tataatttgc
     6061 tatgacttca ggttaattta tttgtgtttg catagtttga gcaggatgtt ttgtgaagta
     6121 tgtttgtatt tatttgccta ctttgtactt gatgtgtttt gtaatgtgca ctgaatttgt
     6181 tttcttttca actatgttaa tgatcaatac tgtaaattgg gtcttttgta aacaaaaagg
     6241 caatgatgta tgcatttttt ttaatttgag gtagtttgtt tgtatactgt ttctccaaac
     6301 acttaatatt tcttacatca aagcaacaaa attgtgttca gtgctgtaca tttggtgtat
     6361 ggtaggaaat aaaaattgat aacga
//
