LOCUS       NM_007107               4236 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens signal sequence receptor subunit 3 (SSR3), transcript
            variant 2, mRNA.
ACCESSION   NM_007107
VERSION     NM_007107.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4236)
  AUTHORS   Hu,Q., Wu,G., Ma,H., Zhang,J. and Yang,Z.
  TITLE     Signal sequence receptor subunit 3: A novel indicator of
            immunosuppressive tumor microenvironment and clinical benefits from
            immunotherapy
  JOURNAL   Cell Signal 111, 110871 (2023)
   PUBMED   37652395
  REMARK    GeneRIF: Signal sequence receptor subunit 3: A novel indicator of
            immunosuppressive tumor microenvironment and clinical benefits from
            immunotherapy.
REFERENCE   2  (bases 1 to 4236)
  AUTHORS   Dmello,C., Sonabend,A., Arrieta,V.A., Zhang,D.Y., Kanojia,D.,
            Chen,L., Gould,A., Zhang,J., Kang,S.J., Winter,J., Horbinski,C.,
            Amidei,C., Gyorffy,B., Cordero,A., Chang,C.L., Castro,B., Hsu,P.,
            Ahmed,A.U., Lesniak,M.S., Stupp,R. and Sonabend,A.M.
  TITLE     Translocon-associated Protein Subunit SSR3 Determines and Predicts
            Susceptibility to Paclitaxel in Breast Cancer and Glioblastoma
  JOURNAL   Clin Cancer Res 28 (14), 3156-3169 (2022)
   PUBMED   35552677
  REMARK    GeneRIF: Translocon-associated Protein Subunit SSR3 Determines and
            Predicts Susceptibility to Paclitaxel in Breast Cancer and
            Glioblastoma.
REFERENCE   3  (bases 1 to 4236)
  AUTHORS   Xu,X., Huang,Y., Li,X., Arvan,P. and Liu,M.
  TITLE     The Role of TRAPgamma/SSR3 in Preproinsulin Translocation Into the
            Endoplasmic Reticulum
  JOURNAL   Diabetes 71 (3), 440-452 (2022)
   PUBMED   34857543
  REMARK    GeneRIF: The Role of TRAPgamma/SSR3 in Preproinsulin Translocation
            Into the Endoplasmic Reticulum.
REFERENCE   4  (bases 1 to 4236)
  AUTHORS   Dittner-Moormann,S., Lourenco,C.M., Reunert,J., Nishinakamura,R.,
            Tanaka,S.S., Werner,C., Debus,V., Zimmer,K.P., Wetzel,G.,
            Naim,H.Y., Wada,Y., Rust,S. and Marquardt,T.
  TITLE     TRAPgamma-CDG shows asymmetric glycosylation and an effect on
            processing of proteins required in higher organisms
  JOURNAL   J Med Genet 58 (3), 213-216 (2021)
   PUBMED   32332102
  REMARK    GeneRIF: TRAPgamma-CDG shows asymmetric glycosylation and an effect
            on processing of proteins required in higher organisms.
REFERENCE   5  (bases 1 to 4236)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4236)
  AUTHORS   Ng,B.G., Lourenco,C.M., Losfeld,M.E., Buckingham,K.J., Kircher,M.,
            Nickerson,D.A., Shendure,J., Bamshad,M.J. and Freeze,H.H.
  CONSRTM   University of Washington Center for Mendelian Genomics
  TITLE     Mutations in the translocon-associated protein complex subunit SSR3
            cause a novel congenital disorder of glycosylation
  JOURNAL   J Inherit Metab Dis 42 (5), 993-997 (2019)
   PUBMED   30945312
  REMARK    GeneRIF: Mutations in the translocon-associated protein complex
            subunit SSR3 cause a novel congenital disorder of glycosylation.
REFERENCE   7  (bases 1 to 4236)
  AUTHORS   Huang,S., Zhong,W., Shi,Z., Wang,K., Jin,H., Zhang,Z., Wang,H.,
            Wei,Y., Chen,S., Zhou,Q. and He,X.
  TITLE     Overexpression of signal sequence receptor gamma predicts poor
            survival in patients with hepatocellular carcinoma
  JOURNAL   Hum Pathol 81, 47-54 (2018)
   PUBMED   29940286
  REMARK    GeneRIF: SSR3 acts as an oncogene in hepatocellular carcinoma with
            overexpression predicting poor survival.
REFERENCE   8  (bases 1 to 4236)
  AUTHORS   Pfeffer,S., Dudek,J., Schaffer,M., Ng,B.G., Albert,S.,
            Plitzko,J.M., Baumeister,W., Zimmermann,R., Freeze,H.H., Engel,B.D.
            and Forster,F.
  TITLE     Dissecting the molecular organization of the translocon-associated
            protein complex
  JOURNAL   Nat Commun 8, 14516 (2017)
   PUBMED   28218252
  REMARK    GeneRIF: Data suggest that the mutation leads to complete absence
            of TRAP gamma (SSR3).
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4236)
  AUTHORS   Chen,H.Z., Wen,Q., Wang,W.J., He,J.P. and Wu,Q.
  TITLE     The orphan nuclear receptor TR3/Nur77 regulates ER stress and
            induces apoptosis via interaction with TRAPgamma
  JOURNAL   Int J Biochem Cell Biol 45 (8), 1600-1609 (2013)
   PUBMED   23660295
  REMARK    GeneRIF: translocon-associated protein subunit gamma (TRAPgamma)
            was identified as a novel TR3 binding partner.
REFERENCE   10 (bases 1 to 4236)
  AUTHORS   Hartmann,E., Gorlich,D., Kostka,S., Otto,A., Kraft,R., Knespel,S.,
            Burger,E., Rapoport,T.A. and Prehn,S.
  TITLE     A tetrameric complex of membrane proteins in the endoplasmic
            reticulum
  JOURNAL   Eur J Biochem 214 (2), 375-381 (1993)
   PUBMED   7916687
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA750309.1, BC017203.1,
            AF110647.1, CX786292.1, CN409041.1, BM988383.1, BU532041.1,
            BJ997360.1, AC092927.5 and AI225105.1.
            
            On Feb 27, 2020 this sequence version replaced NM_007107.4.
            
            Summary: The signal sequence receptor (SSR) is a glycosylated
            endoplasmic reticulum (ER) membrane receptor associated with
            protein translocation across the ER membrane. The SSR is comprised
            of four membrane proteins/subunits: alpha, beta, gamma, and delta.
            The first two are glycosylated subunits and the latter two are
            non-glycosylated subunits. This gene encodes the gamma subunit,
            which is predicted to span the membrane four times. [provided by
            RefSeq, Aug 2010].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region compared to variant 1. It
            encodes isoform 2 which is shorter compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF110647.1, BC017203.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2147920
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265044.7/ ENSP00000265044.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-506               DA750309.1         68-573
            507-1160            BC017203.1         536-1189
            1161-1266           AF110647.1         1188-1293
            1267-2371           BC017203.1         1295-2399
            2372-2555           AF110647.1         2397-2580
            2556-3046           CX786292.1         39-529
            3047-3168           CN409041.1         163-284
            3169-3294           BM988383.1         4-129
            3295-3639           BU532041.1         79-423
            3640-4145           BJ997360.1         48-553
            4146-4182           AC092927.5         166710-166746
            4183-4236           AI225105.1         13-66               c
FEATURES             Location/Qualifiers
     source          1..4236
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.31"
     gene            1..4236
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /note="signal sequence receptor subunit 3"
                     /db_xref="GeneID:6747"
                     /db_xref="HGNC:HGNC:11325"
                     /db_xref="MIM:606213"
     exon            1..161
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..586
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /note="isoform 2 is encoded by transcript variant 2;
                     translocon-associated protein gamma subunit; TRAP-gamma;
                     SSR gamma; translocon-associated protein subunit gamma;
                     TRAP-complex gamma subunit; signal sequence receptor
                     subunit gamma; signal sequence receptor, gamma
                     (translocon-associated protein gamma)"
                     /codon_start=1
                     /product="translocon-associated protein subunit gamma
                     isoform 2"
                     /protein_id="NP_009038.1"
                     /db_xref="CCDS:CCDS3176.1"
                     /db_xref="GeneID:6747"
                     /db_xref="HGNC:HGNC:11325"
                     /db_xref="MIM:606213"
                     /translation="MAPKGSSKQQSEEDLLLQDFSRNLSAKSSALFFGNAFIVSAIPI
                     WLYWRIWHMDLIQSAVLYSVMTLVSTYLVAFAYKNVKFVLKHKVAQKREDAVSKEVTR
                     KLSEADNRKMSRKEKDERILWKKNEVADYEATTFSIFYNNTLFLVVVIVASFFILKNF
                     NPTVNYILSISASSGLIALLSTGSK"
     exon            162..288
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /inference="alignment:Splign:2.1.0"
     exon            289..387
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /inference="alignment:Splign:2.1.0"
     exon            388..519
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /inference="alignment:Splign:2.1.0"
     exon            520..4236
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      768..773
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /note="hexamer: AATGAA"
     polyA_site      785
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /note="major polyA site"
     regulatory      3625..3630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /note="hexamer: ATTAAA"
     polyA_site      3645
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
     regulatory      3702..3707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /note="hexamer: ATTATA"
     polyA_site      3721
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
     regulatory      4216..4221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /note="hexamer: AATATA"
     polyA_site      4236
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
ORIGIN      
        1 gttccctgtt ctcgcctgca gctccgccat ggctcctaaa ggcagctcca aacagcagtc
       61 tgaggaggac ctgctcctgc aggatttcag ccgcaatctc tcggccaagt cctccgcgct
      121 cttcttcgga aacgcgttca tcgtgtctgc catccccatc tggttatact ggcgaatatg
      181 gcatatggat cttattcagt ctgctgtttt gtatagtgtg atgaccctag taagcacata
      241 tttggtagcc tttgcataca agaatgtgaa atttgttctc aagcacaaag tagcacagaa
      301 gagggaggat gctgtttcca aagaagtgac tcgaaaactt tctgaagctg ataatagaaa
      361 gatgtctcgg aaggagaaag atgaaagaat cttgtggaag aagaatgaag ttgctgatta
      421 tgaagctaca acattttcca tcttctataa caacactctg ttcctggtcg tggtcattgt
      481 tgcttccttc ttcatattga agaacttcaa ccccacagtg aactacatat tgtccataag
      541 tgcttcatca ggactcatcg ccctcctgtc tactggctcc aaatagacca tgtcagcttc
      601 accccctggc tttgtgtcta tgggtggcct gtggtatatg gaaaagtagc agggtggtca
      661 gggtgggaga cacaagatgt ttttatagtc tagagccttt aaaaaaccca gcagaatgta
      721 attcagtatt tgtttattgg ctgttttttg acagattgtt gaaattaaat gaattgaaag
      781 ggaaactcag agtactagga cgtttattaa aaggaaaaaa atgtcttgca atgtgctgta
      841 atcacaagag gagaaaataa cttgtttcct tgatctgtca gaggtcacag taacctgggc
      901 cgagctgtta ttatttatta tataatagta gtaggaagtt aataactggt tctctgtgtt
      961 ccaagcacaa tattacaact tcttttgaac cgtaaatatc agaatgaatc ctcttcccag
     1021 gggattgaac agaagcttaa tgtttacaag tgtttgaatt tgtgatctga aataacacaa
     1081 aattaaaaac atgatttctc taattttcca actagaggaa gagaaacttg tggaaaagtt
     1141 cttttttttt cttttttttt tcttaaagaa gggcagccaa ggtagtaacc taaaaatagt
     1201 gcccaggcat atgagagttg tcctacgagg ttaaagaaca cactgttcca ctgtatggct
     1261 ttggccctga gtggccaggg aggtcaactt gaccctgcca tgttggtttg acttactaag
     1321 acacaggaat cactgttttc cttgaccagg gtctcacacc ctggaggaat gttaagtaag
     1381 agaaagaacc tctttcctga atattgacat gtaaaagacc aaagtaattt ttctgaactt
     1441 ctgcaattct gagaactctc caaggaattt acagtgattt tagtgcttgt cagcattttt
     1501 ccatgaggac tttcatacat ttgactcttt agttcacagg ttcccattga ttgtgagcaa
     1561 gatatttatc tctttagccc ttggggatcc agctgagagc aatctcttgc atttttttac
     1621 ccgtgtatgt acagatatca tttcttgtgt atgccatgac ttgaaaaagt ttgggaagct
     1681 ctttagcaat atcagctaaa aggatatgaa atcacaggtg atagcagttg tcattcagta
     1741 atttcctaca agcagcaccc caaaggaaat atagtcctaa tctttactat ccacttctaa
     1801 atttaatgtg aatttcatac atgttattag ttgttttctt tataatttta taaaaattat
     1861 tcatcgggag tttaacttcc acttccatgc tatcggatgt gttgggctcc atgcaagaac
     1921 ttggaagaaa aacaggcagg aatgcatttg cataatgacc cagatcatca ttttctgcaa
     1981 ctgagaatta tatttcatca ttgcttctag aagtctgcaa ttctttactt ttctttggtg
     2041 cattattatc taggtgccat cactggataa tgtggagtga ctagagaagt cacatatcac
     2101 tgtaaggtac agttagggta acactttaga ggtttattat ttttaaaaaa cttttcttga
     2161 actcctggcc aacatggtga aaccccgtct ctactaaaaa taccaaaatt agccaggcgt
     2221 gatggtgggc gcctgtaatc tcagctactt gggaggctga agcaggagaa ctgcctgaac
     2281 ccaggaggca gaggttgcgg tgagtcgaga tcgtgctact actgcctggg tggcaagggt
     2341 gagactccat ctcaaaaaag aaacaaaaaa acccaaaaag ttttctttac tgttggttaa
     2401 aaaaaaaagc cagaccatag tttgactggt ggcatggaat ttgtgtatca aataaatgca
     2461 tttgcttatt tgacaaacca tcagtgtcca ctatttgtta ccagagttgg gccactatct
     2521 tttaaaattg ctggtgaaaa cttgccacta gatggcagtg cctgtataga tggggaaaaa
     2581 attgccacca ttcttggtat aatacagtgt agcttagatg aggtggtgaa ataggggtat
     2641 cagccgaata ttcctaatat agtttctctt gaattaataa actgaagatt tgtaggaaaa
     2701 tgagtgagca aaatttgttt actgttgtga atttttccta cagcactgtt tttaatcttg
     2761 atgttttcca actttctgta ctaatagata catttctgtg cataagatta taaagcatat
     2821 actcacagtt cagtagtttt cgttaaggat ttactgtgtg agtactttac tgtgaggaat
     2881 tgcagaacct tttcccctct actcttgtct aaaagttctg tgtggcacac agagatgcga
     2941 cctactcaat ctgacttagt aaaaccatgc tgtagaattt ttgtcttaaa aagaccacat
     3001 acccagcacc catgaaataa aagattcatc tgtaattggg attcaaagtg attaaattcc
     3061 tttgttcata ctcataaata gcactaaagt gttataacat tttcatttac ctatttttag
     3121 ttccttcatt ttaacttaat aaaaatcttg gattgatatt cttttttttt tttttttttt
     3181 tttgagacag cgtctcgctc tgtcacccag gctggagtac agtggctcta tcttggctca
     3241 ctgcgagctc cgcctcccag gttcacgcca ttctcctgcc tcagcctgcc gagtagctgg
     3301 gactacaggc gcccgccacc acacccggct aatttttttg tatttttagt agagacgggg
     3361 tttcaccctg ttagccagga tggtctcgat ctcctgacct cgtgatccac ctgcctcggc
     3421 ctcccaaagt gctggaatta caggcgtgag ccaccgcgcc cggcctagat tgatattctt
     3481 aagcaataaa agtttactgg ttgtcctatt tgccatatta ttgaaacttg gaaaggataa
     3541 tttgaaacaa ggtttgaagt taactgaaat atggagattg aatttatact caattcttgt
     3601 gaaaagtctt gcttaataag tatgattaaa ctttgcttct taaaatttgt attttcccta
     3661 cacttcttta taagaatcct atgatgaagt acgtaatctt tattatatta ttttacatta
     3721 accatctttt ttttcaaatt gttttatttt ttattttact ttaagttctg ggatacatgt
     3781 gctgaccatg caggtttggt acatatgtat acatgtaacc atcattttaa tatctcacac
     3841 atgtaaatgc acatctttgt agttaccaat caaatgtatg tgaggcaatg aaaggcattg
     3901 agcagttaca gtaaagggca gacatcaggc ctctgccagt atgtacctgc tgtgccttcc
     3961 tgcctgccct atttctttgt tttcagtgtg catgccagtc actgctgctt ctggagacag
     4021 gatggaagga tacatgtatg tgtacattta tggagaaaac caatttatag atgtatcaga
     4081 gctctaaggg attctctttc acttccttgg gactcccaag cagaggaatt aatagattag
     4141 gagggtcttt tggggggttg gtttaaattt tcagggcgat agaggctaac ttctcgttgg
     4201 ccttcatgaa ttttcaatat atcatctttt cgctga
//
