LOCUS       NP_009038                185 aa            linear   PRI 07-APR-2024
DEFINITION  translocon-associated protein subunit gamma isoform 2 [Homo
            sapiens].
ACCESSION   NP_009038
VERSION     NP_009038.1
DBSOURCE    REFSEQ: accession NM_007107.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 185)
  AUTHORS   Hu,Q., Wu,G., Ma,H., Zhang,J. and Yang,Z.
  TITLE     Signal sequence receptor subunit 3: A novel indicator of
            immunosuppressive tumor microenvironment and clinical benefits from
            immunotherapy
  JOURNAL   Cell Signal 111, 110871 (2023)
   PUBMED   37652395
  REMARK    GeneRIF: Signal sequence receptor subunit 3: A novel indicator of
            immunosuppressive tumor microenvironment and clinical benefits from
            immunotherapy.
REFERENCE   2  (residues 1 to 185)
  AUTHORS   Dmello,C., Sonabend,A., Arrieta,V.A., Zhang,D.Y., Kanojia,D.,
            Chen,L., Gould,A., Zhang,J., Kang,S.J., Winter,J., Horbinski,C.,
            Amidei,C., Gyorffy,B., Cordero,A., Chang,C.L., Castro,B., Hsu,P.,
            Ahmed,A.U., Lesniak,M.S., Stupp,R. and Sonabend,A.M.
  TITLE     Translocon-associated Protein Subunit SSR3 Determines and Predicts
            Susceptibility to Paclitaxel in Breast Cancer and Glioblastoma
  JOURNAL   Clin Cancer Res 28 (14), 3156-3169 (2022)
   PUBMED   35552677
  REMARK    GeneRIF: Translocon-associated Protein Subunit SSR3 Determines and
            Predicts Susceptibility to Paclitaxel in Breast Cancer and
            Glioblastoma.
REFERENCE   3  (residues 1 to 185)
  AUTHORS   Xu,X., Huang,Y., Li,X., Arvan,P. and Liu,M.
  TITLE     The Role of TRAPgamma/SSR3 in Preproinsulin Translocation Into the
            Endoplasmic Reticulum
  JOURNAL   Diabetes 71 (3), 440-452 (2022)
   PUBMED   34857543
  REMARK    GeneRIF: The Role of TRAPgamma/SSR3 in Preproinsulin Translocation
            Into the Endoplasmic Reticulum.
REFERENCE   4  (residues 1 to 185)
  AUTHORS   Dittner-Moormann,S., Lourenco,C.M., Reunert,J., Nishinakamura,R.,
            Tanaka,S.S., Werner,C., Debus,V., Zimmer,K.P., Wetzel,G.,
            Naim,H.Y., Wada,Y., Rust,S. and Marquardt,T.
  TITLE     TRAPgamma-CDG shows asymmetric glycosylation and an effect on
            processing of proteins required in higher organisms
  JOURNAL   J Med Genet 58 (3), 213-216 (2021)
   PUBMED   32332102
  REMARK    GeneRIF: TRAPgamma-CDG shows asymmetric glycosylation and an effect
            on processing of proteins required in higher organisms.
REFERENCE   5  (residues 1 to 185)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (residues 1 to 185)
  AUTHORS   Ng,B.G., Lourenco,C.M., Losfeld,M.E., Buckingham,K.J., Kircher,M.,
            Nickerson,D.A., Shendure,J., Bamshad,M.J. and Freeze,H.H.
  CONSRTM   University of Washington Center for Mendelian Genomics
  TITLE     Mutations in the translocon-associated protein complex subunit SSR3
            cause a novel congenital disorder of glycosylation
  JOURNAL   J Inherit Metab Dis 42 (5), 993-997 (2019)
   PUBMED   30945312
  REMARK    GeneRIF: Mutations in the translocon-associated protein complex
            subunit SSR3 cause a novel congenital disorder of glycosylation.
REFERENCE   7  (residues 1 to 185)
  AUTHORS   Huang,S., Zhong,W., Shi,Z., Wang,K., Jin,H., Zhang,Z., Wang,H.,
            Wei,Y., Chen,S., Zhou,Q. and He,X.
  TITLE     Overexpression of signal sequence receptor gamma predicts poor
            survival in patients with hepatocellular carcinoma
  JOURNAL   Hum Pathol 81, 47-54 (2018)
   PUBMED   29940286
  REMARK    GeneRIF: SSR3 acts as an oncogene in hepatocellular carcinoma with
            overexpression predicting poor survival.
REFERENCE   8  (residues 1 to 185)
  AUTHORS   Pfeffer,S., Dudek,J., Schaffer,M., Ng,B.G., Albert,S.,
            Plitzko,J.M., Baumeister,W., Zimmermann,R., Freeze,H.H., Engel,B.D.
            and Forster,F.
  TITLE     Dissecting the molecular organization of the translocon-associated
            protein complex
  JOURNAL   Nat Commun 8, 14516 (2017)
   PUBMED   28218252
  REMARK    GeneRIF: Data suggest that the mutation leads to complete absence
            of TRAP gamma (SSR3).
            Publication Status: Online-Only
REFERENCE   9  (residues 1 to 185)
  AUTHORS   Chen,H.Z., Wen,Q., Wang,W.J., He,J.P. and Wu,Q.
  TITLE     The orphan nuclear receptor TR3/Nur77 regulates ER stress and
            induces apoptosis via interaction with TRAPgamma
  JOURNAL   Int J Biochem Cell Biol 45 (8), 1600-1609 (2013)
   PUBMED   23660295
  REMARK    GeneRIF: translocon-associated protein subunit gamma (TRAPgamma)
            was identified as a novel TR3 binding partner.
REFERENCE   10 (residues 1 to 185)
  AUTHORS   Hartmann,E., Gorlich,D., Kostka,S., Otto,A., Kraft,R., Knespel,S.,
            Burger,E., Rapoport,T.A. and Prehn,S.
  TITLE     A tetrameric complex of membrane proteins in the endoplasmic
            reticulum
  JOURNAL   Eur J Biochem 214 (2), 375-381 (1993)
   PUBMED   7916687
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA750309.1, BC017203.1,
            AF110647.1, CX786292.1, CN409041.1, BM988383.1, BU532041.1,
            BJ997360.1, AC092927.5 and AI225105.1.
            
            Summary: The signal sequence receptor (SSR) is a glycosylated
            endoplasmic reticulum (ER) membrane receptor associated with
            protein translocation across the ER membrane. The SSR is comprised
            of four membrane proteins/subunits: alpha, beta, gamma, and delta.
            The first two are glycosylated subunits and the latter two are
            non-glycosylated subunits. This gene encodes the gamma subunit,
            which is predicted to span the membrane four times. [provided by
            RefSeq, Aug 2010].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region compared to variant 1. It
            encodes isoform 2 which is shorter compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF110647.1, BC017203.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2147920
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265044.7/ ENSP00000265044.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..185
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.31"
     Protein         1..185
                     /product="translocon-associated protein subunit gamma
                     isoform 2"
                     /note="translocon-associated protein gamma subunit;
                     TRAP-gamma; SSR gamma; translocon-associated protein
                     subunit gamma; TRAP-complex gamma subunit; signal sequence
                     receptor subunit gamma; signal sequence receptor, gamma
                     (translocon-associated protein gamma)"
                     /calculated_mol_wt=20949
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000269|PubMed:25732826; propagated from
                     UniProtKB/Swiss-Prot (Q9UNL2.1)"
     Site            7
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9DCF9; propagated from
                     UniProtKB/Swiss-Prot (Q9UNL2.1)"
     Site            11
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:23186163,
                     ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (Q9UNL2.1)"
     Region          12..183
                     /region_name="TRAP-gamma"
                     /note="Translocon-associated protein, gamma subunit
                     (TRAP-gamma); pfam07074"
                     /db_xref="CDD:399809"
     Site            28..48
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UNL2.1)"
     Site            55..76
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UNL2.1)"
     Site            105
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9DCF9; propagated from
                     UniProtKB/Swiss-Prot (Q9UNL2.1)"
     Site            136..157
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UNL2.1)"
     Site            164..184
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UNL2.1)"
     CDS             1..185
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /coded_by="NM_007107.5:29..586"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS3176.1"
                     /db_xref="GeneID:6747"
                     /db_xref="HGNC:HGNC:11325"
                     /db_xref="MIM:606213"
ORIGIN      
        1 mapkgsskqq seedlllqdf srnlsakssa lffgnafivs aipiwlywri whmdliqsav
       61 lysvmtlvst ylvafayknv kfvlkhkvaq kredavskev trklseadnr kmsrkekder
      121 ilwkknevad yeattfsify nntlflvvvi vasffilknf nptvnyilsi sassgliall
      181 stgsk
//
