LOCUS       NM_175698               1281 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens SSX family member 2 (SSX2), transcript variant 2,
            mRNA.
ACCESSION   NM_175698 XM_001128182 XM_001128200 XM_001128212
VERSION     NM_175698.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1281)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1281)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1281)
  AUTHORS   Bruckmann,N.H., Bennedsen,S.N., Duijf,P.H.G., Terp,M.G.,
            Thomassen,M., Larsen,M., Pedersen,C.B., Kruse,T., Alcaraz,N.,
            Ditzel,H.J. and Gjerstorff,M.F.
  TITLE     A functional genetic screen identifies the Mediator complex as
            essential for SSX2-induced senescence
  JOURNAL   Cell Death Dis 10 (11), 841 (2019)
   PUBMED   31695025
  REMARK    GeneRIF: A functional genetic screen identifies the Mediator
            complex as essential for SSX2-induced senescence.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1281)
  AUTHORS   Ren,H., Xu,Z., Guo,W., Deng,Z. and Yu,X.
  TITLE     Rab3IP interacts with SSX2 and enhances the invasiveness of gastric
            cancer cells
  JOURNAL   Biochem Biophys Res Commun 503 (4), 2563-2568 (2018)
   PUBMED   30005870
  REMARK    GeneRIF: co-expression of and interplay between Rab3IP and SSX2
            during gastric cancer progression
REFERENCE   5  (bases 1 to 1281)
  AUTHORS   Gure,A.O., Wei,I.J., Old,L.J. and Chen,Y.T.
  TITLE     The SSX gene family: characterization of 9 complete genes
  JOURNAL   Int J Cancer 101 (5), 448-453 (2002)
   PUBMED   12216073
REFERENCE   6  (bases 1 to 1281)
  AUTHORS   Tureci,O., Sahin,U., Schobert,I., Koslowski,M., Scmitt,H.,
            Schild,H.J., Stenner,F., Seitz,G., Rammensee,H.G. and
            Pfreundschuh,M.
  TITLE     The SSX-2 gene, which is involved in the t(X;18) translocation of
            synovial sarcomas, codes for the human tumor antigen HOM-MEL-40
  JOURNAL   Cancer Res 56 (20), 4766-4772 (1996)
   PUBMED   8840996
REFERENCE   7  (bases 1 to 1281)
  AUTHORS   Fligman,I., Lonardo,F., Jhanwar,S.C., Gerald,W.L., Woodruff,J. and
            Ladanyi,M.
  TITLE     Molecular diagnosis of synovial sarcoma and characterization of a
            variant SYT-SSX2 fusion transcript
  JOURNAL   Am J Pathol 147 (6), 1592-1599 (1995)
   PUBMED   7495284
REFERENCE   8  (bases 1 to 1281)
  AUTHORS   de Leeuw,B., Balemans,M., Olde Weghuis,D. and Geurts van Kessel,A.
  TITLE     Identification of two alternative fusion genes, SYT-SSX1 and
            SYT-SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas
  JOURNAL   Hum Mol Genet 4 (6), 1097-1099 (1995)
   PUBMED   7655467
REFERENCE   9  (bases 1 to 1281)
  AUTHORS   Crew,A.J., Clark,J., Fisher,C., Gill,S., Grimer,R., Chand,A.,
            Shipley,J., Gusterson,B.A. and Cooper,C.S.
  TITLE     Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with
            homology to the Kruppel-associated box in human synovial sarcoma
  JOURNAL   EMBO J 14 (10), 2333-2340 (1995)
   PUBMED   7539744
REFERENCE   10 (bases 1 to 1281)
  AUTHORS   Clark,J., Rocques,P.J., Crew,A.J., Gill,S., Shipley,J., Chan,A.M.,
            Gusterson,B.A. and Cooper,C.S.
  TITLE     Identification of novel genes, SYT and SSX, involved in the
            t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma
  JOURNAL   Nat Genet 7 (4), 502-508 (1994)
   PUBMED   7951320
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC244505.1 and AL450023.21.
            
            On Dec 21, 2020 this sequence version replaced NM_175698.3.
            
            Summary: The product of this gene belongs to the family of highly
            homologous synovial sarcoma X (SSX) breakpoint proteins. These
            proteins may function as transcriptional repressors. They are also
            capable of eliciting spontaneous humoral and cellular immune
            responses in cancer patients, and are potentially useful targets in
            cancer vaccine-based immunotherapy. This gene, and also the SSX1
            and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2)
            translocations that are characteristically found in all synovial
            sarcomas. This translocation results in the fusion of the synovial
            sarcoma translocation gene on chromosome 18 to one of the SSX genes
            on chromosome X. The encoded hybrid proteins are likely responsible
            for transforming activity. Alternative splicing of this gene
            results in multiple transcript variants. This gene also has an
            identical duplicate, GeneID: 727837, located about 45 kb downstream
            in the opposite orientation on chromosome X. [provided by RefSeq,
            Jul 2013].
            
            Transcript Variant: This variant (2) lacks an alternate exon which
            results in a frameshift in the 3' coding region, compared to
            variant 1. The encoded isoform (b) contains a shorter and distinct
            C-terminus, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007343.2, Z49105.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337502.6/ ENSP00000338561.5
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC244505.1         157215-157281
            68-156              AC244505.1         158624-158712
            157-271             AC244505.1         159151-159265
            272-367             AC244505.1         159801-159896
            368-417             AC244505.1         161763-161812
            418-553             AL450023.21        128663-128798       c
            554-658             AL450023.21        126204-126308       c
            659-1281            AL450023.21        125116-125738       c
FEATURES             Location/Qualifiers
     source          1..1281
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.22"
     gene            1..1281
                     /gene="SSX2"
                     /gene_synonym="CT5.2; CT5.2A; HD21; HOM-MEL-40; SSX"
                     /note="SSX family member 2"
                     /db_xref="GeneID:6757"
                     /db_xref="HGNC:HGNC:11336"
                     /db_xref="MIM:300192"
     exon            1..67
                     /gene="SSX2"
                     /gene_synonym="CT5.2; CT5.2A; HD21; HOM-MEL-40; SSX"
                     /inference="alignment:Splign:2.1.0"
     exon            68..156
                     /gene="SSX2"
                     /gene_synonym="CT5.2; CT5.2A; HD21; HOM-MEL-40; SSX"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..654
                     /gene="SSX2"
                     /gene_synonym="CT5.2; CT5.2A; HD21; HOM-MEL-40; SSX"
                     /note="isoform b is encoded by transcript variant 2;
                     cancer/testis antigen family 5, member 2a; sarcoma,
                     synovial, X-chromosome-related 2; protein SSX2; synovial
                     sarcoma, X breakpoint 2B; cancer/testis antigen 5.2; tumor
                     antigen HOM-MEL-40"
                     /codon_start=1
                     /product="protein SSX2 isoform b"
                     /protein_id="NP_783629.1"
                     /db_xref="CCDS:CCDS14344.2"
                     /db_xref="GeneID:6757"
                     /db_xref="HGNC:HGNC:11336"
                     /db_xref="MIM:300192"
                     /translation="MNGDDAFARRPTVGAQIPEKIQKAFDDIAKYFSKEEWEKMKASE
                     KIFYVYMKRKYEAMTKLGFKATLPPFMCNKRAEDFQGNDLDNDPNRGNQVERPQMTFG
                     RLQGISPKIMPKKPAEEGNDSEEVPEASGPQNDGKELCPPGKPTTSEKIHERSGPKRG
                     EHAWTHRLRERKQLVIYEEISDPEEDDE"
     exon            157..271
                     /gene="SSX2"
                     /gene_synonym="CT5.2; CT5.2A; HD21; HOM-MEL-40; SSX"
                     /inference="alignment:Splign:2.1.0"
     exon            272..367
                     /gene="SSX2"
                     /gene_synonym="CT5.2; CT5.2A; HD21; HOM-MEL-40; SSX"
                     /inference="alignment:Splign:2.1.0"
     exon            368..417
                     /gene="SSX2"
                     /gene_synonym="CT5.2; CT5.2A; HD21; HOM-MEL-40; SSX"
                     /inference="alignment:Splign:2.1.0"
     exon            418..553
                     /gene="SSX2"
                     /gene_synonym="CT5.2; CT5.2A; HD21; HOM-MEL-40; SSX"
                     /inference="alignment:Splign:2.1.0"
     exon            554..658
                     /gene="SSX2"
                     /gene_synonym="CT5.2; CT5.2A; HD21; HOM-MEL-40; SSX"
                     /inference="alignment:Splign:2.1.0"
     exon            659..1281
                     /gene="SSX2"
                     /gene_synonym="CT5.2; CT5.2A; HD21; HOM-MEL-40; SSX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1261..1266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSX2"
                     /gene_synonym="CT5.2; CT5.2A; HD21; HOM-MEL-40; SSX"
                     /note="hexamer: AATAAA"
     polyA_site      1281
                     /gene="SSX2"
                     /gene_synonym="CT5.2; CT5.2A; HD21; HOM-MEL-40; SSX"
                     /note="major polyA site"
ORIGIN      
        1 ctttcgattc ttccatactc agagtacgca cggtctgatt ttctctttgg attcttccaa
       61 aatcagagtc agactgctcc cggtgccatg aacggagacg acgcctttgc aaggagaccc
      121 acggttggtg ctcaaatacc agagaagatc caaaaggcct tcgatgatat tgccaaatac
      181 ttctctaagg aagagtggga aaagatgaaa gcctcggaga aaatcttcta tgtgtatatg
      241 aagagaaagt atgaggctat gactaaacta ggtttcaagg ccaccctccc acctttcatg
      301 tgtaataaac gggccgaaga cttccagggg aatgatttgg ataatgaccc taaccgtggg
      361 aatcaggttg aacgtcctca gatgactttc ggcaggctcc agggaatctc cccgaagatc
      421 atgcccaaga agccagcaga ggaaggaaat gattcggagg aagtgccaga agcatctggc
      481 ccacaaaatg atgggaaaga gctgtgcccc ccgggaaaac caactacctc tgagaagatt
      541 cacgagagat ctggacccaa aaggggggaa catgcctgga cccacagact gcgtgagaga
      601 aaacagctgg tgatttatga agagatcagc gaccctgagg aagatgacga gtaactcccc
      661 tcagggatac gacacatgcc catgatgaga agcagaacgt ggtgaccttt cacgaacatg
      721 ggcatggctg cggacccctc gtcatcaggt gcatagcaag tgaaagcaag tgttcacaac
      781 agtgaaaagt tgagcgtcat ttttcttagt gtgccaagag ttcgatgtta gcgtttacgt
      841 tgtattttct tacactgtgt cattctgtta gatactaaca ttttcattga tgagcaagac
      901 atacttaatg catattttgg tttgtgtatc catgcaccta ccttagaaaa caagtattgt
      961 cggttacctc tgcatggaac agcattaccc tcctctctcc ccagatgtga ctactgaggg
     1021 cagttctgag tgtttaattt cagatttttt cctctgcatt tacacacaca cgcacacaaa
     1081 ccacaccaca cacacacaca cacacacaca cacacacaca cacacacacc aagtaccagt
     1141 ataagcatct gccatctgct tttcccattg ccatgcgtcc tggtcaagct cccctcactc
     1201 tgtttcctgg tcagcatgta ctcccctcat ccgattcccc tgtagcagtc actgacagtt
     1261 aataaacctt tgcaaacgtt c
//
