LOCUS       NM_003145               1108 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens signal sequence receptor subunit 2 (SSR2), mRNA.
ACCESSION   NM_003145 XM_941769 XM_945427 XM_945428 XM_945430
VERSION     NM_003145.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1108)
  AUTHORS   Kriegler,T., Kiburg,G. and Hessa,T.
  TITLE     Translocon-Associated Protein Complex (TRAP) is Crucial for
            Co-Translational Translocation of Pre-Proinsulin
  JOURNAL   J Mol Biol 432 (24), 166694 (2020)
   PUBMED   33137310
  REMARK    GeneRIF: Translocon-Associated Protein Complex (TRAP) is Crucial
            for Co-Translational Translocation of Pre-Proinsulin.
REFERENCE   2  (bases 1 to 1108)
  AUTHORS   Garg,B., Pathria,G., Wagner,C., Maurer,M. and Wagner,S.N.
  TITLE     Signal Sequence Receptor 2 is required for survival of human
            melanoma cells as part of an unfolded protein response to
            endoplasmic reticulum stress
  JOURNAL   Mutagenesis 31 (5), 573-582 (2016)
   PUBMED   27180333
  REMARK    GeneRIF: The Unfolded Protein Response (UPR) to ER stress was shown
            as an inducer of SSR2 via transcriptional regulation through X-Box
            Binding Protein 1s (XBP1s).
REFERENCE   3  (bases 1 to 1108)
  AUTHORS   Ishikawa,H. and Barber,G.N.
  TITLE     STING is an endoplasmic reticulum adaptor that facilitates innate
            immune signalling
  JOURNAL   Nature 455 (7213), 674-678 (2008)
   PUBMED   18724357
  REMARK    Erratum:[Nature. 2008 Nov 13;456(7219):274]
REFERENCE   4  (bases 1 to 1108)
  AUTHORS   Sikorska,M., Sandhu,J.K., Deb-Rinker,P., Jezierski,A., Leblanc,J.,
            Charlebois,C., Ribecco-Lutkiewicz,M., Bani-Yaghoub,M. and
            Walker,P.R.
  TITLE     Epigenetic modifications of SOX2 enhancers, SRR1 and SRR2,
            correlate with in vitro neural differentiation
  JOURNAL   J Neurosci Res 86 (8), 1680-1693 (2008)
   PUBMED   18293417
REFERENCE   5  (bases 1 to 1108)
  AUTHORS   Zhang,H., Li,X.J., Martin,D.B. and Aebersold,R.
  TITLE     Identification and quantification of N-linked glycoproteins using
            hydrazide chemistry, stable isotope labeling and mass spectrometry
  JOURNAL   Nat Biotechnol 21 (6), 660-666 (2003)
   PUBMED   12754519
REFERENCE   6  (bases 1 to 1108)
  AUTHORS   Dodson,G. and Steiner,D.
  TITLE     The role of assembly in insulin's biosynthesis
  JOURNAL   Curr Opin Struct Biol 8 (2), 189-194 (1998)
   PUBMED   9631292
  REMARK    Review article
REFERENCE   7  (bases 1 to 1108)
  AUTHORS   Chinen,K., Sudo,K., Takahashi,E. and Nakamura,Y.
  TITLE     Isolation and mapping of the human beta-signal sequence receptor
            gene (SSR2)
  JOURNAL   Cytogenet Cell Genet 70 (3-4), 215-217 (1995)
   PUBMED   7789174
REFERENCE   8  (bases 1 to 1108)
  AUTHORS   Bodescot,M. and Brison,O.
  TITLE     Cloning and sequence analysis of the beta subunit of the human
            translocon-associated protein
  JOURNAL   Biochim Biophys Acta 1217 (1), 101-102 (1994)
   PUBMED   8286409
REFERENCE   9  (bases 1 to 1108)
  AUTHORS   Hartmann,E., Gorlich,D., Kostka,S., Otto,A., Kraft,R., Knespel,S.,
            Burger,E., Rapoport,T.A. and Prehn,S.
  TITLE     A tetrameric complex of membrane proteins in the endoplasmic
            reticulum
  JOURNAL   Eur J Biochem 214 (2), 375-381 (1993)
   PUBMED   7916687
REFERENCE   10 (bases 1 to 1108)
  AUTHORS   Tajima,S., Lauffer,L., Rath,V.L. and Walter,P.
  TITLE     The signal recognition particle receptor is a complex that contains
            two distinct polypeptide chains
  JOURNAL   J Cell Biol 103 (4), 1167-1178 (1986)
   PUBMED   3021779
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP196192.1, X74104.1 and
            AK222600.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003145.3.
            
            Summary: The signal sequence receptor (SSR) is a glycosylated
            endoplasmic reticulum (ER) membrane receptor associated with
            protein translocation across the ER membrane. The SSR consists of 2
            subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD
            glycoprotein (beta-SSR or SSR2). The human beta-signal sequence
            receptor gene (SSR2) maps to chromosome bands 1q21-q23. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.19014.1,
                                           SRR5189667.257487.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            MANE Ensembl match               :: ENST00000295702.9/
                                                ENSP00000295702.4
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BP196192.1         17-31
            16-1103             X74104.1           2-1089
            1104-1108           AK222600.1         1063-1067
FEATURES             Location/Qualifiers
     source          1..1108
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1108
                     /gene="SSR2"
                     /gene_synonym="HSD25; TLAP; TRAP-BETA; TRAPB"
                     /note="signal sequence receptor subunit 2"
                     /db_xref="GeneID:6746"
                     /db_xref="HGNC:HGNC:11324"
                     /db_xref="MIM:600867"
     exon            1..64
                     /gene="SSR2"
                     /gene_synonym="HSD25; TLAP; TRAP-BETA; TRAPB"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..616
                     /gene="SSR2"
                     /gene_synonym="HSD25; TLAP; TRAP-BETA; TRAPB"
                     /note="translocon-associated protein beta;
                     translocon-associated protein subunit beta; SSR-beta;
                     signal sequence receptor subunit beta; signal sequence
                     receptor, beta (translocon-associated protein beta)"
                     /codon_start=1
                     /product="translocon-associated protein subunit beta
                     precursor"
                     /protein_id="NP_003136.1"
                     /db_xref="CCDS:CCDS1126.1"
                     /db_xref="GeneID:6746"
                     /db_xref="HGNC:HGNC:11324"
                     /db_xref="MIM:600867"
                     /translation="MRLLSFVVLALFAVTQAEEGARLLASKSLLNRYAVEGRDLTLQY
                     NIYNVGSSAALDVELSDDSFPPEDFGIVSGMLNVKWDRIAPASNVSHTVVLRPLKAGY
                     FNFTSATITYLAQEDGPVVIGSTSAPGQGGILAQREFDRRFSPHFLDWAAFGVMTLPS
                     IGIPLLLWYSSKRKYDTPKTKKN"
     exon            65..219
                     /gene="SSR2"
                     /gene_synonym="HSD25; TLAP; TRAP-BETA; TRAPB"
                     /inference="alignment:Splign:2.1.0"
     exon            220..318
                     /gene="SSR2"
                     /gene_synonym="HSD25; TLAP; TRAP-BETA; TRAPB"
                     /inference="alignment:Splign:2.1.0"
     exon            319..427
                     /gene="SSR2"
                     /gene_synonym="HSD25; TLAP; TRAP-BETA; TRAPB"
                     /inference="alignment:Splign:2.1.0"
     exon            428..505
                     /gene="SSR2"
                     /gene_synonym="HSD25; TLAP; TRAP-BETA; TRAPB"
                     /inference="alignment:Splign:2.1.0"
     exon            506..1108
                     /gene="SSR2"
                     /gene_synonym="HSD25; TLAP; TRAP-BETA; TRAPB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1086..1091
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSR2"
                     /gene_synonym="HSD25; TLAP; TRAP-BETA; TRAPB"
                     /note="hexamer: AATAAA"
     polyA_site      1108
                     /gene="SSR2"
                     /gene_synonym="HSD25; TLAP; TRAP-BETA; TRAPB"
                     /note="major polyA site"
ORIGIN      
        1 ctttcggatg ctgacgctct cttcctgtct ttgtggctcc ggaaaggcgt ttgggatgcc
       61 aacgatgagg ctgctgtcat ttgtggtgtt ggctctattt gctgtcactc aagcagagga
      121 aggagccagg cttttggctt ccaaatcact gctgaacaga tacgccgtgg agggacgaga
      181 cctgaccttg cagtacaaca tctacaatgt tggctcaagt gctgcattag acgtggaact
      241 atctgatgat tccttccctc cagaagactt tggcattgtg tctggaatgc tcaatgtcaa
      301 atgggaccgg attgcccctg ctagcaatgt ctcccacact gtggtcctgc gccctctcaa
      361 ggctggttat ttcaacttca cctcggcaac aattacttac ctggcccagg aggatgggcc
      421 cgttgtgatt ggctctacca gtgcacctgg acagggagga atcctggctc agcgggagtt
      481 tgacaggcga ttctcccctc attttctgga ctgggcagcc tttggggtca tgacccttcc
      541 ctccatcggc atccccctgc tattgtggta ctccagcaag aggaaatatg acactcccaa
      601 aacgaagaag aactgattgg ggcttccaca gccctcctct cccaagaaat ccaggctcct
      661 ctcccaagaa atccaggtgc tttccagact ccaaagggta tcttaaatgc aatctcttct
      721 ctcttagccc ttggccactt tctcctggat cctgccctgc tctcagccat agtgaaggac
      781 cagccctagg agtctgcgag agcctccttg gttccatcgt gaagccataa acaggaatgc
      841 ctttggcaat agccttgagc ctagagggcc ctctgatgcc ccactgaggt gctgttggtt
      901 tattgctggc aacgtgaatt ctctcagggg tctaggaggg gcattttgga gactgcctga
      961 caccacccct atcccctgcc tccccctctc agaagagggt ggaagatgaa atgaaagcta
     1021 tgggactctt ggaggatacc cagtgtctat tctgggttag agaagtgctt actaaggggt
     1081 tttctaataa aaacaaatgc cacattga
//
