LOCUS       NM_080725               2528 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens sulfiredoxin 1 (SRXN1), mRNA.
ACCESSION   NM_080725
VERSION     NM_080725.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2528)
  AUTHORS   Rao,Q., Guo,M., Sun,J., Yang,B., Cao,X. and Xia,J.
  TITLE     Sulfiredoxin-1 promotes the growth of hepatocellular carcinoma by
            inhibiting TFEB-mediated autophagy and lysosome biogenesis
  JOURNAL   Exp Cell Res 441 (2), 114169 (2024)
   PUBMED   39029574
  REMARK    GeneRIF: Sulfiredoxin-1 promotes the growth of hepatocellular
            carcinoma by inhibiting TFEB-mediated autophagy and lysosome
            biogenesis.
REFERENCE   2  (bases 1 to 2528)
  AUTHORS   Wei,J., Qiu,D., Yang,X., Wang,J., Shi,M., Sun,L., Lu,X., Wang,C.,
            Liu,H. and Li,R.
  TITLE     Unraveling the role of sulfiredoxin-1 in early-onset preeclampsia:
            A key player in trophoblast ferroptosis
  JOURNAL   J Reprod Immunol 164, 104273 (2024)
   PUBMED   38852489
  REMARK    GeneRIF: Unraveling the role of sulfiredoxin-1 in early-onset
            preeclampsia: A key player in trophoblast ferroptosis.
REFERENCE   3  (bases 1 to 2528)
  AUTHORS   Wang,X., Yu,J., Wen,H., Yan,J., Peng,K. and Zhou,H.
  TITLE     Antioxidative stress protein SRXN1 can be used as a radiotherapy
            prognostic marker for prostate cancer
  JOURNAL   BMC Urol 23 (1), 148 (2023)
   PUBMED   37726767
  REMARK    GeneRIF: Antioxidative stress protein SRXN1 can be used as a
            radiotherapy prognostic marker for prostate cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2528)
  AUTHORS   Luo,J., Tian,Z., Zhou,Y., Xiao,Z., Park,S.Y., Sun,H., Zhuang,T.,
            Wang,Y., Li,P. and Zhao,X.
  TITLE     CircABCA13 acts as a miR-4429 sponge to facilitate esophageal
            squamous cell carcinoma development by stabilizing SRXN1
  JOURNAL   Cancer Sci 114 (7), 2835-2847 (2023)
   PUBMED   37017121
  REMARK    GeneRIF: CircABCA13 acts as a miR-4429 sponge to facilitate
            esophageal squamous cell carcinoma development by stabilizing
            SRXN1.
REFERENCE   5  (bases 1 to 2528)
  AUTHORS   Rao,Q.W., Zhang,S.L., Guo,M.Z., Yuan,F.F., Sun,J.L., Qi,F.,
            Wang,L.S., Yang,B.W. and Xia,J.L.
  TITLE     Sulfiredoxin-1 is a promising novel prognostic biomarker for
            hepatocellular carcinoma
  JOURNAL   Cancer Med 9 (22), 8318-8332 (2020)
   PUBMED   32955798
  REMARK    GeneRIF: Sulfiredoxin-1 is a promising novel prognostic biomarker
            for hepatocellular carcinoma.
REFERENCE   6  (bases 1 to 2528)
  AUTHORS   Findlay,V.J., Townsend,D.M., Morris,T.E., Fraser,J.P., He,L. and
            Tew,K.D.
  TITLE     A novel role for human sulfiredoxin in the reversal of
            glutathionylation
  JOURNAL   Cancer Res 66 (13), 6800-6806 (2006)
   PUBMED   16818657
  REMARK    GeneRIF: Actin and protein tyrosine phosphatase 1B were identified
            in vitro as targets of sulfiredoxin 1 (Srx1)-dependent
            deglutathionylation.
REFERENCE   7  (bases 1 to 2528)
  AUTHORS   Jeong,W., Park,S.J., Chang,T.S., Lee,D.Y. and Rhee,S.G.
  TITLE     Molecular mechanism of the reduction of cysteine sulfinic acid of
            peroxiredoxin to cysteine by mammalian sulfiredoxin
  JOURNAL   J Biol Chem 281 (20), 14400-14407 (2006)
   PUBMED   16565085
  REMARK    GeneRIF: analysis of the reduction of cysteine sulfinic acid of
            peroxiredoxin to cysteine by mammalian sulfiredoxin
REFERENCE   8  (bases 1 to 2528)
  AUTHORS   Jonsson,T.J., Murray,M.S., Johnson,L.C., Poole,L.B. and
            Lowther,W.T.
  TITLE     Structural basis for the retroreduction of inactivated
            peroxiredoxins by human sulfiredoxin
  JOURNAL   Biochemistry 44 (24), 8634-8642 (2005)
   PUBMED   15952770
  REMARK    GeneRIF: The reduction of the cysteine sulfinic acid moiety within
            the active site of the peroxiredoxin by sulfiredoxin involves novel
            sulfur chemistry and the use of ATP and Mg(2+).
REFERENCE   9  (bases 1 to 2528)
  AUTHORS   Woo,H.A., Jeong,W., Chang,T.S., Park,K.J., Park,S.J., Yang,J.S. and
            Rhee,S.G.
  TITLE     Reduction of cysteine sulfinic acid by sulfiredoxin is specific to
            2-cys peroxiredoxins
  JOURNAL   J Biol Chem 280 (5), 3125-3128 (2005)
   PUBMED   15590625
REFERENCE   10 (bases 1 to 2528)
  AUTHORS   Chang,T.S., Jeong,W., Woo,H.A., Lee,S.M., Park,S. and Rhee,S.G.
  TITLE     Characterization of mammalian sulfiredoxin and its reactivation of
            hyperoxidized peroxiredoxin through reduction of cysteine sulfinic
            acid in the active site to cysteine
  JOURNAL   J Biol Chem 279 (49), 50994-51001 (2004)
   PUBMED   15448164
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL833944.1.
            
            On Jun 2, 2019 this sequence version replaced NM_080725.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1112809.1,
                                           SRR7346977.1056581.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381962.4/ ENSP00000371388.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2528              AL833944.1         47-2574
FEATURES             Location/Qualifiers
     source          1..2528
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..2528
                     /gene="SRXN1"
                     /gene_synonym="C20orf139; Npn3; SRX; SRX1"
                     /note="sulfiredoxin 1"
                     /db_xref="GeneID:140809"
                     /db_xref="HGNC:HGNC:16132"
                     /db_xref="MIM:617583"
     exon            1..225
                     /gene="SRXN1"
                     /gene_synonym="C20orf139; Npn3; SRX; SRX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..429
                     /gene="SRXN1"
                     /gene_synonym="C20orf139; Npn3; SRX; SRX1"
                     /EC_number="1.8.98.2"
                     /note="sulphiredoxin"
                     /codon_start=1
                     /product="sulfiredoxin-1"
                     /protein_id="NP_542763.1"
                     /db_xref="CCDS:CCDS13005.1"
                     /db_xref="GeneID:140809"
                     /db_xref="HGNC:HGNC:16132"
                     /db_xref="MIM:617583"
                     /translation="MGLRAGGTLGRAGAGRGAPEGPGPSGGAQGGSIHSGRIAAVHNV
                     PLSVLIRPLPSVLDPAKVQSLVDTIREDPDSVPPIDVLWIKGAQGGDYFYSFGGCHRY
                     AAYQQLQRETIPAKLVQSTLSDLRVYLGASTPDLQ"
     exon            226..2528
                     /gene="SRXN1"
                     /gene_synonym="C20orf139; Npn3; SRX; SRX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1253..1258
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRXN1"
                     /gene_synonym="C20orf139; Npn3; SRX; SRX1"
                     /note="hexamer: AATAAA"
     polyA_site      1285
                     /gene="SRXN1"
                     /gene_synonym="C20orf139; Npn3; SRX; SRX1"
                     /note="major polyA site"
     regulatory      2296..2301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRXN1"
                     /gene_synonym="C20orf139; Npn3; SRX; SRX1"
                     /note="hexamer: AACAAA"
     polyA_site      2322
                     /gene="SRXN1"
                     /gene_synonym="C20orf139; Npn3; SRX; SRX1"
                     /note="major polyA site"
ORIGIN      
        1 gcggcggcgg cgacgatggg gctgcgtgca ggaggaacgc tgggcagggc cggcgcgggt
       61 cggggggcgc ccgaggggcc cgggccgagc ggcggcgcgc agggcggcag catccactcg
      121 ggccgcatcg ccgcggtgca caacgtgccg ctgagcgtgc tcatccggcc gctgccgtcc
      181 gtgttggacc ccgccaaggt gcagagcctc gtggacacga tccgggagga cccagacagc
      241 gtgcccccca tcgatgtcct ctggatcaaa ggggcccagg gaggtgacta cttctactcc
      301 tttgggggct gccaccgcta cgcggcctac cagcaactgc agcgagagac catccccgcc
      361 aagcttgtcc agtccactct ctcagaccta agggtgtacc tgggagcatc cacaccagac
      421 ttgcagtagc agcctccttg gcacctgctg ccaccttcaa gagcccagaa gacacacctg
      481 gcctccagca ggctgggcca tgcagaaggg atagcagggg tgcattctct ttgcacctgg
      541 cgagagggtc tgactctggg cacccctctc accagctaca aggccttgga ctcactgtac
      601 agtgtgggag ccccagttcc cacctctgtg acaataggat catggcctta cccttgaagc
      661 attaccgaga aggagaacag agatgggctt gaagagccac gtgctgccgg ctccaaattc
      721 ccaaggacaa ggatccctct gcatttttgt ctatgtaacc tcttatatgg actacattca
      781 gctgcaagga aaggaaaacc ttgattgcag tggtttaaac aaacagaaga ttgtttttcc
      841 acatagcatg gattctggag atgggtggct aatggtattg gttcaacaac tccacgaagg
      901 taggggtcac gtcttggatc cttttgcctt aatctcagtg ctcgttactt catggtccca
      961 agatggctgc tgtatcccca agaatcatgt ctgcgttcaa ggaaggaggg gtggaggaag
     1021 aggaagggcc aaactagctg gacccgtcac cttctatcag aaagtaaaac ctcgtcagaa
     1081 gtctgtttcc tgctctctcc ctctgcatat cttcacttag atgcccttgg cccgagccag
     1141 ctaccattgc acctctagct gcaaacaaag ctaagacagc agggaacaga attgtcatgg
     1201 ctgaatagac caatcgtgtt ccatctactg agactggcac actgcctcct gcaataaaac
     1261 tgggatccca ttaccaagag agaaatgcag aattgtgtac cagttagctt ttgctgtgta
     1321 acaaaccatc cccaaacttg gcagctagaa acaaaccctg tattttccca caatcctatg
     1381 ggttggcaat ttgggctggg ctcaacaggg cagttctgct gctcacacct gggatccctc
     1441 atggagctaa ggtcagctgt tacctcagct gggcctggat ggtctaggat agccttactc
     1501 acttgcctgg caggtgacag gctgttggct ggaattgctt ggttctcctc catgtggcct
     1561 ctccagcagg ctagctcagg cttattcaca tgatggcttc aggattccaa agagagtgag
     1621 agtagaagct gaaagacttc ttgagttctt ggcctggaac tgggactagg acagtgtcac
     1681 ttctgctaag ttcttttggt cagagcaaat cacaaggctt tacccagatt caagggatga
     1741 gaaacagact acatgtcttg atgaggggaa ccacaaagag cttgtggcca tttttcacct
     1801 atcacaaata attttggatg ggtatttatt tggataaagg tatttccctc ttcccccttt
     1861 ctctctgtct catggggcct cactctgcca agttggaagg cactaagaca ttgtcctggc
     1921 cctcagggtc taggggaaga ggtgttgggg caggaagtga gtctctccat gggctggacc
     1981 cactgtagta ggagtgcctc cttgtctgca ctgctggtat ggggttaggc caggtaggac
     2041 attccagagg ggcttctgaa aaccaagagt ccctggggaa agggaacaga gtaaggcagg
     2101 ccttgttctc actgccctct aagggaactt ggtcactcgg cacttttaag cctcagtttc
     2161 tccagttcaa taataaggac aagagctttt cccatgcatt ctctttcccc gggaaagttg
     2221 actgaggtga ccagtaatag aattgaaaag ggagagtgtc ttcagtgcaa tgtggcatcc
     2281 tggattgggt cttggaacaa aaacaggaca ttagtgggaa aattggaaat ctgaaaaaag
     2341 tctgaatttt agttaatata ccaatttcag tctcttggtt ttgacagatg taccatggtg
     2401 atgtaagatg ttgaccttgg ggtaggctgg gtgaagggta tacaggaact ctttgtacta
     2461 tctctgcaac ttctctgtaa atctagtatc attccaaaat aaaagtttat ttaatttaaa
     2521 aaaaaaaa
//
