LOCUS       NM_021978               3305 bp    mRNA    linear   PRI 13-MAY-2024
DEFINITION  Homo sapiens ST14 transmembrane serine protease matriptase (ST14),
            mRNA.
ACCESSION   NM_021978
VERSION     NM_021978.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3305)
  AUTHORS   Ye,F., Yuan,Z., Tang,Y., Li,J., Liu,X., Sun,X., Chen,S., Ye,X.,
            Zeng,Z., Zhang,X.K. and Zhou,H.
  TITLE     Endocytic activation and exosomal secretion of matriptase stimulate
            the second wave of EGF signaling to promote skin and breast cancer
            invasion
  JOURNAL   Cell Rep 43 (4), 114002 (2024)
   PUBMED   38547126
  REMARK    GeneRIF: Endocytic activation and exosomal secretion of matriptase
            stimulate the second wave of EGF signaling to promote skin and
            breast cancer invasion.
REFERENCE   2  (bases 1 to 3305)
  AUTHORS   Jang,J., Cho,E.H., Cho,Y., Ganzorig,B., Kim,K.Y., Kim,M.G. and
            Kim,C.
  TITLE     Environment-Sensitive Ectodomain Shedding of Epithin/PRSS14
            Increases Metastatic Potential of Breast Cancer Cells by Producing
            CCL2
  JOURNAL   Mol Cells 45 (8), 564-574 (2022)
   PUBMED   35950457
  REMARK    GeneRIF: Environment-Sensitive Ectodomain Shedding of
            Epithin/PRSS14 Increases Metastatic Potential of Breast Cancer
            Cells by Producing CCL2.
REFERENCE   3  (bases 1 to 3305)
  AUTHORS   Serra,G., Memo,L., Cavicchioli,P., Cutrone,M., Giuffre,M., La
            Torre,M.L., Schierz,I.A.M. and Corsello,G.
  TITLE     Novel mutations of the ABCA12, KRT1 and ST14 genes in three
            unrelated newborns showing congenital ichthyosis
  JOURNAL   Ital J Pediatr 48 (1), 145 (2022)
   PUBMED   35964051
  REMARK    GeneRIF: Novel mutations of the ABCA12, KRT1 and ST14 genes in
            three unrelated newborns showing congenital ichthyosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3305)
  AUTHORS   Yamashita,F., Kaieda,T., Shimomura,T., Kawaguchi,M., Lin,C.Y.,
            Johnson,M.D., Tanaka,H., Kiwaki,T., Fukushima,T. and Kataoka,H.
  TITLE     Role of the polycystic kidney disease domain in matriptase
            chaperone activity and localization of hepatocyte growth factor
            activator inhibitor-1
  JOURNAL   FEBS J 289 (12), 3422-3439 (2022)
   PUBMED   35020274
  REMARK    GeneRIF: Role of the polycystic kidney disease domain in matriptase
            chaperone activity and localization of hepatocyte growth factor
            activator inhibitor-1.
            Review article
REFERENCE   5  (bases 1 to 3305)
  AUTHORS   Dai,Y.H., Wang,Y.F., Shen,P.C., Lo,C.H., Yang,J.F., Lin,C.S.,
            Chao,H.L. and Huang,W.Y.
  TITLE     Gene-associated methylation status of ST14 as a predictor of
            survival and hormone receptor positivity in breast Cancer
  JOURNAL   BMC Cancer 21 (1), 945 (2021)
   PUBMED   34418985
  REMARK    GeneRIF: Gene-associated methylation status of ST14 as a predictor
            of survival and hormone receptor positivity in breast Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3305)
  AUTHORS   Takeuchi,T., Harris,J.L., Huang,W., Yan,K.W., Coughlin,S.R. and
            Craik,C.S.
  TITLE     Cellular localization of membrane-type serine protease 1 and
            identification of protease-activated receptor-2 and single-chain
            urokinase-type plasminogen activator as substrates
  JOURNAL   J Biol Chem 275 (34), 26333-26342 (2000)
   PUBMED   10831593
REFERENCE   7  (bases 1 to 3305)
  AUTHORS   Takeuchi,T., Shuman,M.A. and Craik,C.S.
  TITLE     Reverse biochemistry: use of macromolecular protease inhibitors to
            dissect complex biological processes and identify a membrane-type
            serine protease in epithelial cancer and normal tissue
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11054-11061 (1999)
   PUBMED   10500122
REFERENCE   8  (bases 1 to 3305)
  AUTHORS   Lin,C.Y., Anders,J., Johnson,M. and Dickson,R.B.
  TITLE     Purification and characterization of a complex containing
            matriptase and a Kunitz-type serine protease inhibitor from human
            milk
  JOURNAL   J Biol Chem 274 (26), 18237-18242 (1999)
   PUBMED   10373425
REFERENCE   9  (bases 1 to 3305)
  AUTHORS   Lin,C.Y., Anders,J., Johnson,M., Sang,Q.A. and Dickson,R.B.
  TITLE     Molecular cloning of cDNA for matriptase, a matrix-degrading serine
            protease with trypsin-like activity
  JOURNAL   J Biol Chem 274 (26), 18231-18236 (1999)
   PUBMED   10373424
REFERENCE   10 (bases 1 to 3305)
  AUTHORS   Zhang,Y., Cai,X., Schlegelberger,B. and Zheng,S.
  TITLE     Assignment1 of human putative tumor suppressor genes ST13 (alias
            SNC6) and ST14 (alias SNC19) to human chromosome bands 22q13 and
            11q24-->q25 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 83 (1-2), 56-57 (1998)
   PUBMED   9925927
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001183.6, BM791311.1,
            AB030036.1 and BC005826.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_021978.3.
            
            Summary: The protein encoded by this gene is an epithelial-derived,
            integral membrane serine protease. This protease forms a complex
            with the Kunitz-type serine protease inhibitor, HAI-1, and is found
            to be activated by sphingosine 1-phosphate. This protease has been
            shown to cleave and activate hepatocyte growth factor/scattering
            factor, and urokinase plasminogen activator, which suggest the
            function of this protease as an epithelial membrane activator for
            other proteases and latent growth factors. The expression of this
            protease has been associated with breast, colon, prostate, and
            ovarian tumors, which implicates its role in cancer invasion, and
            metastasis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030532.1, AF133086.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000278742.6/ ENSP00000278742.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AP001183.6         60574-60578
            6-183               BM791311.1         1-178
            184-2218            AB030036.1         1-2035
            2219-3305           BC005826.2         1034-2120
FEATURES             Location/Qualifiers
     source          1..3305
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.3"
     gene            1..3305
                     /gene="ST14"
                     /gene_synonym="ARCI11; CAP3; HAI; MT-SP1; MTSP1; PRSS14;
                     SNC19; TADG15; TMPRSS14"
                     /note="ST14 transmembrane serine protease matriptase"
                     /db_xref="GeneID:6768"
                     /db_xref="HGNC:HGNC:11344"
                     /db_xref="MIM:606797"
     exon            1..279
                     /gene="ST14"
                     /gene_synonym="ARCI11; CAP3; HAI; MT-SP1; MTSP1; PRSS14;
                     SNC19; TADG15; TMPRSS14"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..2766
                     /gene="ST14"
                     /gene_synonym="ARCI11; CAP3; HAI; MT-SP1; MTSP1; PRSS14;
                     SNC19; TADG15; TMPRSS14"
                     /EC_number="3.4.21.109"
                     /note="suppression of tumorigenicity 14 (colon carcinoma,
                     matriptase, epithin); membrane-type serine protease 1;
                     serine protease 14; prostamin; serine protease TADG-15;
                     tumor associated differentially expressed gene 15 protein;
                     suppression of tumorigenicity 14 (colon carcinoma);
                     channel-activating protein 3"
                     /codon_start=1
                     /product="suppressor of tumorigenicity 14 protein"
                     /protein_id="NP_068813.1"
                     /db_xref="CCDS:CCDS8487.1"
                     /db_xref="GeneID:6768"
                     /db_xref="HGNC:HGNC:11344"
                     /db_xref="MIM:606797"
                     /translation="MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLPVNNV
                     KKVEKHGPGRWVVLAAVLIGLLLVLLGIGFLVWHLQYRDVRVQKVFNGYMRITNENFV
                     DAYENSNSTEFVSLASKVKDALKLLYSGVPFLGPYHKESAVTAFSEGSVIAYYWSEFS
                     IPQHLVEEAERVMAEERVVMLPPRARSLKSFVVTSVVAFPTDSKTVQRTQDNSCSFGL
                     HARGVELMRFTTPGFPDSPYPAHARCQWALRGDADSVLSLTFRSFDLASCDERGSDLV
                     TVYNTLSPMEPHALVQLCGTYPPSYNLTFHSSQNVLLITLITNTERRHPGFEATFFQL
                     PRMSSCGGRLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGV
                     PAGTCPKDYVEINGEKYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSS
                     DPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVC
                     DSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVT
                     CTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCGLRSFTRQARVVGGTDADEG
                     EWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQS
                     QRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHVFP
                     AGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLLPQQITPRMMCVGFLSGGV
                     DSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIKENTGV"
     exon            280..439
                     /gene="ST14"
                     /gene_synonym="ARCI11; CAP3; HAI; MT-SP1; MTSP1; PRSS14;
                     SNC19; TADG15; TMPRSS14"
                     /inference="alignment:Splign:2.1.0"
     exon            440..567
                     /gene="ST14"
                     /gene_synonym="ARCI11; CAP3; HAI; MT-SP1; MTSP1; PRSS14;
                     SNC19; TADG15; TMPRSS14"
                     /inference="alignment:Splign:2.1.0"
     exon            568..638
                     /gene="ST14"
                     /gene_synonym="ARCI11; CAP3; HAI; MT-SP1; MTSP1; PRSS14;
                     SNC19; TADG15; TMPRSS14"
                     /inference="alignment:Splign:2.1.0"
     exon            639..796
                     /gene="ST14"
                     /gene_synonym="ARCI11; CAP3; HAI; MT-SP1; MTSP1; PRSS14;
                     SNC19; TADG15; TMPRSS14"
                     /inference="alignment:Splign:2.1.0"
     exon            797..832
                     /gene="ST14"
                     /gene_synonym="ARCI11; CAP3; HAI; MT-SP1; MTSP1; PRSS14;
                     SNC19; TADG15; TMPRSS14"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1073
                     /gene="ST14"
                     /gene_synonym="ARCI11; CAP3; HAI; MT-SP1; MTSP1; PRSS14;
                     SNC19; TADG15; TMPRSS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1213
                     /gene="ST14"
                     /gene_synonym="ARCI11; CAP3; HAI; MT-SP1; MTSP1; PRSS14;
                     SNC19; TADG15; TMPRSS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1311
                     /gene="ST14"
                     /gene_synonym="ARCI11; CAP3; HAI; MT-SP1; MTSP1; PRSS14;
                     SNC19; TADG15; TMPRSS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1421
                     /gene="ST14"
                     /gene_synonym="ARCI11; CAP3; HAI; MT-SP1; MTSP1; PRSS14;
                     SNC19; TADG15; TMPRSS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1552
                     /gene="ST14"
                     /gene_synonym="ARCI11; CAP3; HAI; MT-SP1; MTSP1; PRSS14;
                     SNC19; TADG15; TMPRSS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1657
                     /gene="ST14"
                     /gene_synonym="ARCI11; CAP3; HAI; MT-SP1; MTSP1; PRSS14;
                     SNC19; TADG15; TMPRSS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1768
                     /gene="ST14"
                     /gene_synonym="ARCI11; CAP3; HAI; MT-SP1; MTSP1; PRSS14;
                     SNC19; TADG15; TMPRSS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1882
                     /gene="ST14"
                     /gene_synonym="ARCI11; CAP3; HAI; MT-SP1; MTSP1; PRSS14;
                     SNC19; TADG15; TMPRSS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2005
                     /gene="ST14"
                     /gene_synonym="ARCI11; CAP3; HAI; MT-SP1; MTSP1; PRSS14;
                     SNC19; TADG15; TMPRSS14"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2192
                     /gene="ST14"
                     /gene_synonym="ARCI11; CAP3; HAI; MT-SP1; MTSP1; PRSS14;
                     SNC19; TADG15; TMPRSS14"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2467
                     /gene="ST14"
                     /gene_synonym="ARCI11; CAP3; HAI; MT-SP1; MTSP1; PRSS14;
                     SNC19; TADG15; TMPRSS14"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2604
                     /gene="ST14"
                     /gene_synonym="ARCI11; CAP3; HAI; MT-SP1; MTSP1; PRSS14;
                     SNC19; TADG15; TMPRSS14"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..3305
                     /gene="ST14"
                     /gene_synonym="ARCI11; CAP3; HAI; MT-SP1; MTSP1; PRSS14;
                     SNC19; TADG15; TMPRSS14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3282..3287
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST14"
                     /gene_synonym="ARCI11; CAP3; HAI; MT-SP1; MTSP1; PRSS14;
                     SNC19; TADG15; TMPRSS14"
                     /note="hexamer: AGTAAA"
     polyA_site      3305
                     /gene="ST14"
                     /gene_synonym="ARCI11; CAP3; HAI; MT-SP1; MTSP1; PRSS14;
                     SNC19; TADG15; TMPRSS14"
                     /note="major polyA site"
ORIGIN      
        1 gtgagagcgg agctgcagcc ggagaaagag gaagagggag agagagcgcg ccagggcgag
       61 ggcaccgccg ccggtcgggc gcgctgggcc tgcccggaat cccgccgcct gcgccccgcg
      121 ccccgcgccc tgcgggccat gggagccggc cgccggcagg gacgacgcct gtgagacccg
      181 cgagcggcct cggggaccat ggggagcgat cgggcccgca agggcggagg gggcccgaag
      241 gacttcggcg cgggactcaa gtacaactcc cggcacgaga aagtgaatgg cttggaggaa
      301 ggcgtggagt tcctgccagt caacaacgtc aagaaggtgg aaaagcatgg cccggggcgc
      361 tgggtggtgc tggcagccgt gctgatcggc ctcctcttgg tcttgctggg gatcggcttc
      421 ctggtgtggc atttgcagta ccgggacgtg cgtgtccaga aggtcttcaa tggctacatg
      481 aggatcacaa atgagaattt tgtggatgcc tacgagaact ccaactccac tgagtttgta
      541 agcctggcca gcaaggtgaa ggacgcgctg aagctgctgt acagcggagt cccattcctg
      601 ggcccctacc acaaggagtc ggctgtgacg gccttcagcg agggcagcgt catcgcctac
      661 tactggtctg agttcagcat cccgcagcac ctggtggagg aggccgagcg cgtcatggcc
      721 gaggagcgcg tagtcatgct gcccccgcgg gcgcgctccc tgaagtcctt tgtggtcacc
      781 tcagtggtgg ctttccccac ggactccaaa acagtacaga ggacccagga caacagctgc
      841 agctttggcc tgcacgcccg cggtgtggag ctgatgcgct tcaccacgcc cggcttccct
      901 gacagcccct accccgctca tgcccgctgc cagtgggccc tgcgggggga cgccgactca
      961 gtgctgagcc tcaccttccg cagctttgac cttgcgtcct gcgacgagcg cggcagcgac
     1021 ctggtgacgg tgtacaacac cctgagcccc atggagcccc acgccctggt gcagttgtgt
     1081 ggcacctacc ctccctccta caacctgacc ttccactcct cccagaacgt cctgctcatc
     1141 acactgataa ccaacactga gcggcggcat cccggctttg aggccacctt cttccagctg
     1201 cctaggatga gcagctgtgg aggccgctta cgtaaagccc aggggacatt caacagcccc
     1261 tactacccag gccactaccc acccaacatt gactgcacat ggaacattga ggtgcccaac
     1321 aaccagcatg tgaaggtgcg cttcaaattc ttctacctgc tggagcccgg cgtgcctgcg
     1381 ggcacctgcc ccaaggacta cgtggagatc aacggggaga aatactgcgg agagaggtcc
     1441 cagttcgtcg tcaccagcaa cagcaacaag atcacagttc gcttccactc agatcagtcc
     1501 tacaccgaca ccggcttctt agctgaatac ctctcctacg actccagtga cccatgcccg
     1561 gggcagttca cgtgccgcac ggggcggtgt atccggaagg agctgcgctg tgatggctgg
     1621 gccgactgca ccgaccacag cgatgagctc aactgcagtt gcgacgccgg ccaccagttc
     1681 acgtgcaaga acaagttctg caagcccctc ttctgggtct gcgacagtgt gaacgactgc
     1741 ggagacaaca gcgacgagca ggggtgcagt tgtccggccc agaccttcag gtgttccaat
     1801 gggaagtgcc tctcgaaaag ccagcagtgc aatgggaagg acgactgtgg ggacgggtcc
     1861 gacgaggcct cctgccccaa ggtgaacgtc gtcacttgta ccaaacacac ctaccgctgc
     1921 ctcaatgggc tctgcttgag caagggcaac cctgagtgtg acgggaagga ggactgtagc
     1981 gacggctcag atgagaagga ctgcgactgt gggctgcggt cattcacgag acaggctcgt
     2041 gttgttgggg gcacggatgc ggatgagggc gagtggccct ggcaggtaag cctgcatgct
     2101 ctgggccagg gccacatctg cggtgcttcc ctcatctctc ccaactggct ggtctctgcc
     2161 gcacactgct acatcgatga cagaggattc aggtactcag accccacgca gtggacggcc
     2221 ttcctgggct tgcacgacca gagccagcgc agcgcccctg gggtgcagga gcgcaggctc
     2281 aagcgcatca tctcccaccc cttcttcaat gacttcacct tcgactatga catcgcgctg
     2341 ctggagctgg agaaaccggc agagtacagc tccatggtgc ggcccatctg cctgccggac
     2401 gcctcccatg tcttccctgc cggcaaggcc atctgggtca cgggctgggg acacacccag
     2461 tatggaggca ctggcgcgct gatcctgcaa aagggtgaga tccgcgtcat caaccagacc
     2521 acctgcgaga acctcctgcc gcagcagatc acgccgcgca tgatgtgcgt gggcttcctc
     2581 agcggcggcg tggactcctg ccagggtgat tccgggggac ccctgtccag cgtggaggcg
     2641 gatgggcgga tcttccaggc cggtgtggtg agctggggag acggctgcgc tcagaggaac
     2701 aagccaggcg tgtacacaag gctccctctg tttcgggact ggatcaaaga gaacactggg
     2761 gtataggggc cggggccacc caaatgtgta cacctgcggg gccacccatc gtccacccca
     2821 gtgtgcacgc ctgcaggctg gagactggac cgctgactgc accagcgccc ccagaacata
     2881 cactgtgaac tcaatctcca gggctccaaa tctgcctaga aaacctctcg cttcctcagc
     2941 ctccaaagtg gagctgggag gtagaagggg aggacactgg tggttctact gacccaactg
     3001 ggggcaaagg tttgaagaca cagcctcccc cgccagcccc aagctgggcc gaggcgcgtt
     3061 tgtgcatatc tgcctcccct gtctctaagg agcagcggga acggagcttc ggggcctcct
     3121 cagtgaaggt ggtggggctg ccggatctgg gctgtggggc ccttgggcca cgctcttgag
     3181 gaagcccagg ctcggaggac cctggaaaac agacgggtct gagactgaaa ttgttttacc
     3241 agctcccagg gtggacttca gtgtgtgtat ttgtgtaaat gagtaaaaca ttttatttct
     3301 tttta
//
