LOCUS       NM_080744               2800 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens scavenger receptor cysteine rich family member with 4
            domains (SSC4D), mRNA.
ACCESSION   NM_080744
VERSION     NM_080744.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2800)
  AUTHORS   Cardoso,M.S., Santos,R.F., Almeida,S., Sa,M., Perez-Cabezas,B.,
            Oliveira,L., Tavares,J. and Carmo,A.M.
  TITLE     Physical Interactions With Bacteria and Protozoan Parasites
            Establish the Scavenger Receptor SSC4D as a Broad-Spectrum Pattern
            Recognition Receptor
  JOURNAL   Front Immunol 12, 760770 (2021)
   PUBMED   35003072
  REMARK    GeneRIF: Physical Interactions With Bacteria and Protozoan
            Parasites Establish the Scavenger Receptor SSC4D as a
            Broad-Spectrum Pattern Recognition Receptor.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2800)
  AUTHORS   Padilla,O., Pujana,M.A., Lopez-de la Iglesia,A., Gimferrer,I.,
            Arman,M., Vila,J.M., Places,L., Vives,J., Estivill,X. and Lozano,F.
  TITLE     Cloning of S4D-SRCRB, a new soluble member of the group B scavenger
            receptor cysteine-rich family (SRCR-SF) mapping to human chromosome
            7q11.23
  JOURNAL   Immunogenetics 54 (9), 621-634 (2002)
   PUBMED   12466895
  REMARK    GeneRIF: Cloning of S4D-SRCRB, a new soluble member of the group B
            scavenger receptor cysteine-rich family (SRCR-SF) mapping to human
            chromosome 7q11.23.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005522.2 and AJ312755.1.
            
            On Nov 22, 2018 this sequence version replaced NM_080744.1.
            
            Summary: The scavenger receptor cysteine-rich (SRCR) superfamily is
            an ancient and highly conserved group of cell surface and/or
            secreted proteins, some of which are involved in the development of
            the immune system and the regulation of both innate and adaptive
            immune responses. Group B SRCR domains usually contain 8 regularly
            spaced cysteines that give rise to a well-defined intradomain
            disulfide-bond pattern.[supplied by OMIM, Apr 2004].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172783.1, AJ312755.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145774, SAMEA2159080
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000275560.4/ ENSP00000275560.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC005522.2         91485-91486
            3-2800              AJ312755.1         1-2798
FEATURES             Location/Qualifiers
     source          1..2800
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..2800
                     /gene="SSC4D"
                     /gene_synonym="S4D-SRCRB; SRCRB-S4D; SRCRB4D"
                     /note="scavenger receptor cysteine rich family member with
                     4 domains"
                     /db_xref="GeneID:136853"
                     /db_xref="HGNC:HGNC:14461"
                     /db_xref="MIM:607639"
     exon            1..284
                     /gene="SSC4D"
                     /gene_synonym="S4D-SRCRB; SRCRB-S4D; SRCRB4D"
                     /inference="alignment:Splign:2.1.0"
     exon            285..483
                     /gene="SSC4D"
                     /gene_synonym="S4D-SRCRB; SRCRB-S4D; SRCRB4D"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..2078
                     /gene="SSC4D"
                     /gene_synonym="S4D-SRCRB; SRCRB-S4D; SRCRB4D"
                     /note="scavenger receptor cysteine-rich protein SRCRB-S4D;
                     scavenger receptor cysteine-rich domain-containing group B
                     protein; scavenger receptor cysteine rich domain
                     containing, group B (4 domains); four scavenger receptor
                     cysteine-rich domains-containing protein; scavenger
                     receptor cysteine rich family, 4 domains"
                     /codon_start=1
                     /product="scavenger receptor cysteine-rich
                     domain-containing group B protein precursor"
                     /protein_id="NP_542782.1"
                     /db_xref="CCDS:CCDS5585.1"
                     /db_xref="GeneID:136853"
                     /db_xref="HGNC:HGNC:14461"
                     /db_xref="MIM:607639"
                     /translation="MHKEAEMLIGPQLDEKRWGWRLGDGSAAPPFLPQALSFLLLLPL
                     ASALQPTPLPFQELRLVGGPSRCRGRLEVMHGGSWGSVCDDDWDVVDANVVCRQLGCG
                     LALPVPRPLAFGQGRGPILLDNVECRGQEAALSECGSRGWGVHNCFHYEDVAVLCDEF
                     LPTQPPTRKMLTSRAPPTTLPNGKSEGSVRLVGGANLCQGRVEILHSGLWGTVCDDDW
                     GLPDAAVVCRQLGCGAAMAATTNAFFGYGTGHILLDNVHCEGGEPRLAACQSLGWGVH
                     NCGHHEDAGALCAGLGPPTLTALPSSATREDWAWQTDPSATGVGPQPSRETALLTTAA
                     WAAGKKSGRLRLVGGPGPCRGRVEVLHAGGWGTVCDDDWDFADARVACREAGCGPALG
                     ATGLGHFGYGRGPVLLDNVGCAGTEARLSDCFHLGWGQHNCGHHEDAGALCAGPEELG
                     LQVQQDGSETTRVPTPRPRDGHLRLVNGAHRCEGRVELYLGQRWGTVCDDAWDLRAAG
                     VLCRQLGCGQALAAPGEAHFGPGRGPILLDNVKCRGEESALLLCSHIRWDAHNCDHSE
                     DASVLCQPS"
     exon            484..519
                     /gene="SSC4D"
                     /gene_synonym="S4D-SRCRB; SRCRB-S4D; SRCRB4D"
                     /inference="alignment:Splign:2.1.0"
     exon            520..825
                     /gene="SSC4D"
                     /gene_synonym="S4D-SRCRB; SRCRB-S4D; SRCRB4D"
                     /inference="alignment:Splign:2.1.0"
     exon            826..903
                     /gene="SSC4D"
                     /gene_synonym="S4D-SRCRB; SRCRB-S4D; SRCRB4D"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1218
                     /gene="SSC4D"
                     /gene_synonym="S4D-SRCRB; SRCRB-S4D; SRCRB4D"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1296
                     /gene="SSC4D"
                     /gene_synonym="S4D-SRCRB; SRCRB-S4D; SRCRB4D"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1371
                     /gene="SSC4D"
                     /gene_synonym="S4D-SRCRB; SRCRB-S4D; SRCRB4D"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1683
                     /gene="SSC4D"
                     /gene_synonym="S4D-SRCRB; SRCRB-S4D; SRCRB4D"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1761
                     /gene="SSC4D"
                     /gene_synonym="S4D-SRCRB; SRCRB-S4D; SRCRB4D"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..2800
                     /gene="SSC4D"
                     /gene_synonym="S4D-SRCRB; SRCRB-S4D; SRCRB4D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2775..2780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSC4D"
                     /gene_synonym="S4D-SRCRB; SRCRB-S4D; SRCRB4D"
                     /note="hexamer: AATAAA"
     polyA_site      2800
                     /gene="SSC4D"
                     /gene_synonym="S4D-SRCRB; SRCRB-S4D; SRCRB4D"
                     /note="major polyA site"
ORIGIN      
        1 ctttttctgg ggccgctcca gctggtgccg gccacctcca ctcccctttg cttcttgctg
       61 tccctaaggt cggatgggga caggctgggg ccaccagcca gctccatgga cagggacttt
      121 gcctctgctc accttccagc tgtggaaaga aaagaagaaa cgcctgtgtt gatttccatt
      181 tggaagatcc ttcctcctcc taaacttcca ggggcagaca aagtgattcg atcttggatt
      241 gactgtagaa gaagggacag aaagagccca gaacattccc ccagatgttc caactgtgac
      301 ttctccctgg cgccttgatg ggagcatctg aaacaccctt caccatctag atgcacaagg
      361 aagcagagat gctaattggt ccccagctgg atgagaagcg ctgggggtgg aggttgggag
      421 atgggagtgc tgcccctccc ttcctccccc aagccctgtc tttccttctc ctcctgccac
      481 tggccagcgc cctacagccc actccactgc cctttcaaga gctgaggctg gtggggggcc
      541 ccagccgctg ccggggccgc ctggaagtca tgcacggtgg ctcctggggc agcgtctgtg
      601 atgacgactg ggacgtggtg gacgccaacg tagtgtgtcg ccagctgggc tgtggcctgg
      661 cactgcccgt gccacggccc cttgcctttg gccaaggccg aggccccatc ctgctggaca
      721 acgtggagtg ccgcgggcag gaagctgcgc tgagcgagtg cggcagccgc ggctggggcg
      781 tccacaattg ctttcactac gaggatgtgg ctgtcctgtg tgatgaattc ttgccaacgc
      841 agcccccaac aaggaagatg ttaaccagta gagcacctcc tacgacactg ccgaatggaa
      901 aaagtgaggg cagcgtacgc ctggtagggg gcgcgaacct gtgtcagggc cgagtggaga
      961 tcctgcacag tggcctgtgg ggcaccgtgt gtgacgacga ctgggggctg ccggatgccg
     1021 ctgtggtctg tcgtcagctg ggctgcgggg cggccatggc cgccaccacc aacgccttct
     1081 tcggctatgg caccggacac atcctgctgg acaacgtgca ctgcgaaggc ggcgagcccc
     1141 gcctggcagc ctgccagagc ctgggctggg gtgtgcacaa ctgcggccac cacgaggacg
     1201 cgggcgcgct ctgcgcaggc ctgggtcccc caacgctcac agcactgcca tcctcagcca
     1261 caagagagga ctgggcttgg cagacagatc cgtccgctac aggagttggc ccccagcctt
     1321 cccgggagac agcactgctc accaccgccg cctgggccgc ggggaagaaa agtggacggc
     1381 tgcgactggt gggcggcccg ggtccgtgcc gcggccgcgt ggaggtgttg cacgccgggg
     1441 gctggggcac cgtgtgcgac gatgactggg actttgcgga cgcgcgcgtg gcctgccgcg
     1501 aagcgggctg cgggcctgcg ctgggcgcta cgggactggg ccacttcggc tacggccgcg
     1561 gccccgtgct gctggacaac gtgggctgcg ccggcaccga ggctcgcctg agcgactgct
     1621 tccacctggg ctggggccag cacaactgcg gccaccacga ggacgcggga gcgctctgcg
     1681 caggcccaga ggagctggga ctgcaagtcc agcaggatgg ttctgagacc acgcgggtgc
     1741 ccactcctcg gcccagggac gggcatctac gtctggtcaa tggagcccac cgatgcgagg
     1801 gacgtgtaga gctctaccta gggcaacggt ggggcactgt ctgtgatgat gcttgggacc
     1861 tgcgggcagc cggtgtcctg tgccgccagc tgggctgtgg ccaggccctc gcagcccctg
     1921 gcgaggctca ctttggccca ggccgaggcc ccattctcct ggacaatgtc aagtgccgtg
     1981 gggaagaaag tgctctgctg ctctgctctc atatccgctg ggatgcccac aactgtgacc
     2041 acagcgagga tgccagtgtc ctgtgccagc cttcatgacc cagcccgctc tgcagaccac
     2101 ctcttcttct gggagctgtg acctcccttc ctcctccagg aagccctcct cttgtgatga
     2161 ctacagttca ctttgcccct ccttcccttg cctgggagag agcctaccta gacagtgcag
     2221 tcctgcttgg gggagcctgg ctgtaccccc gtccacttac tgcgtgacct cagcctgtca
     2281 tcgactgttg tgagcccaat tcagtgaaag ctcctgtggt tttgctcagc caaaaccaaa
     2341 acgaggggaa gaggatgatt cctaactctt ctgtttggtg gggctctttt tatagcacca
     2401 gactctgcct tccttgacct agatccagga ggctcagggg ctctttaaat ggggtatctc
     2461 ctcttccccc aacccatctt gggatcccca agaagaggga aggcaggagg ggcctacagc
     2521 tcctaccttg ggccctcagg ggctgcagag gaacctgggt ccctgtcctg ccctgctccg
     2581 cgagggcctg gactaactca gatggtgctc ggctggacaa ggggactggg ggaggggcca
     2641 aagcagggac agtggcccct ccctgcagct ggaaccagca tctctgattt atgccgtctc
     2701 caccacagag cctccacttt gcaggagtga agaaccctgg gggcctgtag ccaccagttc
     2761 ataggtgcca agtcaataaa gcattgtccc ccgtctctta
//
