LOCUS       NM_001051               4256 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens somatostatin receptor 3 (SSTR3), transcript variant 1,
            mRNA.
ACCESSION   NM_001051
VERSION     NM_001051.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4256)
  AUTHORS   Sagie,N., Romanov,E., Kezerle,Y., Meirovitz,A. and Sheva,K.
  TITLE     Expression Analysis of SSTR 1, 2 and 3 in Small-cell Lung Cancer
            Patients as Targets for Future Peptide Receptor Radionuclide
            Therapy
  JOURNAL   Anticancer Res 44 (9), 3807-3812 (2024)
   PUBMED   39197921
  REMARK    GeneRIF: Expression Analysis of SSTR 1, 2 and 3 in Small-cell Lung
            Cancer Patients as Targets for Future Peptide Receptor Radionuclide
            Therapy.
REFERENCE   2  (bases 1 to 4256)
  AUTHORS   Barbeito,P., Tachibana,Y., Martin-Morales,R., Moreno,P.,
            Mykytyn,K., Kobayashi,T. and Garcia-Gonzalo,F.R.
  TITLE     HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and
            C-terminal tails
  JOURNAL   Life Sci Alliance 4 (3), e202000746 (2020)
   PUBMED   33372037
  REMARK    GeneRIF: HTR6 and SSTR3 ciliary targeting relies on both IC3 loops
            and C-terminal tails.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4256)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4256)
  AUTHORS   Badgandi,H.B., Hwang,S.H., Shimada,I.S., Loriot,E. and
            Mukhopadhyay,S.
  TITLE     Tubby family proteins are adapters for ciliary trafficking of
            integral membrane proteins
  JOURNAL   J Cell Biol 216 (3), 743-760 (2017)
   PUBMED   28154160
REFERENCE   5  (bases 1 to 4256)
  AUTHORS   Lehmann,A., Kliewer,A., Gunther,T., Nagel,F. and Schulz,S.
  TITLE     Identification of Phosphorylation Sites Regulating sst3
            Somatostatin Receptor Trafficking
  JOURNAL   Mol Endocrinol 30 (6), 645-659 (2016)
   PUBMED   27101376
  REMARK    GeneRIF: the C-terminal phosphorylation motif of the human sst3
            receptor that regulates its agonist-promoted phosphorylation,
            beta-arrestin recruitment, and internalization of this clinically
            relevant receptor, is reported.
REFERENCE   6  (bases 1 to 4256)
  AUTHORS   Law,S.F., Zaina,S., Sweet,R., Yasuda,K., Bell,G.I., Stadel,J. and
            Reisine,T.
  TITLE     Gi alpha 1 selectively couples somatostatin receptor subtype 3 to
            adenylyl cyclase: identification of the functional domains of this
            alpha subunit necessary for mediating the inhibition by
            somatostatin of cAMP formation
  JOURNAL   Mol Pharmacol 45 (4), 587-590 (1994)
   PUBMED   8183236
REFERENCE   7  (bases 1 to 4256)
  AUTHORS   Corness,J.D., Demchyshyn,L.L., Seeman,P., Van Tol,H.H.,
            Srikant,C.B., Kent,G., Patel,Y.C. and Niznik,H.B.
  TITLE     A human somatostatin receptor (SSTR3), located on chromosome 22,
            displays preferential affinity for somatostatin-14 like peptides
  JOURNAL   FEBS Lett 321 (2-3), 279-284 (1993)
   PUBMED   8097479
REFERENCE   8  (bases 1 to 4256)
  AUTHORS   Yamada,Y., Reisine,T., Law,S.F., Ihara,Y., Kubota,A., Kagimoto,S.,
            Seino,M., Seino,Y., Bell,G.I. and Seino,S.
  TITLE     Somatostatin receptors, an expanding gene family: cloning and
            functional characterization of human SSTR3, a protein coupled to
            adenylyl cyclase
  JOURNAL   Mol Endocrinol 6 (12), 2136-2142 (1992)
   PUBMED   1337145
REFERENCE   9  (bases 1 to 4256)
  AUTHORS   Yamada,Y., Post,S.R., Wang,K., Tager,H.S., Bell,G.I. and Seino,S.
  TITLE     Cloning and functional characterization of a family of human and
            mouse somatostatin receptors expressed in brain, gastrointestinal
            tract, and kidney
  JOURNAL   Proc Natl Acad Sci U S A 89 (1), 251-255 (1992)
   PUBMED   1346068
REFERENCE   10 (bases 1 to 4256)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z82188.2, AK291165.1 and
            BF514979.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001051.4.
            
            Summary: This gene encodes a member of the somatostatin receptor
            protein family. Somatostatins are peptide hormones that regulate
            diverse cellular functions such as neurotransmission, cell
            proliferation, and endocrine signaling as well as inhibiting the
            release of many hormones and other secretory proteins. Somatostatin
            has two active forms of 14 and 28 amino acids. The biological
            effects of somatostatins are mediated by a family of G-protein
            coupled somatostatin receptors that are expressed in a
            tissue-specific manner. Somatostatin receptors form homodimers and
            heterodimers with other members of the superfamily as well as with
            other G-protein coupled receptors and receptor tyrosine kinases.
            This protein is functionally coupled to adenylyl cyclase. Alternate
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.57378.1, AK291165.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000610913.2/ ENSP00000480971.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-537               Z82188.2           60372-60908         c
            538-2381            AK291165.1         433-2276
            2382-4179           Z82188.2           52745-54542         c
            4180-4256           BF514979.1         17-93               c
FEATURES             Location/Qualifiers
     source          1..4256
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..4256
                     /gene="SSTR3"
                     /gene_synonym="SS-3-R; SS3-R; SS3R; SSR-28; SST3"
                     /note="somatostatin receptor 3"
                     /db_xref="GeneID:6753"
                     /db_xref="HGNC:HGNC:11332"
                     /db_xref="MIM:182453"
     exon            1..653
                     /gene="SSTR3"
                     /gene_synonym="SS-3-R; SS3-R; SS3R; SSR-28; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            654..4256
                     /gene="SSTR3"
                     /gene_synonym="SS-3-R; SS3-R; SS3R; SSR-28; SST3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4236..4241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSTR3"
                     /gene_synonym="SS-3-R; SS3-R; SS3R; SSR-28; SST3"
                     /note="hexamer: AATAAA"
     polyA_site      4256
                     /gene="SSTR3"
                     /gene_synonym="SS-3-R; SS3-R; SS3R; SSR-28; SST3"
                     /note="major polyA site"
ORIGIN      
        1 actccctcct tcacgggctc catgtcacca tctgtggcac agtccctctc tgtcactctc
       61 cctgccaccc cctcattctc cttcctccct cctgcctctc tctgcatctc tccctctcac
      121 ccgtgtctcc tctcctctct ttccttctcg tcttctccct gtcacgcatc tctcatcact
      181 ccccctcatt ctgcctttcc tcctactcac ggtctcctct ccctctccct ctctctctct
      241 ccccctccct ctttctctct ctctctcttt ctccacctcc tcccgacccc ctttcccctc
      301 tatttctatt ggcttctgtg tcccttgctc ccctcttctc ttcctcaccc tgggaagctt
      361 ctccccccta tccttgcccc tgccccccca ggatgtgtcc tggagatggg gggtgacgta
      421 ccaggctctg gttgggaagt cagggccgga gaccagatgg gagaggctct gtggacagcc
      481 gtggccgagg gcctgggagg gaacctgagc ccgcaagcgg tctagaagtg ggtgccttgt
      541 ggggacccta gttaggagtg ccctgggggc acctggggac tgggcaggga gaggggacag
      601 cagaatgata accagcctgg cggcaaggag ggaagccctc accccatggg caggcaaata
      661 gctgactgct gaccaccctc ccctcagcca tggacatgct tcatccatca tcggtgtcca
      721 cgacctcaga acctgagaat gcctcctcgg cctggccccc agatgccacc ctgggcaacg
      781 tgtcggcggg cccaagcccg gcagggctgg ccgtcagtgg cgttctgatc cccctggtct
      841 acctggtggt gtgcgtggtg ggcctgctgg gtaactcgct ggtcatctat gtggtcctgc
      901 ggcacacggc cagcccttca gtcaccaacg tctacatcct caacctggcg ctggccgacg
      961 agctcttcat gctggggctg cccttcctgg ccgcccagaa cgccctgtcc tactggccct
     1021 tcggctccct catgtgccgc ctggtcatgg cggtggatgg catcaaccag ttcaccagca
     1081 tattctgcct gactgtcatg agcgtggacc gctacctggc cgtggtacat cccacccgct
     1141 cggcccgctg gcgcacagct ccggtggccc gcacggtcag cgcggctgtg tgggtggcct
     1201 cagccgtggt ggtgctgccc gtggtggtct tctcgggagt gccccgcggc atgagcacct
     1261 gccacatgca gtggcccgag ccggcggcgg cctggcgagc cggcttcatc atctacacgg
     1321 ccgcactggg cttcttcggg ccgctgctgg tcatctgcct ctgctacctg ctcatcgtgg
     1381 tgaaggtgcg ctcagctggg cgccgggtgt gggcaccctc gtgccagcgg cggcggcgct
     1441 ccgaacgcag ggtcacgcgc atggtggtgg ccgtggtggc gctcttcgtg ctctgctgga
     1501 tgcccttcta cgtgctcaac atcgtcaacg tggtgtgccc actgcccgag gagcctgcct
     1561 tctttgggct ctacttcctg gtggtggcgc tgccctatgc caacagctgt gccaacccca
     1621 tcctttatgg cttcctctcc taccgcttca agcagggctt ccgcagggtc ctgctgcggc
     1681 cctcccgccg tgtgcgcagc caggagccca ctgtggggcc cccggagaag actgaggagg
     1741 aggatgagga ggaggaggat ggggaggaga gcagggaggg gggcaagggg aaggagatga
     1801 acggccgggt cagccagatc acgcagcctg gcaccagcgg gcaggagcgg ccgcccagca
     1861 gagtggccag caaggagcag cagctcctac cccaagaggc ttccactggg gagaagtcca
     1921 gcacgatgcg catcagctac ctgtaggggc ctggggaaag ccaggatggc ccgaggaaga
     1981 ggcagaagcc gtgggtgtgc ctagggccta cttcccaagg tgccacaggc ccatgatggg
     2041 atgttgaggg gcctggactt tgatgctatt gctgccaggt cttgctgtgt gaccttgggt
     2101 aggttgcttc tactctctgg gccttgtttt ctcctctgtg actcagggat aggagtcatc
     2161 agcctggatg agctatgtca gatgagaggt ttggagggca ctgttgctgg gctgacctgg
     2221 ctgagcaggc aaaaggtggg tgcagactgg cctcccccca gggatggagt gtcttggggc
     2281 atcaactaga atcttggccc tcagagggat aaaccaaggc caggatttct tgggctcaga
     2341 gtcaggaaca caggagctgc tgggggctgg gctggaaacc taaacagaag aaagcctaac
     2401 ccggtgggag gagtggggca gaaatggtca ggccccagat cagctccctc ccctcgactg
     2461 tgaggccttg gaccagctct gctcctctct aggcctcagg cttcacctgg gtaaaaccca
     2521 acaacctcta cacccttttg gcccaggcag tcaatgctgg aggtcctgtg ctcctggacg
     2581 ggaagagcag gtgaatttcc tgctcatgga agcgaatgaa gtccagcttc agggtctctc
     2641 actgcctggg cttttgcaag gccctgcatc tacttttgta cttgtcattt tgtattcgtt
     2701 ttcttaaaga gggacctcga actgcataag cttaggccac ccaaagcctg gctctgcccc
     2761 tgctgaggtc agccacccaa tccccaagga agctcatgtt gggtcttatg gctggagtag
     2821 gggcccccgg gggttcccag gtcttttgag ggcttccagg cacctccttg taggaagggc
     2881 catccctgtt cctctccttg tgacccatat tctcccttcc tggagaccga gacagggacc
     2941 cagcccatga ggactggcat ggaaaggcag agtgtctgaa gagcgctgtg aggagaagga
     3001 agaggaaggg agaagaggaa gaggaaggag aaggaagagg aagacaaggg ggaaagggga
     3061 ggatgaggag ggggaaggag aagtacagat ctgtttcctg gagccgtctt tggcccccct
     3121 gggctgagct cagtggtagc atctgtgaac ctgagttgcc gacaacagcc ccacccaacc
     3181 agtactgagg gaaggacacg atcagggtgg aacagccagg gtgcaatggc aaatgcacag
     3241 agtacagaca ggcacagggc ctgcgtccct gaggggcctc agagtgctgc caagagggct
     3301 caggccttaa taaagcccta gggtggagct ggctaccagg gacattggga ggactgggga
     3361 gctccctccc catgctctat catcctggag actacaggtc gggaggccca gggaagacaa
     3421 gaagaggctg aagtgggact gtggaggggg accatgggga gcagccacca tccaaggctg
     3481 ggcctagact ccctcccaga gatggtccct cagagctgtg gtgaggctgg ccctgggagg
     3541 gtgagacccc cggtgaaatc cttccgcttc cccacccctt gcagagggca ggggtcctca
     3601 gggaaagcac aggaaccaga cttttggaga cttggatctt cagcacacct cagggtcctg
     3661 ggctggcatt ggccttccgg gcctcaattt ccccatcaac aaatggagat gaatcccagc
     3721 ttggctgcct cctgggatct aacgagaaaa tgagtcatgt gaggtaactt ccaggctcac
     3781 tgcaatgggt acggtggggt gtatcagatt ataaagtggg ggtgccctcc tcacccccag
     3841 gcttggccta tacccccctc tccatcaagt ggcctctctg tgtctgtcct ttggggtgag
     3901 gacactgtag gccatgagaa atgggcagtt ggggggtcag aggccaaggg ttagggaggc
     3961 agggcttggg gagagtgtgg gaccatcaga agagaaggaa gtttacaaaa ccacattttg
     4021 tgtggagatg gaggctggag gcccggccct gggacttggt ctggggtttc ttgaggaaga
     4081 tctgagggtc caagggagga aggatgccct ggccttctgg ccttctctgg ctgatcctgc
     4141 cttcttgctg cctaggacag gagagtaatg tcctagaatg gtccctggga ggccagttag
     4201 gaaacccttt gctgcttctg tctctagctc ttgtcaataa agacggtgac acctga
//
