LOCUS       NM_003731                863 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens SS nuclear autoantigen 1 (SSNA1), mRNA.
ACCESSION   NM_003731
VERSION     NM_003731.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 863)
  AUTHORS   Wu,L.W. and Hu,X.
  TITLE     SSNA1 Promotes Hepatocellular Carcinoma Metastasis Via STAT3/EMT
            Induction
  JOURNAL   Anticancer Res 43 (8), 3479-3486 (2023)
   PUBMED   37500134
  REMARK    GeneRIF: SSNA1 Promotes Hepatocellular Carcinoma Metastasis Via
            STAT3/EMT Induction.
REFERENCE   2  (bases 1 to 863)
  AUTHORS   Lawrence,E.J., Arpag,G., Arnaiz,C. and Zanic,M.
  TITLE     SSNA1 stabilizes dynamic microtubules and detects microtubule
            damage
  JOURNAL   Elife 10, e67282 (2021)
   PUBMED   34970964
  REMARK    GeneRIF: SSNA1 stabilizes dynamic microtubules and detects
            microtubule damage.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 863)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 863)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 863)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 863)
  AUTHORS   Takahashi,M., Yamagiwa,A., Nishimura,T., Mukai,H. and Ono,Y.
  TITLE     Centrosomal proteins CG-NAP and kendrin provide microtubule
            nucleation sites by anchoring gamma-tubulin ring complex
  JOURNAL   Mol Biol Cell 13 (9), 3235-3245 (2002)
   PUBMED   12221128
REFERENCE   7  (bases 1 to 863)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   8  (bases 1 to 863)
  AUTHORS   Mayor,T., Stierhof,Y.D., Tanaka,K., Fry,A.M. and Nigg,E.A.
  TITLE     The centrosomal protein C-Nap1 is required for cell cycle-regulated
            centrosome cohesion
  JOURNAL   J Cell Biol 151 (4), 837-846 (2000)
   PUBMED   11076968
REFERENCE   9  (bases 1 to 863)
  AUTHORS   Ramos-Morales,F., Infante,C., Fedriani,C., Bornens,M. and Rios,R.M.
  TITLE     NA14 is a novel nuclear autoantigen with a coiled-coil domain
  JOURNAL   J Biol Chem 273 (3), 1634-1639 (1998)
   PUBMED   9430706
REFERENCE   10 (bases 1 to 863)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC000864.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003731.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.254204.1, BC000864.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322310.10/ ENSP00000313752.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-863               BC000864.1         30-892
FEATURES             Location/Qualifiers
     source          1..863
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..863
                     /gene="SSNA1"
                     /gene_synonym="N14; NA-14; NA14"
                     /note="SS nuclear autoantigen 1"
                     /db_xref="GeneID:8636"
                     /db_xref="HGNC:HGNC:11321"
                     /db_xref="MIM:610882"
     exon            1..103
                     /gene="SSNA1"
                     /gene_synonym="N14; NA-14; NA14"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..411
                     /gene="SSNA1"
                     /gene_synonym="N14; NA-14; NA14"
                     /note="Sjogren's syndrome nuclear autoantigen 1; sjoegren
                     syndrome nuclear autoantigen 1; Sjogren syndrome nuclear
                     autoantigen 1; nuclear autoantigen of 14 kDa"
                     /codon_start=1
                     /product="microtubule nucleation factor SSNA1"
                     /protein_id="NP_003722.2"
                     /db_xref="CCDS:CCDS7034.1"
                     /db_xref="GeneID:8636"
                     /db_xref="HGNC:HGNC:11321"
                     /db_xref="MIM:610882"
                     /translation="MTQQGAALQNYNNELVKCIEELCQKREELCRQIQEEEDEKQRLQ
                     NEVRQLTEKLARVNENLARKIASRNEFDRTIAETEAAYLKILESSQTLLSVLKREAGN
                     LTKATAPDQKSSGGRDS"
     exon            104..303
                     /gene="SSNA1"
                     /gene_synonym="N14; NA-14; NA14"
                     /inference="alignment:Splign:2.1.0"
     exon            304..863
                     /gene="SSNA1"
                     /gene_synonym="N14; NA-14; NA14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      843..848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSNA1"
                     /gene_synonym="N14; NA-14; NA14"
                     /note="hexamer: AATAAA"
     polyA_site      863
                     /gene="SSNA1"
                     /gene_synonym="N14; NA-14; NA14"
                     /note="major polyA site"
ORIGIN      
        1 agcgctgctt ccgcggcggt tggggtggtg gggccccggg cggcgttgac catgacccag
       61 cagggcgcgg cgctgcagaa ctacaacaac gagctggtca agtgcataga ggagctgtgc
      121 cagaagcggg aggagctgtg ccggcagatc caggaggagg aggacgagaa gcagcggctg
      181 cagaatgagg tgaggcagct gacagagaag ctggcccgcg tcaacgagaa cctggcacgc
      241 aagattgcct ctcgcaacga gttcgaccgg accatcgcgg agacggaggc cgcctacctc
      301 aagatcctgg agagctccca gactttgctc agcgttctca agagggaagc tgggaacctg
      361 accaaggcta cagccccaga ccagaaaagt agcggcggca gggacagctg accagaccac
      421 gggcagggcc tgcctccgtg tgcccctcag ctcagcccca gcaagtgtgt gctcagagca
      481 tctttgttct tcacggcagc agctaccttc cctcactgtc tcaggtgccg agaggggcag
      541 gtgccagcct ccactggcat cagtgacaag cccagggcac agcccacccg ggggtcctcg
      601 cttcatgctc acacaggcta tggggatggt gggctccagg tcagctctgc aaggggcttg
      661 tctctgtggc acccacactc ctgccctgcc agggaggctc tggttgtctg agcaccatgg
      721 gggccccctc accttgtccc tcctcagcca gcagaggccc agggcaaggg acaggaggac
      781 aggggttctc cttcaccaca gaacccaaac ctcaggtctc acccctgtgg cctgtgatta
      841 tgaataaaga ttatctttgt aaa
//
