LOCUS       NM_003932               3212 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens ST13 Hsp70 interacting protein (ST13), transcript
            variant 1, mRNA.
ACCESSION   NM_003932
VERSION     NM_003932.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3212)
  AUTHORS   Stetskaya,T.A., Krapiva,A.B., Kobzeva,K.A., Gurtovoy,D.E.,
            Komkova,G.V., Polonikov,A.V. and Bushueva,O.Y.
  TITLE     Polymorphism in Genes Encoding Adaptor Proteins ST13 and STIP1 and
            the Risk of Ischemic Stroke: a Pilot Study
  JOURNAL   Bull Exp Biol Med 176 (4), 477-480 (2024)
   PUBMED   38492099
  REMARK    GeneRIF: Polymorphism in Genes Encoding Adaptor Proteins ST13 and
            STIP1 and the Risk of Ischemic Stroke: a Pilot Study.
REFERENCE   2  (bases 1 to 3212)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3212)
  AUTHORS   Luo,M.S., Huang,G.J. and Liu,H.B.
  TITLE     An autophagy-related model of 4 key genes for predicting prognosis
            of patients with laryngeal cancer
  JOURNAL   Medicine (Baltimore) 99 (30), e21163 (2020)
   PUBMED   32791689
  REMARK    GeneRIF: An autophagy-related model of 4 key genes for predicting
            prognosis of patients with laryngeal cancer.
REFERENCE   4  (bases 1 to 3212)
  AUTHORS   Vijverberg,S.J., Koster,E.S., Tavendale,R., Leusink,M.,
            Koenderman,L., Raaijmakers,J.A., Postma,D.S., Koppelman,G.H.,
            Turner,S.W., Mukhopadhyay,S., Tse,S.M., Tantisira,K.G.,
            Hawcutt,D.B., Francis,B., Pirmohamed,M., Pino-Yanes,M., Eng,C.,
            Burchard,E.G., Palmer,C.N. and Maitland-van der Zee,A.H.
  TITLE     ST13 polymorphisms and their effect on exacerbations in
            steroid-treated asthmatic children and young adults
  JOURNAL   Clin Exp Allergy 45 (6), 1051-1059 (2015)
   PUBMED   25616159
  REMARK    GeneRIF: A novel susceptibility gene, ST13, coding for a
            cochaperone of the glucocorticoid receptor, is associated with
            exacerbations in asthmatic children and young adults despite their
            ICS use.
REFERENCE   5  (bases 1 to 3212)
  AUTHORS   Hosp,F., Vossfeldt,H., Heinig,M., Vasiljevic,D., Arumughan,A.,
            Wyler,E., Landthaler,M., Hubner,N., Wanker,E.E., Lannfelt,L.,
            Ingelsson,M., Lalowski,M., Voigt,A. and Selbach,M.
  CONSRTM   Genetic and Environmental Risk for Alzheimer's Disease GERAD1
            Consortium
  TITLE     Quantitative interaction proteomics of neurodegenerative disease
            proteins
  JOURNAL   Cell Rep 11 (7), 1134-1146 (2015)
   PUBMED   25959826
REFERENCE   6  (bases 1 to 3212)
  AUTHORS   Johnson,B.D., Schumacher,R.J., Ross,E.D. and Toft,D.O.
  TITLE     Hop modulates Hsp70/Hsp90 interactions in protein folding
  JOURNAL   J Biol Chem 273 (6), 3679-3686 (1998)
   PUBMED   9452498
REFERENCE   7  (bases 1 to 3212)
  AUTHORS   Cao,J., Cai,X., Zheng,L., Geng,L., Shi,Z., Pao,C.C. and Zheng,S.
  TITLE     Characterization of colorectal-cancer-related cDNA clones obtained
            by subtractive hybridization screening
  JOURNAL   J Cancer Res Clin Oncol 123 (8), 447-451 (1997)
   PUBMED   9292708
REFERENCE   8  (bases 1 to 3212)
  AUTHORS   Prapapanich,V., Chen,S., Toran,E.J., Rimerman,R.A. and Smith,D.F.
  TITLE     Mutational analysis of the hsp70-interacting protein Hip
  JOURNAL   Mol Cell Biol 16 (11), 6200-6207 (1996)
   PUBMED   8887650
REFERENCE   9  (bases 1 to 3212)
  AUTHORS   Mo,Y., Zheng,S. and Shen,D.
  TITLE     [Differential expression of HSU17714 gene in colorectal cancer and
            normal colonic mucosa]
  JOURNAL   Zhonghua Zhong Liu Za Zhi 18 (4), 241-243 (1996)
   PUBMED   9387309
REFERENCE   10 (bases 1 to 3212)
  AUTHORS   Prapapanich,V., Chen,S., Nair,S.C., Rimerman,R.A. and Smith,D.F.
  TITLE     Molecular cloning of human p48, a transient component of
            progesterone receptor complexes and an Hsp70-binding protein
  JOURNAL   Mol Endocrinol 10 (4), 420-431 (1996)
   PUBMED   8721986
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z98048.1, BC121107.1, U17714.1
            and BM679025.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003932.4.
            
            Summary: The protein encoded by this gene is an adaptor protein
            that mediates the association of the heat shock proteins HSP70 and
            HSP90. This protein has been shown to be involved in the assembly
            process of glucocorticoid receptor, which requires the assistance
            of multiple molecular chaperones. The expression of this gene is
            reported to be downregulated in colorectal carcinoma tissue
            suggesting that it is a candidate tumor suppressor gene.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Jun 2013].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.910865.1,
                                           SRR1660805.170772.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216218.8/ ENSP00000216218.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                Z98048.1           71480-71553         c
            75-1022             BC121107.1         52-999
            1023-3152           U17714.1           998-3127
            3153-3212           BM679025.1         17-76               c
FEATURES             Location/Qualifiers
     source          1..3212
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..3212
                     /gene="ST13"
                     /gene_synonym="AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP;
                     HSPABP1; P48; PRO0786; SNC6"
                     /note="ST13 Hsp70 interacting protein"
                     /db_xref="GeneID:6767"
                     /db_xref="HGNC:HGNC:11343"
                     /db_xref="MIM:606796"
     exon            1..209
                     /gene="ST13"
                     /gene_synonym="AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP;
                     HSPABP1; P48; PRO0786; SNC6"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1209
                     /gene="ST13"
                     /gene_synonym="AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP;
                     HSPABP1; P48; PRO0786; SNC6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     progesterone receptor-associated p48 protein;
                     Hsp70-interacting protein; putative tumor suppressor ST13;
                     heat shock 70kD protein binding protein; hsc70-interacting
                     protein; aging-associated protein 2; renal carcinoma
                     antigen NY-REN-33; suppression of tumorigenicity 13
                     protein; suppression of tumorigenicity 13 (colon
                     carcinoma) (Hsp70 interacting protein); testis secretory
                     sperm-binding protein Li 233m"
                     /codon_start=1
                     /product="hsc70-interacting protein isoform 1"
                     /protein_id="NP_003923.2"
                     /db_xref="CCDS:CCDS14006.1"
                     /db_xref="GeneID:6767"
                     /db_xref="HGNC:HGNC:11343"
                     /db_xref="MIM:606796"
                     /translation="MDPRKVNELRAFVKMCKQDPSVLHTEEMRFLREWVESMGGKVPP
                     ATQKAKSEENTKEEKPDSKKVEEDLKADEPSSEESDLEIDKEGVIEPDTDAPQEMGDE
                     NAEITEEMMDQANDKKVAAIEALNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVK
                     LQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLALACKLDYDEDAS
                     AMLKEVQPRAQKIAEHRRKYERKREEREIKERIERVKKAREEHERAQREEEARRQSGA
                     QYGSFPGGFPGGMPGNFPGGMPGMGGGMPGMAGMPGLNEILSDPEVLAAMQDPEVMVA
                     FQDVAQNPANMSKYQSNPKVMNLISKLSAKFGGQA"
     exon            210..267
                     /gene="ST13"
                     /gene_synonym="AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP;
                     HSPABP1; P48; PRO0786; SNC6"
                     /inference="alignment:Splign:2.1.0"
     exon            268..343
                     /gene="ST13"
                     /gene_synonym="AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP;
                     HSPABP1; P48; PRO0786; SNC6"
                     /inference="alignment:Splign:2.1.0"
     exon            344..414
                     /gene="ST13"
                     /gene_synonym="AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP;
                     HSPABP1; P48; PRO0786; SNC6"
                     /inference="alignment:Splign:2.1.0"
     exon            415..481
                     /gene="ST13"
                     /gene_synonym="AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP;
                     HSPABP1; P48; PRO0786; SNC6"
                     /inference="alignment:Splign:2.1.0"
     exon            482..566
                     /gene="ST13"
                     /gene_synonym="AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP;
                     HSPABP1; P48; PRO0786; SNC6"
                     /inference="alignment:Splign:2.1.0"
     exon            567..677
                     /gene="ST13"
                     /gene_synonym="AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP;
                     HSPABP1; P48; PRO0786; SNC6"
                     /inference="alignment:Splign:2.1.0"
     exon            678..780
                     /gene="ST13"
                     /gene_synonym="AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP;
                     HSPABP1; P48; PRO0786; SNC6"
                     /inference="alignment:Splign:2.1.0"
     exon            781..897
                     /gene="ST13"
                     /gene_synonym="AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP;
                     HSPABP1; P48; PRO0786; SNC6"
                     /inference="alignment:Splign:2.1.0"
     exon            898..946
                     /gene="ST13"
                     /gene_synonym="AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP;
                     HSPABP1; P48; PRO0786; SNC6"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1080
                     /gene="ST13"
                     /gene_synonym="AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP;
                     HSPABP1; P48; PRO0786; SNC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..3212
                     /gene="ST13"
                     /gene_synonym="AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP;
                     HSPABP1; P48; PRO0786; SNC6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1587..1592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST13"
                     /gene_synonym="AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP;
                     HSPABP1; P48; PRO0786; SNC6"
                     /note="hexamer: AATAAA"
     polyA_site      1617
                     /gene="ST13"
                     /gene_synonym="AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP;
                     HSPABP1; P48; PRO0786; SNC6"
                     /note="major polyA site"
     regulatory      1628..1633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST13"
                     /gene_synonym="AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP;
                     HSPABP1; P48; PRO0786; SNC6"
                     /note="hexamer: GATAAA"
     polyA_site      1633
                     /gene="ST13"
                     /gene_synonym="AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP;
                     HSPABP1; P48; PRO0786; SNC6"
     regulatory      3131..3136
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST13"
                     /gene_synonym="AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP;
                     HSPABP1; P48; PRO0786; SNC6"
                     /note="hexamer: AGTAAA"
     polyA_site      3152
                     /gene="ST13"
                     /gene_synonym="AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP;
                     HSPABP1; P48; PRO0786; SNC6"
     regulatory      3186..3191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ST13"
                     /gene_synonym="AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP;
                     HSPABP1; P48; PRO0786; SNC6"
                     /note="hexamer: AATATA"
     polyA_site      3212
                     /gene="ST13"
                     /gene_synonym="AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP;
                     HSPABP1; P48; PRO0786; SNC6"
ORIGIN      
        1 cttgcggcag ccgccccctt ctgcgcggtc acgccgagcc agcgcctggg cctggaaccg
       61 ggccgtagcc cccccagttt cgcccaccac ctccctacca tggacccccg caaagtgaac
      121 gagcttcggg cctttgtgaa aatgtgtaag caggatccga gcgttctgca caccgaggaa
      181 atgcgcttcc tgagggagtg ggtggagagc atgggtggta aagtaccacc tgctactcag
      241 aaagctaaat cagaagaaaa taccaaggaa gaaaaacctg atagtaagaa ggtggaggaa
      301 gacttaaagg cagacgaacc atcaagtgag gaaagtgatc tagaaattga taaagaaggt
      361 gtgattgaac cagacactga tgctcctcaa gaaatgggag atgaaaatgc ggagataacg
      421 gaggagatga tggatcaggc aaatgataaa aaagtggctg ctattgaagc cctaaatgat
      481 ggtgaactcc agaaagccat tgacttattc acagatgcca tcaagctgaa tcctcgcttg
      541 gccattttgt atgccaagag ggccagtgtc ttcgtcaaat tacagaagcc aaatgctgcc
      601 atccgagact gtgacagagc cattgaaata aatcctgatt cagctcagcc ttacaagtgg
      661 cgggggaaag cacacagact tctaggccac tgggaagaag cagcccatga tcttgccctt
      721 gcctgtaaat tggattatga tgaagatgct agtgcaatgc tgaaagaagt tcaacctagg
      781 gcacagaaaa ttgcagaaca tcggagaaag tatgagcgaa aacgtgaaga gcgagagatc
      841 aaagaaagaa tagaacgagt taagaaggct cgagaagagc atgagagagc ccagagggag
      901 gaagaagcca gacgacagtc aggagctcag tatggctctt ttccaggtgg ctttcctggg
      961 ggaatgcctg gtaattttcc cggaggaatg cctggaatgg gagggggcat gcctggaatg
     1021 gctggaatgc ctggactcaa tgaaattctt agtgatccag aggttcttgc agccatgcag
     1081 gatccagaag ttatggtggc tttccaggat gtggctcaga acccagcaaa tatgtcaaaa
     1141 taccagagca acccaaaggt tatgaatctc atcagtaaat tgtcagccaa atttggaggt
     1201 caagcgtaat gtccttctga taaataaagc ccttgctgaa ggaaaagcaa cctagatcac
     1261 cttatggatg tcgcaataat acaaaccagt gtacctctga ccttctcatc aagagagctg
     1321 gggtgctttg aagataatcc ctacccctct cccccaaatg cagctgaagc attttacagt
     1381 ggtttgccat tagggtattc attcagataa tgttttccta ctaggaatta caaactttaa
     1441 acacttttta aatcttcaaa atatttaaaa caaatttaaa gggcctgtta attcttatat
     1501 ttttctttac taatcatttt ggattttttt ctttgaatta ttggcaggga atatacttat
     1561 gtatggaaga ttactgctct gagtgaaata aaagttatta gtgcgaggca aacataactc
     1621 atttgaggat aaagtttgtg ttggatatgt ggttcctgat gcattttgac ttgtcttttt
     1681 aaatgcttta tctttttctt taaagattta tttcaataaa actaattggg accacccgta
     1741 tttcagtagg acctgggtag ggattggaag tacttggcag ggcagcagca atcttgctgt
     1801 gtttgatata acatgcatcc ttgggcaggt tgcccttaaa tcttacactg tggtgaaggg
     1861 atgttttttt tgtaatgctg cagtagagtt ggagtactta gttctcttgt tgtccagtat
     1921 atctaataag tgtttttcat attatttcca cgtaagggaa ataaggtagt acttttcttt
     1981 ttatatttct atgcttaaaa ttctctttcc tagtcaaaaa ttgcccaaat ctgtgtttgc
     2041 tttctgcttg ctacatttgt ctcccttact tttcttgagc taaagacagg ctttttccac
     2101 cggcatcatc actgctatca tcattaacag cgtaattata caagcatatt taatgctgag
     2161 tttaatttaa tatgtaatac atatggtaat tgtagggtaa tacccacaac aactgtagtt
     2221 tcttacttgg ccaagagaat gcttatttaa gtgttagact tccattctgg caaaatcttg
     2281 ccttatcaga agacattgga aagagggatt ccctttggtg tttggtcttc tacttagaaa
     2341 aacctattgc agttagttta tcttgtagta ttcatctttg tattctgaag ataaggtttg
     2401 aattaaattg atacacacag aggggaaccg atttttttta tccaatgtga attataaatg
     2461 agataatcca cagttattca ttgtggagtt gttgagacta tgaaagactc attgtctttg
     2521 tattcagctc ttaaatagtg taactatatc cccacctctg cttgctttct ttccctcccc
     2581 tccaatgata aagaaaatga taaattttct gttgtgcatt caattcttat tttaaataag
     2641 actaagtata ggcattgtac ctgacattgc tacgtttcta ccagtgtttc aatttaaagt
     2701 gctagtgttt aaaaacattt tcaagggata aggccttctg tactttgctt atttgaagaa
     2761 tcagtggtag gagcagtgaa gtaaattcta tggagtacat ttctaaaata ccacatttct
     2821 gaaatcataa ataagtttat tcaggttcta accctttgct gtacacaagc agacagaaat
     2881 gcatctgtta cataaatgag aaaaagctat tatgctgatg gagcatgctt tttaaatcct
     2941 ttaaaaacac tcaccatata aacttgcatt tgagcttgtg tgttcttttg ttaatgtgta
     3001 gagttctcct ttctcgaaat tgccagtgtg tacttggctt aactcaagaa cagtttcttc
     3061 tggattcctt atttgattta tttaacctaa ttatattcta atattgcaaa tattaccata
     3121 agtgggtaaa agtaaaattc ctcttctgaa aatgtgtcct gtgcttttag atttttaaat
     3181 tccataatat acattcttaa ttttcaactc aa
//
