LOCUS       NM_017857               2781 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens slingshot protein phosphatase 3 (SSH3), mRNA.
ACCESSION   NM_017857
VERSION     NM_017857.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2781)
  AUTHORS   Shi,Q.S., Zhang,Y.H., Long,J., Qian,Z.L. and Hu,C.X.
  TITLE     SSH3 promotes malignant progression of HCC by activating
            FGF1-mediated FGF/FGFR pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (22), 11561-11568 (2020)
   PUBMED   33275222
  REMARK    GeneRIF: SSH3 promotes malignant progression of HCC by activating
            FGF1-mediated FGF/FGFR pathway.
REFERENCE   2  (bases 1 to 2781)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2781)
  AUTHORS   Kousaka,K., Kiyonari,H., Oshima,N., Nagafuchi,A., Shima,Y.,
            Chisaka,O. and Uemura,T.
  TITLE     Slingshot-3 dephosphorylates ADF/cofilin but is dispensable for
            mouse development
  JOURNAL   Genesis 46 (5), 246-255 (2008)
   PUBMED   18442045
REFERENCE   4  (bases 1 to 2781)
  AUTHORS   Kligys,K., Claiborne,J.N., DeBiase,P.J., Hopkinson,S.B., Wu,Y.,
            Mizuno,K. and Jones,J.C.
  TITLE     The slingshot family of phosphatases mediates Rac1 regulation of
            cofilin phosphorylation, laminin-332 organization, and motility
            behavior of keratinocytes
  JOURNAL   J Biol Chem 282 (44), 32520-32528 (2007)
   PUBMED   17848544
  REMARK    GeneRIF: Expression of phosphatase-dead versions of SSH proteins,
            SSH1, SSH2 & SSH3 results in phosphorylation/inactivation of
            cofilin, changes in cytoskeleton organization, loss of cell
            polarity, and assembly of aberrant arrays of laminin-332 in
            keratinocytes.
REFERENCE   5  (bases 1 to 2781)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   6  (bases 1 to 2781)
  AUTHORS   Soosairajah,J., Maiti,S., Wiggan,O., Sarmiere,P., Moussi,N.,
            Sarcevic,B., Sampath,R., Bamburg,J.R. and Bernard,O.
  TITLE     Interplay between components of a novel LIM kinase-slingshot
            phosphatase complex regulates cofilin
  JOURNAL   EMBO J 24 (3), 473-486 (2005)
   PUBMED   15660133
REFERENCE   7  (bases 1 to 2781)
  AUTHORS   Ohta,Y., Kousaka,K., Nagata-Ohashi,K., Ohashi,K., Muramoto,A.,
            Shima,Y., Niwa,R., Uemura,T. and Mizuno,K.
  TITLE     Differential activities, subcellular distribution and tissue
            expression patterns of three members of Slingshot family
            phosphatases that dephosphorylate cofilin
  JOURNAL   Genes Cells 8 (10), 811-824 (2003)
   PUBMED   14531860
REFERENCE   8  (bases 1 to 2781)
  AUTHORS   Niwa,R., Nagata-Ohashi,K., Takeichi,M., Mizuno,K. and Uemura,T.
  TITLE     Control of actin reorganization by Slingshot, a family of
            phosphatases that dephosphorylate ADF/cofilin
  JOURNAL   Cell 108 (2), 233-246 (2002)
   PUBMED   11832213
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK074432.1, AP001885.4 and BU689839.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017857.3.
            
            Summary: The ADF (actin-depolymerizing factor)/cofilin family (see
            MIM 601442) is composed of stimulus-responsive mediators of actin
            dynamics. ADF/cofilin proteins are inactivated by kinases such as
            LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to
            play a role in actin dynamics by reactivating ADF/cofilin proteins
            in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM,
            Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK074432.1, SRR3476690.5064.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308127.9/ ENSP00000312081.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2017              AK074432.1         1-2017
            2018-2018           AP001885.4         165377-165377
            2019-2470           AK074432.1         2019-2470
            2471-2781           BU689839.1         32-342              c
FEATURES             Location/Qualifiers
     source          1..2781
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..2781
                     /gene="SSH3"
                     /gene_synonym="SSH3L"
                     /note="slingshot protein phosphatase 3"
                     /db_xref="GeneID:54961"
                     /db_xref="HGNC:HGNC:30581"
                     /db_xref="MIM:606780"
     exon            1..162
                     /gene="SSH3"
                     /gene_synonym="SSH3L"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..2076
                     /gene="SSH3"
                     /gene_synonym="SSH3L"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="slingshot 3; SSH-3L; hSSH-3L; SSH-like protein 3;
                     slingshot homolog 3"
                     /codon_start=1
                     /product="protein phosphatase Slingshot homolog 3"
                     /protein_id="NP_060327.3"
                     /db_xref="CCDS:CCDS8157.1"
                     /db_xref="GeneID:54961"
                     /db_xref="HGNC:HGNC:30581"
                     /db_xref="MIM:606780"
                     /translation="MALVTVSRSPPGSGASTPVGPWDQAVQRRSRLQRRQSFAVLRGA
                     VLGLQDGGDNDDAAEASSEPTEKAPSEEELHGDQTDFGQGSQSPQKQEEQRQHLHLMV
                     QLLRPQDDIRLAAQLEAPRPPRLRYLLVVSTREGEGLSQDETVLLGVDFPDSSSPSCT
                     LGLVLPLWSDTQVYLDGDGGFSVTSGGQSRIFKPISIQTMWATLQVLHQACEAALGSG
                     LVPGGSALTWASHYQERLNSEQSCLNEWTAMADLESLRPPSAEPGGSSEQEQMEQAIR
                     AELWKVLDVSDLESVTSKEIRQALELRLGLPLQQYRDFIDNQMLLLVAQRDRASRIFP
                     HLYLGSEWNAANLEELQRNRVTHILNMAREIDNFYPERFTYHNVRLWDEESAQLLPHW
                     KETHRFIEAARAQGTHVLVHCKMGVSRSAATVLAYAMKQYECSLEQALRHVQELRPIA
                     RPNPGFLRQLQIYQGILTASRQSHVWEQKVGGVSPEEHPAPEVSTPFPPLPPEPEGGG
                     EEKVVGMEESQAAPKEEPGPRPRINLRGVMRSISLLEPSLELESTSETSDMPEVFSSH
                     ESSHEEPLQPFPQLARTKGGQQVDRGPQPALKSRQSVVTLQGSAVVANRTQAFQEQEQ
                     GQGQGQGEPCISSTPRFRKVVRQASVHDSGEEGEA"
     exon            163..200
                     /gene="SSH3"
                     /gene_synonym="SSH3L"
                     /inference="alignment:Splign:2.1.0"
     exon            201..435
                     /gene="SSH3"
                     /gene_synonym="SSH3L"
                     /inference="alignment:Splign:2.1.0"
     exon            436..560
                     /gene="SSH3"
                     /gene_synonym="SSH3L"
                     /inference="alignment:Splign:2.1.0"
     exon            561..632
                     /gene="SSH3"
                     /gene_synonym="SSH3L"
                     /inference="alignment:Splign:2.1.0"
     exon            633..698
                     /gene="SSH3"
                     /gene_synonym="SSH3L"
                     /inference="alignment:Splign:2.1.0"
     exon            699..887
                     /gene="SSH3"
                     /gene_synonym="SSH3L"
                     /inference="alignment:Splign:2.1.0"
     exon            888..981
                     /gene="SSH3"
                     /gene_synonym="SSH3L"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1110
                     /gene="SSH3"
                     /gene_synonym="SSH3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1157
                     /gene="SSH3"
                     /gene_synonym="SSH3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1304
                     /gene="SSH3"
                     /gene_synonym="SSH3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1505
                     /gene="SSH3"
                     /gene_synonym="SSH3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1779
                     /gene="SSH3"
                     /gene_synonym="SSH3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..2781
                     /gene="SSH3"
                     /gene_synonym="SSH3L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2763..2768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSH3"
                     /gene_synonym="SSH3L"
                     /note="hexamer: AATAAA"
     polyA_site      2781
                     /gene="SSH3"
                     /gene_synonym="SSH3L"
                     /note="major polyA site"
ORIGIN      
        1 gtccgtcctt cctggtcctg cgggtccagg actgtccgcg gggttgaggg aaggggccgt
       61 gcccggtgcc agcccaggtg ctcgcggcct ggctccatgg ccctggtcac agtgagccgt
      121 tcgcccccgg gcagcggcgc ctccacgccc gtggggccct gggaccaggc ggtccagcga
      181 aggagtcgac tccagcgaag gcagagcttt gcggtgctcc gtggggctgt cctgggactg
      241 caggatggag gggacaatga tgatgcagca gaggccagtt ctgagccaac agagaaggcc
      301 ccgagtgagg aggagctcca cggggaccag acagacttcg ggcaaggatc ccagagtccc
      361 cagaagcagg aggagcagag gcagcacctg cacctcatgg tacagctgct gaggccgcag
      421 gatgacatcc gcctggcagc ccagctggag gcaccccggc ctccccggct ccgctacctg
      481 ctggtagttt ctacacgaga aggagaaggt ctgagccagg atgagacggt cctcctgggc
      541 gtggatttcc ctgacagcag ctcccccagc tgcaccctgg gcctggtctt gcccctctgg
      601 agtgacaccc aggtgtactt agatggagac gggggcttca gcgtgacgtc tggtgggcaa
      661 agccggatct tcaagcccat ctccatccag accatgtggg ccacactcca ggtattgcac
      721 caagcatgtg aggcagctct aggcagcggc cttgtaccgg gtggcagtgc cctcacctgg
      781 gccagccact accaggagag actgaactcc gaacagagct gcctcaatga gtggacggct
      841 atggccgacc tggagtctct gcggcctccc agcgccgagc ctggcgggtc ctcagaacag
      901 gagcagatgg agcaggcgat ccgtgctgag ctgtggaaag tgttggatgt cagtgacctg
      961 gagagtgtca cttccaaaga gatccgccag gctctggagc tgcgcctggg gctccccctc
     1021 cagcagtacc gtgacttcat cgacaaccag atgctgctgc tggtggcaca gcgggaccga
     1081 gcctcccgca tcttccccca cctctacctg ggctcagagt ggaacgcagc aaacctggag
     1141 gagctgcaga ggaacagggt cacccacatc ttgaacatgg cccgggagat tgacaacttc
     1201 taccctgagc gcttcaccta ccacaatgtg cgcctctggg atgaggagtc ggcccagctg
     1261 ctgccgcact ggaaggagac gcaccgcttc attgaggctg caagagcaca gggcacccac
     1321 gtgctggtcc actgcaagat gggcgtcagc cgctcagcgg ccacagtgct ggcctatgcc
     1381 atgaagcagt acgaatgcag cctggagcag gccctgcgcc acgtgcagga gctccggccc
     1441 atcgcccgcc ccaaccctgg cttcctgcgc cagctgcaga tctaccaggg catcctgacg
     1501 gccagccgcc agagccatgt ctgggagcag aaagtgggtg gggtctcccc agaggagcac
     1561 ccagcccctg aagtctctac accattccca cctcttccgc cagaacctga gggtggtggg
     1621 gaggagaagg ttgtaggcat ggaagagagc caggcagccc cgaaagaaga gcctgggcca
     1681 cggccacgta taaacctccg aggggtcatg aggtccatca gtcttctgga gccctccttg
     1741 gagctggaga gcacctcaga gaccagtgac atgccagagg tcttctcttc ccacgagtct
     1801 tcacatgaag agcctctgca gcccttccca cagcttgcaa ggaccaaggg aggccagcag
     1861 gtggacaggg ggcctcagcc tgccctgaag tcccgccagt cagtggttac cctccagggc
     1921 agtgccgtgg tggccaaccg gacccaggcc ttccaggagc aggagcaggg gcaggggcag
     1981 gggcagggag agccctgcat ttcctctacg cccaggttcc ggaaggtggt gagacaggcc
     2041 agcgtgcatg acagtggaga ggagggcgag gcctgagccc tcacacatgc ccacgctccc
     2101 ctgacactga agaggatcca caactccttg gagaaacacc ctcacgtctg ttgccgcaca
     2161 cattcctctc agctccgccc catacccgtc actacagcct cacctcccac ccctgtcact
     2221 acggcctcac ctcccacccc tgtcactaca gcctcacctc ctacagcctt aagtcccagg
     2281 cccatgtctg cctgtccaag ggctcaagac tttctaactg ggatgtggta gagggactga
     2341 aggtaccttt gggggcaaca gcaccctagt ttcattctca actctagccc tgcacactca
     2401 cctgtggcac ggaatgaaaa cagagcttcc cgtgcaaaaa gggtcacgcc tcccaccccc
     2461 gccccctccc tgcacctcct gtcctctccc agttcattcc tggaaccagc caggccaggc
     2521 aaccagtggc ccccaaaggc aggcaggatc ctcaggcccc agccgcggga ggctggaagg
     2581 gctggcagat cgcttccctc atccacctcc accggtccag gtctttgctg ctgtccccag
     2641 acctcctgtg acaccacgcc agatcacagg gcaccaggcc agagatagtc ttctttttgt
     2701 cctttctggc ctctggctag tcagtttttc atagccttac agtatctggc tttgtactga
     2761 gaaataaaac acattttcat a
//
