LOCUS       NM_001308197            4275 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens signal sequence receptor subunit 3 (SSR3), transcript
            variant 1, mRNA.
ACCESSION   NM_001308197 XM_011513099
VERSION     NM_001308197.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4275)
  AUTHORS   Hu,Q., Wu,G., Ma,H., Zhang,J. and Yang,Z.
  TITLE     Signal sequence receptor subunit 3: A novel indicator of
            immunosuppressive tumor microenvironment and clinical benefits from
            immunotherapy
  JOURNAL   Cell Signal 111, 110871 (2023)
   PUBMED   37652395
  REMARK    GeneRIF: Signal sequence receptor subunit 3: A novel indicator of
            immunosuppressive tumor microenvironment and clinical benefits from
            immunotherapy.
REFERENCE   2  (bases 1 to 4275)
  AUTHORS   Dmello,C., Sonabend,A., Arrieta,V.A., Zhang,D.Y., Kanojia,D.,
            Chen,L., Gould,A., Zhang,J., Kang,S.J., Winter,J., Horbinski,C.,
            Amidei,C., Gyorffy,B., Cordero,A., Chang,C.L., Castro,B., Hsu,P.,
            Ahmed,A.U., Lesniak,M.S., Stupp,R. and Sonabend,A.M.
  TITLE     Translocon-associated Protein Subunit SSR3 Determines and Predicts
            Susceptibility to Paclitaxel in Breast Cancer and Glioblastoma
  JOURNAL   Clin Cancer Res 28 (14), 3156-3169 (2022)
   PUBMED   35552677
  REMARK    GeneRIF: Translocon-associated Protein Subunit SSR3 Determines and
            Predicts Susceptibility to Paclitaxel in Breast Cancer and
            Glioblastoma.
REFERENCE   3  (bases 1 to 4275)
  AUTHORS   Xu,X., Huang,Y., Li,X., Arvan,P. and Liu,M.
  TITLE     The Role of TRAPgamma/SSR3 in Preproinsulin Translocation Into the
            Endoplasmic Reticulum
  JOURNAL   Diabetes 71 (3), 440-452 (2022)
   PUBMED   34857543
  REMARK    GeneRIF: The Role of TRAPgamma/SSR3 in Preproinsulin Translocation
            Into the Endoplasmic Reticulum.
REFERENCE   4  (bases 1 to 4275)
  AUTHORS   Dittner-Moormann,S., Lourenco,C.M., Reunert,J., Nishinakamura,R.,
            Tanaka,S.S., Werner,C., Debus,V., Zimmer,K.P., Wetzel,G.,
            Naim,H.Y., Wada,Y., Rust,S. and Marquardt,T.
  TITLE     TRAPgamma-CDG shows asymmetric glycosylation and an effect on
            processing of proteins required in higher organisms
  JOURNAL   J Med Genet 58 (3), 213-216 (2021)
   PUBMED   32332102
  REMARK    GeneRIF: TRAPgamma-CDG shows asymmetric glycosylation and an effect
            on processing of proteins required in higher organisms.
REFERENCE   5  (bases 1 to 4275)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4275)
  AUTHORS   Ng,B.G., Lourenco,C.M., Losfeld,M.E., Buckingham,K.J., Kircher,M.,
            Nickerson,D.A., Shendure,J., Bamshad,M.J. and Freeze,H.H.
  CONSRTM   University of Washington Center for Mendelian Genomics
  TITLE     Mutations in the translocon-associated protein complex subunit SSR3
            cause a novel congenital disorder of glycosylation
  JOURNAL   J Inherit Metab Dis 42 (5), 993-997 (2019)
   PUBMED   30945312
  REMARK    GeneRIF: Mutations in the translocon-associated protein complex
            subunit SSR3 cause a novel congenital disorder of glycosylation.
REFERENCE   7  (bases 1 to 4275)
  AUTHORS   Huang,S., Zhong,W., Shi,Z., Wang,K., Jin,H., Zhang,Z., Wang,H.,
            Wei,Y., Chen,S., Zhou,Q. and He,X.
  TITLE     Overexpression of signal sequence receptor gamma predicts poor
            survival in patients with hepatocellular carcinoma
  JOURNAL   Hum Pathol 81, 47-54 (2018)
   PUBMED   29940286
  REMARK    GeneRIF: SSR3 acts as an oncogene in hepatocellular carcinoma with
            overexpression predicting poor survival.
REFERENCE   8  (bases 1 to 4275)
  AUTHORS   Pfeffer,S., Dudek,J., Schaffer,M., Ng,B.G., Albert,S.,
            Plitzko,J.M., Baumeister,W., Zimmermann,R., Freeze,H.H., Engel,B.D.
            and Forster,F.
  TITLE     Dissecting the molecular organization of the translocon-associated
            protein complex
  JOURNAL   Nat Commun 8, 14516 (2017)
   PUBMED   28218252
  REMARK    GeneRIF: Data suggest that the mutation leads to complete absence
            of TRAP gamma (SSR3).
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4275)
  AUTHORS   Chen,H.Z., Wen,Q., Wang,W.J., He,J.P. and Wu,Q.
  TITLE     The orphan nuclear receptor TR3/Nur77 regulates ER stress and
            induces apoptosis via interaction with TRAPgamma
  JOURNAL   Int J Biochem Cell Biol 45 (8), 1600-1609 (2013)
   PUBMED   23660295
  REMARK    GeneRIF: translocon-associated protein subunit gamma (TRAPgamma)
            was identified as a novel TR3 binding partner.
REFERENCE   10 (bases 1 to 4275)
  AUTHORS   Hartmann,E., Gorlich,D., Kostka,S., Otto,A., Kraft,R., Knespel,S.,
            Burger,E., Rapoport,T.A. and Prehn,S.
  TITLE     A tetrameric complex of membrane proteins in the endoplasmic
            reticulum
  JOURNAL   Eur J Biochem 214 (2), 375-381 (1993)
   PUBMED   7916687
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY035536.1, AK304364.1,
            AC092927.5 and AI225105.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001308197.1.
            
            Summary: The signal sequence receptor (SSR) is a glycosylated
            endoplasmic reticulum (ER) membrane receptor associated with
            protein translocation across the ER membrane. The SSR is comprised
            of four membrane proteins/subunits: alpha, beta, gamma, and delta.
            The first two are glycosylated subunits and the latter two are
            non-glycosylated subunits. This gene encodes the gamma subunit,
            which is predicted to span the membrane four times. [provided by
            RefSeq, Aug 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14243140.10739317.1,
                                           SRR6380202.143674.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                HY035536.1         84-102
            20-1007             AK304364.1         1-988
            1008-4221           AC092927.5         163533-166746
            4222-4275           AI225105.1         13-66               c
FEATURES             Location/Qualifiers
     source          1..4275
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.31"
     gene            1..4275
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /note="signal sequence receptor subunit 3"
                     /db_xref="GeneID:6747"
                     /db_xref="HGNC:HGNC:11325"
                     /db_xref="MIM:606213"
     exon            1..161
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..625
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /note="isoform 1 is encoded by transcript variant 1;
                     translocon-associated protein gamma subunit; TRAP-gamma;
                     SSR gamma; translocon-associated protein subunit gamma;
                     TRAP-complex gamma subunit; signal sequence receptor
                     subunit gamma; signal sequence receptor, gamma
                     (translocon-associated protein gamma)"
                     /codon_start=1
                     /product="translocon-associated protein subunit gamma
                     isoform 1"
                     /protein_id="NP_001295126.1"
                     /db_xref="CCDS:CCDS77846.1"
                     /db_xref="GeneID:6747"
                     /db_xref="HGNC:HGNC:11325"
                     /db_xref="MIM:606213"
                     /translation="MAPKGSSKQQSEEDLLLQDFSRNLSAKSSALFFGNAFIVSAIPI
                     WLYWRIWHMDLIQSAVLYSVMTLVSTYLVAFAYKNVKFVLKHKVAQKREDAVSKEVTR
                     KLSEADNRKMSRKEKDERFDSCLKYGHHKRGILWKKNEVADYEATTFSIFYNNTLFLV
                     VVIVASFFILKNFNPTVNYILSISASSGLIALLSTGSK"
     exon            162..288
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /inference="alignment:Splign:2.1.0"
     exon            289..426
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /inference="alignment:Splign:2.1.0"
     exon            427..558
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /inference="alignment:Splign:2.1.0"
     exon            559..4275
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      807..812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /note="hexamer: AATGAA"
     polyA_site      824
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /note="major polyA site"
     regulatory      3664..3669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /note="hexamer: ATTAAA"
     polyA_site      3684
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
     regulatory      3741..3746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /note="hexamer: ATTATA"
     polyA_site      3760
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
     regulatory      4255..4260
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
                     /note="hexamer: AATATA"
     polyA_site      4275
                     /gene="SSR3"
                     /gene_synonym="TRAPG"
ORIGIN      
        1 gttccctgtt ctcgcctgca gctccgccat ggctcctaaa ggcagctcca aacagcagtc
       61 tgaggaggac ctgctcctgc aggatttcag ccgcaatctc tcggccaagt cctccgcgct
      121 cttcttcgga aacgcgttca tcgtgtctgc catccccatc tggttatact ggcgaatatg
      181 gcatatggat cttattcagt ctgctgtttt gtatagtgtg atgaccctag taagcacata
      241 tttggtagcc tttgcataca agaatgtgaa atttgttctc aagcacaaag tagcacagaa
      301 gagggaggat gctgtttcca aagaagtgac tcgaaaactt tctgaagctg ataatagaaa
      361 gatgtctcgg aaggagaaag atgaaaggtt tgactcctgt ttaaagtatg gccatcataa
      421 aaggggaatc ttgtggaaga agaatgaagt tgctgattat gaagctacaa cattttccat
      481 cttctataac aacactctgt tcctggtcgt ggtcattgtt gcttccttct tcatattgaa
      541 gaacttcaac cccacagtga actacatatt gtccataagt gcttcatcag gactcatcgc
      601 cctcctgtct actggctcca aatagaccat gtcagcttca ccccctggct ttgtgtctat
      661 gggtggcctg tggtatatgg aaaagtagca gggtggtcag ggtgggagac acaagatgtt
      721 tttatagtct agagccttta aaaaacccag cagaatgtaa ttcagtattt gtttattggc
      781 tgttttttga cagattgttg aaattaaatg aattgaaagg gaaactcaga gtactaggac
      841 gtttattaaa aggaaaaaaa tgtcttgcaa tgtgctgtaa tcacaagagg agaaaataac
      901 ttgtttcctt gatctgtcag aggtcacagt aacctgggcc gagctgttat tatttattat
      961 ataatagtag taggaagtta ataactggtt ctctgtgttc caagcacaat attacaactt
     1021 cttttgaacc gtaaatatca gaatgaatcc tcttcccagg ggattgaaca gaagcttaat
     1081 gtttacaagt gtttgaattt gtgatctgaa ataacacaaa attaaaaaca tgatttctct
     1141 aattttccaa ctagaggaag agaaacttgt ggaaaagttc tttttttttc tttttttttt
     1201 cttaaagaag ggcagccaag gtagtaacct aaaaatagtg cccaggcata tgagagttgt
     1261 cctacgaggt taaagaacac actgttccac tgtatggctt tggccctgag tggccaggga
     1321 ggtcaacttg accctgccat gttggtttga cttactaaga cacaggaatc actgttttcc
     1381 ttgaccaggg tctcacaccc tggaggaatg ttaagtaaga gaaagaacct ctttcctgaa
     1441 tattgacatg taaaagacca aagtaatttt tctgaacttc tgcaattctg agaactctcc
     1501 aaggaattta cagtgatttt agtgcttgtc agcatttttc catgaggact ttcatacatt
     1561 tgactcttta gttcacaggt tcccattgat tgtgagcaag atatttatct ctttagccct
     1621 tggggatcca gctgagagca atctcttgca tttttttacc cgtgtatgta cagatatcat
     1681 ttcttgtgta tgccatgact tgaaaaagtt tgggaagctc tttagcaata tcagctaaaa
     1741 ggatatgaaa tcacaggtga tagcagttgt cattcagtaa tttcctacaa gcagcacccc
     1801 aaaggaaata tagtcctaat ctttactatc cacttctaaa tttaatgtga atttcataca
     1861 tgttattagt tgttttcttt ataattttat aaaaattatt catcgggagt ttaacttcca
     1921 cttccatgct atcggatgtg ttgggctcca tgcaagaact tggaagaaaa acaggcagga
     1981 atgcatttgc ataatgaccc agatcatcat tttctgcaac tgagaattat atttcatcat
     2041 tgcttctaga agtctgcaat tctttacttt tctttggtgc attattatct aggtgccatc
     2101 actggataat gtggagtgac tagagaagtc acatatcact gtaaggtaca gttagggtaa
     2161 cactttagag gtttattatt tttaaaaaac ttttcttgaa ctcctggcca acatggtgaa
     2221 accccgtctc tactaaaaat accaaaatta gccaggcgtg atggtgggcg cctgtaatct
     2281 cagctacttg ggaggctgaa gcaggagaac tgcctgaacc caggaggcag aggttgcggt
     2341 gagtcgagat cgtgctacta ctgcctgggt ggcaagggtg agactccatc tcaaaaaaga
     2401 aacaaaaaaa cccaaaaagt tttctttact gttggttaaa aaaaaaagcc agaccatagt
     2461 ttgactggtg gcatggaatt tgtgtatcaa ataaatgcat ttgcttattt gacaaaccat
     2521 cagtgtccac tatttgttac cagagttggg ccactatctt ttaaaattgc tggtgaaaac
     2581 ttgccactag atggcagtgc ctgtatagat ggggaaaaaa ttgccaccat tcttggtata
     2641 atacagtgta gcttagatga ggtggtgaaa taggggtatc agccgaatat tcctaatata
     2701 gtttctcttg aattaataaa ctgaagattt gtaggaaaat gagtgagcaa aatttgttta
     2761 ctgttgtgaa tttttcctac agcactgttt ttaatcttga tgttttccaa ctttctgtac
     2821 taatagatac atttctgtgc ataagattat aaagcatata ctcacagttc agtagttttc
     2881 gttaaggatt tactgtgtga gtactttact gtgaggaatt gcagaacctt ttcccctcta
     2941 ctcttgtcta aaagttctgt gtggcacaca gagatgcgac ctactcaatc tgacttagta
     3001 aaaccatgct gtagaatttt tgtcttaaaa agaccacata cccagcaccc atgaaataaa
     3061 agattcatct gtaattggga ttcaaagtga ttaaattcct ttgttcatac tcataaatag
     3121 cactaaagtg ttataacatt ttcatttacc tatttttagt tccttcattt taacttaata
     3181 aaaatcttgg attgatattc tttttttttt tttttttttt ttgagacagc gtctcgctct
     3241 gtcacccagg ctggagtaca gtggctctat cttggctcac tgcgagctcc gcctcccagg
     3301 ttcacgccat tctcctgcct cagcctgccg agtagctggg actacaggcg cccgccacca
     3361 cacccggcta atttttttgt atttttagta gagacggggt ttcaccctgt tagccaggat
     3421 ggtctcgatc tcctgacctc gtgatccacc tgcctcggcc tcccaaagtg ctggaattac
     3481 aggcgtgagc caccgcgccc ggcctagatt gatattctta agcaataaaa gtttactggt
     3541 tgtcctattt gccatattat tgaaacttgg aaaggataat ttgaaacaag gtttgaagtt
     3601 aactgaaata tggagattga atttatactc aattcttgtg aaaagtcttg cttaataagt
     3661 atgattaaac tttgcttctt aaaatttgta ttttccctac acttctttat aagaatccta
     3721 tgatgaagta cgtaatcttt attatattat tttacattaa ccatcttttt tttcaaattg
     3781 ttttattttt tattttactt taagttctgg gatacatgtg ctgaccatgc aggtttggta
     3841 catatgtata catgtaacca tcattttaat atctcacaca tgtaaatgca catctttgta
     3901 gttaccaatc aaatgtatgt gaggcaatga aaggcattga gcagttacag taaagggcag
     3961 acatcaggcc tctgccagta tgtacctgct gtgccttcct gcctgcccta tttctttgtt
     4021 ttcagtgtgc atgccagtca ctgctgcttc tggagacagg atggaaggat acatgtatgt
     4081 gtacatttat ggagaaaacc aatttataga tgtatcagag ctctaaggga ttctctttca
     4141 cttccttggg actcccaagc agaggaatta atagattagg agggtctttt ggggggttgg
     4201 tttaaatttt cagggcgata gaggctaact tctcgttggc cttcatgaat tttcaatata
     4261 tcatcttttc gctga
//
