LOCUS       NM_001172560            2689 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens somatostatin receptor 5 (SSTR5), transcript variant 2,
            mRNA.
ACCESSION   NM_001172560
VERSION     NM_001172560.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2689)
  AUTHORS   Pedraza-Arevalo,S., Ibanez-Costa,A., Blazquez-Encinas,R.,
            Branco,M.R., Vazquez-Borrego,M.C., Herrera-Martinez,A.D.,
            Venegas-Moreno,E., Serrano-Blanch,R., Arjona-Sanchez,A.,
            Galvez-Moreno,M.A., Korbonits,M., Soto-Moreno,A., Gahete,M.D.,
            Charalambous,M., Luque,R.M. and Castano,J.P.
  TITLE     Epigenetic and post-transcriptional regulation of somatostatin
            receptor subtype 5 (SST5) in pituitary and pancreatic
            neuroendocrine tumors
  JOURNAL   Mol Oncol 16 (3), 764-779 (2022)
   PUBMED   34601790
  REMARK    GeneRIF: Epigenetic and post-transcriptional regulation of
            somatostatin receptor subtype 5 (SST5 ) in pituitary and pancreatic
            neuroendocrine tumors.
REFERENCE   2  (bases 1 to 2689)
  AUTHORS   Fuentes-Fayos,A.C., G-Garcia,M.E., Perez-Gomez,J.M., Peel,A.,
            Blanco-Acevedo,C., Solivera,J., Ibanez-Costa,A., Gahete,M.D.,
            Castano,J.P. and Luque,R.M.
  TITLE     Somatostatin Receptor Splicing Variant sst5TMD4 Overexpression in
            Glioblastoma Is Associated with Poor Survival, Increased
            Aggressiveness Features, and Somatostatin Analogs Resistance
  JOURNAL   Int J Mol Sci 23 (3), 1143 (2022)
   PUBMED   35163067
  REMARK    GeneRIF: Somatostatin Receptor Splicing Variant sst5TMD4
            Overexpression in Glioblastoma Is Associated with Poor Survival,
            Increased Aggressiveness Features, and Somatostatin Analogs
            Resistance.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2689)
  AUTHORS   Li,Y., Li,X., Geng,C., Guo,Y. and Wang,C.
  TITLE     Somatostatin receptor 5 is critical for protecting intestinal
            barrier function in vivo and in vitro
  JOURNAL   Mol Cell Endocrinol 535, 111390 (2021)
   PUBMED   34224803
  REMARK    GeneRIF: Somatostatin receptor 5 is critical for protecting
            intestinal barrier function in vivo and in vitro.
REFERENCE   4  (bases 1 to 2689)
  AUTHORS   Treppiedi,D., Di Muro,G., Mangili,F., Catalano,R., Giardino,E.,
            Barbieri,A.M., Locatelli,M., Arosio,M., Spada,A., Peverelli,E. and
            Mantovani,G.
  TITLE     Filamin A is required for somatostatin receptor type 5 expression
            and pasireotide-mediated signaling in pituitary corticotroph tumor
            cells
  JOURNAL   Mol Cell Endocrinol 524, 111159 (2021)
   PUBMED   33428965
  REMARK    GeneRIF: Filamin A is required for somatostatin receptor type 5
            expression and pasireotide-mediated signaling in pituitary
            corticotroph tumor cells.
REFERENCE   5  (bases 1 to 2689)
  AUTHORS   Soukup,J., Hornychova,H., Manethova,M., Michalova,K., Michnova,L.,
            Popovska,L., Skarkova,V., Cesak,T., Netuka,D., Ryska,A., Cap,J.,
            Hana,V., Hana,V. Jr., Krsek,M., Dvorakova,E., Krcma,M.,
            Lazurova,I., Olsovska,V., Stary,K., Vanuga,P. and Gabalec,F.
  TITLE     Predictive and prognostic significance of tumour subtype, SSTR1-5
            and e-cadherin expression in a well-defined cohort of patients with
            acromegaly
  JOURNAL   J Cell Mol Med 25 (5), 2484-2492 (2021)
   PUBMED   33491286
  REMARK    GeneRIF: Predictive and prognostic significance of tumour subtype,
            SSTR1-5 and e-cadherin expression in a well-defined cohort of
            patients with acromegaly.
REFERENCE   6  (bases 1 to 2689)
  AUTHORS   Takeda,J., Fernald,A.A., Yamagata,K., Le Beau,M.M. and Bell,G.I.
  TITLE     Localization of human somatostatin receptor 5 gene (SSTR5) to
            chromosome band 16p13.3 by fluorescence in situ hybridization
  JOURNAL   Genomics 26 (3), 638-639 (1995)
   PUBMED   7607700
REFERENCE   7  (bases 1 to 2689)
  AUTHORS   Panetta,R., Greenwood,M.T., Warszynska,A., Demchyshyn,L.L., Day,R.,
            Niznik,H.B., Srikant,C.B. and Patel,Y.C.
  TITLE     Molecular cloning, functional characterization, and chromosomal
            localization of a human somatostatin receptor (somatostatin
            receptor type 5) with preferential affinity for somatostatin-28
  JOURNAL   Mol Pharmacol 45 (3), 417-427 (1994)
   PUBMED   7908405
REFERENCE   8  (bases 1 to 2689)
  AUTHORS   Yamada,Y., Post,S.R., Wang,K., Tager,H.S., Bell,G.I. and Seino,S.
  TITLE     Cloning and functional characterization of a family of human and
            mouse somatostatin receptors expressed in brain, gastrointestinal
            tract, and kidney
  JOURNAL   Proc Natl Acad Sci U S A 89 (1), 251-255 (1992)
   PUBMED   1346068
REFERENCE   9  (bases 1 to 2689)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
REFERENCE   10 (bases 1 to 2689)
  AUTHORS   Montminy,M.R., Goodman,R.H., Horovitch,S.J. and Habener,J.F.
  TITLE     Primary structure of the gene encoding rat preprosomatostatin
  JOURNAL   Proc Natl Acad Sci U S A 81 (11), 3337-3340 (1984)
   PUBMED   6145156
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009041.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 24, 2021 this sequence version replaced NM_001172560.2.
            
            Summary: Somatostatin and its related peptide cortistatin exert
            multiple biological actions on normal and tumoral tissue targets by
            interacting with somatostatin receptors (SSTRs). The protein
            encoded by this gene is one of the SSTRs, which is a multi-pass
            membrane protein and belongs to the G-protein coupled receptor 1
            family. The activity of this receptor is mediated by G proteins
            which inhibit adenylyl cyclase, and different regions of this
            receptor molecule are required for the activation of different
            signaling pathways. A mutation in this gene results in somatostatin
            analog resistance. Alternatively spliced transcript variants have
            been identified in this gene.[provided by RefSeq, Feb 2010].
            
            Transcript Variant: This variant (2) has an alternate 5' UTR, as
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.4437641.1,
                                           SRR14372080.3827670.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145774 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000689027.1/ ENSP00000508487.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC009041.10        143098-143173
            77-2689             AC009041.10        149193-151805
FEATURES             Location/Qualifiers
     source          1..2689
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..2689
                     /gene="SSTR5"
                     /gene_synonym="SS-5-R; SST5"
                     /note="somatostatin receptor 5"
                     /db_xref="GeneID:6755"
                     /db_xref="HGNC:HGNC:11334"
                     /db_xref="MIM:182455"
     exon            1..76
                     /gene="SSTR5"
                     /gene_synonym="SS-5-R; SST5"
                     /inference="alignment:Splign:2.1.0"
     exon            77..2689
                     /gene="SSTR5"
                     /gene_synonym="SS-5-R; SST5"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1198
                     /gene="SSTR5"
                     /gene_synonym="SS-5-R; SST5"
                     /note="somatostatin receptor subtype 5"
                     /codon_start=1
                     /product="somatostatin receptor type 5"
                     /protein_id="NP_001166031.1"
                     /db_xref="CCDS:CCDS10429.1"
                     /db_xref="GeneID:6755"
                     /db_xref="HGNC:HGNC:11334"
                     /db_xref="MIM:182455"
                     /translation="MEPLFPASTPSWNASSPGAASGGGDNRTLVGPAPSAGARAVLVP
                     VLYLLVCAAGLGGNTLVIYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQNAA
                     SFWPFGPVLCRLVMTLDGVNQFTSVFCLTVMSVDRYLAVVHPLSSARWRRPRVAKLAS
                     AAAWVLSLCMSLPLLVFADVQEGGTCNASWPEPVGLWGAVFIIYTAVLGFFAPLLVIC
                     LCYLLIVVKVRAAGVRVGCVRRRSERKVTRMVLVVVLVFAGCWLPFFTVNIVNLAVAL
                     PQEPASAGLYFFVVILSYANSCANPVLYGFLSDNFRQSFQKVLCLRKGSGAKDADATE
                     PRPDRIRQQQEATPPAHRAAANGLMQTSKL"
     regulatory      2667..2672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSTR5"
                     /gene_synonym="SS-5-R; SST5"
                     /note="hexamer: AATAAA"
     polyA_site      2689
                     /gene="SSTR5"
                     /gene_synonym="SS-5-R; SST5"
                     /note="major polyA site"
ORIGIN      
        1 agccggcgcc cgggagcccg gagccagtgc cgcgcggaca tcggggctcc cccgttcaga
       61 gggcgccgcc gcccagagcc tgacgcaccc cagggctgcc gccatggagc ccctgttccc
      121 agcctccacg cccagctgga acgcctcctc cccgggggct gcctctggag gcggtgacaa
      181 caggacgctg gtggggccgg cgccctcggc aggggcccgg gcggtgctgg tgcccgtgct
      241 gtacctgctg gtgtgtgcgg ccgggctggg cgggaacacg ctggtcatct acgtggtgct
      301 gcgcttcgcc aagatgaaga ccgtcaccaa catctacatt ctcaacctgg cagtggccga
      361 cgtcctgtac atgctggggc tgcctttcct ggccacgcag aacgccgcgt ccttctggcc
      421 cttcggcccc gtcctgtgcc gcctggtcat gacgctggac ggcgtcaacc agttcaccag
      481 tgtcttctgc ctgacagtca tgagcgtgga ccgctacctg gcagtggtgc acccgctgag
      541 ctcggcccgc tggcgccgcc cgcgtgtggc caagctggcg agcgccgcgg cctgggtcct
      601 gtctctgtgc atgtcgctgc cgctcctggt gttcgcggac gtgcaggagg gcggtacctg
      661 caacgccagc tggccggagc ccgtggggct gtggggcgcc gtcttcatca tctacacggc
      721 cgtgctgggc ttcttcgcgc cgctgctggt catctgcctg tgctacctgc tcatcgtggt
      781 gaaggtgagg gcggcgggcg tgcgcgtggg ctgcgtgcgg cggcgctcgg agcggaaggt
      841 gacgcgcatg gtgttggtgg tggtgctggt gtttgcggga tgttggctgc ccttcttcac
      901 cgtcaacatc gtcaacctgg ccgtggcgct gccccaggag cccgcctccg ccggcctcta
      961 cttcttcgtg gtcatcctct cctacgccaa cagctgtgcc aaccccgtcc tctacggctt
     1021 cctctctgac aacttccgcc agagcttcca gaaggttctg tgcctccgca agggctctgg
     1081 tgccaaggac gctgacgcca cggagccgcg tccagacagg atccggcagc agcaggaggc
     1141 cacgccaccc gcgcaccgcg ccgcagccaa cgggcttatg cagaccagca agctgtgaga
     1201 gtgcaggcgg ggggtgggcg gccccgtgtc acccccagga gcggaggttg cactgcggtg
     1261 acccccaccc atgacctgcc agtcaggatg ctccccggcg gtggtgtgag gacagagctg
     1321 gctgaagcca ggctggggta gacacagggc agtaggttcc ccaccgtgac cgaccatccc
     1381 ctctaaccgt ctgccacaca gcgggggctc ccgggaggta ggggaggtgg ccagaccggt
     1441 ggggggctcc gccatgccgt gcaagtgctc agggccgcct caccctccat ctggccccag
     1501 cccatgccgg ccttccctct ggggagcgac ttttccagaa ggccggccag gcgagagggt
     1561 cttcctgacg gcggagctga cctgcccggc ccaccagctg catgtcagct ccgagccacc
     1621 gggtccccgt ccaaggctgc tctgctaagt taaagacacc cgaaagcgct tgactcaggt
     1681 ccccggagtc cctggccagg gccccagccc ctcgcttgcc ctgcactgtg tggactctgg
     1741 ggatgcaggt gtaaggggag tgtggctggg cagcccctgg tcagccaggg tcacgcctgt
     1801 cctgggggcc ccaccctgct gcccgacacc ccccatggga ggctgcgggc ggcagttgct
     1861 gtctcagaga ggggagtgtg ggggcttggg cgctggccta gccaggggcg aggtggggag
     1921 gcggctggtg cagaggagag ctgggggctg aggttggggt gaaggctgca gccctccagg
     1981 ctgctggggg tgcagatggc tgtgccgtgc tgagattggc tctgtctgga ggggtccagt
     2041 gtggggtgcc tgagggcact agggagaggt gctcctgctg caggaggacc tgagggtcag
     2101 ggcttggaga ggacagggaa cctgcggccg tctcttctgc tttggggcag gggctctggc
     2161 ccgggagagg gaacggggac aggagcagag gacggtcatc caggcgcagc ggggagctgc
     2221 tccccaggcc acagcagaca gcactgctga gaggcagcgg ccgcgcgggt gacgcaaatg
     2281 gcaggccctg ggaatcccgc cgcctcccac ctagaattgt cctacctccc ccaccccaaa
     2341 caccagcttt tcctggcgcc ccaggcccag aacgtgggcc cagagagcct tgctggggtc
     2401 tctggggcac cttggccttg ctctgaggct ggaaggagaa ggaccagggt gcggcatcac
     2461 tcggcctcag ggacccctct gccctgccca gcactggccc cgacccgtgc tcccgccgtc
     2521 tgcccagagc aggacctcaa cctcctggag ggcacaggga gcggctgagt gggcacaaat
     2581 cctggcagga gaaaggccca ggctgaggcc aggcctggga aacatccaag cagtgaggac
     2641 acgcgtgttt gacaactgct cccctgaata aatgcgagga taaatgttt
//
