LOCUS       NM_173358               1340 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens SSX family member 7 (SSX7), mRNA.
ACCESSION   NM_173358
VERSION     NM_173358.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1340)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1340)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   3  (bases 1 to 1340)
  AUTHORS   Gure,A.O., Wei,I.J., Old,L.J. and Chen,Y.T.
  TITLE     The SSX gene family: characterization of 9 complete genes
  JOURNAL   Int J Cancer 101 (5), 448-453 (2002)
   PUBMED   12216073
REFERENCE   4  (bases 1 to 1340)
  AUTHORS   Chen,C.H., Chen,G.J., Lee,H.S., Huang,G.T., Yang,P.M., Tsai,L.J.,
            Chen,D.S. and Sheu,J.C.
  TITLE     Expressions of cancer-testis antigens in human hepatocellular
            carcinomas
  JOURNAL   Cancer Lett 164 (2), 189-195 (2001)
   PUBMED   11179834
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BK000687.1.
            
            On Feb 25, 2003 this sequence version replaced NM_173358.1.
            
            Summary: The product of this gene belongs to the family of highly
            homologous synovial sarcoma X (SSX) breakpoint proteins. These
            proteins may function as transcriptional repressors. They are also
            capable of eliciting spontaneously humoral and cellular immune
            responses in cancer patients, and are potentially useful targets in
            cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have
            been involved in the t(X;18) translocation characteristically found
            in all synovial sarcomas. This gene appears not to be involved in
            this type of chromosome translocation. [provided by RefSeq, Jul
            2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK000687.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298181.6/ ENSP00000298181.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1340
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.22"
     gene            1..1340
                     /gene="SSX7"
                     /note="SSX family member 7"
                     /db_xref="GeneID:280658"
                     /db_xref="HGNC:HGNC:19653"
                     /db_xref="MIM:300542"
     exon            1..139
                     /gene="SSX7"
                     /inference="alignment:Splign:2.1.0"
     exon            140..228
                     /gene="SSX7"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..726
                     /gene="SSX7"
                     /note="synovial sarcoma, X breakpoint 7"
                     /codon_start=1
                     /product="protein SSX7"
                     /protein_id="NP_775494.1"
                     /db_xref="CCDS:CCDS14343.1"
                     /db_xref="GeneID:280658"
                     /db_xref="HGNC:HGNC:19653"
                     /db_xref="MIM:300542"
                     /translation="MNGDDAFARRPRAGAQIPEKIQKSFDDIAKYFSKKEWEKMKSLE
                     KISYVYMKRKYEAMTKLGFKATLPPFMHNTGATDLQGNDFDNDRNQGNQVERPQMTFC
                     RLQRIFPKIMPKKPAEEGNDSKGVPEASGSQNDGKHLCPPGKPSTSEKINKTSGPKRG
                     KHAWTHRLRERKQLVIYEEISDPEEDDE"
     exon            229..343
                     /gene="SSX7"
                     /inference="alignment:Splign:2.1.0"
     exon            344..439
                     /gene="SSX7"
                     /inference="alignment:Splign:2.1.0"
     exon            440..489
                     /gene="SSX7"
                     /inference="alignment:Splign:2.1.0"
     exon            490..625
                     /gene="SSX7"
                     /inference="alignment:Splign:2.1.0"
     exon            626..730
                     /gene="SSX7"
                     /inference="alignment:Splign:2.1.0"
     exon            731..1340
                     /gene="SSX7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaggctcca gggacagaac cttctcaaag tgggggtgga gactctgatt ttcccgccta
       61 aagcatcccc tgggattggc tactttaagt tcagagtatg catgctctga ctttctctct
      121 cgattcttcc atactcagag tcagactgct cctggtgcca tgaacggaga cgacgccttt
      181 gcaaggagac ctagggctgg tgctcaaata ccagagaaga tccaaaagtc cttcgatgat
      241 attgccaaat acttctctaa gaaagagtgg gaaaagatga aatccttgga gaaaatcagc
      301 tatgtgtata tgaagagaaa gtatgaggcc atgactaaac taggcttcaa ggccaccctc
      361 ccacctttca tgcataatac aggggccaca gacctccagg ggaatgattt tgataatgac
      421 cgtaaccaag ggaatcaggt tgaacgtcct cagatgactt tttgcaggct ccagagaatc
      481 ttcccgaaga tcatgcccaa gaagccagca gaggaaggaa atgattcgaa gggagtgcca
      541 gaagcatctg gctcacagaa cgatgggaaa cacctgtgcc ctccaggaaa accaagtacc
      601 tctgagaaga ttaacaagac atccggaccc aaaaggggga aacatgcctg gacccacaga
      661 ctgcgtgaga gaaagcagct ggtgatttat gaagagatca gcgaccctga agaagacgac
      721 gagtaactcc cctcggggat acgacatatg cccatgatga gaagcagaac gtggtgacct
      781 ttcacgaaca tgggcatggc tgcggacccc tcgtcatcag gtgcatagca agtgaaagca
      841 agtgttcaca acagtgaaaa gttgagcgtc gtttttctta gtgtgacaag agttcgatgt
      901 tagtgtttcc attgtatttt cttacagtgt gccattctgt tagatattag cgttttcatt
      961 gatgagcaag acatgcttaa tgtgtatttc ggtttgtgta tccatgcacc tacctcagaa
     1021 agcaagtata gtcaggtatt ctctccatag aacagcacta ccctcctctc tccccagatg
     1081 tgactactga gggcagatct gagtgtttaa tttccgattt tcccctctgc atttacacac
     1141 cagacacaca aacacacaca cacagacaca cacacacaca gacacaccaa gtaccagtat
     1201 aagcatctcc catatgcttt tccccattgc catgagtcct ggtcaagccc cccttcaatt
     1261 tgtttcctgt tcagcatgta ctcccctcct ctgattcccc gtatcagtca ctgacagtta
     1321 atacaccttt gcaaacgttc
//
