LOCUS       NM_014188               1284 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens SSU72 homolog, RNA polymerase II CTD phosphatase
            (SSU72), mRNA.
ACCESSION   NM_014188
VERSION     NM_014188.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1284)
  AUTHORS   Hwang,S., Kim,M.H. and Lee,C.W.
  TITLE     Ssu72 Dual-Specific Protein Phosphatase: From Gene to Diseases
  JOURNAL   Int J Mol Sci 22 (7), 3791 (2021)
   PUBMED   33917542
  REMARK    GeneRIF: Ssu72 Dual-Specific Protein Phosphatase: From Gene to
            Diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1284)
  AUTHORS   Liu,C., Zhang,W. and Xing,W.
  TITLE     Diverse and conserved roles of the protein Ssu72 in eukaryotes:
            from yeast to higher organisms
  JOURNAL   Curr Genet 67 (2), 195-206 (2021)
   PUBMED   33244642
  REMARK    GeneRIF: Diverse and conserved roles of the protein Ssu72 in
            eukaryotes: from yeast to higher organisms.
            Review article
REFERENCE   3  (bases 1 to 1284)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1284)
  AUTHORS   Spector,B.M., Turek,M.E. and Price,D.H.
  TITLE     Functional interaction of human Ssu72 with RNA polymerase II
            complexes
  JOURNAL   PLoS One 14 (3), e0213598 (2019)
   PUBMED   30901332
  REMARK    GeneRIF: results demonstrate when Ssu72 can act on early
            transcription complexes and suggest that Ssu72 may also function in
            thepreinitiation complex prior to initiation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1284)
  AUTHORS   Bratkowski,M., Unarta,I.C., Zhu,L., Shubbar,M., Huang,X. and Liu,X.
  TITLE     Structural dissection of an interaction between transcription
            initiation and termination factors implicated in
            promoter-terminator cross-talk
  JOURNAL   J Biol Chem 293 (5), 1651-1665 (2018)
   PUBMED   29158257
  REMARK    GeneRIF: a hand-off model in which Ssu72 mediates a conformational
            transition in TFIIB, accounting for the role of Ssu72 in
            transcription reinitiation, gene looping, and promoter-terminator
            cross-talk.
REFERENCE   6  (bases 1 to 1284)
  AUTHORS   Kim,H.S., Baek,K.H., Ha,G.H., Lee,J.C., Kim,Y.N., Lee,J.,
            Park,H.Y., Lee,N.R., Lee,H., Cho,Y. and Lee,C.W.
  TITLE     The hsSsu72 phosphatase is a cohesin-binding protein that regulates
            the resolution of sister chromatid arm cohesion
  JOURNAL   EMBO J 29 (20), 3544-3557 (2010)
   PUBMED   20818333
  REMARK    GeneRIF: Data suggest that Ssu72 is a novel cohesin-binding protein
            capable of regulating cohesion between sister chromatid arms.
REFERENCE   7  (bases 1 to 1284)
  AUTHORS   Xiang,K., Nagaike,T., Xiang,S., Kilic,T., Beh,M.M., Manley,J.L. and
            Tong,L.
  TITLE     Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide
            complex
  JOURNAL   Nature 467 (7316), 729-733 (2010)
   PUBMED   20861839
  REMARK    GeneRIF: crystal structure at 2.4 A resolution of the
            amino-terminal domain (residues 30-340) of human symplekin in a
            ternary complex with the Pol II carboxy-terminal domain (CTD) Ser 5
            phosphatase Ssu72 and a CTD Ser 5 phosphopeptide
REFERENCE   8  (bases 1 to 1284)
  AUTHORS   Zhang,H., Sol-Church,K., Rydbeck,H., Stabley,D., Spotila,L.D. and
            Devoto,M.
  TITLE     High resolution linkage and linkage disequilibrium analyses of
            chromosome 1p36 SNPs identify new positional candidate genes for
            low bone mineral density
  JOURNAL   Osteoporos Int 20 (2), 341-346 (2009)
   PUBMED   18597038
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 1284)
  AUTHORS   St-Pierre,B., Liu,X., Kha,L.C., Zhu,X., Ryan,O., Jiang,Z. and
            Zacksenhaus,E.
  TITLE     Conserved and specific functions of mammalian ssu72
  JOURNAL   Nucleic Acids Res 33 (2), 464-477 (2005)
   PUBMED   15659578
  REMARK    GeneRIF: Molecular cloning and characterization of functions of
            human ssu72.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1284)
  AUTHORS   Krishnamurthy,S., He,X., Reyes-Reyes,M., Moore,C. and Hampsey,M.
  TITLE     Ssu72 Is an RNA polymerase II CTD phosphatase
  JOURNAL   Mol Cell 14 (3), 387-394 (2004)
   PUBMED   15125841
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF594026.1, AJ276409.1 and AF161530.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014188.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018909.2, SRR1163657.401257.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000291386.4/ ENSP00000291386.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-530               CF594026.1         50-579
            531-1283            AJ276409.1         338-1090
            1284-1284           AF161530.1         1043-1043
FEATURES             Location/Qualifiers
     source          1..1284
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..1284
                     /gene="SSU72"
                     /gene_synonym="HSPC182; PNAS-120"
                     /note="SSU72 homolog, RNA polymerase II CTD phosphatase"
                     /db_xref="GeneID:29101"
                     /db_xref="HGNC:HGNC:25016"
                     /db_xref="MIM:617680"
     exon            1..386
                     /gene="SSU72"
                     /gene_synonym="HSPC182; PNAS-120"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..891
                     /gene="SSU72"
                     /gene_synonym="HSPC182; PNAS-120"
                     /EC_number="3.1.3.16"
                     /note="CTD phosphatase SSU72"
                     /codon_start=1
                     /product="RNA polymerase II subunit A C-terminal domain
                     phosphatase SSU72"
                     /protein_id="NP_054907.1"
                     /db_xref="CCDS:CCDS32.1"
                     /db_xref="GeneID:29101"
                     /db_xref="HGNC:HGNC:25016"
                     /db_xref="MIM:617680"
                     /translation="MPSSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKL
                     PGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCK
                     DLFDLILTCEERVYDQVVEDLNSREQETCQPVHVVNVDIQDNHEEATLGAFLICELCQ
                     CIQHTEDMENEIDELLQEFEEKSGRTFLHTVCFY"
     exon            387..530
                     /gene="SSU72"
                     /gene_synonym="HSPC182; PNAS-120"
                     /inference="alignment:Splign:2.1.0"
     exon            531..670
                     /gene="SSU72"
                     /gene_synonym="HSPC182; PNAS-120"
                     /inference="alignment:Splign:2.1.0"
     exon            671..789
                     /gene="SSU72"
                     /gene_synonym="HSPC182; PNAS-120"
                     /inference="alignment:Splign:2.1.0"
     exon            790..1284
                     /gene="SSU72"
                     /gene_synonym="HSPC182; PNAS-120"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1264..1269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSU72"
                     /gene_synonym="HSPC182; PNAS-120"
                     /note="hexamer: AATAAA"
     polyA_site      1284
                     /gene="SSU72"
                     /gene_synonym="HSPC182; PNAS-120"
                     /note="major polyA site"
ORIGIN      
        1 gtgacgctca gccgggcctt gtggagtgcg ggtctctgct gcggacgccg ggggccggcg
       61 cggcgttggc cgcccccggc ctcgccgagt gcagcgcgcc cgaaggccag tgcctgcgct
      121 ccgtccgcgg cccggcgccc agggtgggcg gggaggccgc cgcgcagtcg ccgcacgcta
      181 caccgccggc gccgtcgttt cgcgtcgccc gcttccggcc accgcggccg ccattttgtt
      241 cgcgcggaag cgccgcggta gggtgggaac ccaagcggga gagccgcggg atttgcggcc
      301 gccgccatgc cgtcgtcccc gctgcgggtg gcggtggtgt gctcgagcaa ccagaaccgg
      361 agcatggagg cgcacaacat cctcagcaaa cggggattca gcgtccgatc ctttggaaca
      421 gggactcacg tgaagcttcc aggaccagct cccgacaagc ccaatgttta tgatttcaaa
      481 accacatatg accagatgta caatgatctt cttaggaaag acaaagaact ctatacacag
      541 aatgggattt tacatatgct ggacagaaat aagagaatca agccccggcc agaaagattc
      601 cagaactgca aagacctgtt tgatctgatc ctcacttgcg aagagagagt gtatgaccag
      661 gtggtggaag atctgaattc cagagaacag gagacctgcc agcctgtgca cgtggtcaat
      721 gtggacatcc aggacaacca cgaggaggcc accctggggg cgtttctcat ctgtgagctc
      781 tgccagtgta tccagcacac ggaagacatg gagaacgaga tcgacgagct gctgcaggag
      841 ttcgaggaga agagtggccg cacctttctg cacaccgtct gcttctactg agcccagcgc
      901 ccgcatggag ccgcctctgg agcttcctgt tgttcatact ttttccttcc tgacatttgt
      961 ttttacttac aggtgttctg ctggtgacgg tagcattacc caaataaact gtgcatatga
     1021 aatgggagag gagatgccaa aacgccagat gaaagcaatc aagtttcttc ttttccactt
     1081 ttacttatga gcaggatatt gattacaaag tttttcttct ttaaccaaaa aggaaagaca
     1141 acggtttgtg tgcacttccc gacatacctg tgtcttcgtg tgcctgcctt ccctccctcc
     1201 tccccaccgg gccggactgt acagagccct gctgcggcgt gttaggaatg acctggaatt
     1261 gtcaataaac agatgctgct gtca
//
