LOCUS       NM_001256732            8865 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens single stranded DNA binding protein 2 (SSBP2),
            transcript variant 1, mRNA.
ACCESSION   NM_001256732
VERSION     NM_001256732.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8865)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 8865)
  AUTHORS   Schwab,C., Roberts,K., Boer,J.M., Gohring,G., Steinemann,D.,
            Vora,A., Macartney,C., Hough,R., Thorn,Z., Dillon,R., Escherich,G.,
            Cazzaniga,G., Schlegelberger,B., Loh,M., den Boer,M.L.,
            Moorman,A.V. and Harrison,C.J.
  TITLE     SSBP2-CSF1R is a recurrent fusion in B-lineage acute lymphoblastic
            leukemia with diverse genetic presentation and variable outcome
  JOURNAL   Blood 137 (13), 1835-1838 (2021)
   PUBMED   33197935
  REMARK    GeneRIF: SSBP2-CSF1R is a recurrent fusion in B-lineage acute
            lymphoblastic leukemia with diverse genetic presentation and
            variable outcome.
REFERENCE   3  (bases 1 to 8865)
  AUTHORS   Lawson,T., El-Kamand,S., Boucher,D., Duong,D.C., Kariawasam,R.,
            Bonvin,A.M.J.J., Richard,D.J., Gamsjaeger,R. and Cubeddu,L.
  TITLE     The structural details of the interaction of single-stranded DNA
            binding protein hSSB2 (NABP1/OBFC2A) with UV-damaged DNA
  JOURNAL   Proteins 88 (2), 319-326 (2020)
   PUBMED   31443132
  REMARK    GeneRIF: The structural details of the interaction of
            single-stranded DNA binding protein hSSB2 (NABP1/OBFC2A) with
            UV-damaged DNA.
REFERENCE   4  (bases 1 to 8865)
  AUTHORS   Wang,H., Kim,J., Wang,Z., Yan,X.X., Dean,A. and Xu,W.
  TITLE     Crystal structure of human LDB1 in complex with SSBP2
  JOURNAL   Proc Natl Acad Sci U S A 117 (2), 1042-1048 (2020)
   PUBMED   31892537
  REMARK    GeneRIF: Single-stranded DNA binding proteins (SSBPs) interact
            specifically with the LDB/Chip conserved domain (LCCD) of LDB
            proteins and stabilize LDBs by preventing their proteasomal
            degradation, thus promoting their functions in gene regulation.
REFERENCE   5  (bases 1 to 8865)
  AUTHORS   Kim,H., Kim,Y., Bang,S., Park,S., Jee,S., Sim,J., Shin,S.J.,
            Paik,S.S. and Jang,K.
  TITLE     Low Expression of Single-stranded DNA Binding Protein 2 (SSBP2)
            Predicts Unfavourable Postoperative Outcomes in Patients With Clear
            Cell Renal Cell Carcinoma
  JOURNAL   In Vivo 34 (1), 101-107 (2020)
   PUBMED   31882468
  REMARK    GeneRIF: CcRCC with low SSBP2 expression was associated with
            adverse clinicopathological characteristics and poor patient
            outcomes.
REFERENCE   6  (bases 1 to 8865)
  AUTHORS   Fleisig,H.B., Orazio,N.I., Liang,H., Tyler,A.F., Adams,H.P.,
            Weitzman,M.D. and Nagarajan,L.
  TITLE     Adenoviral E1B55K oncoprotein sequesters candidate leukemia
            suppressor sequence-specific single-stranded DNA-binding protein 2
            into aggresomes
  JOURNAL   Oncogene 26 (33), 4797-4805 (2007)
   PUBMED   17311003
  REMARK    GeneRIF: Results suggest that subverting SSBP2 function by
            oncoprotein E1B55K may contribute to cell transformation by viral
            oncoproteins.
REFERENCE   7  (bases 1 to 8865)
  AUTHORS   Liang,H., Samanta,S. and Nagarajan,L.
  TITLE     SSBP2, a candidate tumor suppressor gene, induces growth arrest and
            differentiation of myeloid leukemia cells
  JOURNAL   Oncogene 24 (16), 2625-2634 (2005)
   PUBMED   15782145
  REMARK    GeneRIF: Our findings are consistent with human SSBP2 being a novel
            regulator of hematopoietic growth and differentiation, whose loss
            confers a block in differentiation advantage to myeloid leukemic
            cells.
REFERENCE   8  (bases 1 to 8865)
  AUTHORS   Castro,P., Liang,H., Liang,J.C. and Nagarajan,L.
  TITLE     A novel, evolutionarily conserved gene family with putative
            sequence-specific single-stranded DNA-binding activity
  JOURNAL   Genomics 80 (1), 78-85 (2002)
   PUBMED   12079286
  REMARK    GeneRIF: Member of a closely related, evolutionarily conserved, and
            ubiquitously expressed gene family, potential tumor suppressor
REFERENCE   9  (bases 1 to 8865)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   10 (bases 1 to 8865)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC016562.7, AC093250.3,
            AC026419.5 and AC010623.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 15, 2021 this sequence version replaced NM_001256732.2.
            
            Summary: This gene encodes a subunit of a protein complex that
            interacts with single-stranded DNA and is involved in the DNA
            damage response and maintenance of genome stability. The encoded
            protein may also play a role in telomere repair. A variant of this
            gene may be associated with survival in human glioblastoma
            patients. [provided by RefSeq, Sep 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.207332.1,
                                           SRR1803614.180999.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000615665.5/ ENSP00000483921.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               AC016562.7         135698-135814       c
            118-190             AC016562.7         34984-35056         c
            191-252             AC093250.3         9603-9664
            253-337             AC093250.3         30664-30748
            338-427             AC026419.5         64298-64387
            428-487             AC026419.5         88706-88765
            488-554             AC010623.10        11782-11848
            555-625             AC010623.10        12574-12644
            626-717             AC010623.10        19279-19370
            718-766             AC010623.10        25241-25289
            767-802             AC010623.10        37519-37554
            803-857             AC010623.10        39422-39476
            858-928             AC010623.10        43621-43691
            929-1007            AC010623.10        45708-45786
            1008-1036           AC010623.10        48886-48914
            1037-1135           AC010623.10        57661-57759
            1136-8865           AC010623.10        65811-73540
FEATURES             Location/Qualifiers
     source          1..8865
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q14.1"
     gene            1..8865
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /note="single stranded DNA binding protein 2"
                     /db_xref="GeneID:23635"
                     /db_xref="HGNC:HGNC:15831"
                     /db_xref="MIM:607389"
     exon            1..117
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1165
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sequence-specific single-stranded-DNA-binding protein 2"
                     /codon_start=1
                     /product="single-stranded DNA-binding protein 2 isoform 1"
                     /protein_id="NP_001243661.1"
                     /db_xref="CCDS:CCDS75268.1"
                     /db_xref="GeneID:23635"
                     /db_xref="HGNC:HGNC:15831"
                     /db_xref="MIM:607389"
                     /translation="MYGKGKSNSSAVPSDSQAREKLALYVYEYLLHVGAQKSAQTFLS
                     EIRWEKNITLGEPPGFLHSWWCVFWDLYCAAPERRETCEHSSEAKAFHDYSAAAAPSP
                     VLGNIPPGDGMPVGPVPPGFFQPFMSPRYPGGPRPPLRIPNQALGGVPGSQPLLPSGM
                     DPTRQQGHPNMGGPMQRMTPPRGMVPLGPQSDPWLSLQNYGGAMRPPLNALGGPGMPG
                     MNMGPGGGRPWPNPTNANSIPYSSASPGNYVGPPGGGGPPGTPIMPSPADSTNSGDNM
                     YTLMNAVPPGPNRPNFPMGPGSDGPMGGLGGMESHHMNGSLGSGDMDSISKNSPNNMS
                     LSNQPGTPRDDGEMGGNFLNPFQSESYSPSMTMSV"
     exon            118..190
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            191..252
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            253..337
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            338..427
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            428..487
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            488..554
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            555..625
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            626..717
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            718..766
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            767..802
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            803..857
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            858..928
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1007
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1036
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1135
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..8865
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1705..1710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /note="hexamer: AATAAA"
     regulatory      1732..1737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /note="hexamer: ATTAAA"
     polyA_site      1737
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /note="major polyA site"
     polyA_site      1756
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
     regulatory      8251..8256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /note="hexamer: AATATA"
     polyA_site      8273
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
     regulatory      8473..8478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /note="hexamer: CATAAA"
     polyA_site      8500
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
     regulatory      8531..8536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /note="hexamer: AATACA"
     polyA_site      8550
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
     regulatory      8840..8845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
                     /note="hexamer: ATTAAA"
     polyA_site      8865
                     /gene="SSBP2"
                     /gene_synonym="HSPC116; SOSS-B2"
ORIGIN      
        1 gaggctgtga tgggttgaca ggtgcgtgac agtgggagct gctctcggca caagcatgta
       61 cggcaaaggc aagagtaaca gcagcgccgt cccgtccgac agccaggccc gggagaagtt
      121 agcactctac gtatatgaat atctgctcca tgtaggagct cagaaatcag ctcaaacatt
      181 tttatcagag ataagatggg aaaaaaacat cacattgggg gaaccaccag gattcttaca
      241 ttcttggtgg tgtgtatttt gggatctcta ctgtgcagct ccagagagac gtgaaacatg
      301 tgaacactca agtgaagcaa aagccttcca tgattacagt gctgcagcag ctcccagtcc
      361 agtgctagga aacattcccc caggagatgg catgccagta ggtcctgtac caccagggtt
      421 ctttcagcct tttatgtcac ctcggtaccc tggaggtcca aggcccccat tgaggatacc
      481 taatcaggca cttggaggtg tcccaggaag tcagccatta ctccccagtg gaatggatcc
      541 aactcgacaa caaggacatc caaatatggg tgggccaatg cagagaatga ctcctccaag
      601 aggaatggtg cccttaggac cacagtctga cccttggtta tcattacaga actatggagg
      661 tgcaatgaga cccccactga atgctttagg tggccctgga atgcctggaa tgaacatggg
      721 tccaggtggt ggtagacctt ggccaaaccc aacaaatgcc aattcaatac catactcctc
      781 agcatctcct gggaattatg taggtcctcc aggaggtgga gggccaccag gaacacccat
      841 catgcctagt ccagcagatt caaccaactc tggtgataac atgtatactt taatgaatgc
      901 agtacctcct ggacctaaca gacctaattt tccaatgggt cctgggtcag atggtcccat
      961 gggtggatta ggaggaatgg agtcacatca catgaatggc tctttaggct caggagatat
     1021 ggacagtatt tccaagaatt ctcccaataa tatgagcctg agtaatcaac cgggcactcc
     1081 aagggatgat ggcgaaatgg ggggaaattt cttaaatcct tttcagagtg agagttactc
     1141 ccctagcatg acaatgagcg tgtgatccat taccaagtct cctcatgaaa accacagtga
     1201 gtcagccctt cacagaacta ctacggaaga aaattattca tcacagtgta cagttaaaca
     1261 aaggaatctc agtcacacca aaccaacctt tttatttcct gctctctccc ctcttttgtg
     1321 aagaaagcgg gtccaaatgt gattcaaaca actgtacgga gtggcatatt agaattgccc
     1381 taaactgaac tgcaaataat tatgtgtgta tgtatatgtg tgggaaagag aatgtactgt
     1441 atatgtgtat gttatacaga catatacaca tacatacatt gacccacagg acattgtaaa
     1501 atattatcac atgacatctt aagtagaaat aagtagggac ttttattcca tccttttttt
     1561 cacgtttaca ttttaattat tacaagttgc tcctgccccc tccctgaact attttgtgct
     1621 gtgtatatca ctgctttata taagttattt tttaaggtga actcagatgt tatggttttg
     1681 taaatgtctg caatcatgga taggaataaa atcgcttatt tgagagcttt cattaaattg
     1741 cgtctgatgc aagttatcct gtgaatcaca aagtgtactg tctcaaaaaa tagaagaaaa
     1801 tgtgtcttcg tctttatgtt gaatcaaaca atttctcagt taccttcagt gaaaagtatt
     1861 tttttaattt ttatttgaga aaaacacttc aaatcagtaa aagcttaact ggggcctcac
     1921 acagtatatt tctgcaataa ctgctttaaa cggagttctt gatttgtttg tcttagatga
     1981 tacagaaatc attaaatagc ccaaatcatt tagaccatag caataaagtg accggggttg
     2041 tcatatattt agcaacatct tttctcttta acatgatgaa gcccaaaagt gataacaaaa
     2101 gcatttgctt gaatttgtca cttctcacca ggagtactag aggtaaattt ttaataacat
     2161 actaatgtga aatggtatct ggtttttatt cagacttttt gtgagcatat tcttatagac
     2221 actagaaata aatacataga aggagacttt gagcacaagg gagaagagag ttattagcac
     2281 tcctgaggcc tctggaatgc tgcttttcta tccaggtatc ttgcttgcta ccagcagaat
     2341 tgactggtat tggttctcac tggccaggga gcctctgctc tgttcctgga atataaggct
     2401 tttattcagg agcaaatcat tgatagtaac tttgctttat ctagccattg acttcagcag
     2461 gctaaaacta cattgtgtaa ctgactgttc aaaaaagaat aagtaaattt tttttaatct
     2521 aattccctta tggaaagcac cttgctctat ggcactttcc agatcttttg ggattttgtg
     2581 cttaattata catacataca ccaaaatcac aatagaaaga tatgaagact ttaattttag
     2641 actctgaaag ataactgggt gatcctttgt gttaaaattg tgatacaaac aaccattgat
     2701 aaataccaac tatgaatcca aactctagag actttgaaaa gcattgttta attgcaggta
     2761 agaggaatct tctctttcct ttaggcttat agtctctaaa gtgaaaattt ggcaggatat
     2821 agtcatgcag ctcataatga cattccaatc aaccacagac tgcatataca gcagtggtcc
     2881 tataagatta taataccata tttttagcat atcttttcta tgcttagata cacaaatacc
     2941 attgtattac agttgccttt ggtattcagt acagtaacat gctgtacagg tttgtagcct
     3001 aggagcaata gtttatatta tatagcctag gtgtgtagga gcctatacca tctaggtttg
     3061 tgtaagtaca ctctatgatg ttcagacaag gacaatattg cctgacaatg catttctcag
     3121 aatgtatact tatcattaag taacatatga ctgtatgtac tagttcctga tgacttactt
     3181 ctctcaaatt cataatgatt tagtccttgt aaaaataaag attttgcctg tgcctaaaca
     3241 gggatactag gcagaactgt tgagaaaaaa aagctgaatt aaatttatgt tgcagattta
     3301 aactatcata aaatgagcct cagttaatca cacacagtat tcaggtgcct aggagtgcac
     3361 accggagaac agcctcatgc tgtcaagctg cagaaacctt tcatgcaaat tcagatgaaa
     3421 aggtctttac ctcaagccag ggtaacctga atgaaggtga tagtttgtcc agacacctga
     3481 ctttaccaag aagaattttg actttcatat tttatgacaa tcatataaaa attgacagtc
     3541 ctttgattat taagcttaat cttataatgc tagaattttc aaatattttg ttgactcttc
     3601 tccattgtta ccgatcttga aattcttttc ttcgccttct gagaaggtat tatttcttat
     3661 cacaaagaat gatgaatatg attttatcta cccttatttt gggggtaata cgagaatatg
     3721 aattgcatca tgatccccat tatttctaac ctaaaagtaa aattcgtttt ttttttcaag
     3781 gcagagcagt caattgatta taagtattta tttctttttt cttcttggag cccagattaa
     3841 aaagagttat tttagattta aaaatttcct gaaatagttg aaaaattatt tttgaggaga
     3901 aaattgtatc caagaaaccc agaatgtaag gatacttgat ttttatatcc agataattct
     3961 ttcatgcact gaatggaaga cagtatatct gtatattaat ttttgtttag attttgaatc
     4021 atttaaccct tatccttttt tcttgtaata agactattta atgtttttct cttgtgtttt
     4081 ccatctttat caatgcattc gtgttggtct tgatgtatac tacctgttcc tagtgttatt
     4141 tttacacgtc atctcacagt aataatatca gcaattcttg ctgcattgaa catattaaat
     4201 acacatgtaa aatgaaaaag taagcagtag gtaaaatctt gttactctgc tttgcattct
     4261 gcctaactca ctgcatttga aaatacatgt caaattcttt ctgagggtat gtatgattct
     4321 taactacgtg tcttacagca aagttgccca tgggaacaaa ggctgtaggg tgtcattgat
     4381 cttgtaatac aacacatatt tgatgggtga atcttattag cactcctttg aaaatgttcc
     4441 agtatggagt cagttgctga taaagaggaa gttcacagct aggaatccga agttaagatt
     4501 tctcaattgc cgcctgggca ctcatgcctg taatcccagc acttgggagg ccaaggtggg
     4561 cagatcacct gaggtcggga gttcaagacc agcctggcca acctggtgaa acccccccat
     4621 ctctactaaa aatacaaaaa ttagccaggt atggtggtgg ctgcctgtaa tcccagctac
     4681 tcaagaggct gaggcgggag aatcacttga acccaggagg cggaggttgc agtgagccga
     4741 gattgtgcca ctgcactcca gcctgggtga cagagcaaga ctccatctca aaaatagaaa
     4801 agatttctca attgccaaaa agattaacaa gtaaatcaat tctgctcccc cagccatgaa
     4861 aagtgcccaa aacagccctt tccctccaga ataaaataaa acttccattt ctatttttat
     4921 gattctctaa gatatctgaa ctccattgca tttcataggg ttattcagtt agcacttctg
     4981 tggtttaaaa gacaacaaat gaaaataagt aagttcagtt tggggcatga agaagtccca
     5041 catctgtcta tatcttttct tcatcatatt gtccctagga atgtatagca aagcattcag
     5101 aactgctcct ttggctgggg aagttttcca ccgtccttaa tactatgaag tcttgattac
     5161 ttcttccgtg gctttatcct tgcctccctc ccaatccctg catcttccag gagaaataaa
     5221 ataccaactg aacactgtta ccttctcagc ccttaccatt ttcatctgca tatagtgtat
     5281 agtactaaga gtagttttcc caggagaaat aattgcaatt ttcatttctt gattatcact
     5341 gctaattcga aggagtgcca caaatcatag ccacttgatt ttgattttgg aatgcatttt
     5401 agtgttttga cactggtttt cctttttttt aaattttttt ttcttttttt tttttgagac
     5461 agtcttgctc tgtcacccag gctggagtgc agtggcacaa tcttggctca ctgccgtctc
     5521 cgcctcccag gttccagaga ttctcctgcc tcagcctcca gagtagctgg attacaggca
     5581 tgcgtcacag gctaattttt gtatttttag tagaggcagg gtttcaccat gttggccagg
     5641 ctggtctgga actcctgacc tcaagtgatc tgcccgcctc agcctcccaa agtgctggga
     5701 ttacaggcat gagccactat gcttgatcag gttttcctct tttttttttt tttttttgag
     5761 tcagaatctt gctctgtcac ccaggctgga gtgcaatggt gtgatctcgg ctcactgcaa
     5821 ccttcacctc ccgggttcat gcaattctcc tgcctcagcc tcccgagtgg ctgggactac
     5881 aggtgctcac caccatgccc agctaatttt ttgtattttt agtagagacc gggtttcacc
     5941 gtgttagcca ggatggtctc gatctcctga cctcgtgatc cacccgcctt ggcctcccaa
     6001 agtgttggga ttacaggcat gagccaccgt acctggccca ggttttcctt tttttttatg
     6061 tcttctgtac aatagagttg gccctccata tccacaggtt ccacatccct gattcaatca
     6121 actcctgata aaaaatattg gaaaaaattt ttataacaat aaaaaccaat aatacaacaa
     6181 taattacaaa taatacattg taacaatgat ttccatggca tttataatac attgtattag
     6241 gtattataag taaacgagat gatttgaagt atattggagg atgtgcatag gttatactat
     6301 gccgttttat ataaaggact taagcgtctg tggattttgg tatctgcaga ggtcctggaa
     6361 ccggtctccc ttggatacgg agggacaact gtagttctct gtctttgaaa acattaatcg
     6421 atacaagtgg ccagtgaatg tatagtatgg gagggagtaa tccagtatgg gggacaaggt
     6481 tgccatatat ttgccaaaag tagttgaatc ttctttctgt ttttccctcc tggtggaata
     6541 agtttattgt ttgctatgag gagccagagg ctgtgtttgt ttaaagcaat ggtacccaat
     6601 cttaagcatg tgtaaaggtc tccctgggtc tgtgaaccat accttgagaa ataactagaa
     6661 aagtaaaaga atggtgaacc actattaata atacttccat tttgcatact aaatatgttg
     6721 cgtgtacctg tgtgtgtgtg ttgggaatag taatatgaag tttgctcaca aaacactccc
     6781 actgtgattc acattatttt atagcacaac caataatgat taaacataat tatttccttt
     6841 gactactttt catttcagtg gtaaaacagc tgatgaaagt tatttgggat ggaaagagta
     6901 atacaagaca tacgcagatg gagtctcctg tgcgtaggtt tagcacaccc atgttagctt
     6961 gtccacatta ggccttcttt tgaaggtact gtatctaaag ataagggcat aagtgatcat
     7021 ttaattctca gccacttcac tgatactaca aggtgttaca cagtaattat agtggtttga
     7081 tacagacatt tgtttacaag aaactgaatt ggcattatta acttatttca cacaaaaaaa
     7141 gttagcttta cccatgaact gtaattcaga ttgataaggt gacctaccca tgaaaaagac
     7201 acctgagacc tgtttacttt tttaaactat gaagtgaaat cctcagttca ataagtgtcc
     7261 caaggagaat ttcctctgtt aaattttccc tgttaactta gtataattgg ttttcttgaa
     7321 tagaagaata atgatttctg taagatattt taatgtgaat atttttgctg tcttcatctt
     7381 taaaaattaa atacagtact atatatagat attaaaattt taaagtggga ctaggtgttt
     7441 ttatgtatac aattacagtt tgtctcctct ctttgcaaat ttactggcta ttatcagaat
     7501 aaaggttgga ctcattttgc ttatcccagt cattaaaatg ttgtgatctg tttctaacat
     7561 atttagcatt tcatttttaa aatgagatgt gccattatca taacaaaggc aactattaat
     7621 gttcctagaa aaaatgatgt aaaggactta ctcctagtca atattaacac ttaatcccac
     7681 tttctttttt ccaccaaatg gcctcagtac attgccaaga gagtgaaatt tggattcctc
     7741 acagtactca gaacacaata tgatatttgt cagctaactt tccatcatgt cttggtaaaa
     7801 ttgctcagtt aaatataatt ggccatctac ttattaaaaa acaattcaaa taatctgtac
     7861 agttaccata atttgacaac aaattacttt aaatttagca ccatcttaga aatcttctta
     7921 atataaacta ctgattgaaa tgtgtttata ctttctatca tatttcaaac tgttttactt
     7981 tccttgcatt aagacaatta aaacacaaac tacatgttag aatgaataat ttaaaggaca
     8041 tgctgctgtt tcagcataaa aaatggtaaa gtctttataa atagaatact tatgatagcc
     8101 attaacgtat tgaattgttt aattaaccta gttgtgattt tccgaattta agacgttttc
     8161 ttactacatg tgttaaattg ttacctataa tatcttcctg gaaaaataga agtatttgta
     8221 aggtttttat aaatgcacaa tttatgtata aatataattg gaatctggga tgactcttag
     8281 taatctacta ttcttaattc aacgatggcc accagctacc tgacacattt tgtaaattta
     8341 gcatctgtgt atgtgtgttc gtgtatgtgt gtgtgcgtgc atgtgcacat tactgcattt
     8401 attctcaaat ggatttataa tttagtgttt ttgtacaagt acttgagcta ttcatgtaat
     8461 gggataagtt gccataaaga tgtacataaa tgacccttaa tttggcacgt tttcacattt
     8521 aattttttaa aatacagctt ttcatataca gttcctaccc tttcatttct agcctgtact
     8581 tcattacttg ttgaaaaagt caagtttgta tgaagccagc ataaacatca aaatataact
     8641 aatgtggaca tctgtgtata taattgaatt agacattatg ccttatataa aattcaggag
     8701 gttctaatat caaaggatct atatgcatgg aagaagaggc tacaatgcat atatcaatgg
     8761 ctggctctat gtggtcagat aactaaacat ggaatgccaa aaaaaaacta atgttattag
     8821 caaatagata tgttaatgaa ttaaactttg gtattttact gcaaa
//
