LOCUS       NM_001308205            4208 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens signal sequence receptor subunit 3 (SSR3), transcript
            variant 4, mRNA.
ACCESSION   NM_001308205
VERSION     NM_001308205.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4208)
  AUTHORS   Hu,Q., Wu,G., Ma,H., Zhang,J. and Yang,Z.
  TITLE     Signal sequence receptor subunit 3: A novel indicator of
            immunosuppressive tumor microenvironment and clinical benefits from
            immunotherapy
  JOURNAL   Cell Signal 111, 110871 (2023)
   PUBMED   37652395
  REMARK    GeneRIF: Signal sequence receptor subunit 3: A novel indicator of
            immunosuppressive tumor microenvironment and clinical benefits from
            immunotherapy.
REFERENCE   2  (bases 1 to 4208)
  AUTHORS   Dmello,C., Sonabend,A., Arrieta,V.A., Zhang,D.Y., Kanojia,D.,
            Chen,L., Gould,A., Zhang,J., Kang,S.J., Winter,J., Horbinski,C.,
            Amidei,C., Gyorffy,B., Cordero,A., Chang,C.L., Castro,B., Hsu,P.,
            Ahmed,A.U., Lesniak,M.S., Stupp,R. and Sonabend,A.M.
  TITLE     Translocon-associated Protein Subunit SSR3 Determines and Predicts
            Susceptibility to Paclitaxel in Breast Cancer and Glioblastoma
  JOURNAL   Clin Cancer Res 28 (14), 3156-3169 (2022)
   PUBMED   35552677
  REMARK    GeneRIF: Translocon-associated Protein Subunit SSR3 Determines and
            Predicts Susceptibility to Paclitaxel in Breast Cancer and
            Glioblastoma.
REFERENCE   3  (bases 1 to 4208)
  AUTHORS   Xu,X., Huang,Y., Li,X., Arvan,P. and Liu,M.
  TITLE     The Role of TRAPgamma/SSR3 in Preproinsulin Translocation Into the
            Endoplasmic Reticulum
  JOURNAL   Diabetes 71 (3), 440-452 (2022)
   PUBMED   34857543
  REMARK    GeneRIF: The Role of TRAPgamma/SSR3 in Preproinsulin Translocation
            Into the Endoplasmic Reticulum.
REFERENCE   4  (bases 1 to 4208)
  AUTHORS   Dittner-Moormann,S., Lourenco,C.M., Reunert,J., Nishinakamura,R.,
            Tanaka,S.S., Werner,C., Debus,V., Zimmer,K.P., Wetzel,G.,
            Naim,H.Y., Wada,Y., Rust,S. and Marquardt,T.
  TITLE     TRAPgamma-CDG shows asymmetric glycosylation and an effect on
            processing of proteins required in higher organisms
  JOURNAL   J Med Genet 58 (3), 213-216 (2021)
   PUBMED   32332102
  REMARK    GeneRIF: TRAPgamma-CDG shows asymmetric glycosylation and an effect
            on processing of proteins required in higher organisms.
REFERENCE   5  (bases 1 to 4208)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4208)
  AUTHORS   Ng,B.G., Lourenco,C.M., Losfeld,M.E., Buckingham,K.J., Kircher,M.,
            Nickerson,D.A., Shendure,J., Bamshad,M.J. and Freeze,H.H.
  CONSRTM   University of Washington Center for Mendelian Genomics
  TITLE     Mutations in the translocon-associated protein complex subunit SSR3
            cause a novel congenital disorder of glycosylation
  JOURNAL   J Inherit Metab Dis 42 (5), 993-997 (2019)
   PUBMED   30945312
  REMARK    GeneRIF: Mutations in the translocon-associated protein complex
            subunit SSR3 cause a novel congenital disorder of glycosylation.
REFERENCE   7  (bases 1 to 4208)
  AUTHORS   Huang,S., Zhong,W., Shi,Z., Wang,K., Jin,H., Zhang,Z., Wang,H.,
            Wei,Y., Chen,S., Zhou,Q. and He,X.
  TITLE     Overexpression of signal sequence receptor gamma predicts poor
            survival in patients with hepatocellular carcinoma
  JOURNAL   Hum Pathol 81, 47-54 (2018)
   PUBMED   29940286
  REMARK    GeneRIF: SSR3 acts as an oncogene in hepatocellular carcinoma with
            overexpression predicting poor survival.
REFERENCE   8  (bases 1 to 4208)
  AUTHORS   Pfeffer,S., Dudek,J., Schaffer,M., Ng,B.G., Albert,S.,
            Plitzko,J.M., Baumeister,W., Zimmermann,R., Freeze,H.H., Engel,B.D.
            and Forster,F.
  TITLE     Dissecting the molecular organization of the translocon-associated
            protein complex
  JOURNAL   Nat Commun 8, 14516 (2017)
   PUBMED   28218252
  REMARK    GeneRIF: Data suggest that the mutation leads to complete absence
            of TRAP gamma (SSR3).
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4208)
  AUTHORS   Chen,H.Z., Wen,Q., Wang,W.J., He,J.P. and Wu,Q.
  TITLE     The orphan nuclear receptor TR3/Nur77 regulates ER stress and
            induces apoptosis via interaction with TRAPgamma
  JOURNAL   Int J Biochem Cell Biol 45 (8), 1600-1609 (2013)
   PUBMED   23660295
  REMARK    GeneRIF: translocon-associated protein subunit gamma (TRAPgamma)
            was identified as a novel TR3 binding partner.
REFERENCE   10 (bases 1 to 4208)
  AUTHORS   Hartmann,E., Gorlich,D., Kostka,S., Otto,A., Kraft,R., Knespel,S.,
            Burger,E., Rapoport,T.A. and Prehn,S.
  TITLE     A tetrameric complex of membrane proteins in the endoplasmic
            reticulum
  JOURNAL   Eur J Biochem 214 (2), 375-381 (1993)
   PUBMED   7916687
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA725890.1, BC017203.1,
            AF110647.1, CX786292.1, CN409041.1, BM988383.1, BU532041.1,
            BJ997360.1, AC092927.5 and AI225105.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001308205.1.
            
            Summary: The signal sequence receptor (SSR) is a glycosylated
            endoplasmic reticulum (ER) membrane receptor associated with
            protein translocation across the ER membrane. The SSR is comprised
            of four membrane proteins/subunits: alpha, beta, gamma, and delta.
            The first two are glycosylated subunits and the latter two are
            non-glycosylated subunits. This gene encodes the gamma subunit,
            which is predicted to span the membrane four times. [provided by
            RefSeq, Aug 2010].
            
            Transcript Variant: This variant (4) lacks a 5' exon, contains an
            alternate 5' terminal exon, uses a downstream start codon, and uses
            an alternate in-frame splice site in the central coding region,
            compared to variant 1. It encodes isoform 3 which is shorter
            compared to isoform 1. Both variants 3 and 4 encode the same
            isoform (3).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA725890.1, SRR14243140.10969112.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               DA725890.1         1-133
            134-1132            BC017203.1         191-1189
            1133-1238           AF110647.1         1188-1293
            1239-2343           BC017203.1         1295-2399
            2344-2527           AF110647.1         2397-2580
            2528-3018           CX786292.1         39-529
            3019-3140           CN409041.1         163-284
            3141-3266           BM988383.1         4-129
            3267-3611           BU532041.1         79-423
            3612-4117           BJ997360.1         48-553
            4118-4154           AC092927.5         166710-166746
            4155-4208           AI225105.1         13-66               c
FEATURES             Location/Qualifiers
     source          1..4208
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.31"
     gene            1..4208
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /note="signal sequence receptor subunit 3"
                     /db_xref="GeneID:6747"
                     /db_xref="HGNC:HGNC:11325"
                     /db_xref="MIM:606213"
     exon            1..133
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /inference="alignment:Splign:2.1.0"
     exon            134..260
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..558
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /note="isoform 3 is encoded by transcript variant 4;
                     translocon-associated protein gamma subunit; TRAP-gamma;
                     SSR gamma; translocon-associated protein subunit gamma;
                     TRAP-complex gamma subunit; signal sequence receptor
                     subunit gamma; signal sequence receptor, gamma
                     (translocon-associated protein gamma)"
                     /codon_start=1
                     /product="translocon-associated protein subunit gamma
                     isoform 3"
                     /protein_id="NP_001295134.1"
                     /db_xref="CCDS:CCDS82865.1"
                     /db_xref="GeneID:6747"
                     /db_xref="HGNC:HGNC:11325"
                     /db_xref="MIM:606213"
                     /translation="MDLIQSAVLYSVMTLVSTYLVAFAYKNVKFVLKHKVAQKREDAV
                     SKEVTRKLSEADNRKMSRKEKDERILWKKNEVADYEATTFSIFYNNTLFLVVVIVASF
                     FILKNFNPTVNYILSISASSGLIALLSTGSK"
     exon            261..359
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /inference="alignment:Splign:2.1.0"
     exon            360..491
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /inference="alignment:Splign:2.1.0"
     exon            492..4208
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      740..745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /note="hexamer: AATGAA"
     polyA_site      757
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /note="major polyA site"
     regulatory      3597..3602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /note="hexamer: ATTAAA"
     polyA_site      3617
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
     regulatory      3674..3679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /note="hexamer: ATTATA"
     polyA_site      3693
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
     regulatory      4188..4193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /note="hexamer: AATATA"
     polyA_site      4208
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
ORIGIN      
        1 attttggaat ggcctgtgtt tcgcatgcta gtaccctgat gaatgaaatt tgaagtctga
       61 cttgtgatta cgttgagcca gagtttgttc tcattttaga agttgaaatc tcatctggac
      121 tagtaatagg aagggttata ctggcgaata tggcatatgg atcttattca gtctgctgtt
      181 ttgtatagtg tgatgaccct agtaagcaca tatttggtag cctttgcata caagaatgtg
      241 aaatttgttc tcaagcacaa agtagcacag aagagggagg atgctgtttc caaagaagtg
      301 actcgaaaac tttctgaagc tgataataga aagatgtctc ggaaggagaa agatgaaaga
      361 atcttgtgga agaagaatga agttgctgat tatgaagcta caacattttc catcttctat
      421 aacaacactc tgttcctggt cgtggtcatt gttgcttcct tcttcatatt gaagaacttc
      481 aaccccacag tgaactacat attgtccata agtgcttcat caggactcat cgccctcctg
      541 tctactggct ccaaatagac catgtcagct tcaccccctg gctttgtgtc tatgggtggc
      601 ctgtggtata tggaaaagta gcagggtggt cagggtggga gacacaagat gtttttatag
      661 tctagagcct ttaaaaaacc cagcagaatg taattcagta tttgtttatt ggctgttttt
      721 tgacagattg ttgaaattaa atgaattgaa agggaaactc agagtactag gacgtttatt
      781 aaaaggaaaa aaatgtcttg caatgtgctg taatcacaag aggagaaaat aacttgtttc
      841 cttgatctgt cagaggtcac agtaacctgg gccgagctgt tattatttat tatataatag
      901 tagtaggaag ttaataactg gttctctgtg ttccaagcac aatattacaa cttcttttga
      961 accgtaaata tcagaatgaa tcctcttccc aggggattga acagaagctt aatgtttaca
     1021 agtgtttgaa tttgtgatct gaaataacac aaaattaaaa acatgatttc tctaattttc
     1081 caactagagg aagagaaact tgtggaaaag ttcttttttt ttcttttttt tttcttaaag
     1141 aagggcagcc aaggtagtaa cctaaaaata gtgcccaggc atatgagagt tgtcctacga
     1201 ggttaaagaa cacactgttc cactgtatgg ctttggccct gagtggccag ggaggtcaac
     1261 ttgaccctgc catgttggtt tgacttacta agacacagga atcactgttt tccttgacca
     1321 gggtctcaca ccctggagga atgttaagta agagaaagaa cctctttcct gaatattgac
     1381 atgtaaaaga ccaaagtaat ttttctgaac ttctgcaatt ctgagaactc tccaaggaat
     1441 ttacagtgat tttagtgctt gtcagcattt ttccatgagg actttcatac atttgactct
     1501 ttagttcaca ggttcccatt gattgtgagc aagatattta tctctttagc ccttggggat
     1561 ccagctgaga gcaatctctt gcattttttt acccgtgtat gtacagatat catttcttgt
     1621 gtatgccatg acttgaaaaa gtttgggaag ctctttagca atatcagcta aaaggatatg
     1681 aaatcacagg tgatagcagt tgtcattcag taatttccta caagcagcac cccaaaggaa
     1741 atatagtcct aatctttact atccacttct aaatttaatg tgaatttcat acatgttatt
     1801 agttgttttc tttataattt tataaaaatt attcatcggg agtttaactt ccacttccat
     1861 gctatcggat gtgttgggct ccatgcaaga acttggaaga aaaacaggca ggaatgcatt
     1921 tgcataatga cccagatcat cattttctgc aactgagaat tatatttcat cattgcttct
     1981 agaagtctgc aattctttac ttttctttgg tgcattatta tctaggtgcc atcactggat
     2041 aatgtggagt gactagagaa gtcacatatc actgtaaggt acagttaggg taacacttta
     2101 gaggtttatt atttttaaaa aacttttctt gaactcctgg ccaacatggt gaaaccccgt
     2161 ctctactaaa aataccaaaa ttagccaggc gtgatggtgg gcgcctgtaa tctcagctac
     2221 ttgggaggct gaagcaggag aactgcctga acccaggagg cagaggttgc ggtgagtcga
     2281 gatcgtgcta ctactgcctg ggtggcaagg gtgagactcc atctcaaaaa agaaacaaaa
     2341 aaacccaaaa agttttcttt actgttggtt aaaaaaaaaa gccagaccat agtttgactg
     2401 gtggcatgga atttgtgtat caaataaatg catttgctta tttgacaaac catcagtgtc
     2461 cactatttgt taccagagtt gggccactat cttttaaaat tgctggtgaa aacttgccac
     2521 tagatggcag tgcctgtata gatggggaaa aaattgccac cattcttggt ataatacagt
     2581 gtagcttaga tgaggtggtg aaataggggt atcagccgaa tattcctaat atagtttctc
     2641 ttgaattaat aaactgaaga tttgtaggaa aatgagtgag caaaatttgt ttactgttgt
     2701 gaatttttcc tacagcactg tttttaatct tgatgttttc caactttctg tactaataga
     2761 tacatttctg tgcataagat tataaagcat atactcacag ttcagtagtt ttcgttaagg
     2821 atttactgtg tgagtacttt actgtgagga attgcagaac cttttcccct ctactcttgt
     2881 ctaaaagttc tgtgtggcac acagagatgc gacctactca atctgactta gtaaaaccat
     2941 gctgtagaat ttttgtctta aaaagaccac atacccagca cccatgaaat aaaagattca
     3001 tctgtaattg ggattcaaag tgattaaatt cctttgttca tactcataaa tagcactaaa
     3061 gtgttataac attttcattt acctattttt agttccttca ttttaactta ataaaaatct
     3121 tggattgata ttcttttttt tttttttttt tttttgagac agcgtctcgc tctgtcaccc
     3181 aggctggagt acagtggctc tatcttggct cactgcgagc tccgcctccc aggttcacgc
     3241 cattctcctg cctcagcctg ccgagtagct gggactacag gcgcccgcca ccacacccgg
     3301 ctaatttttt tgtattttta gtagagacgg ggtttcaccc tgttagccag gatggtctcg
     3361 atctcctgac ctcgtgatcc acctgcctcg gcctcccaaa gtgctggaat tacaggcgtg
     3421 agccaccgcg cccggcctag attgatattc ttaagcaata aaagtttact ggttgtccta
     3481 tttgccatat tattgaaact tggaaaggat aatttgaaac aaggtttgaa gttaactgaa
     3541 atatggagat tgaatttata ctcaattctt gtgaaaagtc ttgcttaata agtatgatta
     3601 aactttgctt cttaaaattt gtattttccc tacacttctt tataagaatc ctatgatgaa
     3661 gtacgtaatc tttattatat tattttacat taaccatctt ttttttcaaa ttgttttatt
     3721 ttttatttta ctttaagttc tgggatacat gtgctgacca tgcaggtttg gtacatatgt
     3781 atacatgtaa ccatcatttt aatatctcac acatgtaaat gcacatcttt gtagttacca
     3841 atcaaatgta tgtgaggcaa tgaaaggcat tgagcagtta cagtaaaggg cagacatcag
     3901 gcctctgcca gtatgtacct gctgtgcctt cctgcctgcc ctatttcttt gttttcagtg
     3961 tgcatgccag tcactgctgc ttctggagac aggatggaag gatacatgta tgtgtacatt
     4021 tatggagaaa accaatttat agatgtatca gagctctaag ggattctctt tcacttcctt
     4081 gggactccca agcagaggaa ttaatagatt aggagggtct tttggggggt tggtttaaat
     4141 tttcagggcg atagaggcta acttctcgtt ggccttcatg aattttcaat atatcatctt
     4201 ttcgctga
//
