LOCUS       NM_001394367            2996 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens single stranded DNA binding protein 3 (SSBP3),
            transcript variant 11, mRNA.
ACCESSION   NM_001394367
VERSION     NM_001394367.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2996)
  AUTHORS   Toren,E., Kepple,J.D., Coutinho,K.V., Poole,S.O., Deeba,I.M.,
            Pierre,T.H., Liu,Y., Bethea,M.M. and Hunter,C.S.
  TITLE     The SSBP3 co-regulator is required for glucose homeostasis,
            pancreatic islet architecture, and beta-cell identity
  JOURNAL   Mol Metab 76, 101785 (2023)
   PUBMED   37536498
  REMARK    GeneRIF: The SSBP3 co-regulator is required for glucose
            homeostasis, pancreatic islet architecture, and beta-cell identity.
REFERENCE   2  (bases 1 to 2996)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2996)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2996)
  AUTHORS   Hubel,P., Urban,C., Bergant,V., Schneider,W.M., Knauer,B.,
            Stukalov,A., Scaturro,P., Mann,A., Brunotte,L., Hoffmann,H.H.,
            Schoggins,J.W., Schwemmle,M., Mann,M., Rice,C.M. and Pichlmair,A.
  TITLE     A protein-interaction network of interferon-stimulated genes
            extends the innate immune system landscape
  JOURNAL   Nat Immunol 20 (4), 493-502 (2019)
   PUBMED   30833792
REFERENCE   5  (bases 1 to 2996)
  AUTHORS   Yin,Z., Zhang,K., Peng,X., Jiang,Z., Yuan,W., Wang,Y., Li,Y.,
            Ye,X., Dong,Y., Wan,Y., Ni,B., Zhu,P., Fan,X., Wu,X. and Mo,X.
  TITLE     [SIVA1 Regulates the Stability of Single-Stranded DNA-Binding
            Protein 3 Isoforms]
  JOURNAL   Mol Biol (Mosk) 52 (5), 817-825 (2018)
   PUBMED   30363057
  REMARK    GeneRIF: SIVA1 enhances SSBP3 ubiquitination and promotes SSBP3
            protein turnover
REFERENCE   6  (bases 1 to 2996)
  AUTHORS   Dey-Guha,I., Malik,N., Lesourne,R., Love,P.E. and Westphal,H.
  TITLE     Tyrosine phosphorylation controls nuclear localization and
            transcriptional activity of Ssdp1 in mammalian cells
  JOURNAL   J Cell Biochem 103 (6), 1856-1865 (2008)
   PUBMED   18080319
  REMARK    GeneRIF: phosphorylation involving N-terminal tyrosine residues of
            Ssdp1 is a means of regulating its nuclear localization and
            subsequent transcriptional activation of LIM-HD complexes.
REFERENCE   7  (bases 1 to 2996)
  AUTHORS   Wu,L.
  TITLE     Structure and functional characterization of single-strand DNA
            binding protein SSDP1: carboxyl-terminal of SSDP1 has transcription
            activity
  JOURNAL   Biochem Biophys Res Commun 339 (3), 977-984 (2006)
   PUBMED   16325762
  REMARK    GeneRIF: Thus, biochemical data of SSDP1 presented by this study
            provides biochemical evidence for a better understanding of
            transcriptional regulation.
REFERENCE   8  (bases 1 to 2996)
  AUTHORS   Chen,L., Segal,D., Hukriede,N.A., Podtelejnikov,A.V.,
            Bayarsaihan,D., Kennison,J.A., Ogryzko,V.V., Dawid,I.B. and
            Westphal,H.
  TITLE     Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to
            regulate development
  JOURNAL   Proc Natl Acad Sci U S A 99 (22), 14320-14325 (2002)
   PUBMED   12381786
  REMARK    GeneRIF: Ssdp proteins interact with the LIM-domain-binding protein
            Ldb1 to regulate development
REFERENCE   9  (bases 1 to 2996)
  AUTHORS   Castro,P., Liang,H., Liang,J.C. and Nagarajan,L.
  TITLE     A novel, evolutionarily conserved gene family with putative
            sequence-specific single-stranded DNA-binding activity
  JOURNAL   Genomics 80 (1), 78-85 (2002)
   PUBMED   12079286
REFERENCE   10 (bases 1 to 2996)
  AUTHORS   Raval-Fernandes,S., Kickhoefer,V.A. and Rome,L.H.
  TITLE     Cloning of a cDNA encoding a sequence-specific
            single-stranded-DNA-binding protein from Rattus norvegicus
  JOURNAL   Gene 237 (1), 201-207 (1999)
   PUBMED   10524251
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL035415.22 and AL161644.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               AL035415.22        54552-54686
            136-208             AL035415.22        63112-63184
            209-270             AL035415.22        63405-63466
            271-355             AL035415.22        66097-66181
            356-523             AL035415.22        128889-129056
            524-613             AL161644.6         66912-67001         c
            614-673             AL161644.6         42601-42660         c
            674-740             AL161644.6         37268-37334         c
            741-817             AL161644.6         37090-37166         c
            818-882             AL161644.6         28709-28773         c
            883-931             AL161644.6         27638-27686         c
            932-986             AL161644.6         26379-26433         c
            987-1057            AL161644.6         24603-24673         c
            1058-1136           AL161644.6         14222-14300         c
            1137-1165           AL161644.6         13923-13951         c
            1166-1267           AL161644.6         13729-13830         c
            1268-2996           AL161644.6         10906-12634         c
FEATURES             Location/Qualifiers
     source          1..2996
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..2996
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /note="single stranded DNA binding protein 3"
                     /db_xref="GeneID:23648"
                     /db_xref="HGNC:HGNC:15674"
                     /db_xref="MIM:607390"
     exon            1..135
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            136..208
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            209..270
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            271..355
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            356..523
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            524..613
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             578..1297
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /note="isoform j is encoded by transcript variant 11;
                     sequence-specific single-stranded-DNA-binding protein"
                     /codon_start=1
                     /product="single-stranded DNA-binding protein 3 isoform j"
                     /protein_id="NP_001381296.1"
                     /db_xref="GeneID:23648"
                     /db_xref="HGNC:HGNC:15674"
                     /db_xref="MIM:607390"
                     /translation="MPGGPIPPGFFQPFMSPRYAGGPRPPIRMGNQPPGGVPGTQPLL
                     PNSMDPTRQQGHPNMGGSMQRMNPPRGMGPMGPGPQNYGSGMRPPPNSLGPAMPGINM
                     GPGAGRPWPNPNSANSGPPGGGGPPGTPIMPSPADSTNSSDNIYTMINPVPPGGSRSN
                     FPMGPGSDGPMGGMGGMEPHHMNGSLGSGDIDGLPKNSPNNISGISNPPGTPRDDGEL
                     GGNFLHSFQNDNYSPSMTMSV"
     exon            614..673
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            674..740
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            741..817
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..882
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            883..931
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..986
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1057
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1136
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1165
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1267
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..2996
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1887..1892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /note="hexamer: AATAAA"
     polyA_site      1909
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
     polyA_site      2854
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
     regulatory      2972..2977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /note="hexamer: ATTAAA"
     polyA_site      2996
                     /gene="SSBP3"
                     /gene_synonym="CSDP; SSDP; SSDP1"
                     /note="major polyA site"
ORIGIN      
        1 ctctggagct ccttttactc tggaaagaac atgacagaca tcctctgccc ttcagcctgt
       61 gccccagaat gagagaccca tgggacagac tcaagctgta ccctgaagca gagctgccca
      121 gttgactgca gacctgttag ctttatacgt ctacgaatat ttactgcacg taggagcaca
      181 gaaatctgca cagaccttct tatcggagat tcgatgggaa aaaaacatca cgttgggaga
      241 accgcctggg tttttgcact cgtggtggtg tgtattttgg gacctttact gtgcagctcc
      301 tgaaaggaga gacacttgtg aacattcaag tgaagcaaaa gcctttcatg attatattgc
      361 accaaatggt gataggtgaa gggtctctgg agagggcagg atactttgga ggctggaatt
      421 gaaccatgtt gtcttaatcc agagcctgtg ggagagagaa ggcccatgaa agcactctgc
      481 agactgtaaa gtgctacatg aaataaaagg catgtgagaa aagagtgcag cagctgcccc
      541 gagccccgtg cttggcaaca ttccccccaa cgatgggatg ccgggaggcc ccatcccgcc
      601 aggtttcttt cagcctttta tgtcaccgcg atacgcaggc ggccccaggc ccccgatcag
      661 aatgggaaac cagcctccgg gaggagttcc tgggacacag ccattgctgc ccaattctat
      721 ggatcccaca cgacaacaag gccaccccaa catgggagga tcaatgcaga gaatgaaccc
      781 tccccgaggc atggggccca tgggtcccgg cccacagaat tacggcagcg gcatgagacc
      841 accacccaac tccctcggcc ccgccatgcc cgggattaac atgggcccgg gagctggcag
      901 accctggccc aatcctaaca gtgctaactc aggaccccct ggtggtggcg gtcctccagg
      961 aacacccatt atgcccagtc ccgcagattc aacaaattcc agtgacaaca tctacacaat
     1021 gattaatcca gtgccgcctg gaggcagccg gtccaacttc ccgatgggtc ccggctcgga
     1081 cggtccgatg ggcggcatgg gtggcatgga gccacaccac atgaatggat cattagggtc
     1141 aggcgacata gacggacttc caaaaaattc tcctaacaac ataagtggca ttagcaatcc
     1201 tccaggcacc cctcgagatg acggcgagct aggagggaac ttcctccact cctttcagaa
     1261 cgacaattat tctccaagca tgacgatgag tgtgtgatcc ccccttctcc gagacgctga
     1321 gagagcaggc attgcaggcg ggaagatgcc agaaattatg caagaagtga ggtgtcatta
     1381 tccaggagct ggtggggagg gcatctccct gctcccctca accccctccc accccatcca
     1441 cgccccctac ctttcccaat tttagtttca tgcaataaaa aggccaaact ttttattcca
     1501 taaaacaaga aggacaaaac tctcaaaaat gtatttcaag tcagtgacca gaaaaatccc
     1561 accccttgcc ctttccccaa aggacctttt ctgtacatga cacttttttg ttgttttttg
     1621 tttggggttt taccattgtt gggatttttt tatttgtttt caggggggtt ttttggggga
     1681 aaattttttt aaatggaagc ttctagcaag ccccccaccc caatcaacct ctatgctttc
     1741 ttcttaaaaa aaaaaaaaaa ggaaaaagga aaaaaaaaaa aggaaaacca gaagccctgc
     1801 tgtctgtctg tgcccaagcc cttccaccag aaaagctagt ctaggtgtga gagcccacat
     1861 tgtctgtagc catcaaaaat aataataata aactggacag tttacaatcg ttggtttctt
     1921 tcaaaaggcc ttttttggaa agaagaaaag gcagtcaccg ttttccactt ggggttttgg
     1981 tttgtgcaac aggcagggga ggagtgggga cgcgtttgtt ctagcttgat ttccatggca
     2041 acagcagcgg cacgcttgga ccccagaacc cagcaccctc atcctgtggc cagaggggcc
     2101 ggaccactga cccctttcag gattccacca cagcccagac cgtcaccgtg acccggtggc
     2161 atgcactgtt cccaggacac cctcctcctc tcctggacct cccttccgtc ctggcctccc
     2221 tgcctctcca gcccctcctc tgcccccacc ccagtcttcc cagtgagaat cctgccagct
     2281 gggtggtggc ctggcgcaga gtgggagagg ctgccactga caggatggct atgacctggg
     2341 acatggaaac agtgacctcc gcgttctggt cccgagatcc tcgcatcagc gtcatcgtgt
     2401 gcaccggctt ggggggctgg agttccggtt ttctttgttt tttctcttta ttcgtccttt
     2461 ctcaaagatg ggatactgat cagaattgct ctgtatatgc ttgggactgg atggaaagac
     2521 tttggagcag ctgtgggggg tggggggaca ccgacaacca aacagacgtg ctggctccag
     2581 tcctgttttt actttcaaaa accaacaagc ccgacagtgg agcctgtccc ctcccgggag
     2641 ggtgctcatg gccccactca cctcatcacc ccacggaaac ctttgtgtct tgccctggaa
     2701 gacacccgaa ttctttgtac attgacatgc ccttctcctt cctccctccc ctgtagctgg
     2761 tctttgtttt actccctccc tttctgatcc atgtatatca tattatgtga gatatcatct
     2821 gcctgaaaaa agactttgtg cggattattg ggaacattgt agctgtttct gtgttttttc
     2881 ttaccttgta gtctggttct gaattaagag aggaaaaaaa agtaattatg atacattgta
     2941 gtttgtgtac gatatatgtt gataacgttt tattaaaggg acatcttttt tccgca
//
