LOCUS       NM_001049               4390 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens somatostatin receptor 1 (SSTR1), mRNA.
ACCESSION   NM_001049
VERSION     NM_001049.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4390)
  AUTHORS   Sagie,N., Romanov,E., Kezerle,Y., Meirovitz,A. and Sheva,K.
  TITLE     Expression Analysis of SSTR 1, 2 and 3 in Small-cell Lung Cancer
            Patients as Targets for Future Peptide Receptor Radionuclide
            Therapy
  JOURNAL   Anticancer Res 44 (9), 3807-3812 (2024)
   PUBMED   39197921
  REMARK    GeneRIF: Expression Analysis of SSTR 1, 2 and 3 in Small-cell Lung
            Cancer Patients as Targets for Future Peptide Receptor Radionuclide
            Therapy.
REFERENCE   2  (bases 1 to 4390)
  AUTHORS   Vitali,E., Piccini,S., Trivellin,G., Smiroldo,V., Lavezzi,E.,
            Zerbi,A., Pepe,G. and Lania,A.G.
  TITLE     The impact of SST2 trafficking and signaling in the treatment of
            pancreatic neuroendocrine tumors
  JOURNAL   Mol Cell Endocrinol 527, 111226 (2021)
   PUBMED   33675866
  REMARK    GeneRIF: The impact of SST2 trafficking and signaling in the
            treatment of pancreatic neuroendocrine tumors.
            Review article
REFERENCE   3  (bases 1 to 4390)
  AUTHORS   Guo,R.Y., Wang,H.M., Dong,X., Hu,Y., Li,J., Zang,Y. and Li,X.
  TITLE     Selectivity Comparison of Tumor-Imaging Probes Designed Based on
            Various Tumor-Targeting Strategies: A Proof of Concept Study
  JOURNAL   ACS Appl Bio Mater 4 (3), 2058-2065 (2021)
   PUBMED   35014332
  REMARK    GeneRIF: Selectivity Comparison of Tumor-Imaging Probes Designed
            Based on Various Tumor-Targeting Strategies: A Proof of Concept
            Study.
REFERENCE   4  (bases 1 to 4390)
  AUTHORS   Soukup,J., Hornychova,H., Manethova,M., Michalova,K., Michnova,L.,
            Popovska,L., Skarkova,V., Cesak,T., Netuka,D., Ryska,A., Cap,J.,
            Hana,V., Hana,V. Jr., Krsek,M., Dvorakova,E., Krcma,M.,
            Lazurova,I., Olsovska,V., Stary,K., Vanuga,P. and Gabalec,F.
  TITLE     Predictive and prognostic significance of tumour subtype, SSTR1-5
            and e-cadherin expression in a well-defined cohort of patients with
            acromegaly
  JOURNAL   J Cell Mol Med 25 (5), 2484-2492 (2021)
   PUBMED   33491286
  REMARK    GeneRIF: Predictive and prognostic significance of tumour subtype,
            SSTR1-5 and e-cadherin expression in a well-defined cohort of
            patients with acromegaly.
REFERENCE   5  (bases 1 to 4390)
  AUTHORS   Kaemmerer,D., Schindler,R., Mussbach,F., Dahmen,U.,
            Altendorf-Hofmann,A., Dirsch,O., Sanger,J., Schulz,S. and Lupp,A.
  TITLE     Somatostatin and CXCR4 chemokine receptor expression in
            hepatocellular and cholangiocellular carcinomas: tumor capillaries
            as promising targets
  JOURNAL   BMC Cancer 17 (1), 896 (2017)
   PUBMED   29282035
  REMARK    GeneRIF: High SSTR1 expression is associated with hepatocellular
            and cholangiocellular carcinomas in tumor capillaries.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4390)
  AUTHORS   Le Romancer,M., Cherifi,Y., Levasseur,S., Laigneau,J.P.,
            Peranzi,G., Jais,P., Lewin,M.J. and Reyl-Desmars,F.
  TITLE     Messenger RNA expression of somatostatin receptor subtypes in human
            and rat gastric mucosae
  JOURNAL   Life Sci 58 (13), 1091-1098 (1996)
   PUBMED   8622562
REFERENCE   7  (bases 1 to 4390)
  AUTHORS   Fujita,T., Yamaji,Y., Sato,M., Murao,K. and Takahara,J.
  TITLE     Gene expression of somatostatin receptor subtypes, SSTR1 and SSTR2,
            in human lung cancer cell lines
  JOURNAL   Life Sci 55 (23), 1797-1806 (1994)
   PUBMED   7968260
REFERENCE   8  (bases 1 to 4390)
  AUTHORS   Kaupmann,K., Bruns,C., Hoyer,D., Seuwen,K. and Lubbert,H.
  TITLE     Distribution and second messenger coupling of four somatostatin
            receptor subtypes expressed in brain
  JOURNAL   FEBS Lett 331 (1-2), 53-59 (1993)
   PUBMED   8405411
REFERENCE   9  (bases 1 to 4390)
  AUTHORS   Yamada,Y., Stoffel,M., Espinosa,R. 3rd, Xiang,K.S., Seino,M.,
            Seino,S., Le Beau,M.M. and Bell,G.I.
  TITLE     Human somatostatin receptor genes: localization to human
            chromosomes 14, 17, and 22 and identification of simple tandem
            repeat polymorphisms
  JOURNAL   Genomics 15 (2), 449-452 (1993)
   PUBMED   8449518
REFERENCE   10 (bases 1 to 4390)
  AUTHORS   Yamada,Y., Post,S.R., Wang,K., Tager,H.S., Bell,G.I. and Seino,S.
  TITLE     Cloning and functional characterization of a family of human and
            mouse somatostatin receptors expressed in brain, gastrointestinal
            tract, and kidney
  JOURNAL   Proc Natl Acad Sci U S A 89 (1), 251-255 (1992)
   PUBMED   1346068
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL450109.3.
            
            On Nov 26, 2018 this sequence version replaced NM_001049.2.
            
            Summary: Somatostatins are peptide hormones that regulate diverse
            cellular functions such as neurotransmission, cell proliferation,
            and endocrine signaling as well as inhibiting the release of many
            hormones and other secretory proteins. Somatostatin has two active
            forms of 14 and 28 amino acids. The biological effects of
            somatostatins are mediated by a family of G-protein coupled
            somatostatin receptors that are expressed in a tissue-specific
            manner. The protein encoded by this gene is a member of the
            superfamily of somatostatin receptors having seven transmembrane
            segments. Somatostatin receptors form homodimers and heterodimers
            with other members of the superfamily as well as with other
            G-protein coupled receptors and receptor tyrosine kinases. This
            somatostatin receptor has greater affinity for somatostatin-14 than
            -28. [provided by RefSeq, Jul 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX248780.1, AL556152.3 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267377.3/ ENSP00000267377.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               AL450109.3         64126-64326
            202-368             AL450109.3         64665-64831
            369-4390            AL450109.3         65268-69289
FEATURES             Location/Qualifiers
     source          1..4390
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q21.1"
     gene            1..4390
                     /gene="SSTR1"
                     /gene_synonym="SRIF-2; SS-1-R; SS1-R; SS1R; SST1"
                     /note="somatostatin receptor 1"
                     /db_xref="GeneID:6751"
                     /db_xref="HGNC:HGNC:11330"
                     /db_xref="MIM:182451"
     exon            1..201
                     /gene="SSTR1"
                     /gene_synonym="SRIF-2; SS-1-R; SS1-R; SS1R; SST1"
                     /inference="alignment:Splign:2.1.0"
     exon            202..368
                     /gene="SSTR1"
                     /gene_synonym="SRIF-2; SS-1-R; SS1-R; SS1R; SST1"
                     /inference="alignment:Splign:2.1.0"
     exon            369..4390
                     /gene="SSTR1"
                     /gene_synonym="SRIF-2; SS-1-R; SS1-R; SS1R; SST1"
                     /inference="alignment:Splign:2.1.0"
     CDS             713..1888
                     /gene="SSTR1"
                     /gene_synonym="SRIF-2; SS-1-R; SS1-R; SS1R; SST1"
                     /codon_start=1
                     /product="somatostatin receptor type 1"
                     /protein_id="NP_001040.1"
                     /db_xref="CCDS:CCDS9666.1"
                     /db_xref="GeneID:6751"
                     /db_xref="HGNC:HGNC:11330"
                     /db_xref="MIM:182451"
                     /translation="MFPNGTASSPSSSPSPSPGSCGEGGGSRGPGAGAADGMEEPGRN
                     ASQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAI
                     ADELLMLSVPFLVTSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVV
                     HPIKAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQR
                     WLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMV
                     VMVFVICWMPFYVVQLVNVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKRSF
                     QRILCLSWMDNAAEEPVDYYATALKSRAYSVEDFQPENLESGGVFRNGTCTSRITTL"
     regulatory      4363..4368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSTR1"
                     /gene_synonym="SRIF-2; SS-1-R; SS1-R; SS1R; SST1"
                     /note="hexamer: AATAAA"
     polyA_site      4390
                     /gene="SSTR1"
                     /gene_synonym="SRIF-2; SS-1-R; SS1-R; SS1R; SST1"
                     /note="major polyA site"
ORIGIN      
        1 agctcacaaa tcaagcctca gaaagagctg acatcctagc tcttcccgga aaaactcgaa
       61 tgtcgccctg ccgttcctgg ggttggtgac aggtctggtc atcgcacggc ggcagctcct
      121 cacctggatt tagaagagct ggcgtccccg cccgcccaag cctttaaact ctcgtctgcc
      181 agaacccgcc aactctccag gcttagggcc agtttccgcg attctaagag taattgcgtg
      241 ggcacctgtg ctggggccag gcgcaaagaa gggagttggt ctgcgcgaag atcgtcaacc
      301 tgctaacaga ccgcacatgc actttgcacc gaccatctac gtctcagtct ggaggttgcg
      361 cactttggct gctgacgcgc tggtggtgcc tattaatcat ttaccagtcc agagccgcgc
      421 cagttaatgg ctgtgccgtg cggtgctccc acatcctggc ctctcctctc cacggtcgcc
      481 tgtgcccggg caccccggag ctgcaaactg cagagcccag gcaaccgctg ggctgtgcgc
      541 cccgccggcg ccggtaggag ccgcgctccc cgcagcggtt gcgctctacc cggaggcgct
      601 gggcggctgt gggctgcagg caagcggtcg ggtggggagg gagggcgcag gcggcgggtg
      661 cgcgaggaga aagccccagc cctggcagcc ccactggccc ccctcagctg ggatgttccc
      721 caatggcacc gcctcctctc cttcctcctc tcctagcccc agcccgggca gctgcggcga
      781 aggcggcggc agcaggggcc ccggggccgg cgctgcggac ggcatggagg agccagggcg
      841 aaatgcgtcc cagaacggga ccttgagcga gggccagggc agcgccatcc tgatctcttt
      901 catctactcc gtggtgtgcc tggtggggct gtgtgggaac tctatggtca tctacgtgat
      961 cctgcgctat gccaagatga agacggccac caacatctac atcctaaatc tggccattgc
     1021 tgatgagctg ctcatgctca gcgtgccctt cctagtcacc tccacgttgt tgcgccactg
     1081 gcccttcggt gcgctgctct gccgcctcgt gctcagcgtg gacgcggtca acatgttcac
     1141 cagcatctac tgtctgactg tgctcagcgt ggaccgctac gtggccgtgg tgcatcccat
     1201 caaggcggcc cgctaccgcc ggcccaccgt ggccaaggta gtaaacctgg gcgtgtgggt
     1261 gctatcgctg ctcgtcatcc tgcccatcgt ggtcttctct cgcaccgcgg ccaacagcga
     1321 cggcacggtg gcttgcaaca tgctcatgcc agagcccgct caacgctggc tggtgggctt
     1381 cgtgttgtac acatttctca tgggcttcct gctgcccgtg ggggctatct gcctgtgcta
     1441 cgtgctcatc attgctaaga tgcgcatggt ggccctcaag gccggctggc agcagcgcaa
     1501 gcgctcggag cgcaagatca ccttaatggt gatgatggtg gtgatggtgt ttgtcatctg
     1561 ctggatgcct ttctacgtgg tgcagctggt caacgtgttt gctgagcagg acgacgccac
     1621 ggtgagtcag ctgtcggtca tcctcggcta tgccaacagc tgcgccaacc ccatcctcta
     1681 tggctttctc tcagacaact tcaagcgctc tttccaacgc atcctatgcc tcagctggat
     1741 ggacaacgcc gcggaggagc cggttgacta ttacgccacc gcgctcaaga gccgtgccta
     1801 cagtgtggaa gacttccaac ctgagaacct ggagtccggc ggcgtcttcc gtaatggcac
     1861 ctgcacgtcc cggatcacga cgctctgagc ccgggccacg caggggctct gagcccgggc
     1921 cacgcagggg ccctgagcca aaagaggggg agaatgagaa gggaaggccg ggtgcgaaag
     1981 ggacggtatc cagggcgcca gggtgctgtc gggataacgt ggggctagga cactgacagc
     2041 ctttgatgga ggaacccaag aaaggcgcgc gacaatggta gaagtgagag ctttgcttat
     2101 aaactgggaa ggctttcagg ctaccttttt ctgggtctcc cactttctgt tccttcctcc
     2161 actgcgctta ctcctctgac cctccttcta ttttccctac cctgcaactt ctatcctttc
     2221 ttccgcaccg tcccgccagt gcagatcacg aactcattaa caactcattc tgatcctcag
     2281 cccctccagt cgttatttct gtttgtttaa gctgagccac ggataccgcc acgggtttcc
     2341 ctcggcgtta gtccctagcc gcgcggggcc gctgtccagg ttctgtctgg tgcccctact
     2401 ggagtcccgg gaatgaccgc tctccctttg cgcagcccta ccttaaggaa agttggactt
     2461 gagaaagatc taagcagctg gtcttttctc ctactcttgg gtgaaggtgc atctttccct
     2521 gccctcccct gtccccctct cgccgcccgc ccgccaccac cactctcact ccacccagag
     2581 tagagccagg tgcttagtaa aataggtccc gcgcttcgaa ctccaggctt tctggagttc
     2641 ccacccaagc cctcctttgg agcaaagaag gagctgagaa caagccgaat gaggagtttt
     2701 tataagattg cggggtcgga gtgtgggcgc gtaataggaa tcaccctcct actgcgcgtt
     2761 ttcaaagacc aagcgctggg cgctcccggg ccgcgcgtct gcgttaggca gggcagggta
     2821 gtgcagggca caccttcccc ggggttcggg gttcggggtt cggttgcagg gctgcagccc
     2881 gccttggctt tctccctcac ccaagtttcc ggaggagccg acctaaaagt aacaatagat
     2941 aaggtttcct gctccagtgt atctcaaaag accgggcgcc aggggcgggg gacctagggc
     3001 gacgtcttca gagtccgcca gtgttggcgg tgtcgccgca acctgcaggc tcccgagtgg
     3061 ggcctgcctg gtctctagag ggttgctgcc tttcaagcgg tgcctaagaa gttattttct
     3121 tgtttaacat atatatttat taatttattt gtcgtgttgg aaaatgtgtc tctgctttcc
     3181 ttttctctgc ttgcctagcc ccaggtcttt tctttgggac cctgggggcg ggcatggaag
     3241 tggaagtagg ggcaagctct tgccccactc cctggccatc tcaacgcctc tcctcaatgc
     3301 tgggccctct tatctcatcc tttcctctag cttttctatt tttgattgtg ttgagtgaag
     3361 tttggagatt tttcatactt ttcttactat agtctcttgt ttgtcttatt aggataatac
     3421 ataaatgata atgtgggtta tcctcctctc catgcacagt ggaaagtcct gaactcctgg
     3481 ctttccagga gacatatata ggggaacatc accctatata taatttgagt gtatatatat
     3541 ttatatatat gatgtggaca tatgtatact tatcttgctc cattgtcatg agtccatgag
     3601 tctaagtata gccactgatg gtgacaggtg tgagtctggc tggaacactt tcagtttcag
     3661 gagtgcaagc agcactcaaa cctggagctg aggaatctaa ttcagacaga gactttaatc
     3721 actgctgaag atgcccctgc tccctctggg ttccagcaga ggtgattctt acatatgatc
     3781 cagttaacat catcactttt tttgaggaca ttgaaagtga aataatttgt gtctgtgttt
     3841 aatattacca actacattgg aagcctgagc agggcgagga ccaataattt taattattta
     3901 tatttcctgt attgctttag tatgctggct tgtacatagt aggcactaaa tacatgtttg
     3961 ttggttgatt gtttaagcca gagtgtatta caacaatctg gagatactaa atctggggtt
     4021 ctcaggttca ctcattgaca tgatatacaa tggttaaaat cactattgaa aaatacgttt
     4081 tgtgtatatt tgcttcaaca actttgtgct ttcctgaaag cagtaaccaa gagttaagat
     4141 atccctaatg ttttgcttaa actaatgaac aaatatgctt tgggtcataa atcagaaagt
     4201 ttagatctgt cccttaataa aaatatatat tactactcct ttggaaaata gatttttaat
     4261 ggttaagaac tgtgaaattt acaaatcaaa atcttaatca ttatccttct aagaggatac
     4321 aaatttagtg ctcttaactt gttaccattg taatattaac taaataaaca gatgtattat
     4381 gctgttgcaa
//
