LOCUS       NM_003769               1152 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens serine and arginine rich splicing factor 9 (SRSF9),
            mRNA.
ACCESSION   NM_003769
VERSION     NM_003769.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1152)
  AUTHORS   Wang,R., Lv,C., Li,D., Song,Y. and Yan,Z.
  TITLE     EEF1D stabilized by SRSF9 promotes colorectal cancer via enhancing
            the proliferation and metastasis
  JOURNAL   Int J Cancer 155 (8), 1487-1499 (2024)
   PUBMED   38771720
  REMARK    GeneRIF: EEF1D stabilized by SRSF9 promotes colorectal cancer via
            enhancing the proliferation and metastasis.
REFERENCE   2  (bases 1 to 1152)
  AUTHORS   Yu,S., Sun,Z., Ju,T., Liu,Y., Mei,Z., Wang,C., Qu,Z., Li,N., Wu,F.,
            Liu,K., Lu,M., Huang,M., Pang,X., Jia,Y., Li,Y., Zhang,Y., Dou,S.,
            Jiang,J., Dong,X., Huang,C., Li,W., Zhang,Y., Yuan,Y., Yang,B. and
            Du,W.
  TITLE     The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by
            Regulating SRSF9-Mediated Splicing of NFATc4
  JOURNAL   Adv Sci (Weinh) 11 (29), e2308769 (2024)
   PUBMED   38810124
  REMARK    GeneRIF: The m7G Methyltransferase Mettl1 Drives Cardiac
            Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4.
REFERENCE   3  (bases 1 to 1152)
  AUTHORS   Luo,C., He,J., Yang,Y., Wu,K., Fu,X., Cheng,J., Ming,Y., Liu,W. and
            Peng,Y.
  TITLE     SRSF9 promotes cell proliferation and migration of glioblastoma
            through enhancing CDK1 expression
  JOURNAL   J Cancer Res Clin Oncol 150 (6), 292 (2024)
   PUBMED   38842611
  REMARK    GeneRIF: SRSF9 promotes cell proliferation and migration of
            glioblastoma through enhancing CDK1 expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1152)
  AUTHORS   Kim,G.N., Yu,K.L., Kim,H.I. and You,J.C.
  TITLE     Investigation of the effect of SRSF9 overexpression on HIV-1
            production
  JOURNAL   BMB Rep 55 (12), 639-644 (2022)
   PUBMED   36330710
  REMARK    GeneRIF: Investigation of the effect of SRSF9 overexpression on
            HIV-1 production.
REFERENCE   5  (bases 1 to 1152)
  AUTHORS   Zhang,G., Liu,B., Shang,H., Wu,G., Wu,D., Wang,L., Li,S., Wang,Z.,
            Wang,S. and Yuan,J.
  TITLE     High expression of serine and arginine-rich splicing factor 9
            (SRSF9) is associated with hepatocellular carcinoma progression and
            a poor prognosis
  JOURNAL   BMC Med Genomics 15 (1), 180 (2022)
   PUBMED   35971121
  REMARK    GeneRIF: High expression of serine and arginine-rich splicing
            factor 9 (SRSF9) is associated with hepatocellular carcinoma
            progression and a poor prognosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1152)
  AUTHORS   Stoss,O., Schwaiger,F.W., Cooper,T.A. and Stamm,S.
  TITLE     Alternative splicing determines the intracellular localization of
            the novel nuclear protein Nop30 and its interaction with the
            splicing factor SRp30c
  JOURNAL   J Biol Chem 274 (16), 10951-10962 (1999)
   PUBMED   10196175
REFERENCE   7  (bases 1 to 1152)
  AUTHORS   Petersen-Mahrt,S.K., Estmer,C., Ohrmalm,C., Matthews,D.A.,
            Russell,W.C. and Akusjarvi,G.
  TITLE     The splicing factor-associated protein, p32, regulates RNA splicing
            by inhibiting ASF/SF2 RNA binding and phosphorylation
  JOURNAL   EMBO J 18 (4), 1014-1024 (1999)
   PUBMED   10022843
REFERENCE   8  (bases 1 to 1152)
  AUTHORS   Yuan,Y., Li,D.M. and Sun,H.
  TITLE     PIR1, a novel phosphatase that exhibits high affinity to RNA .
            ribonucleoprotein complexes
  JOURNAL   J Biol Chem 273 (32), 20347-20353 (1998)
   PUBMED   9685386
REFERENCE   9  (bases 1 to 1152)
  AUTHORS   Nayler,O., Stratling,W., Bourquin,J.P., Stagljar,I., Lindemann,L.,
            Jasper,H., Hartmann,A.M., Fackelmayer,F.O., Ullrich,A. and Stamm,S.
  TITLE     SAF-B protein couples transcription and pre-mRNA splicing to
            SAR/MAR elements
  JOURNAL   Nucleic Acids Res 26 (15), 3542-3549 (1998)
   PUBMED   9671816
REFERENCE   10 (bases 1 to 1152)
  AUTHORS   Screaton,G.R., Caceres,J.F., Mayeda,A., Bell,M.V., Plebanski,M.,
            Jackson,D.G., Bell,J.I. and Krainer,A.R.
  TITLE     Identification and characterization of three members of the human
            SR family of pre-mRNA splicing factors
  JOURNAL   EMBO J 14 (17), 4336-4349 (1995)
   PUBMED   7556075
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU786332.1, U30825.1 and
            AI005398.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003769.2.
            
            Summary: The protein encoded by this gene is a member of the
            serine/arginine (SR)-rich family of pre-mRNA splicing factors,
            which constitute part of the spliceosome. Each of these factors
            contains an RNA recognition motif (RRM) for binding RNA and an RS
            domain for binding other proteins. The RS domain is rich in serine
            and arginine residues and facilitates interaction between different
            SR splicing factors. In addition to being critical for mRNA
            splicing, the SR proteins have also been shown to be involved in
            mRNA export from the nucleus and in translation. Two pseudogenes,
            one on chromosome 15 and the other on chromosome 21, have been
            found for this gene. [provided by RefSeq, Sep 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.125813.1,
                                           SRR1163655.38947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000229390.8/ ENSP00000229390.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-280               BU786332.1         49-328
            281-1052            U30825.1           194-965
            1053-1152           AI005398.1         8-107               c
FEATURES             Location/Qualifiers
     source          1..1152
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..1152
                     /gene="SRSF9"
                     /gene_synonym="SFRS9; SRp30c"
                     /note="serine and arginine rich splicing factor 9"
                     /db_xref="GeneID:8683"
                     /db_xref="HGNC:HGNC:10791"
                     /db_xref="MIM:601943"
     exon            1..327
                     /gene="SRSF9"
                     /gene_synonym="SFRS9; SRp30c"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..805
                     /gene="SRSF9"
                     /gene_synonym="SFRS9; SRp30c"
                     /note="splicing factor, arginine/serine-rich 9; SR
                     splicing factor 9; pre-mRNA-splicing factor SRp30C"
                     /codon_start=1
                     /product="serine/arginine-rich splicing factor 9"
                     /protein_id="NP_003760.1"
                     /db_xref="CCDS:CCDS9199.1"
                     /db_xref="GeneID:8683"
                     /db_xref="HGNC:HGNC:10791"
                     /db_xref="MIM:601943"
                     /translation="MSGWADERGGEGDGRIYVGNLPTDVREKDLEDLFYKYGRIREIE
                     LKNRHGLVPFAFVRFEDPRDAEDAIYGRNGYDYGQCRLRVEFPRTYGGRGGWPRGGRN
                     GPPTRRSDFRVLVSGLPPSGSWQDLKDHMREAGDVCYADVQKDGVGMVEYLRKEDMEY
                     ALRKLDDTKFRSHEGETSYIRVYPERSTSYGYSRSRSGSRGRDSPYQSRGSPHYFSPF
                     RPY"
     exon            328..488
                     /gene="SRSF9"
                     /gene_synonym="SFRS9; SRp30c"
                     /inference="alignment:Splign:2.1.0"
     exon            489..661
                     /gene="SRSF9"
                     /gene_synonym="SFRS9; SRp30c"
                     /inference="alignment:Splign:2.1.0"
     exon            662..1152
                     /gene="SRSF9"
                     /gene_synonym="SFRS9; SRp30c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1130..1135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF9"
                     /gene_synonym="SFRS9; SRp30c"
                     /note="hexamer: AATATA"
     polyA_site      1152
                     /gene="SRSF9"
                     /gene_synonym="SFRS9; SRp30c"
                     /note="major polyA site"
ORIGIN      
        1 cccttcgctt ccgctccgcg ttcccacaat gcagtgcggc tgagcgcctc ggagcccgcg
       61 gggacgctgc ggggggaccc gtgctgaggc ggcggcggcg acgtgggctg cggcgggccc
      121 gcggcgtcgg gcggtgcgga tgtcgggctg ggcggacgag cgcggcggcg agggcgacgg
      181 gcgcatctac gtggggaacc ttccgaccga cgtgcgcgag aaggacttgg aggacctgtt
      241 ctacaagtac ggccgcatcc gcgagatcga gctcaagaac cggcacggcc tcgtgccctt
      301 cgccttcgtg cgcttcgagg acccccgaga tgcagaggat gctatttatg gaagaaatgg
      361 ttatgattat ggccagtgtc ggcttcgtgt ggagttcccc aggacttatg gaggtcgggg
      421 tgggtggccc cgtggtggga ggaatgggcc tcctacaaga agatctgatt tccgagttct
      481 tgtttcagga cttcctccgt caggcagctg gcaggacctg aaggatcaca tgcgagaagc
      541 tggggatgtc tgttatgctg atgtgcagaa ggatggagtg gggatggtcg agtatctcag
      601 aaaagaagac atggaatatg ccctgcgtaa actggatgac accaaattcc gctctcatga
      661 gggtgaaact tcctacatcc gagtttatcc tgagagaagc accagctatg gctactcacg
      721 gtctcggtct gggtcaaggg gccgtgactc tccataccaa agcaggggtt ccccacacta
      781 cttctctcct ttcaggccct actgagacag gtgatgggaa ttttttcttt attttttagg
      841 ttaactgagc tgctttgtgc tcagaatcta cattccagat tgaggattta gtgtcttagg
      901 aaattttttt aatttttttt ttttaaagaa gaaaaaaaac tacataattt ctaccagggc
      961 catattagca gtgaaacatt ttaaactgca gaaattgtgg ttttggttca gaaacaagtt
     1021 gtatattttt cacccctgat tatgggaaaa aaatcagttc tgtctttgtg ggttgctcta
     1081 ctatggagat caacagttac tgtgactgag tcggcccatt ctgtttagaa atatatttta
     1141 aatgtttagt aa
//
