LOCUS       NM_001031684            2356 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens serine and arginine rich splicing factor 7 (SRSF7),
            transcript variant 1, mRNA.
ACCESSION   NM_001031684
VERSION     NM_001031684.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2356)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2356)
  AUTHORS   Hong,J., Min,S., Yoon,G. and Lim,S.B.
  TITLE     SRSF7 downregulation induces cellular senescence through generation
            of MDM2 variants
  JOURNAL   Aging (Albany NY) 15 (24), 14591-14606 (2023)
   PUBMED   38159247
  REMARK    GeneRIF: SRSF7 downregulation induces cellular senescence through
            generation of MDM2 variants.
REFERENCE   3  (bases 1 to 2356)
  AUTHORS   Cun,Y., An,S., Zheng,H., Lan,J., Chen,W., Luo,W., Yao,C., Li,X.,
            Huang,X., Sun,X., Wu,Z., Hu,Y., Li,Z., Zhang,S., Wu,G., Yang,M.,
            Tang,M., Yu,R., Liao,X., Gao,G., Zhao,W., Wang,J. and Li,J.
  TITLE     Specific Regulation of m6A by SRSF7 Promotes the Progression of
            Glioblastoma
  JOURNAL   Genomics Proteomics Bioinformatics 21 (4), 707-728 (2023)
   PUBMED   34954129
  REMARK    GeneRIF: Specific Regulation of m[6]A by SRSF7 Promotes the
            Progression of Glioblastoma.
REFERENCE   4  (bases 1 to 2356)
  AUTHORS   Weidman,T., Nagengast,A.A. and DiAngelo,J.R.
  TITLE     The splicing factor 9G8 regulates the expression of NADPH-producing
            enzyme genes in Drosophila
  JOURNAL   Biochem Biophys Res Commun 620, 92-97 (2022)
   PUBMED   35780586
  REMARK    GeneRIF: The splicing factor 9G8 regulates the expression of
            NADPH-producing enzyme genes in Drosophila.
REFERENCE   5  (bases 1 to 2356)
  AUTHORS   Khan,M., Hou,S., Azam,S. and Lei,H.
  TITLE     Sequence-dependent recruitment of SRSF1 and SRSF7 to intronless
            lncRNA NKILA promotes nuclear export via the TREX/TAP pathway
  JOURNAL   Nucleic Acids Res 49 (11), 6420-6436 (2021)
   PUBMED   34096602
  REMARK    GeneRIF: Sequence-dependent recruitment of SRSF1 and SRSF7 to
            intronless lncRNA NKILA promotes nuclear export via the TREX/TAP
            pathway.
REFERENCE   6  (bases 1 to 2356)
  AUTHORS   Venables,J.P., Elliott,D.J., Makarova,O.V., Makarov,E.M.,
            Cooke,H.J. and Eperon,I.C.
  TITLE     RBMY, a probable human spermatogenesis factor, and other hnRNP G
            proteins interact with Tra2beta and affect splicing
  JOURNAL   Hum Mol Genet 9 (5), 685-694 (2000)
   PUBMED   10749975
REFERENCE   7  (bases 1 to 2356)
  AUTHORS   Yuan,Y., Li,D.M. and Sun,H.
  TITLE     PIR1, a novel phosphatase that exhibits high affinity to RNA .
            ribonucleoprotein complexes
  JOURNAL   J Biol Chem 273 (32), 20347-20353 (1998)
   PUBMED   9685386
REFERENCE   8  (bases 1 to 2356)
  AUTHORS   Funke,B., Zuleger,B., Benavente,R., Schuster,T., Goller,M.,
            Stevenin,J. and Horak,I.
  TITLE     The mouse poly(C)-binding protein exists in multiple isoforms and
            interacts with several RNA-binding proteins
  JOURNAL   Nucleic Acids Res 24 (19), 3821-3828 (1996)
   PUBMED   8871564
REFERENCE   9  (bases 1 to 2356)
  AUTHORS   Popielarz,M., Cavaloc,Y., Mattei,M.G., Gattoni,R. and Stevenin,J.
  TITLE     The gene encoding human splicing factor 9G8. Structure, chromosomal
            localization, and expression of alternatively processed transcripts
  JOURNAL   J Biol Chem 270 (30), 17830-17835 (1995)
   PUBMED   7629084
REFERENCE   10 (bases 1 to 2356)
  AUTHORS   Cavaloc,Y., Popielarz,M., Fuchs,J.P., Gattoni,R. and Stevenin,J.
  TITLE     Characterization and cloning of the human splicing factor 9G8: a
            novel 35 kDa factor of the serine/arginine protein family
  JOURNAL   EMBO J 13 (11), 2639-2649 (1994)
   PUBMED   8013463
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY166860.1 and AC074366.6.
            
            On Nov 22, 2018 this sequence version replaced NM_001031684.2.
            
            Summary: The protein encoded by this gene is a member of the
            serine/arginine (SR)-rich family of pre-mRNA splicing factors,
            which constitute part of the spliceosome. Each of these factors
            contains an N-terminal RNA recognition motif (RRM) for binding RNA
            and a C-terminal RS domain for binding other proteins. The RS
            domain is rich in serine and arginine residues and facilitates
            interaction between different SR splicing factors. In addition to
            being critical for mRNA splicing, the SR proteins have also been
            shown to be involved in mRNA export from the nucleus and in
            translation. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, May
            2018].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.61151.1, BC022328.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144, SAMEA2467150
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313117.11/ ENSP00000325905.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1062              AY166860.1         22-1083
            1063-2356           AC074366.6         94416-95709         c
FEATURES             Location/Qualifiers
     source          1..2356
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.1"
     gene            1..2356
                     /gene="SRSF7"
                     /gene_synonym="9G8; AAG3; SFRS7"
                     /note="serine and arginine rich splicing factor 7"
                     /db_xref="GeneID:6432"
                     /db_xref="HGNC:HGNC:10789"
                     /db_xref="MIM:600572"
     exon            1..133
                     /gene="SRSF7"
                     /gene_synonym="9G8; AAG3; SFRS7"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..822
                     /gene="SRSF7"
                     /gene_synonym="9G8; AAG3; SFRS7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     splicing factor, arginine/serine-rich 7, 35kDa; SR
                     splicing factor 7; aging-associated protein 3; splicing
                     factor 9G8; serine/arginine-rich splicing factor 7"
                     /codon_start=1
                     /product="serine/arginine-rich splicing factor 7 isoform
                     1"
                     /protein_id="NP_001026854.1"
                     /db_xref="CCDS:CCDS33183.1"
                     /db_xref="GeneID:6432"
                     /db_xref="HGNC:HGNC:10789"
                     /db_xref="MIM:600572"
                     /translation="MSRYGRYGGETKVYVGNLGTGAGKGELERAFSYYGPLRTVWIAR
                     NPPGFAFVEFEDPRDAEDAVRGLDGKVICGSRVRVELSTGMPRRSRFDRPPARRPFDP
                     NDRCYECGEKGHYAYDCHRYSRRRRSRSRSRSHSRSRGRRYSRSRSRSRGRRSRSASP
                     RRSRSISLRRSRSASLRRSRSGSIKGSRYFQSPSRSRSRSRSISRPRSSRSKSRSPSP
                     KRSRSPSGSPRRSASPERMD"
     exon            134..314
                     /gene="SRSF7"
                     /gene_synonym="9G8; AAG3; SFRS7"
                     /inference="alignment:Splign:2.1.0"
     exon            315..491
                     /gene="SRSF7"
                     /gene_synonym="9G8; AAG3; SFRS7"
                     /inference="alignment:Splign:2.1.0"
     exon            492..566
                     /gene="SRSF7"
                     /gene_synonym="9G8; AAG3; SFRS7"
                     /inference="alignment:Splign:2.1.0"
     exon            567..677
                     /gene="SRSF7"
                     /gene_synonym="9G8; AAG3; SFRS7"
                     /inference="alignment:Splign:2.1.0"
     exon            678..731
                     /gene="SRSF7"
                     /gene_synonym="9G8; AAG3; SFRS7"
                     /inference="alignment:Splign:2.1.0"
     exon            732..767
                     /gene="SRSF7"
                     /gene_synonym="9G8; AAG3; SFRS7"
                     /inference="alignment:Splign:2.1.0"
     exon            768..2356
                     /gene="SRSF7"
                     /gene_synonym="9G8; AAG3; SFRS7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1042..1047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF7"
                     /gene_synonym="9G8; AAG3; SFRS7"
                     /note="hexamer: AATAAA"
     polyA_site      1062
                     /gene="SRSF7"
                     /gene_synonym="9G8; AAG3; SFRS7"
                     /note="major polyA site"
     regulatory      2329..2334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF7"
                     /gene_synonym="9G8; AAG3; SFRS7"
                     /note="hexamer: AATAAA"
     polyA_site      2356
                     /gene="SRSF7"
                     /gene_synonym="9G8; AAG3; SFRS7"
ORIGIN      
        1 gtagtgccgc cgggactctt ggcgggtgaa ggtgtgtgtc agcttttgcg tcactcgagc
       61 cctgggcgct gcttgctaaa gagccgagca cgcgggtctg tcatcatgtc gcgttacggg
      121 cggtacggag gagaaaccaa ggtgtatgtt ggtaacctgg gaactggcgc tggcaaagga
      181 gagttagaaa gggctttcag ttattatggt cctttaagaa ctgtatggat tgcgagaaat
      241 cctccaggat ttgcctttgt ggaattcgaa gatcctagag atgcagaaga tgcagtacga
      301 ggactggatg gaaaggtgat ttgtggctcc cgagtgaggg ttgaactatc gacaggcatg
      361 cctcggagat cacgttttga tagaccacct gcccgacgtc cctttgatcc aaatgataga
      421 tgctatgagt gtggcgaaaa gggacattat gcttatgatt gtcatcgtta cagccggcga
      481 agaagaagca ggtcacggtc tagatcacat tctcgatcca gaggaaggcg atactctcgc
      541 tcacgcagca ggagcagggg acgaaggtca aggtcagcat ctcctcgacg atcaagatct
      601 atctctcttc gtagatcaag atcagcttca ctcagaagat ctaggtctgg ttctataaaa
      661 ggatcgaggt atttccaatc cccgtcgagg tcaagatcaa gatccaggtc tatttcacga
      721 ccaagaagca gccgatcaaa gtccagatct ccatctccaa aaagaagtcg ttccccatca
      781 ggaagtcctc gcagaagtgc aagtcctgaa agaatggact gaagctctca agttcaccct
      841 ttagggaaaa gttattttgt ttacattatt ataagggatt tgtgatgtct gtaaagtgta
      901 acctaggaaa gataattcaa ccatctaatc aaaatggatc tggattacta tgtaaattca
      961 cagcagtaag ataatataaa ttttgttgaa tgtattaaca tcatatggtc tgaaaatgtg
     1021 ggtttttatt tggcacattt aaataaaatg tttctaacta gatttttgat ttgtgttcaa
     1081 tattaacact tcttaatttg atatatttga gagtcagaca ttataattgt taaccttatt
     1141 catacatacc tacattcaga attgaaaggt gttggttaag tcttgaacat cactattcta
     1201 tgcataaaac ttggccagga tcttaaggga ctttgaaaat tccatcttac ccttgtagct
     1261 ctgggtaaga tgacctgagt cccttatgat acagcctgaa tgcatcatga cagatcctta
     1321 agttagctaa tccgtttgaa gttggtgtta gtaggtattg tatgatcagt ggtgaagcaa
     1381 gtaggaccac tgatgtgtct aaatgagcat gacaggaact aaacgaaact gattaaatgt
     1441 atgagaaata gaaacatttc tggatgatct ttatactaat tgcagctttc aggctactag
     1501 gtggcatagt gttaattagg actccccaag atatggggag ttctactctc aatggtcttg
     1561 tttctttgct ttctacatta gttaaccagt tttataccaa aaaatgcatg tttgaggaat
     1621 tgtctgaaat tgggacaaaa caccttcatg taaaccagct ttgcaaaatt ttccagccca
     1681 gatactcttc atctattcaa atggattgtc ttattctgag caaagacctg ttgttaatct
     1741 tcaagctagg ttttgcagtt cccaaccaca acattcttct attttgccag gctggtgcaa
     1801 agtaattaaa gatgtcaatc agaaatgtca atgagactaa agtggttttg taaatctcag
     1861 ctatatttag caacactcca tgtagctaat attttttggt agcatctggt agaccttaga
     1921 atgttacata gccagtaggt tctttattca aattttaagt atcttaagaa tagtagggca
     1981 gtaacagtta cttttgagag ttttctggtc aagcttttac caggcattct ctagccttgg
     2041 tacaaaaaaa aaaaaacctg ctggttgcgc agatacctag gcttgtccat tttatgcatt
     2101 tcagcaaagt cattggatac tattgcaact tgggaatact ggtctgcatc aagtttattc
     2161 ggtagtttga ccgctagtat gttggaagtt atttggattg tttttggaat tttgactggc
     2221 tgaattatgg ttggtataaa gttatgtgta taactggcag gcttatttat ctgttgcact
     2281 tggttagctt taattgttct gtattattta aagataagtt tactcaacaa taaatctgca
     2341 gagattgaac aaataa
//
