LOCUS       NM_001052               3926 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens somatostatin receptor 4 (SSTR4), mRNA.
ACCESSION   NM_001052
VERSION     NM_001052.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3926)
  AUTHORS   Nemes,B., Bolcskei,K., Kecskes,A., Kormos,V., Gaszner,B., Aczel,T.,
            Hegedus,D., Pinter,E., Helyes,Z. and Sandor,Z.
  TITLE     Human Somatostatin SST4 Receptor Transgenic Mice: Construction and
            Brain Expression Pattern Characterization
  JOURNAL   Int J Mol Sci 22 (7), 3758 (2021)
   PUBMED   33916620
  REMARK    GeneRIF: Human Somatostatin SST4 Receptor Transgenic Mice:
            Construction and Brain Expression Pattern Characterization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3926)
  AUTHORS   Kecskes,A., Pohoczky,K., Kecskes,M., Varga,Z.V., Kormos,V.,
            Szoke,E., Henn-Mike,N., Feher,M., Kun,J., Gyenesei,A., Renner,E.,
            Palkovits,M., Ferdinandy,P., Abraham,I.M., Gaszner,B. and Helyes,Z.
  TITLE     Characterization of Neurons Expressing the Novel Analgesic Drug
            Target Somatostatin Receptor 4 in Mouse and Human Brains
  JOURNAL   Int J Mol Sci 21 (20), 7788 (2020)
   PUBMED   33096776
  REMARK    GeneRIF: Characterization of Neurons Expressing the Novel Analgesic
            Drug Target Somatostatin Receptor 4 in Mouse and Human Brains.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3926)
  AUTHORS   Song,K.B., Kim,S.C., Kim,J.H., Seo,D.W., Hong,S.M., Park,K.M.,
            Hwang,D.W., Lee,J.H. and Lee,Y.J.
  TITLE     Prognostic Value of Somatostatin Receptor Subtypes in Pancreatic
            Neuroendocrine Tumors
  JOURNAL   Pancreas 45 (2), 187-192 (2016)
   PUBMED   26474434
  REMARK    GeneRIF: Data showed that the distribution of somatostatin receptor
            (SSTR) subtypes among the 199 pancreatic neuroendocrine tumors
            (PNETs) was: SSTR2 (54.8%), SSTR1 (53.3%), SSTR4 (51.8%), SSTR5
            (33.7%), and SSTR3 (28.6%).
REFERENCE   4  (bases 1 to 3926)
  AUTHORS   Pisarek,H., Pawlikowski,M., Marchlewska,M., Minias,R. and
            Winczyk,K.
  TITLE     An immunohistochemical investigation of the expression of
            somatostatin receptor subtypes - should therapeutic trials be
            performed to determine the efficacy of somatostatin analogs in
            treating advanced thyroid malignances?
  JOURNAL   Exp Clin Endocrinol Diabetes 123 (6), 342-346 (2015)
   PUBMED   25962406
  REMARK    GeneRIF: An immunohistochemical investigation of the expression of
            somatostatin receptor subtypes
REFERENCE   5  (bases 1 to 3926)
  AUTHORS   Yamamoto,J., Ohnuma,K., Hatano,R., Okamoto,T., Komiya,E.,
            Yamazaki,H., Iwata,S., Dang,N.H., Aoe,K., Kishimoto,T., Yamada,T.
            and Morimoto,C.
  TITLE     Regulation of somatostatin receptor 4-mediated cytostatic effects
            by CD26 in malignant pleural mesothelioma
  JOURNAL   Br J Cancer 110 (9), 2232-2245 (2014)
   PUBMED   24743707
  REMARK    GeneRIF: this study shows that CD26 is associated with SSTR4 in
            malignant pleural mesothelioma cells, and this interaction inhibits
            SSTR4-mediated cytostatic effects.
REFERENCE   6  (bases 1 to 3926)
  AUTHORS   Yamada,Y., Kagimoto,S., Kubota,A., Yasuda,K., Masuda,K., Someya,Y.,
            Ihara,Y., Li,Q., Imura,H., Seino,S. et al.
  TITLE     Cloning, functional expression and pharmacological characterization
            of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin
            receptor subtype
  JOURNAL   Biochem Biophys Res Commun 195 (2), 844-852 (1993)
   PUBMED   8373420
REFERENCE   7  (bases 1 to 3926)
  AUTHORS   Yasuda,K., Espinosa,R. 3rd, Davis,E.M., Le Beau,M.M. and Bell,G.I.
  TITLE     Human somatostatin receptor genes: localization of SSTR5 to human
            chromosome 20p11.2
  JOURNAL   Genomics 17 (3), 785-786 (1993)
   PUBMED   8244401
REFERENCE   8  (bases 1 to 3926)
  AUTHORS   Demchyshyn,L.L., Srikant,C.B., Sunahara,R.K., Kent,G., Seeman,P.,
            Van Tol,H.H., Panetta,R., Patel,Y.C. and Niznik,H.B.
  TITLE     Cloning and expression of a human somatostatin-14-selective
            receptor variant (somatostatin receptor 4) located on chromosome 20
  JOURNAL   Mol Pharmacol 43 (6), 894-901 (1993)
   PUBMED   8100352
REFERENCE   9  (bases 1 to 3926)
  AUTHORS   Yamada,Y., Post,S.R., Wang,K., Tager,H.S., Bell,G.I. and Seino,S.
  TITLE     Cloning and functional characterization of a family of human and
            mouse somatostatin receptors expressed in brain, gastrointestinal
            tract, and kidney
  JOURNAL   Proc Natl Acad Sci U S A 89 (1), 251-255 (1992)
   PUBMED   1346068
REFERENCE   10 (bases 1 to 3926)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL049651.2.
            
            On Dec 30, 2019 this sequence version replaced NM_001052.3.
            
            Summary: Somatostatin acts at many sites to inhibit the release of
            many hormones and other secretory proteins.  The biologic effects
            of somatostatin are probably mediated by a family of G
            protein-coupled receptors that are expressed in a tissue-specific
            manner.  SSTR4 is a member of the superfamily of receptors having
            seven transmembrane segments and is expressed in highest levels in
            fetal and adult brain and lung. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC117270.1, SRR7410571.176220.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000255008.5/ ENSP00000255008.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3926              AL049651.2         64353-68278
FEATURES             Location/Qualifiers
     source          1..3926
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.21"
     gene            1..3926
                     /gene="SSTR4"
                     /gene_synonym="SS-4-R; SS4-R; SS4R; SST4"
                     /note="somatostatin receptor 4"
                     /db_xref="GeneID:6754"
                     /db_xref="HGNC:HGNC:11333"
                     /db_xref="MIM:182454"
     exon            1..3926
                     /gene="SSTR4"
                     /gene_synonym="SS-4-R; SS4-R; SS4R; SST4"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1339
                     /gene="SSTR4"
                     /gene_synonym="SS-4-R; SS4-R; SS4R; SST4"
                     /note="G-protein coupled receptor"
                     /codon_start=1
                     /product="somatostatin receptor type 4"
                     /protein_id="NP_001043.2"
                     /db_xref="CCDS:CCDS42856.1"
                     /db_xref="GeneID:6754"
                     /db_xref="HGNC:HGNC:11333"
                     /db_xref="MIM:182454"
                     /translation="MSAPSTLPPGGEEGLGTAWPSAANASSAPAEAEEAVAGPGDARA
                     AGMVAIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPF
                     VASSAALRHWPFGSVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRP
                     SVAKLINLGVWLASLLVTLPIAIFADTRPARGGQAVACNLQWPHPAWSAVFVVYTFLL
                     GFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVVVFVLCWMPFY
                     VVQLLNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRFFQRVLCLRCCLLE
                     GAGGAEEEPLDYYATALKSKGGAGCMCPPLPCQQEALQPEPGRKRIPLTRTTTF"
     regulatory      3901..3906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSTR4"
                     /gene_synonym="SS-4-R; SS4-R; SS4R; SST4"
                     /note="hexamer: AATAAA"
     polyA_site      3926
                     /gene="SSTR4"
                     /gene_synonym="SS-4-R; SS4-R; SS4R; SST4"
                     /note="major polyA site"
ORIGIN      
        1 gggcgcgcgg cgcggggatt ggcgggcgct ccccggtgcc cgcagctctt cagcgtagcc
       61 gggaagagcc gcgcgtctgc gcgccagccc ccgccctggg cccgccgccc gagctctctg
      121 gcgcagcgct agctccgccg cgctcagctg ccctgcgccg gcacccctgg tcatgagcgc
      181 cccctcgacg ctgccccccg ggggcgagga agggctgggg acggcctggc cctctgcagc
      241 caatgccagt agcgctccgg cggaggcgga ggaggcggtg gcggggcccg gggacgcgcg
      301 ggcggcgggc atggtcgcta tccagtgcat ctacgcgctg gtgtgcctgg tggggctggt
      361 gggcaacgcc ctggtcatct tcgtgatcct tcgctacgcc aagatgaaga cggctaccaa
      421 catctacctg ctcaacctgg ccgtagccga cgagctcttc atgctgagcg tgcccttcgt
      481 ggcctcgtcg gccgccctgc gccactggcc cttcggctcc gtgctgtgcc gcgcggtgct
      541 cagcgtcgac ggcctcaaca tgttcaccag cgtcttctgt ctcaccgtgc tcagcgtgga
      601 ccgctacgtg gccgtggtgc accctctgcg cgcggcgacc taccggcggc ccagcgtggc
      661 caagctcatc aacctgggcg tgtggctggc atccctgttg gtcactctcc ccatcgccat
      721 cttcgcagac accagaccgg ctcgcggcgg ccaggccgtg gcctgcaacc tgcagtggcc
      781 acacccggcc tggtcggcag tcttcgtggt ctacactttc ctgctgggct tcctgctgcc
      841 cgtgctggcc attggcctgt gctacctgct catcgtgggc aagatgcgcg ccgtggccct
      901 gcgcgctggc tggcagcagc gcaggcgctc ggagaagaaa atcaccaggc tggtgctgat
      961 ggtcgtggtc gtctttgtgc tctgctggat gcctttctac gtggtgcagc tgctgaacct
     1021 cttcgtgacc agccttgatg ccaccgtcaa ccacgtgtcc cttatcctta gctatgccaa
     1081 cagctgcgcc aaccccattc tctatggctt cctctccgac aacttccgcc gattcttcca
     1141 gcgggttctc tgcctgcgct gctgcctcct ggaaggtgct ggaggtgctg aggaggagcc
     1201 cctggactac tatgccactg ctctcaagag caaaggtggg gcagggtgca tgtgcccccc
     1261 actcccctgc cagcaggaag ccctgcaacc agaacccggc cgcaagcgca tccccctcac
     1321 caggaccacc accttctgag gagcccttcc cctacccacc ctgcgtggcc acctcccaag
     1381 gggtgggcac cattcctaca gccccgaaga ctgcatctcc tgaatgctca cctaagctcc
     1441 accacctgtt ccttccagca gcccatgtac ctgccggaga gtgtcagaac tcttctgctg
     1501 ctctcctctc ccctgcactc tggctttcaa aaggatgctt ccatatgggt aggactcctc
     1561 tggaaactgg gctaggatat taatcattcc tgaacctctg gctgttcttc aagggctggg
     1621 aagcaggagg tggtgagaaa tgaatggtcc ctgtgtgtga ctccttacag ccactgcttg
     1681 ggagaggact caagaaggtg gagggaggta gcacccttcc tctctgcaga cgctctgcct
     1741 tgtggtggga gcacagcttg tacaggagag aggaggaagg aagatgcccc caggcacctg
     1801 ccctttatgt ctcttcctga gctcttgtta agtgagactt atgttaacag cctggggcac
     1861 ttacttccct ccccactcac ccccggcctg ggaataacat ctgcttgctg tcacaggtgt
     1921 ctccctgagt tgccctgagc tgggagcagt cttcctgtga gtagaaaagg tttggagaga
     1981 catgacatgg ggtttattgc aaggcataaa accaggtcag taataacaaa gcagatgata
     2041 aaaacttcat ctagctccta tgatgtaatt ttttttccct gatcctttga tgtgggaaca
     2101 tgagaactca ttaaggcagc aatttatact gtggtggtga gtgagagagg agccatgggc
     2161 gggaaaagct gaccagagag cagcgaggga tgggaaccag cccaggtttt ggatagagga
     2221 agcagcttca tcaccacccc ctattttaga atgtcatctt tcagtaaaac atcagccaca
     2281 ttagatatta acatgtaagt tgaacacaat aaaaggccgt atctttgttg cctgatgtgt
     2341 taaccaaagg ataaattatc tttcccaaag ggaaagagct taagaggagc tctaattctg
     2401 ctttctgata aaagcagggg aggggacaaa ggagaacttg gaacacttat gttagcatct
     2461 ggtgtaacaa cataggaaca tgtatgaagt ttgggggacc ccacctggct tagcattcag
     2521 agactacctc tgggtttaac cggcctgatt ctggatgatc attctggtgg tatggggaag
     2581 atggtgtggg gagggggaga gacagccaaa ggtcaacacc ctatgccctt cagagtggtc
     2641 agcctcacag accactctga gagaatgggt agccatgtct gtactacata ctggagacat
     2701 gactgtggaa tggaagtttc aaaactaagt cagagaaccc tctgatcctg caaacacaca
     2761 tgcacacaca cagagacatc aaccatctct aatttgttgg cacccaccag ggataccttg
     2821 ggcatctgaa gtcagtctcc atgtctgtgg gtctcgtgta accataacta cttggagttt
     2881 tttaaaactg cattatttct ttgttcctca gtgtctgaca atgcctgcca ggatgggcac
     2941 tgatgaatat ggttgaacgg aactccaagg accacccagg ttgatagtag tgaggtgagg
     3001 ggttcacagc actggcagtg gtccccaggg cttcttccca gcttgtacgt ggggttgggg
     3061 gtcctttctt tagtctctca gtgatcagac tgggcaaact ctctgataag caagacaggg
     3121 cacctaccag gagtcttggc aacactagtg tgtggctgcc cagattagca tggaataaga
     3181 cacattctat ttagaaatgt cagccttttt aacttagttg atgaaggttg aaggagaggc
     3241 agcttcaggt gatggaaaga aaagtctctg agaggcagga cacctcagcc tcagctaccc
     3301 cgtgagcagt gatttaacct ctctaagcct cagtttccca cttggaatat gtgccaaggg
     3361 aggttcgagt tttgagctct tcccagctgt aaactctgca ttggcagaga caccgtggag
     3421 acacgcgaat caaatggtgg gagggcagga gatagcacgc ttctctgctt agtcctcctt
     3481 ccatcaccac tggaaaatga gcgtgaacac tgcccttgac cctgcagtca taagtcatgc
     3541 aggtggtggc ggggtggggg tgtagggtga gcctacccgc tgctctcttc tttagcttca
     3601 gggccttttc atttcccggc agcaacgagg tgcactgagc acttgtcggg gctgtgtttg
     3661 gagcccatca acagtgctac cagctttagt tccatcaacc ccaggctttt gtaacaactg
     3721 gttgcatgaa accctccctt gtagtttgtg tacagaagac tgcaatgaat tgaagtcatg
     3781 agacatacag ccaggatcct gaaagccacc aacatatgtc acctgcctgg gaggcttgct
     3841 tcgatggtca tcttgttctg cctgctaaga ccaggagtca cagctgttga catcatggtg
     3901 aataaaaaca ttttctgcca caggta
//
