LOCUS       NM_001370300            2697 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens SS18 like 2 (SS18L2), transcript variant 1, mRNA.
ACCESSION   NM_001370300 XM_017006548
VERSION     NM_001370300.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2697)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2697)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 2697)
  AUTHORS   de Bruijn,D.R., Kater-Baats,E., Eleveld,M., Merkx,G. and Geurts Van
            Kessel,A.
  TITLE     Mapping and characterization of the mouse and human SS18 genes, two
            human SS18-like genes and a mouse Ss18 pseudogene
  JOURNAL   Cytogenet Cell Genet 92 (3-4), 310-319 (2001)
   PUBMED   11435705
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD640145.1, BC017804.1 and AC092047.3.
            
            On May 4, 2019 this sequence version replaced XM_017006548.1.
            
            Summary: Synovial sarcomas occur most frequently in the extremities
            around large joints. More than 90% of cases have a recurrent and
            specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which
            the 5-prime end of the SS18 gene (MIM 600192) is fused in-frame to
            the 3-prime end of the SSX1 (MIM 312820), SSX2 (MIM 300192), or
            SSX4 (MIM 300326) gene. The SS18L2 gene is homologous to
            SS18.[supplied by OMIM, Jul 2002].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.219285.1,
                                           SRR1660809.73432.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000011691.6/ ENSP00000011691.4
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                CD640145.1         17-28
            13-752              BC017804.1         1-740
            753-2697            AC092047.3         15766-17710         c
FEATURES             Location/Qualifiers
     source          1..2697
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.1"
     gene            1..2697
                     /gene="SS18L2"
                     /gene_synonym="KIAA-iso"
                     /note="SS18 like 2"
                     /db_xref="GeneID:51188"
                     /db_xref="HGNC:HGNC:15593"
                     /db_xref="MIM:606473"
     exon            1..107
                     /gene="SS18L2"
                     /gene_synonym="KIAA-iso"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..272
                     /gene="SS18L2"
                     /gene_synonym="KIAA-iso"
                     /note="SYT homolog 2; synovial sarcoma translocation gene
                     on chromosome 18-like 2"
                     /codon_start=1
                     /product="SS18-like protein 2"
                     /protein_id="NP_001357229.1"
                     /db_xref="CCDS:CCDS2701.1"
                     /db_xref="GeneID:51188"
                     /db_xref="HGNC:HGNC:15593"
                     /db_xref="MIM:606473"
                     /translation="MSVAFVPDWLRGKAEVNQETIQRLLEENDQLIRCIVEYQNKGRG
                     NECVQYQHVLHRNLIYLATIADASPTSTSKAME"
     exon            108..184
                     /gene="SS18L2"
                     /gene_synonym="KIAA-iso"
                     /inference="alignment:Splign:2.1.0"
     exon            185..2697
                     /gene="SS18L2"
                     /gene_synonym="KIAA-iso"
                     /inference="alignment:Splign:2.1.0"
     regulatory      734..739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SS18L2"
                     /gene_synonym="KIAA-iso"
                     /note="hexamer: AATAAA"
     polyA_site      759
                     /gene="SS18L2"
                     /gene_synonym="KIAA-iso"
                     /note="major polyA site"
     regulatory      844..849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SS18L2"
                     /gene_synonym="KIAA-iso"
                     /note="hexamer: TATAAA"
     polyA_site      877
                     /gene="SS18L2"
                     /gene_synonym="KIAA-iso"
     polyA_site      1050
                     /gene="SS18L2"
                     /gene_synonym="KIAA-iso"
     regulatory      2669..2674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SS18L2"
                     /gene_synonym="KIAA-iso"
                     /note="hexamer: ATTAAA"
     polyA_site      2697
                     /gene="SS18L2"
                     /gene_synonym="KIAA-iso"
ORIGIN      
        1 gagttgcttg gcggtcgtgg ttccggaggt tcctcgggat gtcggtggcc ttcgtaccgg
       61 actggctgag gggcaaggcg gaagtcaatc aagagactat ccagcggctc cttgaggaga
      121 atgaccagct gatccgctgt attgtggagt atcagaacaa gggccgcggg aacgagtgcg
      181 tgcagtacca gcatgtgtta catagaaatc tcatttattt ggctaccatt gcagatgcca
      241 gtccaaccag cacttcaaaa gcaatggaat aatctttcaa aagcaataga ataatcttcc
      301 atttggctgt cgtgaggagt aattgaatgt aatccatctc ttacaaaatg gagacagggt
      361 ctttaccaac tcaactggtt aaaacatgaa tgaaacctct gtggctcttt cgaaacgtga
      421 aaatgtgaag aaagctacta acttagctgt attctcatgt aaatattttt taaataatta
      481 agcaaatccc tcaataagtt gagcccaggt gtcctctttc ctgaacttgg agcatgtttg
      541 gataacaaag acatcactgg gatgttcaag tctacttttt agtttcaacc tgaagaggaa
      601 actcagtagg tgttgggcag gaattggtga gattcctgac ttgatacctt gctaaatgga
      661 catgtaactg tgtgctcctt cctatcagtt tgtaaatgtg gtccccctga ctgctgtttt
      721 cagattgctt tgaaataaag cttatttttc tataaaatac tgatgtggag gtatagaagt
      781 tttcatgtaa taagtattcc atttggtttt caagaataac tgtgaggact taaccataaa
      841 gtatataaaa acaatactat tatcattgcc aacaaaatga atagtgattt ctaattatta
      901 tctaatatca tctgataata gatgatgttt aattttcttc agttatcaga tagtcttttt
      961 gttgatttgt ctgaaccaga atccaaataa gattcacatg ttgtattttg ttgatgttcc
     1021 tttaagtcac ttaaagaata cttaatagtt cctttttttc tttatttgtt gaaataacta
     1081 ggtgtttacc ctagaattct ctcgtgttct acatacagtt gtatctctgt agtgttgtta
     1141 attatgtgcc actatcatcc acttttcctg taaactagta gatctagagg ctcatgcaga
     1201 ctcatgttct aatattttta gcaggaatat attagaaggt gataagtact tgcttttgca
     1261 tcacataagg agtgacctga cttttaagtt cccaaccagc ctttcactta aattatgatc
     1321 cacccagctt tgatgtggta attcattagg gattacataa tgaggatttt ctaatttatc
     1381 attctttctg actttattag ctgtattcta taaaaaactt tcactcttgg agatttatct
     1441 gaaagatgag gcaaagggat tcttgtaagt atatccaaaa ttagaagccc aggtccctgc
     1501 tccttttttt ggagtcaagg gttgcaacct agggcaactg taaaatacat gtaaatagtg
     1561 aagagataac tcattttgaa tcccagctct atcccttaac ctctgaaagc tctgtttcct
     1621 cacctctaaa gtgaggataa tgaaaatagc atctgcctcc tgaggttgtg agactgagat
     1681 aacgtggttg agaactgggc acatgttaat ctatgttagc actaatgtgc tgagggctct
     1741 ggctctttct tttttctttt tcttcttttt tttggttttg ttttgttttg tttttgtttt
     1801 tgtttttttt tgagacggaa tctcgctctg tcggagtgca gtggtgcaat tttggctcac
     1861 tgcaacctct acctcctggg ttcaagtgat tctcctgcct cagcctccca agtagctggg
     1921 attacaggca tgtggcacca tgcctggcta attttggtat ttttagtaga gacggggttt
     1981 ctccatgttg gtcaggctgg tctcgtactc acgacctcag gtgatccacc tgcctcagcc
     2041 tcctagagtg ctgggattac aggcgtaagc caccgcgccc agccgatcat ttctgttttc
     2101 tagaaaatta ttttgtctgt ttccccacta gcattcctga tggttttcca gagtcctatc
     2161 ccctgaagtt ctaattgctg gcataatcac actctaaaag gctgaacccc agaatcatta
     2221 cctgaaaatt cgtactacca gtggttcttc ttcatgataa atcatggaca aattaagcct
     2281 gagtttgtaa actctttgga taccaacttt ctaccactct tggaagagat ggaggaggtg
     2341 tcagtcattt tggttgatac tagccctagg cctgccttgt cccaggagtt tcttcacctt
     2401 aatcacagac caaattgcat acttttatct tcgaatcatc taaaatataa tttcaaatca
     2461 caagacagaa taaaataatc tttgagagag gcagaacctt agaaaggaga tattttatct
     2521 catttatttt acagatgaag aaagtaaact tcagagagat caaagtgatt tgtctcaggt
     2581 cacataacca gtggcagaaa gaagagaatt gctggaatgt caagataaga atgaattcta
     2641 ggtttaaagt tgtttaagta tatcccaaat taaatatttc attcctgagc tctaaaa
//
