LOCUS       NM_021014               1270 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens SSX family member 3 (SSX3), transcript variant 1,
            mRNA.
ACCESSION   NM_021014
VERSION     NM_021014.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1270)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1270)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1270)
  AUTHORS   Greve,K.B., Pohl,M., Olsen,K.E., Nielsen,O., Ditzel,H.J. and
            Gjerstorff,M.F.
  TITLE     SSX2-4 expression in early-stage non-small cell lung cancer
  JOURNAL   Tissue Antigens 83 (5), 344-349 (2014)
   PUBMED   24645645
  REMARK    GeneRIF: SSX2, SSX3, and SSX4 are expressed only in 3.5%
            early-stage non-small cell lung cancer patients.
REFERENCE   4  (bases 1 to 1270)
  AUTHORS   Yau,C., Esserman,L., Moore,D.H., Waldman,F., Sninsky,J. and
            Benz,C.C.
  TITLE     A multigene predictor of metastatic outcome in early stage hormone
            receptor-negative and triple-negative breast cancer
  JOURNAL   Breast Cancer Res 12 (5), R85 (2010)
   PUBMED   20946665
REFERENCE   5  (bases 1 to 1270)
  AUTHORS   Gure,A.O., Wei,I.J., Old,L.J. and Chen,Y.T.
  TITLE     The SSX gene family: characterization of 9 complete genes
  JOURNAL   Int J Cancer 101 (5), 448-453 (2002)
   PUBMED   12216073
REFERENCE   6  (bases 1 to 1270)
  AUTHORS   de Bruijn,D.R., dos Santos,N.R., Kater-Baats,E., Thijssen,J., van
            den Berk,L., Stap,J., Balemans,M., Schepens,M., Merkx,G. and van
            Kessel,A.G.
  TITLE     The cancer-related protein SSX2 interacts with the human homologue
            of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear
            protein, SSX2IP
  JOURNAL   Genes Chromosomes Cancer 34 (3), 285-298 (2002)
   PUBMED   12007189
REFERENCE   7  (bases 1 to 1270)
  AUTHORS   dos Santos,N.R., Torensma,R., de Vries,T.J., Schreurs,M.W., de
            Bruijn,D.R., Kater-Baats,E., Ruiter,D.J., Adema,G.J., van
            Muijen,G.N. and van Kessel,A.G.
  TITLE     Heterogeneous expression of the SSX cancer/testis antigens in human
            melanoma lesions and cell lines
  JOURNAL   Cancer Res 60 (6), 1654-1662 (2000)
   PUBMED   10749136
REFERENCE   8  (bases 1 to 1270)
  AUTHORS   Gure,A.O., Tureci,O., Sahin,U., Tsang,S., Scanlan,M.J., Jager,E.,
            Knuth,A., Pfreundschuh,M., Old,L.J. and Chen,Y.T.
  TITLE     SSX: a multigene family with several members transcribed in normal
            testis and human cancer
  JOURNAL   Int J Cancer 72 (6), 965-971 (1997)
   PUBMED   9378559
REFERENCE   9  (bases 1 to 1270)
  AUTHORS   de Leeuw,B., Balemans,M. and Geurts van Kessel,A.
  TITLE     A novel Kruppel-associated box containing the SSX gene (SSX3) on
            the human X chromosome is not implicated in t(X;18)-positive
            synovial sarcomas
  JOURNAL   Cytogenet Cell Genet 73 (3), 179-183 (1996)
   PUBMED   8697803
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC103862.1, U90840.1,
            AA609599.1 and AL606490.15.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_021014.3.
            
            Summary: The product of this gene belongs to the family of highly
            homologous synovial sarcoma X (SSX) breakpoint proteins. These
            proteins may function as transcriptional repressors. They are also
            capable of eliciting spontaneous humoral and cellular immune
            responses in cancer patients, and are potentially useful targets in
            cancer vaccine-based immunotherapy. While some of the related SSX
            genes are involved in t(X;18)(p11.2;q11.2) translocations that are
            characteristically found in all synovial sarcomas, this gene does
            not appear to be involved in such translocations. [provided by
            RefSeq, Jul 2013].
            
            ##Evidence-Data-START##
            Transcript exon combination :: U90840.1, BC103862.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298396.7/ ENSP00000298396.2
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-754               BC103862.1         50-803
            755-878             U90840.1           718-841
            879-1109            AA609599.1         164-394             c
            1110-1110           AL606490.15        122581-122581
            1111-1269           U90840.1           1074-1232
            1270-1270           AL606490.15        122741-122741
FEATURES             Location/Qualifiers
     source          1..1270
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.23"
     gene            1..1270
                     /gene="SSX3"
                     /gene_synonym="CT5.3"
                     /note="SSX family member 3"
                     /db_xref="GeneID:10214"
                     /db_xref="HGNC:HGNC:11337"
                     /db_xref="MIM:300325"
     exon            1..70
                     /gene="SSX3"
                     /gene_synonym="CT5.3"
                     /inference="alignment:Splign:2.1.0"
     exon            71..159
                     /gene="SSX3"
                     /gene_synonym="CT5.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..657
                     /gene="SSX3"
                     /gene_synonym="CT5.3"
                     /note="cancer/testis antigen 5.3; Kruppel-associated box
                     containing gene product SSX3; synovial sarcoma, X
                     breakpoint 3"
                     /codon_start=1
                     /product="protein SSX3"
                     /protein_id="NP_066294.1"
                     /db_xref="CCDS:CCDS14291.1"
                     /db_xref="GeneID:10214"
                     /db_xref="HGNC:HGNC:11337"
                     /db_xref="MIM:300325"
                     /translation="MNGDDTFARRPTVGAQIPEKIQKAFDDIAKYFSKEEWEKMKVSE
                     KIVYVYMKRKYEAMTKLGFKAILPSFMRNKRVTDFQGNDFDNDPNRGNQVQRPQMTFG
                     RLQGIFPKIMPKKPAEEGNVSKEVPEASGPQNDGKQLCPPGKPTTSEKINMISGPKRG
                     EHAWTHRLRERKQLVIYEEISDPEEDDE"
     exon            160..274
                     /gene="SSX3"
                     /gene_synonym="CT5.3"
                     /inference="alignment:Splign:2.1.0"
     exon            275..370
                     /gene="SSX3"
                     /gene_synonym="CT5.3"
                     /inference="alignment:Splign:2.1.0"
     exon            371..420
                     /gene="SSX3"
                     /gene_synonym="CT5.3"
                     /inference="alignment:Splign:2.1.0"
     exon            421..556
                     /gene="SSX3"
                     /gene_synonym="CT5.3"
                     /inference="alignment:Splign:2.1.0"
     exon            557..661
                     /gene="SSX3"
                     /gene_synonym="CT5.3"
                     /inference="alignment:Splign:2.1.0"
     exon            662..1270
                     /gene="SSX3"
                     /gene_synonym="CT5.3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1250..1255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSX3"
                     /gene_synonym="CT5.3"
                     /note="hexamer: AATAAA"
     polyA_site      1270
                     /gene="SSX3"
                     /gene_synonym="CT5.3"
                     /note="major polyA site"
ORIGIN      
        1 ctctttcgat tcttccatac tcaagagtac gcacggtctg attttctctt tggattcttc
       61 caaaatcaga gtcagactac tccctgtgcc atgaacggag atgacacctt tgcaaggaga
      121 cccacggttg gtgctcaaat accagagaag atacaaaagg ccttcgatga tattgccaaa
      181 tacttctcta aggaagagtg ggaaaagatg aaagtctcgg agaaaatcgt ctatgtgtat
      241 atgaagagaa agtatgaggc catgactaaa ctaggtttca aggccatcct cccatctttc
      301 atgcgtaata aacgggtcac agacttccag gggaatgatt ttgataatga ccctaaccgt
      361 gggaatcagg ttcaacgtcc tcagatgact ttcggcaggc tccagggaat cttcccgaag
      421 atcatgccca agaagccagc agaggaagga aatgtttcga aggaagtgcc agaagcatct
      481 ggcccacaaa acgatgggaa acagctgtgc cccccgggaa aaccaactac ctctgagaag
      541 attaacatga tatctggacc caaaaggggg gaacatgcct ggacccacag actgcgtgag
      601 agaaagcagc tggtgattta tgaagagatc agcgatcctg aggaagatga tgagtaactc
      661 cccttgggga tatgacacat gcccatgatg agaagcagaa cgtggtgacc tttcacgaac
      721 atgggcatgg ctgtggaccc ctcgtcatca ggtgcatagc aagtgaaagc aagtgttcac
      781 aacagtgaaa agttgagcgt catttttctt agtgtgccaa gagtacgata ttagcgtttc
      841 cattgtattt tcttgaagtg tgtcattctg ttagatatta acattttcac tgatgagcaa
      901 gacatactta atgcatattt tggtttgtgt atccatgcac ctaccttaga aaacaagtat
      961 tgtcagttac ctctgcatgg aacagcatta ccctcctctc tccctagatg tgactactga
     1021 gggcagttct gagtgtttaa tttcagattt tttcctctgc atttacacac acacacaaac
     1081 cacaccacac acacacacac acacacacag acacacacca agtaccagta taagcatctc
     1141 ccatctgctt ttcccattgc catgcgtcct ggtcaggctt ccctcactct gtttcctggt
     1201 cagcatgtac tcccctcatc cgattcccct gtagcagtca ctgacagtaa ataaaccttt
     1261 gcaaacgttc
//
