LOCUS       NM_003142               1650 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens small RNA binding exonuclease protection factor La
            (SSB), transcript variant 1, mRNA.
ACCESSION   NM_003142
VERSION     NM_003142.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1650)
  AUTHORS   Kao,T.L., Huang,Y.C., Chen,Y.H., Baumann,P. and Tseng,C.K.
  TITLE     LARP3, LARP7, and MePCE are involved in the early stage of human
            telomerase RNA biogenesis
  JOURNAL   Nat Commun 15 (1), 5955 (2024)
   PUBMED   39009594
  REMARK    GeneRIF: LARP3, LARP7, and MePCE are involved in the early stage of
            human telomerase RNA biogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1650)
  AUTHORS   Wu,H., Zhang,Z., Han,X., Zhang,S., Zhang,J., Han,P., Zhang,Y.,
            Bai,Y. and Zhang,Y.
  TITLE     Upregulated SSB Is Involved in Hepatocellular Carcinoma Progression
            and Metastasis through the Epithelial-Mesenchymal Transition,
            Antiapoptosis, and Altered ROS Level Pathway
  JOURNAL   Oxid Med Cell Longev 2023, 5207431 (2023)
   PUBMED   36785788
  REMARK    GeneRIF: Upregulated SSB Is Involved in Hepatocellular Carcinoma
            Progression and Metastasis through the Epithelial-Mesenchymal
            Transition, Antiapoptosis, and Altered ROS Level Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1650)
  AUTHORS   Argyriou,A.I., Machaliotis,G.A., Makrynitsa,G.I., Kaliatsi,E.G.,
            Stathopoulos,C. and Spyroulias,G.A.
  TITLE     NMR Analysis Suggests Synergy between the RRM2 and the
            Carboxy-Terminal Segment of Human La Protein in the Recognition and
            Interaction with HCV IRES
  JOURNAL   Int J Mol Sci 24 (3), 2572 (2023)
   PUBMED   36768895
  REMARK    GeneRIF: NMR Analysis Suggests Synergy between the RRM2 and the
            Carboxy-Terminal Segment of Human La Protein in the Recognition and
            Interaction with HCV IRES.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1650)
  AUTHORS   Staudacher,A.H., Li,Y., Liapis,V. and Brown,M.P.
  TITLE     The RNA-binding protein La/SSB associates with radiation-induced
            DNA double-strand breaks in lung cancer cell lines
  JOURNAL   Cancer Rep (Hoboken) 5 (8), e1543 (2022)
   PUBMED   34636174
  REMARK    GeneRIF: The RNA-binding protein La/SSB associates with
            radiation-induced DNA double-strand breaks in lung cancer cell
            lines.
REFERENCE   5  (bases 1 to 1650)
  AUTHORS   Grolz,D., Troster,H., Semsei,I. and Bachmann,M.
  TITLE     Analysis of expression of the gene encoding for the nuclear
            autoantigen La/SS-B using reporter gene constructs
  JOURNAL   Biochim Biophys Acta 1396 (3), 278-293 (1998)
   PUBMED   9545582
REFERENCE   6  (bases 1 to 1650)
  AUTHORS   Grolz,D., Laubinger,J., Wilmer,F., Troster,H. and Bachmann,M.
  TITLE     Transfection analysis of expression of mRNA isoforms encoding the
            nuclear autoantigen La/SS-B
  JOURNAL   J Biol Chem 272 (18), 12076-12082 (1997)
   PUBMED   9115276
REFERENCE   7  (bases 1 to 1650)
  AUTHORS   Troster,H., Metzger,T.E., Semsei,I., Schwemmle,M., Winterpacht,A.,
            Zabel,B. and Bachmann,M.
  TITLE     One gene, two transcripts: isolation of an alternative transcript
            encoding for the autoantigen La/SS-B from a cDNA library of a
            patient with primary Sjogrens' syndrome
  JOURNAL   J Exp Med 180 (6), 2059-2067 (1994)
   PUBMED   7964483
REFERENCE   8  (bases 1 to 1650)
  AUTHORS   Pruijn,G.J., Slobbe,R.L. and van Venrooij,W.J.
  TITLE     Analysis of protein--RNA interactions within Ro ribonucleoprotein
            complexes
  JOURNAL   Nucleic Acids Res 19 (19), 5173-5180 (1991)
   PUBMED   1833722
REFERENCE   9  (bases 1 to 1650)
  AUTHORS   Kohsaka,H., Yamamoto,K., Fujii,H., Miura,H., Miyasaka,N.,
            Nishioka,K. and Miyamoto,T.
  TITLE     Fine epitope mapping of the human SS-B/La protein. Identification
            of a distinct autoepitope homologous to a viral gag polyprotein
  JOURNAL   J Clin Invest 85 (5), 1566-1574 (1990)
   PUBMED   1692037
REFERENCE   10 (bases 1 to 1650)
  AUTHORS   Sturgess,A.D., Peterson,M.G., McNeilage,L.J., Whittingham,S. and
            Coppel,R.L.
  TITLE     Characteristics and epitope mapping of a cloned human autoantigen
            La
  JOURNAL   J Immunol 140 (9), 3212-3218 (1988)
   PUBMED   2452201
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD676196.1 and BC001289.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003142.4.
            
            Summary: The protein encoded by this gene is involved in diverse
            aspects of RNA metabolism, including binding and protecting poly(U)
            termini of nascent RNA polymerase III transcripts from exonuclease
            digestion, processing 5' and 3' ends of pre-tRNA precursors, acting
            as an RNA chaperone, and binding viral RNAs associated with
            hepatitis C virus. Autoantibodies reacting with this protein are
            found in the sera of patients with Sjogren syndrome and systemic
            lupus erythematosus. Alternative promoter usage results in two
            different transcript variants which encode the same protein.
            [provided by RefSeq, Jun 2014].
            
            Transcript Variant: This variant (1) and variant 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.797275.1,
                                           SRR3476690.825370.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260956.9/ ENSP00000260956.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                CD676196.1         60-85
            27-1650             BC001289.1         1-1624
FEATURES             Location/Qualifiers
     source          1..1650
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..1650
                     /gene="SSB"
                     /gene_synonym="La; La/SSB; LARP3"
                     /note="small RNA binding exonuclease protection factor La"
                     /db_xref="GeneID:6741"
                     /db_xref="HGNC:HGNC:11316"
                     /db_xref="MIM:109090"
     exon            1..106
                     /gene="SSB"
                     /gene_synonym="La; La/SSB; LARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            107..181
                     /gene="SSB"
                     /gene_synonym="La; La/SSB; LARP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1342
                     /gene="SSB"
                     /gene_synonym="La; La/SSB; LARP3"
                     /note="La ribonucleoprotein domain family, member 3;
                     autoantigen La; SS-B/La protein; la autoantigen; sjoegren
                     syndrome type B antigen; lupus La antigen; Sjogren
                     syndrome antigen B"
                     /codon_start=1
                     /product="lupus La protein"
                     /protein_id="NP_003133.1"
                     /db_xref="CCDS:CCDS2237.1"
                     /db_xref="GeneID:6741"
                     /db_xref="HGNC:HGNC:11316"
                     /db_xref="MIM:109090"
                     /translation="MAENGDNEKMAALEAKICHQIEYYFGDFNLPRDKFLKEQIKLDE
                     GWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRRSPSKPLPEVTD
                     EYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDS
                     IESAKKFVETPGQKYKETDLLILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLE
                     EDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEGIILFK
                     EKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGR
                     RFKGKGKGNKAAQPGSGKGKVQFQGKKTKFASDDEHDEHDENGATGPVKRAREETDKE
                     EPASKQQKTENGAGDQ"
     exon            182..285
                     /gene="SSB"
                     /gene_synonym="La; La/SSB; LARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            286..460
                     /gene="SSB"
                     /gene_synonym="La; La/SSB; LARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            461..568
                     /gene="SSB"
                     /gene_synonym="La; La/SSB; LARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            569..669
                     /gene="SSB"
                     /gene_synonym="La; La/SSB; LARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            670..741
                     /gene="SSB"
                     /gene_synonym="La; La/SSB; LARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            742..784
                     /gene="SSB"
                     /gene_synonym="La; La/SSB; LARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            785..925
                     /gene="SSB"
                     /gene_synonym="La; La/SSB; LARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1112
                     /gene="SSB"
                     /gene_synonym="La; La/SSB; LARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1253
                     /gene="SSB"
                     /gene_synonym="La; La/SSB; LARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1650
                     /gene="SSB"
                     /gene_synonym="La; La/SSB; LARP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1623..1628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SSB"
                     /gene_synonym="La; La/SSB; LARP3"
                     /note="hexamer: AATATA"
     polyA_site      1650
                     /gene="SSB"
                     /gene_synonym="La; La/SSB; LARP3"
                     /note="major polyA site"
ORIGIN      
        1 atcttcttgg agcgctttag gctggccggc ggcgctggga ggtggagtcg ttgctgttgc
       61 tgtttgtgag cctgtggcgc ggcttctgtg ggccggaacc ttaaagatag ccgcaatggc
      121 tgaaaatggt gataatgaaa agatggctgc cctggaggcc aaaatctgtc atcaaattga
      181 gtattatttt ggcgacttca atttgccacg ggacaagttt ctaaaggaac agataaaact
      241 ggatgaaggc tgggtacctt tggagataat gataaaattc aacaggttga accgtctaac
      301 aacagacttt aatgtaattg tggaagcatt gagcaaatcc aaggcagaac tcatggaaat
      361 cagtgaagat aaaactaaaa tcagaaggtc tccaagcaaa cccctacctg aagtgactga
      421 tgagtataaa aatgatgtaa aaaacagatc tgtttatatt aaaggcttcc caactgatgc
      481 aactcttgat gacataaaag aatggttaga agataaaggt caagtactaa atattcagat
      541 gagaagaaca ttgcataaag catttaaggg atcaattttt gttgtgtttg atagcattga
      601 atctgctaag aaatttgtag agacccctgg ccagaagtac aaagaaacag acctgctaat
      661 acttttcaag gacgattact ttgccaaaaa aaatgaagaa agaaaacaaa ataaagtgga
      721 agctaaatta agagctaaac aggagcaaga agcaaaacaa aagttagaag aagatgctga
      781 aatgaaatct ctagaagaaa agattggatg cttgctgaaa ttttcgggtg atttagatga
      841 tcagacctgt agagaagatt tacacatact tttctcaaat catggtgaaa taaaatggat
      901 agacttcgtc agaggagcaa aagaggggat aattctattt aaagaaaaag ccaaggaagc
      961 attgggtaaa gccaaagatg caaataatgg taacctacaa ttaaggaaca aagaagtgac
     1021 ttgggaagta ctagaaggag aggtggaaaa agaagcactg aagaaaataa tagaagacca
     1081 acaagaatcc ctaaacaaat ggaagtcaaa aggtcgtaga tttaaaggaa aaggaaaggg
     1141 taataaagct gcccagcctg ggtctggtaa aggaaaagta cagtttcagg gcaagaaaac
     1201 gaaatttgct agtgatgatg aacatgatga acatgatgaa aatggtgcaa ctggacctgt
     1261 gaaaagagca agagaagaaa cagacaaaga agaacctgca tccaaacaac agaaaacaga
     1321 aaatggtgct ggagaccagt agtttagtaa accaattttt tattcatttt aaataggttt
     1381 taaacgactt ttgtttgcgg ggcttttaaa aggaaaaccg aattaggtcc acttcaatgt
     1441 ccacctgtga gaaaggaaaa atttttttgt tgtttaactt gtctttttgt tatgcaaatg
     1501 agatttcttt gaatgtattg ttctgtttgt gttatttcag atgattcaaa tatcaaaagg
     1561 aagattcttc cattaaattg cctttgtaat atgagaatgt attagtacaa actaactaat
     1621 aaaatatata ctatatgaaa agagcaaaaa
//
