LOCUS       NM_032627               1725 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens single stranded DNA binding protein 4 (SSBP4),
            transcript variant 1, mRNA.
ACCESSION   NM_032627
VERSION     NM_032627.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1725)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1725)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1725)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1725)
  AUTHORS   Michailidou,K., Hall,P., Gonzalez-Neira,A., Ghoussaini,M.,
            Dennis,J., Milne,R.L., Schmidt,M.K., Chang-Claude,J., Bojesen,S.E.,
            Bolla,M.K., Wang,Q., Dicks,E., Lee,A., Turnbull,C., Rahman,N.,
            Fletcher,O., Peto,J., Gibson,L., Dos Santos Silva,I.,
            Nevanlinna,H., Muranen,T.A., Aittomaki,K., Blomqvist,C., Czene,K.,
            Irwanto,A., Liu,J., Waisfisz,Q., Meijers-Heijboer,H., Adank,M., van
            der Luijt,R.B., Hein,R., Dahmen,N., Beckman,L., Meindl,A.,
            Schmutzler,R.K., Muller-Myhsok,B., Lichtner,P., Hopper,J.L.,
            Southey,M.C., Makalic,E., Schmidt,D.F., Uitterlinden,A.G.,
            Hofman,A., Hunter,D.J., Chanock,S.J., Vincent,D., Bacot,F.,
            Tessier,D.C., Canisius,S., Wessels,L.F., Haiman,C.A., Shah,M.,
            Luben,R., Brown,J., Luccarini,C., Schoof,N., Humphreys,K., Li,J.,
            Nordestgaard,B.G., Nielsen,S.F., Flyger,H., Couch,F.J., Wang,X.,
            Vachon,C., Stevens,K.N., Lambrechts,D., Moisse,M., Paridaens,R.,
            Christiaens,M.R., Rudolph,A., Nickels,S., Flesch-Janys,D.,
            Johnson,N., Aitken,Z., Aaltonen,K., Heikkinen,T., Broeks,A.,
            Veer,L.J., van der Schoot,C.E., Guenel,P., Truong,T.,
            Laurent-Puig,P., Menegaux,F., Marme,F., Schneeweiss,A., Sohn,C.,
            Burwinkel,B., Zamora,M.P., Perez,J.I., Pita,G., Alonso,M.R.,
            Cox,A., Brock,I.W., Cross,S.S., Reed,M.W., Sawyer,E.J.,
            Tomlinson,I., Kerin,M.J., Miller,N., Henderson,B.E., Schumacher,F.,
            Le Marchand,L., Andrulis,I.L., Knight,J.A., Glendon,G.,
            Mulligan,A.M., Lindblom,A., Margolin,S., Hooning,M.J.,
            Hollestelle,A., van den Ouweland,A.M., Jager,A., Bui,Q.M.,
            Stone,J., Dite,G.S., Apicella,C., Tsimiklis,H., Giles,G.G.,
            Severi,G., Baglietto,L., Fasching,P.A., Haeberle,L., Ekici,A.B.,
            Beckmann,M.W., Brenner,H., Muller,H., Arndt,V., Stegmaier,C.,
            Swerdlow,A., Ashworth,A., Orr,N., Jones,M., Figueroa,J.,
            Lissowska,J., Brinton,L., Goldberg,M.S., Labreche,F., Dumont,M.,
            Winqvist,R., Pylkas,K., Jukkola-Vuorinen,A., Grip,M., Brauch,H.,
            Hamann,U., Bruning,T., Radice,P., Peterlongo,P., Manoukian,S.,
            Bonanni,B., Devilee,P., Tollenaar,R.A., Seynaeve,C., van
            Asperen,C.J., Jakubowska,A., Lubinski,J., Jaworska,K., Durda,K.,
            Mannermaa,A., Kataja,V., Kosma,V.M., Hartikainen,J.M.,
            Bogdanova,N.V., Antonenkova,N.N., Dork,T., Kristensen,V.N.,
            Anton-Culver,H., Slager,S., Toland,A.E., Edge,S., Fostira,F.,
            Kang,D., Yoo,K.Y., Noh,D.Y., Matsuo,K., Ito,H., Iwata,H., Sueta,A.,
            Wu,A.H., Tseng,C.C., Van Den Berg,D., Stram,D.O., Shu,X.O., Lu,W.,
            Gao,Y.T., Cai,H., Teo,S.H., Yip,C.H., Phuah,S.Y., Cornes,B.K.,
            Hartman,M., Miao,H., Lim,W.Y., Sng,J.H., Muir,K., Lophatananon,A.,
            Stewart-Brown,S., Siriwanarangsan,P., Shen,C.Y., Hsiung,C.N.,
            Wu,P.E., Ding,S.L., Sangrajrang,S., Gaborieau,V., Brennan,P.,
            McKay,J., Blot,W.J., Signorello,L.B., Cai,Q., Zheng,W.,
            Deming-Halverson,S., Shrubsole,M., Long,J., Simard,J.,
            Garcia-Closas,M., Pharoah,P.D., Chenevix-Trench,G., Dunning,A.M.,
            Benitez,J. and Easton,D.F.
  CONSRTM   Breast and Ovarian Cancer Susceptibility Collaboration; Hereditary
            Breast and Ovarian Cancer Research Group Netherlands (HEBON);
            kConFab Investigators; Australian Ovarian Cancer Study Group;
            GENICA (Gene Environment Interaction and Breast Cancer in Germany)
            Network
  TITLE     Large-scale genotyping identifies 41 new loci associated with
            breast cancer risk
  JOURNAL   Nat Genet 45 (4), 353-361 (2013)
   PUBMED   23535729
REFERENCE   5  (bases 1 to 1725)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   6  (bases 1 to 1725)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   7  (bases 1 to 1725)
  AUTHORS   Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B.,
            Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N.,
            Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S.,
            Han,J.H., Hashimoto,T., Hide,W., Hofmann,O., Kamburov,A., Kaur,M.,
            Kawaji,H., Kubosaki,A., Lassmann,T., van Nimwegen,E.,
            MacPherson,C.R., Ogawa,C., Radovanovic,A., Schwartz,A.,
            Teasdale,R.D., Tegner,J., Lenhard,B., Teichmann,S.A., Arakawa,T.,
            Ninomiya,N., Murakami,K., Tagami,M., Fukuda,S., Imamura,K., Kai,C.,
            Ishihara,R., Kitazume,Y., Kawai,J., Hume,D.A., Ideker,T. and
            Hayashizaki,Y.
  TITLE     An atlas of combinatorial transcriptional regulation in mouse and
            man
  JOURNAL   Cell 140 (5), 744-752 (2010)
   PUBMED   20211142
  REMARK    Erratum:[Cell. 2010 Apr 16;141(2):369. Kamburov, Atanas [added];
            Kaur, Mandeep [added]; MacPherson, Cameron Ross [added];
            Radovanovic, Aleksandar [added]; Schwartz, Ariel [added]]
REFERENCE   8  (bases 1 to 1725)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 1725)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   10 (bases 1 to 1725)
  AUTHORS   Castro,P., Liang,H., Liang,J.C. and Nagarajan,L.
  TITLE     A novel, evolutionarily conserved gene family with putative
            sequence-specific single-stranded DNA-binding activity
  JOURNAL   Genomics 80 (1), 78-85 (2002)
   PUBMED   12079286
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX873722.1 and BC000274.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032627.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000274.1, SRR1163658.145525.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000270061.12/ ENSP00000270061.5
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                CX873722.1         63-93
            32-1725             BC000274.1         1-1694
FEATURES             Location/Qualifiers
     source          1..1725
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..1725
                     /gene="SSBP4"
                     /note="single stranded DNA binding protein 4"
                     /db_xref="GeneID:170463"
                     /db_xref="HGNC:HGNC:15676"
                     /db_xref="MIM:607391"
     exon            1..310
                     /gene="SSBP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..1409
                     /gene="SSBP4"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="single-stranded DNA-binding protein 4 isoform a"
                     /protein_id="NP_116016.1"
                     /db_xref="CCDS:CCDS12378.1"
                     /db_xref="GeneID:170463"
                     /db_xref="HGNC:HGNC:15676"
                     /db_xref="MIM:607391"
                     /translation="MYAKGGKGSAVPSDSQAREKLALYVYEYLLHIGAQKSAQTFLSE
                     IRWEKNITLGEPPGFLHSWWCVFWDLYCAAPDRREACEHSGEAKAFQDYSAAAAPSPV
                     MGSMAPGDTMAAGSMAAGFFQGPPGSQPSPHNPNAPMMGPHGQPFMSPRFPGGPRPTL
                     RMPSQPPAGLPGSQPLLPGAMEPSPRAQGHPSMGGPMQRVTPPRGMASVGPQSYGGGM
                     RPPPNSLAGPGLPAMNMGPGVRGPWASPSGNSIPYSSSSPGSYTGPPGGGGPPGTPIM
                     PSPGDSTNSSENMYTIMNPIGQGAGRANFPLGPGPEGPMAAMSAMEPHHVNGSLGSGD
                     MDGLPKSSPGAVAGLSNAPGTPRDDGEMAAAGTFLHPFPSESYSPGMTMSV"
     exon            311..383
                     /gene="SSBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            384..445
                     /gene="SSBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            446..530
                     /gene="SSBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            531..620
                     /gene="SSBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            621..686
                     /gene="SSBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            687..746
                     /gene="SSBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            747..816
                     /gene="SSBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            817..887
                     /gene="SSBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            888..955
                     /gene="SSBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1001
                     /gene="SSBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1037
                     /gene="SSBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1092
                     /gene="SSBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1163
                     /gene="SSBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1242
                     /gene="SSBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1271
                     /gene="SSBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1379
                     /gene="SSBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1725
                     /gene="SSBP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1566..1571
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSBP4"
                     /note="hexamer: ATTAAA"
     polyA_site      1586
                     /gene="SSBP4"
     regulatory      1695..1700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSBP4"
                     /note="hexamer: AATAAA"
     polyA_site      1725
                     /gene="SSBP4"
                     /note="major polyA site"
ORIGIN      
        1 gtttcccgga acagcccgcg cggaggaaag ggaggaaaaa aagccaccct gcggccgggg
       61 ccggagctgg agccgccgct gccgccgccg ccgcggccgt ctggagctcc cccgcgcgga
      121 cgatgcctgc cgtgcccgcc tggggctcgg ggcggtgagg cccggggcgc ggggtagcta
      181 tggcgacggc aagcgcggcc cgcggcgccg cctgacaggt gtgggccccg gcggcggcgg
      241 cgtggagcag catgtacgcc aaggggggca agggttcggc cgtgccctcc gacagccagg
      301 cccgcgagaa gttggcgctg tacgtttatg agtacctgct gcacatcggt gcccagaagt
      361 cagcccagac cttcctgtct gagatccgat gggagaagaa catcacgctg ggggagcccc
      421 ctgggttcct gcactcctgg tggtgcgtct tctgggacct gtactgcgcg gcgcctgaca
      481 gaagagaggc ctgcgagcac tccggcgagg ccaaggcctt ccaggactat agtgctgcag
      541 ccgcccccag ccccgttatg gggagtatgg ccccaggtga cacaatggcc gcaggctcca
      601 tggcggctgg cttcttccag ggcccccccg gctcccagcc gtccccccac aaccccaacg
      661 cccccatgat ggggcctcac ggtcagccct tcatgtcacc gcgcttccca gggggccccc
      721 ggcccaccct gcggatgccg agtcagcctc ccgcaggcct ccctggctcc cagcccctcc
      781 tccctggcgc catggagccc tccccacgag cccaggggca tccgagcatg ggcggcccaa
      841 tgcagagggt gacgcctcct cgtggcatgg ccagcgtggg gccccagagc tatggaggtg
      901 gcatgcgacc cccacccaac tccctcgccg gcccaggcct gcctgccatg aacatgggcc
      961 caggagttcg tggcccgtgg gccagcccca gtggaaactc gatcccctac tcctcctcat
     1021 cccccggcag ctacaccgga cccccaggag gaggtgggcc ccctggaaca cccatcatgc
     1081 ctagccctgg agattccacc aactccagcg aaaacatgta cactatcatg aaccccatcg
     1141 ggcagggcgc cggcagggct aatttcccgc tcggccctgg cccggagggc cccatggccg
     1201 ccatgagcgc gatggagcct caccacgtga acggatccct gggctcgggc gacatggacg
     1261 ggttgccgaa gagttccccc ggcgccgtgg ccggcctgag caacgccccg ggcaccccgc
     1321 gggacgacgg cgagatggcg gccgccggga ccttcctgca cccgttcccg agcgaaagct
     1381 actcgccagg gatgaccatg agcgtgtgat ggggcggcag ccccgggcct ctctgcgggc
     1441 ctaggcttct gcccagcgcc cctgctcagg gcgaggggct gaggtcacac ctcgggcacc
     1501 tggactcctg gccaatcaag gcttgcccag ctgggaggcc ccacacgaaa gactcttacc
     1561 attttattaa aaacgcaagg acctcagaga cgttcttttc tgtatggacc cttcctgcca
     1621 tttgtatttt gtcccagaga gaaaggctct ttggggggcc cctctcccca ggacgtcagg
     1681 gggtggggcc cataaataaa tggaagctgg ttttggtttt tggta
//
