LOCUS       NM_001161331            2459 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens slingshot protein phosphatase 1 (SSH1), transcript
            variant 3, mRNA.
ACCESSION   NM_001161331
VERSION     NM_001161331.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2459)
  AUTHORS   Lai,S.W., Cheng,Y.C., Huang,W.C., Yadav,V.K., Fong,I.H., Yeh,C.T.,
            Yang,C.K., Lee,W.H. and Chen,M.Y.
  TITLE     Dysregulated expression of slingshot protein phosphatase 1 (SSH1)
            disrupts circadian rhythm and WNT signaling associated to
            hepatocellular carcinoma pathogenesis
  JOURNAL   Aging (Albany NY) 15 (20), 11033-11051 (2023)
   PUBMED   37837551
  REMARK    GeneRIF: Dysregulated expression of slingshot protein phosphatase 1
            (SSH1) disrupts circadian rhythm and WNT signaling associated to
            hepatocellular carcinoma pathogenesis.
REFERENCE   2  (bases 1 to 2459)
  AUTHORS   Cazzaro,S., Woo,J.A., Wang,X., Liu,T., Rego,S., Kee,T.R., Koh,Y.,
            Vazquez-Rosa,E., Pieper,A.A. and Kang,D.E.
  TITLE     Slingshot homolog-1-mediated Nrf2 sequestration tips the balance
            from neuroprotection to neurodegeneration in Alzheimer's disease
  JOURNAL   Proc Natl Acad Sci U S A 120 (30), e2217128120 (2023)
   PUBMED   37463212
  REMARK    GeneRIF: Slingshot homolog-1-mediated Nrf2 sequestration tips the
            balance from neuroprotection to neurodegeneration in Alzheimer's
            disease.
REFERENCE   3  (bases 1 to 2459)
  AUTHORS   Chen,F., Aye,L., Yu,L., Liu,L., Liu,Y., Lin,Y., Gao,D., Gao,Q. and
            Zhang,S.
  TITLE     SSH1 promotes progression of intrahepatic cholangiocarcinoma via
            p38 MAPK-CXCL8 axis
  JOURNAL   Carcinogenesis 44 (3), 232-241 (2023)
   PUBMED   36857607
  REMARK    GeneRIF: SSH1 promotes progression of intrahepatic
            cholangiocarcinoma via p38 MAPK-CXCL8 axis.
REFERENCE   4  (bases 1 to 2459)
  AUTHORS   Cazzaro,S., Zhao,X., Zhao,V.K., Kim,Y.K. and Woo,J.A.
  TITLE     Slingshot homolog-1 amplifies mitochondrial abnormalities by
            distinctly impairing health and clearance of mitochondria
  JOURNAL   Hum Mol Genet 32 (10), 1660-1672 (2023)
   PUBMED   36637427
  REMARK    GeneRIF: Slingshot homolog-1 amplifies mitochondrial abnormalities
            by distinctly impairing health and clearance of mitochondria.
REFERENCE   5  (bases 1 to 2459)
  AUTHORS   Song,X., Xie,D., Xia,X., Tan,F., Pei,Q., Li,Y., Zhou,Z., Zhou,Y.,
            Li,C., Wang,K. and Pei,H.
  TITLE     Role of SSH1 in colorectal cancer prognosis and tumor progression
  JOURNAL   J Gastroenterol Hepatol 35 (7), 1180-1188 (2020)
   PUBMED   32020663
  REMARK    GeneRIF: Role of SSH1 in colorectal cancer prognosis and tumor
            progression.
REFERENCE   6  (bases 1 to 2459)
  AUTHORS   Nishita,M., Wang,Y., Tomizawa,C., Suzuki,A., Niwa,R., Uemura,T. and
            Mizuno,K.
  TITLE     Phosphoinositide 3-kinase-mediated activation of cofilin
            phosphatase Slingshot and its role for insulin-induced membrane
            protrusion
  JOURNAL   J Biol Chem 279 (8), 7193-7198 (2004)
   PUBMED   14645219
  REMARK    GeneRIF: findings suggest that SSH1L is activated downstream of
            PI3K and plays a critical role in insulin-induced membrane
            protrusion by dephosphorylating and activating cofilin
REFERENCE   7  (bases 1 to 2459)
  AUTHORS   Ohta,Y., Kousaka,K., Nagata-Ohashi,K., Ohashi,K., Muramoto,A.,
            Shima,Y., Niwa,R., Uemura,T. and Mizuno,K.
  TITLE     Differential activities, subcellular distribution and tissue
            expression patterns of three members of Slingshot family
            phosphatases that dephosphorylate cofilin
  JOURNAL   Genes Cells 8 (10), 811-824 (2003)
   PUBMED   14531860
REFERENCE   8  (bases 1 to 2459)
  AUTHORS   Kaji,N., Ohashi,K., Shuin,M., Niwa,R., Uemura,T. and Mizuno,K.
  TITLE     Cell cycle-associated changes in Slingshot phosphatase activity and
            roles in cytokinesis in animal cells
  JOURNAL   J Biol Chem 278 (35), 33450-33455 (2003)
   PUBMED   12807904
  REMARK    GeneRIF: SSH1 plays a critical role in cytokinesis by
            dephosphorylating and reactivating cofilin in later stages of
            mitosis
REFERENCE   9  (bases 1 to 2459)
  AUTHORS   Endo,M., Ohashi,K., Sasaki,Y., Goshima,Y., Niwa,R., Uemura,T. and
            Mizuno,K.
  TITLE     Control of growth cone motility and morphology by LIM kinase and
            Slingshot via phosphorylation and dephosphorylation of cofilin
  JOURNAL   J Neurosci 23 (7), 2527-2537 (2003)
   PUBMED   12684437
REFERENCE   10 (bases 1 to 2459)
  AUTHORS   Niwa,R., Nagata-Ohashi,K., Takeichi,M., Mizuno,K. and Uemura,T.
  TITLE     Control of actin reorganization by Slingshot, a family of
            phosphatases that dephosphorylate ADF/cofilin
  JOURNAL   Cell 108 (2), 233-246 (2002)
   PUBMED   11832213
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK095421.1 and AB072356.1.
            
            Summary: The protein encoded by this gene belongs to the slingshot
            homolog (SSH) family of phosphatases, which regulate actin filament
            dynamics. The SSH proteins dephosphorylate and activate the actin
            binding/depolymerizing factor cofilin, which subsequently binds to
            actin filaments and stimulates their disassembly. Cofilin is
            inactivated by kinases such as LIM domain kinase-1 (LIMK1), which
            may also be dephosphorylated and inactivated by SSH proteins. The
            SSH family thus appears to play a role in actin dynamics by
            reactivating cofilin proteins. Alternatively spliced transcript
            variants encoding different isoforms have been described for this
            gene. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (3) contains an alternative 5'
            terminal exon, and differs at the 3' end compared to variant 1.
            This results in a shorter isoform (3) with distinct N- and
            C-termini compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK095421.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2432              AK095421.1         2-2433
            2433-2459           AB072356.1         2254-2280
FEATURES             Location/Qualifiers
     source          1..2459
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.11"
     gene            1..2459
                     /gene="SSH1"
                     /gene_synonym="SSH1L"
                     /note="slingshot protein phosphatase 1"
                     /db_xref="GeneID:54434"
                     /db_xref="HGNC:HGNC:30579"
                     /db_xref="MIM:606778"
     exon            1..289
                     /gene="SSH1"
                     /gene_synonym="SSH1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..2258
                     /gene="SSH1"
                     /gene_synonym="SSH1L"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="isoform 3 is encoded by transcript variant 3;
                     protein phosphatase Slingshot homolog 1; hSSH-1L; SSH-like
                     protein 1; slingshot homolog 1"
                     /codon_start=1
                     /product="protein phosphatase Slingshot homolog 1 isoform
                     3"
                     /protein_id="NP_001154803.1"
                     /db_xref="CCDS:CCDS53825.1"
                     /db_xref="GeneID:54434"
                     /db_xref="HGNC:HGNC:30579"
                     /db_xref="MIM:606778"
                     /translation="MARARRAVVGSVRDVSTAATNLFYFTDFCIFLQPTHCFCCPEVS
                     SSNYLSESFFMVKGAALFLQQGSSPQGQRSLQHPHKHAGDLPQHLQVMINLLRCEDRI
                     KLAVRLESAWADRVRYMVVVYSSGRQDTEENILLGVDFSSKESKSCTIGMVLRLWSDT
                     KIHLDGDGGFSVSTAGRMHIFKPVSVQAMWSALQVLHKACEVARRHNYFPGGVALIWA
                     TYYESCISSEQSCINEWNAMQDLESTRPDSPALFVDKPTEGERTERLIKAKLRSIMMS
                     QDLENVTSKEIRNELEKQMNCNLKELKEFIDNEMLLILGQMDKPSLIFDHLYLGSEWN
                     ASNLEELQGSGVDYILNVTREIDNFFPGLFAYHNIRVYDEETTDLLAHWNEAYHFINK
                     AKRNHSKCLVHCKMGVSRSASTVIAYAMKEFGWPLEKAYNYVKQKRSITRPNAGFMRQ
                     LSEYEGILDASKQRHNKLWRQQTDSSLQQPVDDPAGPGDFLPETPDGTPESQLPFLDD
                     AAQPGLGPPLPCCFRRLSDPLLPSPEDETGSLVHLEDPEREALLEEAAPPAEVHRPAR
                     QPQQGSGLCEKDVKKKLEFGSPKGRSGSLLQVEETEREEGLGAGRWGQLPTQLDQNLL
                     NSENLNNNSKRSCPNGMEVGRARPAGWHTPSLPSHSNWPTSASVVGTTGTRHHTQLIF
                     FYCLLWAPSSHLQGPEGSFTG"
     exon            290..393
                     /gene="SSH1"
                     /gene_synonym="SSH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            394..458
                     /gene="SSH1"
                     /gene_synonym="SSH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            459..580
                     /gene="SSH1"
                     /gene_synonym="SSH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            581..649
                     /gene="SSH1"
                     /gene_synonym="SSH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            650..715
                     /gene="SSH1"
                     /gene_synonym="SSH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            716..910
                     /gene="SSH1"
                     /gene_synonym="SSH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1004
                     /gene="SSH1"
                     /gene_synonym="SSH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1133
                     /gene="SSH1"
                     /gene_synonym="SSH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1180
                     /gene="SSH1"
                     /gene_synonym="SSH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1327
                     /gene="SSH1"
                     /gene_synonym="SSH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1528
                     /gene="SSH1"
                     /gene_synonym="SSH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..2439
                     /gene="SSH1"
                     /gene_synonym="SSH1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2409..2414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSH1"
                     /gene_synonym="SSH1L"
                     /note="hexamer: ATTAAA"
     polyA_site      2434
                     /gene="SSH1"
                     /gene_synonym="SSH1L"
                     /note="major polyA site"
ORIGIN      
        1 tttttcagcc aaaatatcag aggaagacaa gagttccaca agagccattt gcttttcggg
       61 taggactctg aggaggagtt ggctccccag ccctcgtgga agcactcggc agcctcctgg
      121 cttttcctga tctccatagg gagcagatgg ccagagctcg gagggcagtt gtagggagcg
      181 ttagagatgt gagcactgca gccacgaacc tcttttattt taccgacttc tgcatcttcc
      241 ttcagccaac ccactgcttc tgctgtccag aggtttccag ctcaaattac ttaagtgaga
      301 gctttttcat ggtgaaaggc gcagccctct tcttacaaca gggaagcagc cctcaaggcc
      361 agcggagtct tcagcacccc cacaagcatg caggtgatct gcctcaacat cttcaggtga
      421 tgatcaacct tctgcgttgc gaagacagaa tcaagctggc agtgcgcctg gagagcgcct
      481 gggcggaccg ggtccggtac atggtggtgg tgtacagcag cgggcgccag gacaccgagg
      541 agaatatctt gctgggagtg gacttttcca gtaaggaaag taaaagctgc accattggga
      601 tggttctccg actgtggagc gacacgaaaa tccaccttga tggagatggt gggttcagcg
      661 tgagcacagc aggaaggatg cacatattta agcctgtgtc tgtccaggcc atgtggtctg
      721 ccctgcaggt gcttcacaag gcctgcgaag tggcccggag gcacaactac ttccccgggg
      781 gtgtagctct catctgggct acctactatg agagctgcat cagctccgag cagagctgca
      841 tcaacgagtg gaacgccatg caggacctgg agtctacgcg gcccgactcc cccgcgctat
      901 ttgtggacaa gcccactgaa ggggaaagga ccgagcgcct catcaaagcc aagctccgaa
      961 gcatcatgat gagccaggat ctagaaaatg tgacttccaa agagattcgt aatgaattag
     1021 agaaacagat gaattgtaac ttgaaggaac tcaaggaatt tatagacaat gagatgctac
     1081 ttatcttggg acagatggac aagccctccc ttatcttcga tcatctttat ctcggctctg
     1141 aatggaatgc atccaatctg gaggaactgc agggctcagg ggttgattac attttaaatg
     1201 ttaccagaga aatcgataat ttttttcctg gcttatttgc atatcataac atccgagtct
     1261 acgatgaaga gaccacagac ctcctcgccc actggaatga agcgtatcat tttataaaca
     1321 aagcgaagag gaaccattcc aagtgcctgg tgcattgcaa aatgggcgtg agtcgctcgg
     1381 cctccacagt catagcctat gcaatgaagg aattcggctg gcctctggaa aaagcatata
     1441 actatgtaaa gcagaagcgc agcatcacgc gccccaacgc gggctttatg aggcagctgt
     1501 ctgagtatga aggcatcttg gatgcaagca aacagcggca caacaagctg tggcgtcagc
     1561 agacagacag cagcctccag cagcctgtgg atgaccctgc aggacctggc gacttcttgc
     1621 cagagacccc agatggcacc ccggaaagcc agctgccctt cttggatgat gccgcccagc
     1681 ccggcttagg gccccccctc ccctgctgtt tccggcgact ctcagacccc cttctgcctt
     1741 cccctgagga tgaaactggc agcttggtcc acctggagga tccggagagg gaggctctgt
     1801 tggaggaagc tgctccacct gcagaggtgc acaggccggc cagacagccc cagcaaggtt
     1861 ccggactctg tgagaaggat gtgaagaaga aactagagtt tgggagtccc aaaggtcgga
     1921 gcggctcctt gctgcaggtg gaggagacgg aaagggagga gggcctggga gcagggaggt
     1981 gggggcagct tccaacccag ctcgatcaaa acctgctcaa ctcggagaac ctaaacaaca
     2041 acagcaagag gagctgtccc aacggcatgg aggtaggcag agcccggcct gcagggtggc
     2101 acaccccatc ccttccatcc cactctaatt ggcctacctc agcctctgta gtagggacta
     2161 caggcacccg ccaccacacc cagctgattt ttttctattg tctcctctgg gcccccagct
     2221 cccatctcca gggacctgag ggttctttca cagggtgatt ctgctggtgg gtacgtagtg
     2281 cataccttat atagcaaatt gagaatctgt tgggaataac acatatctct gcacaccatc
     2341 ttcaccccat gtaccttatt cataccctgg gcagggcttc caactcaatt tctttttgtg
     2401 tatgtaaaat taaaacatat aatttatcag ccaacttcaa aaaaaaaaaa aaaaaaaaa
//
