LOCUS       NM_032102               4307 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens serine and arginine rich splicing factor 8 (SRSF8),
            transcript variant 1, mRNA.
ACCESSION   NM_032102
VERSION     NM_032102.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4307)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4307)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4307)
  AUTHORS   Varjosalo,M., Keskitalo,S., Van Drogen,A., Nurkkala,H.,
            Vichalkovski,A., Aebersold,R. and Gstaiger,M.
  TITLE     The protein interaction landscape of the human CMGC kinase group
  JOURNAL   Cell Rep 3 (4), 1306-1320 (2013)
   PUBMED   23602568
REFERENCE   4  (bases 1 to 4307)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 4307)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 4307)
  AUTHORS   Watanuki,T., Funato,H., Uchida,S., Matsubara,T., Kobayashi,A.,
            Wakabayashi,Y., Otsuki,K., Nishida,A. and Watanabe,Y.
  TITLE     Increased expression of splicing factor SRp20 mRNA in bipolar
            disorder patients
  JOURNAL   J Affect Disord 110 (1-2), 62-69 (2008)
   PUBMED   18281098
REFERENCE   7  (bases 1 to 4307)
  AUTHORS   Lareau,L.F., Inada,M., Green,R.E., Wengrod,J.C. and Brenner,S.E.
  TITLE     Unproductive splicing of SR genes associated with highly conserved
            and ultraconserved DNA elements
  JOURNAL   Nature 446 (7138), 926-929 (2007)
   PUBMED   17361132
REFERENCE   8  (bases 1 to 4307)
  AUTHORS   Li,J., Hawkins,I.C., Harvey,C.D., Jennings,J.L., Link,A.J. and
            Patton,J.G.
  TITLE     Regulation of alternative splicing by SRrp86 and its interacting
            proteins
  JOURNAL   Mol Cell Biol 23 (21), 7437-7447 (2003)
   PUBMED   14559993
REFERENCE   9  (bases 1 to 4307)
  AUTHORS   Grottke,C., Mantwill,K., Dietel,M., Schadendorf,D. and Lage,H.
  TITLE     Identification of differentially expressed genes in human melanoma
            cells with acquired resistance to various antineoplastic drugs
  JOURNAL   Int J Cancer 88 (4), 535-546 (2000)
   PUBMED   11058868
REFERENCE   10 (bases 1 to 4307)
  AUTHORS   Soret,J., Gattoni,R., Guyon,C., Sureau,A., Popielarz,M., Le
            Rouzic,E., Dumon,S., Apiou,F., Dutrillaux,B., Voss,H., Ansorge,W.,
            Stevenin,J. and Perbal,B.
  TITLE     Characterization of SRp46, a novel human SR splicing factor encoded
            by a PR264/SC35 retropseudogene
  JOURNAL   Mol Cell Biol 18 (8), 4924-4934 (1998)
   PUBMED   9671500
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA723253.1, AP001264.4,
            AF031166.1, BC057783.1, AK023379.1 and KF510392.1.
            
            On Aug 5, 2020 this sequence version replaced NM_032102.3.
            
            Summary: This gene encodes a member of a family of proteins
            containing a ribonucleoprotein (RNP)-type RNA binding motif and a
            carboxyl-terminal arginine-serine-rich (RS) domain. The encoded
            protein functions as a pre-mRNA splicing factor. There is a
            pseudogene for this gene on chromosome 7. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jun
            2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF031166.1, SRR7346977.1615514.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000587424.3/ ENSP00000480140.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                DA723253.1         43-103
            62-62               AP001264.4         20836-20836
            63-480              DA723253.1         105-522
            481-1270            AF031166.1         143-932
            1271-1553           BC057783.1         1003-1285
            1554-2092           BC057783.1         1287-1825
            2093-2585           AK023379.1         1474-1966
            2586-4206           AP001264.4         23359-24979
            4207-4307           KF510392.1         1-101
FEATURES             Location/Qualifiers
     source          1..4307
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q21"
     gene            1..4307
                     /gene="SRSF8"
                     /gene_synonym="DSM-1; SFRS2B; SRP46"
                     /note="serine and arginine rich splicing factor 8"
                     /db_xref="GeneID:10929"
                     /db_xref="HGNC:HGNC:16988"
                     /db_xref="MIM:603269"
     exon            1..4307
                     /gene="SRSF8"
                     /gene_synonym="DSM-1; SFRS2B; SRP46"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..1157
                     /gene="SRSF8"
                     /gene_synonym="DSM-1; SFRS2B; SRP46"
                     /note="splicing factor, arginine/serine-rich 2B; SR
                     splicing factor 8; splicing factor, arginine/serine-rich,
                     46kD; pre-mRNA-splicing factor SRP46"
                     /codon_start=1
                     /product="serine/arginine-rich splicing factor 8"
                     /protein_id="NP_115285.1"
                     /db_xref="CCDS:CCDS73370.1"
                     /db_xref="GeneID:10929"
                     /db_xref="HGNC:HGNC:16988"
                     /db_xref="MIM:603269"
                     /translation="MSCGRPPPDVDGMITLKVDNLTYRTSPDSLRRVFEKYGRVGDVY
                     IPREPHTKAPRGFAFVRFHDRRDAQDAEAAMDGAELDGRELRVQVARYGRRDLPRSRQ
                     GEPRGRSRGGGYGRRSRSYGRRSRSPRRRHRSRSRGPSCSRSRSRSRYRGSRYSRSPY
                     SRSPYSRSRYSRSPYSRSRYRESRYGGSHYSSSGYSNSRYSRYHSSRSHSKSGSSTSS
                     RSASTSKSSSARRSKSSSVSRSRSRSRSSSMTRSPPRVSKRKSKSRSRSKRPPKSPEE
                     EGQMSS"
     regulatory      2179..2184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF8"
                     /gene_synonym="DSM-1; SFRS2B; SRP46"
                     /note="hexamer: AATAAA"
     polyA_site      2205
                     /gene="SRSF8"
                     /gene_synonym="DSM-1; SFRS2B; SRP46"
                     /note="major polyA site"
     regulatory      2565..2570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF8"
                     /gene_synonym="DSM-1; SFRS2B; SRP46"
                     /note="hexamer: AATAAA"
     polyA_site      2586
                     /gene="SRSF8"
                     /gene_synonym="DSM-1; SFRS2B; SRP46"
     regulatory      4269..4274
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF8"
                     /gene_synonym="DSM-1; SFRS2B; SRP46"
                     /note="hexamer: AATAAA"
     polyA_site      4307
                     /gene="SRSF8"
                     /gene_synonym="DSM-1; SFRS2B; SRP46"
ORIGIN      
        1 acattagctg ggcgctgatt aggttaggat gttgcccagg tacaaggcca ggatcttcgg
       61 ggcctggctt catttggagt tcagctacca aaaggaaacc ttcctctggg tcctggagta
      121 tttggcctga aattgggaac tcggaagttg ctgctccagg gcgctccctg cggagctccg
      181 ccgcccgcct ctccgcccgg cctttcccgg cgtccccacg cggggcgcaa ccgcgagaaa
      241 gaaacgcagg tcgcaccgtc agcgcccaga gcagcgccag tttccgggcc cgggctgctc
      301 tcggagccat gagctgcggc cgcccccctc ccgacgtgga cggcatgatc accctcaagg
      361 tggacaacct gacctaccgc acctctcccg acagcttgag gcgcgtgttc gagaagtacg
      421 ggcgcgtggg cgacgtgtac atcccgcggg agccccacac caaggcgccc cggggcttcg
      481 ctttcgtccg ctttcacgac cggcgcgacg cccaagacgc cgaggccgcc atggacgggg
      541 cggagctgga cggacgcgag ctgcgggtgc aggtggcgcg ctatggccgc cgggacctgc
      601 cccgcagccg ccagggagag ccacgcggca ggtccagagg cggcggctac ggacggcgga
      661 gccgcagcta cgggcggcgg agccgcagcc ccaggcggcg acaccgcagc cgatcccggg
      721 gtcccagctg ctccaggtcc cgcagccgat ctcgctatag gggttctcgc tatagccggt
      781 ctccctacag ccgatctcct tacagccggt cgcgctacag ccgctctccc tacagcagat
      841 ctcgctacag ggaatctcgc tacggcggat ctcactacag ctcatctggt tacagtaact
      901 ctcgctacag ccgatatcac agcagccggt ctcactcgaa gtctgggtcc tccactagct
      961 ctcgctctgc atcaacctcc aaatcgagct ctgcgcgacg atccaagtcc tcctcggtct
     1021 ccaggtctcg ctcgcggtcc aggtcttcat ctatgaccag gagtcctccc cgggtatcca
     1081 agaggaaatc caagtcaagg tcgcgatcca agaggccccc caagtctcct gaagaggaag
     1141 gacagatgtc ctcttaagaa aatgatgcat caggaagcaa cgtgatggag gacttggggg
     1201 aaaaggatca catactcagt ctatggaagc aacgtccctg gaagaagagg ctgcctattg
     1261 aaaaggttgt gtcacacttt tctacctttt tgccagtttg aagctttgca tcaggtggca
     1321 aaattcattc tatgtgccgt tttgttgtta ttcacatttt attgtaactt aggaggtgaa
     1381 cgacctaaga ttacgttatt gggtttggat atttgaggca aaaatttatt tttatttcta
     1441 tagtgatgac tgttttggtt tgaaatgaac agattggtaa cctaatttgt ggcctcctga
     1501 cttttaagga aacgtgtgca gccattacac acagcctaac gctgtcaaga catgcttcaa
     1561 cattgccttc attccttaaa aacctacaaa aggtggtgta aattaatatg gataatttta
     1621 tttacctcca ggtctaaaag gtagtgtgac ccaaatttgt ataaagattt ttcatgtgaa
     1681 aggactgggg ttttagcaaa cacaggtcta atctcttttg tgtttttgtg caccaggccc
     1741 ggctgcgtag cagttgagtg atgctggtta gctattaagg tggcctgttg cagtgcagag
     1801 tgctgagctg cttcctgttt tcttctgatt gctcctgggg aaaacacgcc ttgtcctgaa
     1861 gaacaaatgg ctgtccagtt tattaaaatg cctgtcaact gcacttccag tcacccaggc
     1921 cttgcagata aataatggag catgcagtga gcacatctag ctgacgataa tcacaccttt
     1981 tcccccgtct tttctgaaaa attgtaaatc tgatcatatc aacatgtatg aacttaaaat
     2041 atggagaatg ttatggaaga aatagtttat aagtttgtta agtacttata acatggttta
     2101 tctttttgat tattaatttt ttacgctaac cattgtttct gtagttaaaa ttgttttctt
     2161 ggtgttatct tttctcagaa taaaattaga aacttttgat ggaaagtagg ttgttttatt
     2221 ttctgtatga cttttggata tttgtacttt tgagaaaatt attagcacca agtgtttctc
     2281 aaaatataat ttttaaaaaa tccttaatag gcttttagct atgtgcttta ttgttttatc
     2341 acaatgcagt ttatttgtag tttctctctt ttttcctcac acctatggtt tttttacttc
     2401 caaaattatt ttcaaataat ccatttttgg ctttcatcat tatccctact agatgttatg
     2461 tgttcttttg caattgtttc tgcttatacc tttactagca aagggaaaaa taacaatttg
     2521 gtgtcaatga tctggtgaca ataggattac attggagcca attgaataaa tttattcttt
     2581 caatcatatg gatcttcatt aatatttttg actgaattat caattaaaaa tatttcattc
     2641 cctttgtgca gaaactgcta aatccagggt tcgattcttg aatgaactgg caaggtggct
     2701 gtggtctgta gatatacatc ccacattttg ttgttataac agttagtagt tagtattgct
     2761 ttcatatata gactccagaa tctaaatttt acgataatga catttcttct ggtcatgaca
     2821 aatgtaatat tttacaaata taaatctacg tagaatccaa agacacacac agagcagtcc
     2881 tgtctgagaa ataaaaaatc aggacaccca tggcatcgta gtagcccctc gcgtccagca
     2941 ggtggcgaag ggaggtgagg tatatttatt aaatgggacc gagtgggacg gggacggggc
     3001 agccctaagg gtagggaagc attgtcaatt tctggggata gaatgagacc caggcatagc
     3061 tggagtttga agctttgaag caaaaatatc tgtagaacat cttaaacgtg accaaaatat
     3121 gatgttaaaa tcagcaactc tttatacgtt aaaaactttg aaacctgtgg ccgggcatgg
     3181 tggctcgcgc ctgtaatccc agcactttgg gaggccaagg caggtggatc acctgaggtc
     3241 aggagctcaa gaccagcctg accaacatgg tgaaaccccg tctctactaa aaatacaaaa
     3301 attagctggg catggtggcg catgcctata atcccagcta ctcggaggct gaggcaggat
     3361 aatcgcttga aaccgggaga cagaggttgt ggtgagccga gatcacgcca ttgcactcca
     3421 gccggggcaa caagagcaaa acttcatctc aaaaaaaaaa aaaaaagaaa aaggaaaaaa
     3481 acaaacaaac aacaactttg aaacctagga acaattttgg acctgttgga gcagaaatgt
     3541 gtagttgtca ttgaaggtgt gaacataccc tacctctact ctacatgtgg aagacctgac
     3601 ccacagagga catgaaccca tgaagaagag tgatgtgaca tgttttgcat tttattagta
     3661 ccatgatcta accaactgag ctaactggcc acaccatttt atcctttata atgatcacta
     3721 tgagggctga gtgcagaatg gagtgtatgt ggtcaagagt ggaagctgtg aggctattgc
     3781 agtaatccag aaagaaaggt gacaatggct tagacttcag tggtagtgtt ggaaatggac
     3841 ataaatagac atattcagga aatatattga tcttagatct aataagacac gtaatagatt
     3901 agaagtaggg aaattaatga aaaagcagaa ttaaggatga cttctcactg gcttgaaatg
     3961 ctaaatggat gacggtgctg tttagtgagt tggggaagac tgggcgtggt gatgggtgta
     4021 gaaattgaga aaggaaaatc aagaatttcc agaactttca gagcaatgtt aaatactttc
     4081 cttgatagtg ggtcagtcat catttataag tgcatttcta aaaatattgc ttaattttgt
     4141 ttttgagctt tgtataagtg gaattttgtg tgtactgatt attttgctca atactatgtc
     4201 tttaagattc tctgtattgt tgcatgtggc tgagtttatt tttgatgctg tgtagtgttt
     4261 tactaattaa taaatcataa ttcagttttt actgttctat tgatgga
//
