LOCUS       NM_145716               3252 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens single stranded DNA binding protein 3 (SSBP3),
            transcript variant 1, mRNA.
ACCESSION   NM_145716 XM_001130465
VERSION     NM_145716.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3252)
  AUTHORS   Toren,E., Kepple,J.D., Coutinho,K.V., Poole,S.O., Deeba,I.M.,
            Pierre,T.H., Liu,Y., Bethea,M.M. and Hunter,C.S.
  TITLE     The SSBP3 co-regulator is required for glucose homeostasis,
            pancreatic islet architecture, and beta-cell identity
  JOURNAL   Mol Metab 76, 101785 (2023)
   PUBMED   37536498
  REMARK    GeneRIF: The SSBP3 co-regulator is required for glucose
            homeostasis, pancreatic islet architecture, and beta-cell identity.
REFERENCE   2  (bases 1 to 3252)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3252)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3252)
  AUTHORS   Hubel,P., Urban,C., Bergant,V., Schneider,W.M., Knauer,B.,
            Stukalov,A., Scaturro,P., Mann,A., Brunotte,L., Hoffmann,H.H.,
            Schoggins,J.W., Schwemmle,M., Mann,M., Rice,C.M. and Pichlmair,A.
  TITLE     A protein-interaction network of interferon-stimulated genes
            extends the innate immune system landscape
  JOURNAL   Nat Immunol 20 (4), 493-502 (2019)
   PUBMED   30833792
REFERENCE   5  (bases 1 to 3252)
  AUTHORS   Yin,Z., Zhang,K., Peng,X., Jiang,Z., Yuan,W., Wang,Y., Li,Y.,
            Ye,X., Dong,Y., Wan,Y., Ni,B., Zhu,P., Fan,X., Wu,X. and Mo,X.
  TITLE     [SIVA1 Regulates the Stability of Single-Stranded DNA-Binding
            Protein 3 Isoforms]
  JOURNAL   Mol Biol (Mosk) 52 (5), 817-825 (2018)
   PUBMED   30363057
  REMARK    GeneRIF: SIVA1 enhances SSBP3 ubiquitination and promotes SSBP3
            protein turnover
REFERENCE   6  (bases 1 to 3252)
  AUTHORS   Dey-Guha,I., Malik,N., Lesourne,R., Love,P.E. and Westphal,H.
  TITLE     Tyrosine phosphorylation controls nuclear localization and
            transcriptional activity of Ssdp1 in mammalian cells
  JOURNAL   J Cell Biochem 103 (6), 1856-1865 (2008)
   PUBMED   18080319
  REMARK    GeneRIF: phosphorylation involving N-terminal tyrosine residues of
            Ssdp1 is a means of regulating its nuclear localization and
            subsequent transcriptional activation of LIM-HD complexes.
REFERENCE   7  (bases 1 to 3252)
  AUTHORS   Wu,L.
  TITLE     Structure and functional characterization of single-strand DNA
            binding protein SSDP1: carboxyl-terminal of SSDP1 has transcription
            activity
  JOURNAL   Biochem Biophys Res Commun 339 (3), 977-984 (2006)
   PUBMED   16325762
  REMARK    GeneRIF: Thus, biochemical data of SSDP1 presented by this study
            provides biochemical evidence for a better understanding of
            transcriptional regulation.
REFERENCE   8  (bases 1 to 3252)
  AUTHORS   Chen,L., Segal,D., Hukriede,N.A., Podtelejnikov,A.V.,
            Bayarsaihan,D., Kennison,J.A., Ogryzko,V.V., Dawid,I.B. and
            Westphal,H.
  TITLE     Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to
            regulate development
  JOURNAL   Proc Natl Acad Sci U S A 99 (22), 14320-14325 (2002)
   PUBMED   12381786
  REMARK    GeneRIF: Ssdp proteins interact with the LIM-domain-binding protein
            Ldb1 to regulate development
REFERENCE   9  (bases 1 to 3252)
  AUTHORS   Castro,P., Liang,H., Liang,J.C. and Nagarajan,L.
  TITLE     A novel, evolutionarily conserved gene family with putative
            sequence-specific single-stranded DNA-binding activity
  JOURNAL   Genomics 80 (1), 78-85 (2002)
   PUBMED   12079286
REFERENCE   10 (bases 1 to 3252)
  AUTHORS   Raval-Fernandes,S., Kickhoefer,V.A. and Rome,L.H.
  TITLE     Cloning of a cDNA encoding a sequence-specific
            single-stranded-DNA-binding protein from Rattus norvegicus
  JOURNAL   Gene 237 (1), 201-207 (1999)
   PUBMED   10524251
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL035415.22, DN602300.1, AF500116.1, BC066365.1, AL161644.6 and
            BF060746.1.
            
            On Jun 2, 2019 this sequence version replaced NM_145716.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066365.1, ERR4643895.40680.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000610401.6/ ENSP00000479674.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AL035415.22        61648-61678
            32-171              DN602300.1         33-172
            172-833             AF500116.1         1-662
            834-2001            BC066365.1         579-1746
            2002-2892           AL161644.6         11266-12156         c
            2893-3252           BF060746.1         7-366               c
FEATURES             Location/Qualifiers
     source          1..3252
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..3252
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /note="single stranded DNA binding protein 3"
                     /db_xref="GeneID:23648"
                     /db_xref="HGNC:HGNC:15674"
                     /db_xref="MIM:607390"
     exon            1..442
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             387..1553
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /note="isoform a is encoded by transcript variant 1;
                     sequence-specific single-stranded-DNA-binding protein"
                     /codon_start=1
                     /product="single-stranded DNA-binding protein 3 isoform a"
                     /protein_id="NP_663768.1"
                     /db_xref="CCDS:CCDS591.1"
                     /db_xref="GeneID:23648"
                     /db_xref="HGNC:HGNC:15674"
                     /db_xref="MIM:607390"
                     /translation="MFAKGKGSAVPSDGQAREKLALYVYEYLLHVGAQKSAQTFLSEI
                     RWEKNITLGEPPGFLHSWWCVFWDLYCAAPERRDTCEHSSEAKAFHDYSAAAAPSPVL
                     GNIPPNDGMPGGPIPPGFFQGPPGSQPSPHAQPPPHNPSSMMGPHSQPFMSPRYAGGP
                     RPPIRMGNQPPGGVPGTQPLLPNSMDPTRQQGHPNMGGSMQRMNPPRGMGPMGPGPQN
                     YGSGMRPPPNSLGPAMPGINMGPGAGRPWPNPNSANSIPYSSSSPGTYVGPPGGGGPP
                     GTPIMPSPADSTNSSDNIYTMINPVPPGGSRSNFPMGPGSDGPMGGMGGMEPHHMNGS
                     LGSGDIDGLPKNSPNNISGISNPPGTPRDDGELGGNFLHSFQNDNYSPSMTMSV"
     exon            443..515
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            516..577
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            578..662
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            663..752
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            753..833
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..893
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            894..960
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1037
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1102
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1151
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1187
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1242
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1313
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1392
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1421
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1523
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..3252
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2143..2148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /note="hexamer: AATAAA"
     polyA_site      2165
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
     polyA_site      3110
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
     regulatory      3228..3233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /note="hexamer: ATTAAA"
     polyA_site      3252
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /note="major polyA site"
ORIGIN      
        1 agaccagcgg cggcggcggc ggcggcggcg gcagcggtgc tggaggcgca gagggcggcg
       61 caggcggagc cgggcgggcg cgcgagcgag cggagagcgg gcggccgtgc gggcggcggc
      121 ggcggcaccc ccaggccgag ccggcgcgga aggagttcca gggcgatggg gccgcggccg
      181 gggctgacgc tttgacagct ggaaagagcg cggagccagc gcctgggggg gagggagggg
      241 agcgcggcga ggagagcgcc agcgagcgag agagcgagcg agcgccgggg agggggccgg
      301 gagcgagggg cagctcggga gagccggagc ggtagcggcg gcggcggcgg cggcggcgag
      361 gctcggcgcc ctcttccctg caaaccatgt ttgccaaagg caaaggctcg gcggtgccct
      421 cggatgggca ggctcgggaa aagttagctt tatacgtcta cgaatattta ctgcacgtag
      481 gagcacagaa atctgcacag accttcttat cggagattcg atgggaaaaa aacatcacgt
      541 tgggagaacc gcctgggttt ttgcactcgt ggtggtgtgt attttgggac ctttactgtg
      601 cagctcctga aaggagagac acttgtgaac attcaagtga agcaaaagcc tttcatgatt
      661 atagtgcagc agctgccccg agccccgtgc ttggcaacat tccccccaac gatgggatgc
      721 cgggaggccc catcccgcca ggtttctttc agggtcctcc ggggtcacag ccctcgccgc
      781 acgcacagcc tccacctcac aatcctagca gcatgatggg accccacagt cagcctttta
      841 tgtcaccgcg atacgcaggc ggccccaggc ccccgatcag aatgggaaac cagcctccgg
      901 gaggagttcc tgggacacag ccattgctgc ccaattctat ggatcccaca cgacaacaag
      961 gccaccccaa catgggagga tcaatgcaga gaatgaaccc tccccgaggc atggggccca
     1021 tgggtcccgg cccacagaat tacggcagcg gcatgagacc accacccaac tccctcggcc
     1081 ccgccatgcc cgggattaac atgggcccgg gagctggcag accctggccc aatcctaaca
     1141 gtgctaactc aattccatac tcctcctcat cacctggtac ctatgtggga ccccctggtg
     1201 gtggcggtcc tccaggaaca cccattatgc ccagtcccgc agattcaaca aattccagtg
     1261 acaacatcta cacaatgatt aatccagtgc cgcctggagg cagccggtcc aacttcccga
     1321 tgggtcccgg ctcggacggt ccgatgggcg gcatgggtgg catggagcca caccacatga
     1381 atggatcatt agggtcaggc gacatagacg gacttccaaa aaattctcct aacaacataa
     1441 gtggcattag caatcctcca ggcacccctc gagatgacgg cgagctagga gggaacttcc
     1501 tccactcctt tcagaacgac aattattctc caagcatgac gatgagtgtg tgatcccccc
     1561 ttctccgaga cgctgagaga gcaggcattg caggcgggaa gatgccagaa attatgcaag
     1621 aagtgaggtg tcattatcca ggagctggtg gggagggcat ctccctgctc ccctcaaccc
     1681 cctcccaccc catccacgcc ccctaccttt cccaatttta gtttcatgca ataaaaaggc
     1741 caaacttttt attccataaa acaagaagga caaaactctc aaaaatgtat ttcaagtcag
     1801 tgaccagaaa aatcccaccc cttgcccttt ccccaaagga ccttttctgt acatgacact
     1861 tttttgttgt tttttgtttg gggttttacc attgttggga tttttttatt tgttttcagg
     1921 ggggtttttt gggggaaaat ttttttaaat ggaagcttct agcaagcccc ccaccccaat
     1981 caacctctat gctttcttct taaaaaaaaa aaaaaaggaa aaaggaaaaa aaaaaaagga
     2041 aaaccagaag ccctgctgtc tgtctgtgcc caagcccttc caccagaaaa gctagtctag
     2101 gtgtgagagc ccacattgtc tgtagccatc aaaaataata ataataaact ggacagttta
     2161 caatcgttgg tttctttcaa aaggcctttt ttggaaagaa gaaaaggcag tcaccgtttt
     2221 ccacttgggg ttttggtttg tgcaacaggc aggggaggag tggggacgcg tttgttctag
     2281 cttgatttcc atggcaacag cagcggcacg cttggacccc agaacccagc accctcatcc
     2341 tgtggccaga ggggccggac cactgacccc tttcaggatt ccaccacagc ccagaccgtc
     2401 accgtgaccc ggtggcatgc actgttccca ggacaccctc ctcctctcct ggacctccct
     2461 tccgtcctgg cctccctgcc tctccagccc ctcctctgcc cccaccccag tcttcccagt
     2521 gagaatcctg ccagctgggt ggtggcctgg cgcagagtgg gagaggctgc cactgacagg
     2581 atggctatga cctgggacat ggaaacagtg acctccgcgt tctggtcccg agatcctcgc
     2641 atcagcgtca tcgtgtgcac cggcttgggg ggctggagtt ccggttttct ttgttttttc
     2701 tctttattcg tcctttctca aagatgggat actgatcaga attgctctgt atatgcttgg
     2761 gactggatgg aaagactttg gagcagctgt ggggggtggg gggacaccga caaccaaaca
     2821 gacgtgctgg ctccagtcct gtttttactt tcaaaaacca acaagcccga cagtggagcc
     2881 tgtcccctcc cgggagggtg ctcatggccc cactcacctc atcaccccac ggaaaccttt
     2941 gtgtcttgcc ctggaagaca cccgaattct ttgtacattg acatgccctt ctccttcctc
     3001 cctcccctgt agctggtctt tgttttactc cctccctttc tgatccatgt atatcatatt
     3061 atgtgagata tcatctgcct gaaaaaagac tttgtgcgga ttattgggaa cattgtagct
     3121 gtttctgtgt tttttcttac cttgtagtct ggttctgaat taagagagga aaaaaaagta
     3181 attatgatac attgtagttt gtgtacgata tatgttgata acgttttatt aaagggacat
     3241 cttttttccg ca
//
