LOCUS       NM_001320214            1496 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens serine and arginine rich splicing factor 5 (SRSF5),
            transcript variant 3, mRNA.
ACCESSION   NM_001320214 XM_005267998
VERSION     NM_001320214.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1496)
  AUTHORS   Zhang,M., Yang,C., Ruan,X., Liu,X., Wang,D., Liu,L., Shao,L.,
            Wang,P., Dong,W. and Xue,Y.
  TITLE     CPEB2 m6A methylation regulates blood-tumor barrier permeability by
            regulating splicing factor SRSF5 stability
  JOURNAL   Commun Biol 5 (1), 908 (2022)
   PUBMED   36064747
  REMARK    GeneRIF: CPEB2 m6A methylation regulates blood-tumor barrier
            permeability by regulating splicing factor SRSF5 stability.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1496)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1496)
  AUTHORS   Szczepankiewicz,D., Narozna,B., Celichowski,P., Sakrajda,K.,
            Kolodziejski,P., Banach,E., Zakowicz,P., Pruszynska-Oszmalek,E.,
            Pawlak,J., Wilkosc,M., Dmitrzak-Weglarz,M., Skibinska,M.,
            Bejger,A., Twarowska-Hauser,J., Rybakowski,J.K., Nogowski,L. and
            Szczepankiewicz,A.
  TITLE     Genes involved in glucocorticoid receptor signalling affect
            susceptibility to mood disorders
  JOURNAL   World J Biol Psychiatry 22 (2), 149-160 (2021)
   PUBMED   32400287
  REMARK    GeneRIF: Genes involved in glucocorticoid receptor signalling
            affect susceptibility to mood disorders.
REFERENCE   4  (bases 1 to 1496)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   5  (bases 1 to 1496)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1496)
  AUTHORS   Du,K. and Taub,R.
  TITLE     Alternative splicing and structure of the human and mouse
            SFRS5/HRS/SRp40 genes
  JOURNAL   Gene 204 (1-2), 243-249 (1997)
   PUBMED   9434190
REFERENCE   7  (bases 1 to 1496)
  AUTHORS   Snow,B.E., Heng,H.H., Shi,X.M., Zhou,Y., Du,K., Taub,R., Tsui,L.C.
            and McInnes,R.R.
  TITLE     Expression analysis and chromosomal assignment of the human
            SFRS5/SRp40 gene
  JOURNAL   Genomics 43 (2), 165-170 (1997)
   PUBMED   9244433
REFERENCE   8  (bases 1 to 1496)
  AUTHORS   Screaton,G.R., Caceres,J.F., Mayeda,A., Bell,M.V., Plebanski,M.,
            Jackson,D.G., Bell,J.I. and Krainer,A.R.
  TITLE     Identification and characterization of three members of the human
            SR family of pre-mRNA splicing factors
  JOURNAL   EMBO J 14 (17), 4336-4349 (1995)
   PUBMED   7556075
REFERENCE   9  (bases 1 to 1496)
  AUTHORS   Diamond,R.H., Du,K., Lee,V.M., Mohn,K.L., Haber,B.A., Tewari,D.S.
            and Taub,R.
  TITLE     Novel delayed-early and highly insulin-induced growth response
            genes. Identification of HRS, a potential regulator of alternative
            pre-mRNA splicing
  JOURNAL   J Biol Chem 268 (20), 15185-15192 (1993)
   PUBMED   7686911
REFERENCE   10 (bases 1 to 1496)
  AUTHORS   Zahler,A.M., Lane,W.S., Stolk,J.A. and Roth,M.B.
  TITLE     SR proteins: a conserved family of pre-mRNA splicing factors
  JOURNAL   Genes Dev 6 (5), 837-847 (1992)
   PUBMED   1577277
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC307911.1, BC040209.1 and
            AL157789.6.
            
            On May 17, 2019 this sequence version replaced NM_001320214.1.
            
            Summary: The protein encoded by this gene is a member of the
            serine/arginine (SR)-rich family of pre-mRNA splicing factors,
            which constitute part of the spliceosome. Each of these factors
            contains an RNA recognition motif (RRM) for binding RNA and an RS
            domain for binding other proteins. The RS domain is rich in serine
            and arginine residues and facilitates interaction between different
            SR splicing factors. In addition to being critical for mRNA
            splicing, the SR proteins have also been shown to be involved in
            mRNA export from the nucleus and in translation. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Feb 2016].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.587891.1,
                                           SRR3476690.609202.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000557154.6/ ENSP00000451088.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                DC307911.1         31-84
            55-842              BC040209.1         1376-2163
            843-1496            AL157789.6         68230-68883
FEATURES             Location/Qualifiers
     source          1..1496
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.1"
     gene            1..1496
                     /gene="SRSF5"
                     /gene_synonym="HRS; SFRS5; SRP40"
                     /note="serine and arginine rich splicing factor 5"
                     /db_xref="GeneID:6430"
                     /db_xref="HGNC:HGNC:10787"
                     /db_xref="MIM:600914"
     exon            1..114
                     /gene="SRSF5"
                     /gene_synonym="HRS; SFRS5; SRP40"
                     /inference="alignment:Splign:2.1.0"
     exon            115..259
                     /gene="SRSF5"
                     /gene_synonym="HRS; SFRS5; SRP40"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..952
                     /gene="SRSF5"
                     /gene_synonym="HRS; SFRS5; SRP40"
                     /note="isoform 1 is encoded by transcript variant 3; SR
                     splicing factor 5; splicing factor, arginine/serine-rich
                     5; delayed-early protein HRS; pre-mRNA-splicing factor
                     SRP40; serine/arginine-rich splicing factor 5"
                     /codon_start=1
                     /product="serine/arginine-rich splicing factor 5 isoform
                     1"
                     /protein_id="NP_001307143.1"
                     /db_xref="CCDS:CCDS32109.1"
                     /db_xref="GeneID:6430"
                     /db_xref="HGNC:HGNC:10787"
                     /db_xref="MIM:600914"
                     /translation="MSGCRVFIGRLNPAAREKDVERFFKGYGRIRDIDLKRGFGFVEF
                     EDPRDADDAVYELDGKELCSERVTIEHARARSRGGRGRGRYSDRFSSRRPRNDRRNAP
                     PVRTENRLIVENLSSRVSWQDLKDFMRQAGEVTFADAHRPKLNEGVVEFASYGDLKNA
                     IEKLSGKEINGRKIKLIEGSKRHSRSRSRSRSRTRSSSRSRSRSRSRSRKSYSRSRSR
                     SRSRSRSKSRSVSRSPVPEKSQKRGSSSRSKSPASVDRQRSRSRSRSRSVDSGN"
     exon            260..330
                     /gene="SRSF5"
                     /gene_synonym="HRS; SFRS5; SRP40"
                     /inference="alignment:Splign:2.1.0"
     exon            331..429
                     /gene="SRSF5"
                     /gene_synonym="HRS; SFRS5; SRP40"
                     /inference="alignment:Splign:2.1.0"
     exon            430..499
                     /gene="SRSF5"
                     /gene_synonym="HRS; SFRS5; SRP40"
                     /inference="alignment:Splign:2.1.0"
     exon            500..573
                     /gene="SRSF5"
                     /gene_synonym="HRS; SFRS5; SRP40"
                     /inference="alignment:Splign:2.1.0"
     exon            574..684
                     /gene="SRSF5"
                     /gene_synonym="HRS; SFRS5; SRP40"
                     /inference="alignment:Splign:2.1.0"
     exon            685..1496
                     /gene="SRSF5"
                     /gene_synonym="HRS; SFRS5; SRP40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1141..1146
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF5"
                     /gene_synonym="HRS; SFRS5; SRP40"
                     /note="hexamer: ATTAAA"
     polyA_site      1161
                     /gene="SRSF5"
                     /gene_synonym="HRS; SFRS5; SRP40"
                     /note="major polyA site"
     regulatory      1477..1482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF5"
                     /gene_synonym="HRS; SFRS5; SRP40"
                     /note="hexamer: AATAAA"
     polyA_site      1496
                     /gene="SRSF5"
                     /gene_synonym="HRS; SFRS5; SRP40"
                     /note="major polyA site"
ORIGIN      
        1 gtcagttgtg gagtggcgta gacgagttaa gtcctggtct gcgtggaggt cgacgactcc
       61 gtcgcagact acggacctgt ctgggtctca gccgccaaag accccgtccg gtaggaagta
      121 ctagccggac atcatgagtg gctgtcgggt attcatcggg agactaaatc cagcggccag
      181 ggagaaggac gtggaaagat tcttcaaggg atatggacgg ataagagata ttgatctgaa
      241 aagaggcttt ggttttgtgg aatttgagga tccaagggat gcagatgatg ctgtgtatga
      301 gcttgatgga aaagaactct gtagtgaaag ggttactatt gaacatgcta gggctcggtc
      361 acgaggtgga agaggtagag gacgatactc tgaccgtttt agtagtcgca gacctcgaaa
      421 tgatagacga aatgctccac ctgtaagaac agaaaatcgt cttatagttg agaatttatc
      481 ctcaagagtc agctggcagg atctcaaaga tttcatgaga caagctgggg aagtaacgtt
      541 tgcggatgca caccgaccta aattaaatga aggggtggtt gagtttgcct cttatggtga
      601 cttaaagaat gctattgaaa aactttctgg aaaggaaata aatgggagaa aaataaaatt
      661 aattgaaggc agcaaaaggc acagtaggtc aagaagcagg tctcgatccc ggaccagaag
      721 ttcctctagg tctcgtagcc gatcccgttc ccgtagtcgc aaatcttaca gccggtcaag
      781 aagcaggagc aggagccgga gccggagcaa gtcccgttct gttagtaggt ctcccgtgcc
      841 tgagaagagc cagaaacgtg gttcttcaag tagatctaag tctccagcat ctgtggatcg
      901 ccagaggtcc cggtcccgat caaggtccag atcagttgac agtggcaatt aaactgtaaa
      961 taacttgccc tgggggcctt tttttaaaaa acaaaaacca caaaaattcc caaaccatac
     1021 ttgctaaaaa ttctggtaag tatgtgcttt tctgtggggg tgggatttgg aaggggggtt
     1081 gggttgggct ggatatcttt gtagatgtgg accaccaagg ggttgttgaa aactaattgt
     1141 attaaatgtc ttttgataag ccttctgctc acatttttgt gaatgtctga agtatatagt
     1201 ttgtgtatat tgacagagct cttttataac taaagcaaat ttaatttttt tgtactagaa
     1261 aaaaatttga acattttagt tcttggttat aaaaatgtta attcagaatt agtttaatgc
     1321 cttaattaaa ctaattaata gctttggaca cttaaaagag ctctaaattt gcttgtacat
     1381 aaaggcttaa tttgttttcc ttgttagggt caagggtgtc ctccactctt taacagctgc
     1441 tggacagaca cattagagca gctgtttgtt attgataata aaatattata aaacta
//
