LOCUS       NM_145268               1160 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens serine rich single-pass membrane protein 1 (SSMEM1),
            mRNA.
ACCESSION   NM_145268
VERSION     NM_145268.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1160)
  AUTHORS   Nozawa,K., Zhang,Q., Miyata,H., Devlin,D.J., Yu,Z., Oura,S.,
            Koyano,T., Matsuyama,M., Ikawa,M. and Matzuk,M.M.
  TITLE     Knockout of serine-rich single-pass membrane protein 1 (Ssmem1)
            causes globozoospermia and sterility in male micedagger
  JOURNAL   Biol Reprod 103 (2), 244-253 (2020)
   PUBMED   32301969
REFERENCE   2  (bases 1 to 1160)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087071.2, BC017587.2 and AC024085.5.
            
            On Nov 23, 2018 this sequence version replaced NM_145268.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017587.2, SRR5189667.359281.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297819.4/ ENSP00000297819.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC087071.2         175288-175291
            5-962               BC017587.2         5-962
            963-963             AC024085.5         33772-33772
            964-1160            BC017587.2         963-1159
FEATURES             Location/Qualifiers
     source          1..1160
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.2"
     gene            1..1160
                     /gene="SSMEM1"
                     /gene_synonym="C7orf45"
                     /note="serine rich single-pass membrane protein 1"
                     /db_xref="GeneID:136263"
                     /db_xref="HGNC:HGNC:29580"
     exon            1..234
                     /gene="SSMEM1"
                     /gene_synonym="C7orf45"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..786
                     /gene="SSMEM1"
                     /gene_synonym="C7orf45"
                     /codon_start=1
                     /product="serine-rich single-pass membrane protein 1"
                     /protein_id="NP_660311.1"
                     /db_xref="CCDS:CCDS5816.1"
                     /db_xref="GeneID:136263"
                     /db_xref="HGNC:HGNC:29580"
                     /translation="MGDLFSLFWEVDPPPIPVNCAIPNQDYECWKDDSCGTIGSFLLW
                     YFVIVFVLMFFSRASVWMSEDKKDEGSGTSTSVRKASKETSCKRQSKDSAWDPSQTMK
                     KPKQNQLTPVTNSEVALVNAYPEQRRARRQSQFNEVNQNQHDSDTTEYGSEESNSEAS
                     SWKESESEHHPSPDSIKRRKMAQRQRNLGSYQMSERHCLHCKALRTNEWLAHHSRQKP
                     SVTPPMKRDSQEESSISDINKKFSKF"
     exon            235..289
                     /gene="SSMEM1"
                     /gene_synonym="C7orf45"
                     /inference="alignment:Splign:2.1.0"
     exon            290..1160
                     /gene="SSMEM1"
                     /gene_synonym="C7orf45"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1119..1124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSMEM1"
                     /gene_synonym="C7orf45"
                     /note="hexamer: AAGAAA"
     polyA_site      1160
                     /gene="SSMEM1"
                     /gene_synonym="C7orf45"
                     /note="major polyA site"
ORIGIN      
        1 agtcatcttt atccctttaa gcatggttta ttttctgagc aaggagtcat catgggagac
       61 cttttttcct tattttggga ggtagatcct cccccaatac ctgtaaattg tgccattcca
      121 aatcaggatt atgaatgctg gaaggatgac tcttgtggaa ccatagggag cttcctgctt
      181 tggtattttg ttatcgtatt tgtcctgatg ttcttctcta gggcttctgt ctggatgtct
      241 gaggataaaa aggatgaagg cagtgggaca agtacttcag taaggaaagc aagcaaagag
      301 acttcctgta agcggcaaag caaagacagt gcctgggatc cctcacaaac aatgaagaaa
      361 ccaaagcaga accaacttac ccctgtaacc aactcagaag tggctttggt caatgcctat
      421 cctgaacaaa gacgagccag gcgccagtct cagttcaatg aggtgaacca gaaccaacat
      481 gacagtgata ctacggagta tggcagtgaa gagtctaact cagaagcctc ctcgtggaag
      541 gagagtgaaa gtgaacacca cccatcacca gacagtatta agaggagaaa aatggctcag
      601 aggcaaagga atctgggaag ttaccaaatg agcgaaaggc actgcctcca ctgcaaagcc
      661 ttgagaacca acgaatggtt ggcgcaccat tcccgacaga agccttcagt aacaccgcca
      721 atgaaaagag acagtcaaga ggaaagttcc atatctgaca ttaacaagaa atttagtaaa
      781 ttttgaattt tatcacgttc ttccttcact tgaagccaaa tgaaagagat gaataaaaca
      841 tgaaaaatca ccagagctat aggtgaggag acttttacaa caaagtctct ctaccaacaa
      901 acaaaaacat acttggaacc caagaggtaa aatctcacac aattcttcgt tcaaaaaaaa
      961 aaaggccatc acgtgtttat ggcaccattg gaacaccaaa gatctatatc tgctatgatt
     1021 tttttatttg aaatagcaca agacagatat tttgtgcctt gagtgtatat attttgtgcc
     1081 ttgagtgtat gtattttgtt tatgtctgta atatgaataa gaaagctctt tgaaaatgta
     1141 ttatttatgt tgagaaacca
//
