LOCUS       NM_001048                607 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens somatostatin (SST), mRNA.
ACCESSION   NM_001048
VERSION     NM_001048.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 607)
  AUTHORS   Dienel,S.J., Fish,K.N. and Lewis,D.A.
  TITLE     The Nature of Prefrontal Cortical GABA Neuron Alterations in
            Schizophrenia: Markedly Lower Somatostatin and Parvalbumin Gene
            Expression Without Missing Neurons
  JOURNAL   Am J Psychiatry 180 (7), 495-507 (2023)
   PUBMED   37073488
  REMARK    GeneRIF: The Nature of Prefrontal Cortical GABA Neuron Alterations
            in Schizophrenia: Markedly Lower Somatostatin and Parvalbumin Gene
            Expression Without Missing Neurons.
REFERENCE   2  (bases 1 to 607)
  AUTHORS   Kothegala,L., Miranda,C., Singh,M., Krieger,J.P. and Gandasi,N.R.
  TITLE     Somatostatin Containing delta-Cell Number Is Reduced in Type-2
            Diabetes
  JOURNAL   Int J Mol Sci 24 (4), 3449 (2023)
   PUBMED   36834860
  REMARK    GeneRIF: Somatostatin Containing delta-Cell Number Is Reduced in
            Type-2 Diabetes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 607)
  AUTHORS   Saez-Martinez,P., Porcel-Pastrana,F., Perez-Gomez,J.M.,
            Pedraza-Arevalo,S., Gomez-Gomez,E., Jimenez-Vacas,J.M., Gahete,M.D.
            and Luque,R.M.
  TITLE     Somatostatin, Cortistatin and Their Receptors Exert Antitumor
            Actions in Androgen-Independent Prostate Cancer Cells: Critical
            Role of Endogenous Cortistatin
  JOURNAL   Int J Mol Sci 23 (21), 13003 (2022)
   PUBMED   36361790
  REMARK    GeneRIF: Somatostatin, Cortistatin and Their Receptors Exert
            Antitumor Actions in Androgen-Independent Prostate Cancer Cells:
            Critical Role of Endogenous Cortistatin.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 607)
  AUTHORS   Flisher,M.F., Shin,D. and Huising,M.O.
  TITLE     Urocortin3: Local inducer of somatostatin release and bellwether of
            beta cell maturity
  JOURNAL   Peptides 151, 170748 (2022)
   PUBMED   35065098
  REMARK    GeneRIF: Urocortin3: Local inducer of somatostatin release and
            bellwether of beta cell maturity.
            Review article
REFERENCE   5  (bases 1 to 607)
  AUTHORS   Rogoza,O., Megnis,K., Kudrjavceva,M., Gerina-Berzina,A. and
            Rovite,V.
  TITLE     Role of Somatostatin Signalling in Neuroendocrine Tumours
  JOURNAL   Int J Mol Sci 23 (3), 1447 (2022)
   PUBMED   35163374
  REMARK    GeneRIF: Role of Somatostatin Signalling in Neuroendocrine Tumours.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 607)
  AUTHORS   Yamada,Y., Reisine,T., Law,S.F., Ihara,Y., Kubota,A., Kagimoto,S.,
            Seino,M., Seino,Y., Bell,G.I. and Seino,S.
  TITLE     Somatostatin receptors, an expanding gene family: cloning and
            functional characterization of human SSTR3, a protein coupled to
            adenylyl cyclase
  JOURNAL   Mol Endocrinol 6 (12), 2136-2142 (1992)
   PUBMED   1337145
REFERENCE   7  (bases 1 to 607)
  AUTHORS   Yamada,Y., Post,S.R., Wang,K., Tager,H.S., Bell,G.I. and Seino,S.
  TITLE     Cloning and functional characterization of a family of human and
            mouse somatostatin receptors expressed in brain, gastrointestinal
            tract, and kidney
  JOURNAL   Proc Natl Acad Sci U S A 89 (1), 251-255 (1992)
   PUBMED   1346068
REFERENCE   8  (bases 1 to 607)
  AUTHORS   Shen,L.P. and Rutter,W.J.
  TITLE     Sequence of the human somatostatin I gene
  JOURNAL   Science 224 (4645), 168-171 (1984)
   PUBMED   6142531
REFERENCE   9  (bases 1 to 607)
  AUTHORS   Shen,L.P., Pictet,R.L. and Rutter,W.J.
  TITLE     Human somatostatin I: sequence of the cDNA
  JOURNAL   Proc Natl Acad Sci U S A 79 (15), 4575-4579 (1982)
   PUBMED   6126875
REFERENCE   10 (bases 1 to 607)
  AUTHORS   Brazeau,P., Vale,W., Burgus,R., Ling,N., Butcher,M., Rivier,J. and
            Guillemin,R.
  TITLE     Hypothalamic polypeptide that inhibits the secretion of
            immunoreactive pituitary growth hormone
  JOURNAL   Science 179 (4068), 77-79 (1973)
   PUBMED   4682131
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from R54287.1, BC032625.1 and
            BM353331.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001048.3.
            
            Summary: The hormone somatostatin has active 14 aa and 28 aa forms
            that are produced by alternate cleavage of the single preproprotein
            encoded by this gene. Somatostatin is expressed throughout the body
            and inhibits the release of numerous secondary hormones by binding
            to high-affinity G-protein-coupled somatostatin receptors. This
            hormone is an important regulator of the endocrine system through
            its interactions with pituitary growth hormone, thyroid stimulating
            hormone, and most hormones of the gastrointestinal tract.
            Somatostatin also affects rates of neurotransmission in the central
            nervous system and proliferation of both normal and tumorigenic
            cells. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.161501.1, BI669290.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287641.4/ ENSP00000287641.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                R54287.1           20-95
            77-602              BC032625.1         1-526
            603-607             BM353331.1         43-47               c
FEATURES             Location/Qualifiers
     source          1..607
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.3"
     gene            1..607
                     /gene="SST"
                     /gene_synonym="SMST; SST1"
                     /note="somatostatin"
                     /db_xref="GeneID:6750"
                     /db_xref="HGNC:HGNC:11329"
                     /db_xref="MIM:182450"
     exon            1..241
                     /gene="SST"
                     /gene_synonym="SMST; SST1"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..454
                     /gene="SST"
                     /gene_synonym="SMST; SST1"
                     /note="somatostatin-14; somatostatin-28; growth hormone
                     release-inhibiting factor; prepro-somatostatin"
                     /codon_start=1
                     /product="somatostatin preproprotein"
                     /protein_id="NP_001039.1"
                     /db_xref="CCDS:CCDS3288.1"
                     /db_xref="GeneID:6750"
                     /db_xref="HGNC:HGNC:11329"
                     /db_xref="MIM:182450"
                     /translation="MLSCRLQCALAALSIVLALGCVTGAPSDPRLRQFLQKSLAAAAG
                     KQELAKYFLAELLSEPNQTENDALEPEDLSQAAEQDEMRLELQRSANSNPAMAPRERK
                     AGCKNFFWKTFTSC"
     exon            242..607
                     /gene="SST"
                     /gene_synonym="SMST; SST1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      580..585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SST"
                     /gene_synonym="SMST; SST1"
                     /note="hexamer: AATAAA"
     polyA_site      607
                     /gene="SST"
                     /gene_synonym="SMST; SST1"
                     /note="major polyA site"
ORIGIN      
        1 acaagccgct ttaggagcga ggttcggagc catcgctgct gcctgctgat ccgcgcctag
       61 agtttgacca gccactctcc agctcggctt tcgcggcgcc gagatgctgt cctgccgcct
      121 ccagtgcgcg ctggctgcgc tgtccatcgt cctggccctg ggctgtgtca ccggcgctcc
      181 ctcggacccc agactccgtc agtttctgca gaagtccctg gctgctgccg cggggaagca
      241 ggaactggcc aagtacttct tggcagagct gctgtctgaa cccaaccaga cggagaatga
      301 tgccctggaa cctgaagatc tgtcccaggc tgctgagcag gatgaaatga ggcttgagct
      361 gcagagatct gctaactcaa acccggctat ggcaccccga gaacgcaaag ctggctgcaa
      421 gaatttcttc tggaagactt tcacatcctg ttagctttct taactagtat tgtccatatc
      481 agacctctga tccctcgccc ccacacccca tctctcttcc ctaatcctcc aagtcttcag
      541 cgagaccctt gcattagaaa ctgaaaactg taaatacaaa ataaaattat ggtgaaatta
      601 tgaaaaa
//
