LOCUS       NM_001166293            5752 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens SSX family member 2 interacting protein (SSX2IP),
            transcript variant 2, mRNA.
ACCESSION   NM_001166293
VERSION     NM_001166293.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5752)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 5752)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   3  (bases 1 to 5752)
  AUTHORS   Fu,X., He,Y., Song,J., Wang,L., Guo,P. and Cao,J.
  TITLE     MiRNA-181b-5p Modulates Cell Proliferation, Cell Cycle, and
            Apoptosis by Targeting SSX2IP in Acute Lymphoblastic Leukemia
  JOURNAL   Turk J Haematol 39 (3), 160-169 (2022)
   PUBMED   35658330
  REMARK    GeneRIF: MiRNA-181b-5p Modulates Cell Proliferation, Cell Cycle,
            and Apoptosis by Targeting SSX2IP in Acute Lymphoblastic Leukemia
REFERENCE   4  (bases 1 to 5752)
  AUTHORS   Chu,Z. and Gruss,O.J.
  TITLE     Mitotic Maturation Compensates for Premature Centrosome Splitting
            and PCM Loss in Human cep135 Knockout Cells
  JOURNAL   Cells 11 (7), 1189 (2022)
   PUBMED   35406752
  REMARK    GeneRIF: Mitotic Maturation Compensates for Premature Centrosome
            Splitting and PCM Loss in Human cep135 Knockout Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5752)
  AUTHORS   Wang,B., He,W., Prosseda,P.P., Li,L., Kowal,T.J., Alvarado,J.A.,
            Wang,Q., Hu,Y. and Sun,Y.
  TITLE     OCRL regulates lysosome positioning and mTORC1 activity through
            SSX2IP-mediated microtubule anchoring
  JOURNAL   EMBO Rep 22 (7), e52173 (2021)
   PUBMED   33987909
  REMARK    GeneRIF: OCRL regulates lysosome positioning and mTORC1 activity
            through SSX2IP-mediated microtubule anchoring.
REFERENCE   6  (bases 1 to 5752)
  AUTHORS   Breslin,A., Denniss,F.A. and Guinn,B.A.
  TITLE     SSX2IP: an emerging role in cancer
  JOURNAL   Biochem Biophys Res Commun 363 (3), 462-465 (2007)
   PUBMED   17904521
  REMARK    Review article
REFERENCE   7  (bases 1 to 5752)
  AUTHORS   Denniss,F.A., Breslin,A., Ingram,W., Hardwick,N.R., Mufti,G.J. and
            Guinn,B.A.
  TITLE     The leukaemia-associated antigen, SSX2IP, is expressed during
            mitosis on the surface of myeloid leukaemia cells
  JOURNAL   Br J Haematol 138 (5), 668-669 (2007)
   PUBMED   17686061
REFERENCE   8  (bases 1 to 5752)
  AUTHORS   Guinn,B.A., Bland,E.A., Lodi,U., Liggins,A.P., Tobal,K.,
            Petters,S., Wells,J.W., Banham,A.H. and Mufti,G.J.
  TITLE     Humoral detection of leukaemia-associated antigens in presentation
            acute myeloid leukaemia
  JOURNAL   Biochem Biophys Res Commun 335 (4), 1293-1304 (2005)
   PUBMED   16112646
REFERENCE   9  (bases 1 to 5752)
  AUTHORS   Asada,M., Irie,K., Morimoto,K., Yamada,A., Ikeda,W., Takeuchi,M.
            and Takai,Y.
  TITLE     ADIP, a novel Afadin- and alpha-actinin-binding protein localized
            at cell-cell adherens junctions
  JOURNAL   J Biol Chem 278 (6), 4103-4111 (2003)
   PUBMED   12446711
REFERENCE   10 (bases 1 to 5752)
  AUTHORS   de Bruijn,D.R., dos Santos,N.R., Kater-Baats,E., Thijssen,J., van
            den Berk,L., Stap,J., Balemans,M., Schepens,M., Merkx,G. and van
            Kessel,A.G.
  TITLE     The cancer-related protein SSX2 interacts with the human homologue
            of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear
            protein, SSX2IP
  JOURNAL   Genes Chromosomes Cancer 34 (3), 285-298 (2002)
   PUBMED   12007189
  REMARK    GeneRIF: Nuclear protein SS2IP interacts with cancer-related
            protein SSX2 and the human homologue of a Ras-like GTPase
            interactor, RABIN3.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB023140.1 and AC114482.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001166293.1.
            
            Summary: This gene encodes a protein that binds the cancer-testis
            antigen Synovial Sarcoma X breakpoint 2 protein. The encoded
            protein may regulate the activity of Synovial Sarcoma X breakpoint
            2 protein in malignant cells. Alternate splicing results in
            multiple transcript variants. A pseudogene of this gene is found on
            chromosome 3. [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2 and 5 encode the same isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB023140.1, BC033637.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342203.8/ ENSP00000340279.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5751              AB023140.1         85-5835
            5752-5752           AC114482.2         30386-30386         c
FEATURES             Location/Qualifiers
     source          1..5752
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.3"
     gene            1..5752
                     /gene="SSX2IP"
                     /gene_synonym="ADIP; hMsd1"
                     /note="SSX family member 2 interacting protein"
                     /db_xref="GeneID:117178"
                     /db_xref="HGNC:HGNC:16509"
                     /db_xref="MIM:608690"
     exon            1..91
                     /gene="SSX2IP"
                     /gene_synonym="ADIP; hMsd1"
                     /inference="alignment:Splign:2.1.0"
     exon            92..223
                     /gene="SSX2IP"
                     /gene_synonym="ADIP; hMsd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..2025
                     /gene="SSX2IP"
                     /gene_synonym="ADIP; hMsd1"
                     /note="isoform 1 is encoded by transcript variant 2;
                     afadin- and alpha-actinin-binding protein; synovial
                     sarcoma, X breakpoint 2 interacting protein;
                     SSX2-interacting protein; afadin DIL domain-interacting
                     protein"
                     /codon_start=1
                     /product="afadin- and alpha-actinin-binding protein
                     isoform 1"
                     /protein_id="NP_001159765.1"
                     /db_xref="CCDS:CCDS699.1"
                     /db_xref="GeneID:117178"
                     /db_xref="HGNC:HGNC:16509"
                     /db_xref="MIM:608690"
                     /translation="MGDWMTVTDPGLSSESKTISQYTSETKMSPSSLYSQQVLCSSIP
                     LSKNVHSFFSAFCTEDNIEQSISYLDQELTTFGFPSLYEESKGKETKRELNIVAVLNC
                     MNELLVLQRKNLLAQENVETQNLKLGSDMDHLQSCYSKLKEQLETSRREMIGLQERDR
                     QLQCKNRNLHQLLKNEKDEVQKLQNIIASRATQYNHDMKRKEREYNKLKERLHQLVMN
                     KKDKKIAMDILNYVGRADGKRGSWRTGKTEARNEDEMYKILLNDYEYRQKQILMENAE
                     LKKVLQQMKKEMISLLSPQKKKPRERVDDSTGTVISDVEEDAGELSRESMWDLSCETV
                     REQLTNSIRKQWRILKSHVEKLDNQVSKVHLEGFNDEDVISRQDHEQETEKLELEIQQ
                     CKEMIKTQQQLLQQQLATAYDDDTTSLLRDCYLLEEKERLKEEWSLFKEQKKNFERER
                     RSFTEAAIRLGLERKAFEEERASWLKQQFLNMTTFDHQNSENVKLFSAFSGSSDWDNL
                     IVHSRQPQKKPHSVSNGSPVCMSKLTKSLPASPSTSDFCQTRSCISEHSSINVLNITA
                     EEIKPNQVGGECTNQKWSVASRPGSQEGCYSGCSLSYTNSHVEKDDLP"
     exon            224..393
                     /gene="SSX2IP"
                     /gene_synonym="ADIP; hMsd1"
                     /inference="alignment:Splign:2.1.0"
     exon            394..606
                     /gene="SSX2IP"
                     /gene_synonym="ADIP; hMsd1"
                     /inference="alignment:Splign:2.1.0"
     exon            607..717
                     /gene="SSX2IP"
                     /gene_synonym="ADIP; hMsd1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..853
                     /gene="SSX2IP"
                     /gene_synonym="ADIP; hMsd1"
                     /inference="alignment:Splign:2.1.0"
     exon            854..929
                     /gene="SSX2IP"
                     /gene_synonym="ADIP; hMsd1"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1107
                     /gene="SSX2IP"
                     /gene_synonym="ADIP; hMsd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1258
                     /gene="SSX2IP"
                     /gene_synonym="ADIP; hMsd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1395
                     /gene="SSX2IP"
                     /gene_synonym="ADIP; hMsd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1569
                     /gene="SSX2IP"
                     /gene_synonym="ADIP; hMsd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1684
                     /gene="SSX2IP"
                     /gene_synonym="ADIP; hMsd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1850
                     /gene="SSX2IP"
                     /gene_synonym="ADIP; hMsd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..5752
                     /gene="SSX2IP"
                     /gene_synonym="ADIP; hMsd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4966..4971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSX2IP"
                     /gene_synonym="ADIP; hMsd1"
                     /note="hexamer: AATATA"
     polyA_site      4981
                     /gene="SSX2IP"
                     /gene_synonym="ADIP; hMsd1"
                     /note="major polyA site"
     regulatory      5521..5526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSX2IP"
                     /gene_synonym="ADIP; hMsd1"
                     /note="hexamer: ATTAAA"
     polyA_site      5545
                     /gene="SSX2IP"
                     /gene_synonym="ADIP; hMsd1"
                     /note="major polyA site"
ORIGIN      
        1 aggcgctgcg aggcgctgct ggccctcggg ctgcgggagc cgggctagga cgccgagcgg
       61 tgactccccg ccgctcccgg gggccgtgac ggagatgcct acatagaaga gtgacagcag
      121 ctagactaaa tgtttaactg ctgaactagt tcctcaggta tcctggctct agagattgct
      181 atgggagatt ggatgactgt tacagatcca ggtctgtctt cagaaagcaa aactatctct
      241 caatatacct cagaaacaaa gatgtctcca tcaagtttat actcacagca agtgctatgt
      301 tcttcaatac ctttatcgaa aaatgtgcac agttttttca gtgccttctg cacagaagat
      361 aatattgaac agagtatctc atatcttgat caggaattga ctacttttgg ttttccttca
      421 ttatatgaag aatccaaagg taaagagaca aagagagagt taaatatagt agctgtacta
      481 aattgtatga atgagctgct tgtgcttcag cggaagaacc ttctagctca ggaaaatgtg
      541 gagacacaga atttgaagct gggaagtgat atggaccatc tacagagctg ctactcaaaa
      601 cttaaggaac aactggaaac ctccaggagg gaaatgattg ggcttcagga aagagacaga
      661 cagttacaat gtaagaacag gaatttgcat cagctactaa agaatgagaa agatgaggtg
      721 caaaaattac aaaatatcat tgcaagtcga gctactcagt ataatcatga tatgaagaga
      781 aaagagcgtg aatataataa actgaaggaa cgtctacatc aacttgttat gaacaagaaa
      841 gataagaaaa tagctatgga cattttgaat tatgtcggga gagctgatgg aaaaagaggc
      901 tcctggagga ctggtaaaac tgaagccagg aatgaagatg aaatgtataa aattctcttg
      961 aatgattatg aatatcgtca gaaacaaatc ctaatggaaa atgcagaact taagaaggtt
     1021 cttcaacaaa tgaaaaagga aatgatttct cttctttctc cccaaaagaa gaaacctaga
     1081 gaaagagtag atgatagtac aggaactgtt atttccgatg ttgaagaaga tgccggggaa
     1141 ctaagcagag agagtatgtg ggacctttcc tgtgaaactg tgagagagca gcttacaaac
     1201 agcatcagaa aacagtggag aattttgaaa agtcatgtag aaaagcttga taaccaagtt
     1261 tcaaaggtac acctggaagg ttttaatgat gaagatgtaa tctcacgaca agaccatgaa
     1321 caagaaactg aaaaactcga gttagaaatt cagcagtgta aagaaatgat taaaactcag
     1381 caacagcttt tacagcagca gctcgctact gcatatgatg atgataccac ttcactatta
     1441 cgagactgtt atttgttgga agaaaaggaa cgtctcaaag aagaatggtc cctttttaaa
     1501 gagcagaaaa agaattttga gagggagaga cgaagcttta cagaagccgc tattcgcctg
     1561 ggattggaga gaaaggcatt tgaagaagaa agagccagtt ggttaaagca gcagtttcta
     1621 aatatgacta cctttgacca ccagaactca gaaaatgtga aacttttcag tgccttctca
     1681 ggaagttctg attgggacaa tcttatagtg cactcgaggc agccgcaaaa gaagcctcac
     1741 agtgtgtcta atgggtctcc agtttgcatg tctaaactta ctaaatctct tcctgcttca
     1801 ccttccactt cagacttttg ccagacacgt tcctgcatat ctgaacatag ttcaatcaat
     1861 gtactgaata taactgctga agaaattaaa ccaaatcagg ttggaggaga atgtacaaat
     1921 caaaaatgga gtgtggcatc aagacctgga tcacaggaag gttgctatag tggatgctcc
     1981 ttgagctaca caaattctca tgtagaaaaa gatgacttac cttagacatg tggactggaa
     2041 tttttttcat taatgtgttc atcaagtttc acatctaagt tgaaacaggg tgtgtcataa
     2101 agtcagttat ctctaataac ttaagatggt ctgagttgtt tgtttggact tccctgtctt
     2161 cccccaaaga gttgaaatct taaatctatt taaaaggata taaaagcttt ggatatgtat
     2221 ttttagtaac agaagcatct ggttctgtga ataaaggaat gtatagatgt ttggatggaa
     2281 acaaaagcac tagactgagt ttcctcttat aggtattaaa aatagcactt ttaggaaact
     2341 gattattgta aatgtttaat tttgtctcaa atatagttgg cattggaagt ttagccttta
     2401 cttgaatgta tactgtagat ttttaacaaa gcgagttcta tatttattat gtttagtgtg
     2461 gtttgaaatt acctctttca tatgttttaa ataaagtgaa atttatgtat gttttgtaca
     2521 tagatacaca tgattatgtt aagaggcttt aagatttaaa agtttcacac aaccataagt
     2581 atagtatttc atgccagtaa aattttttta gtggtattct gtttacagat gtattaggac
     2641 cattgatgca ttacatttaa gaattctctt taatacatct gggcaataaa tattgaaagg
     2701 tattccatga agctgagttc tttagataat caacactact aacattacat ttttgagatt
     2761 tttatgacat tagattttta ttttgtatat gtagaatatt ataattttta aaaggactat
     2821 tgatgataga agaatagggg caagacgaca aaagtacctt tgaataaaac aatttaagaa
     2881 attggtttaa gatattggat gatagaagat atttaagata tctagatggt gatattttcc
     2941 ttacaagatg ggtaccagta tagtaatatc tgtatactaa ctagggcttt gtattgtcaa
     3001 taatttttta ataatttttt aatgaggtat ttaccactga agaaatatga taatataaaa
     3061 ccatcaaatt ttataattga gatgatactc tggaaaaaca tgtcatttca ttttcagaaa
     3121 actcttaagc tctcttcagt ctctgtaatg tttctgattg catgtttctt catgaaaagt
     3181 atgttgttgt tttgatagta ataataataa atgtaggctc agctctttcc caggattttc
     3241 atcaaaaagc tttaagtgcc taaccctgct tgtctctgta catagaagcc tgcacagatc
     3301 caacccttgc taggtatcat agtttaggcc catttacctt cccctgtact ggcagttcag
     3361 ccgcttacat gcactcaccc tgtttgtggc tattttaaat tcatattatt aaaaaacaaa
     3421 aaaaacccac ctatttgtgt tgtccattca ctatacgtaa ctatgtaact ctttggagtt
     3481 gcatagcagc agccattttt tcagggctga taggatatca ttaagagtgt cttatgagac
     3541 attagtggat atactcatag taaccatatt tatagtttta aagagctagc tcttgagcat
     3601 tagtcactac cttcagcttg atgcatggtc acttctttac tatttaaaat actacacatt
     3661 gtacaaaata tcgaagacac taccatatgc taaaggaaga aatctagctg ggatatagga
     3721 tttttgttgt ttttgttttt gtttgttttg ctatttagca ataacatggt caaaaaggca
     3781 atcagaaatt ttaaatacag ttaatggata catttggcaa caattttccc ccgagggttt
     3841 tccatggtgt actttgcaag aaataagcac tctaattttt aaagtaaatc tcttatttta
     3901 gcaaatatta tatttcatga caatggagtt ctagaaagca gcatctgttt tttgttgcgt
     3961 gtttccattt taaagtgagt tgagttctca aattggaaag aaagattcct tgagacgtac
     4021 ttttaaaatc taaagtgtga aagaaacagc agagtaaaag ccagactcat tgcaccttca
     4081 atgtctgcat agatccagaa gttgtacatt ttacctaaca acatcacttt tgttgaacat
     4141 tccaactcca gaatgatccc caatcaccct aatctcagaa tgctggaatg atgtctgttg
     4201 gaaaacccag gactccacac acaaaactcc tgggattttg tttcccatct ctttctaggt
     4261 gtttgcaatg tacaaataat acagctgtgc taatctcaca tttagccatg atagatgatg
     4321 gttctagagt gtacttccat ttgtaagtcc tcctgataag tgctttcttg tttatcacta
     4381 tgtaaatctg aaatattttg tacttcattt gtttttatcc attctgaatt ttcaaagcat
     4441 aaaaatgtca aagaaaaatt gagataaaca ttttgttcac cattaaatgt ttgcatctgc
     4501 agtctatgat gagaaacaat gaaattatga ctaaaattta acaaatagta ttttcttata
     4561 gaagcaatgt attaaatgat tagatacaca ggacagttca cagcaaattg tttacttaca
     4621 tggcataatt gaaatactgt tatttgtaaa gagttctata ctgcctacct tagctaacca
     4681 gaattgttca tagacttgtg ataatatggt gttatgggaa aacacatttt gtgcgcatga
     4741 tgaagagagc accgtgaatc tagtcttgac tgcccctggt ggaacatttg aaagcccttg
     4801 ggactccagg agagaggttt ttgcagcatg tatgctaaat ttgtgagtta gcaagaccct
     4861 gctgtgatta ctatgttgta cagatcttca aagtatattg cctaatatga gtcatgttat
     4921 ttctagattg aatttaaagt aagtatggat tatggaagtc tagtaaatat acttttccct
     4981 atttttgtcc tttttcagtc ttttggtaag catttattaa gtacctgctg tatgtcaagg
     5041 cttactactg ctttccaatc cttggtgata tgaagacaga taagcacgct gcctgctatt
     5101 aggaatctga gctgagtgga aggccaacta ttaaacctac attgtaataa acaatggtgg
     5161 atgctacgga cacattcagt ctgttcataa aacatggact gatgggtctg ctccaggcca
     5221 catttgtttt ttaacagtaa cgtggctagg cttccattta taagtcttag cattatttcc
     5281 tttgtgaagt actatgtaac agatgattgt ttgctagatt ttgttttcta caatcaaaat
     5341 gttgacctgc aaagcagtgt aggattttct ctcctcaaga gcgtgtatta ttatctagta
     5401 gaaaaagcat tcccaaagac ttggtccatg cagataagga taatgaaatt gctcactcta
     5461 atcctttttc taaatacagt gtttttcaag ctggatgtaa attagagtgg gtggatattg
     5521 attaaattat ttgatttata tgaaatcaaa tgactggttg aggttttttt gaacatttac
     5581 aaataatgga ttcctgagag ctcaggaagt actgtaatgt cagtgacata tgaagctcct
     5641 gataaagatc cacctcattc atatatttga gcttcagaaa tacatgtacc tagtataatg
     5701 cttaacagca cataatattt gttgatgaga aatacactga tgaaacaaca ca
//
