LOCUS       NM_005626               2300 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens serine and arginine rich splicing factor 4 (SRSF4),
            mRNA.
ACCESSION   NM_005626
VERSION     NM_005626.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2300)
  AUTHORS   Miano,M., Bertola,N., Grossi,A., Dell'Orso,G., Regis,S.,
            Rusmini,M., Uva,P., Vozzi,D., Fioredda,F., Palmisani,E., Lupia,M.,
            Lanciotti,M., Grilli,F., Corsolini,F., Arcuri,L., Giarratana,M.C.,
            Ceccherini,I., Dufour,C., Cappelli,E. and Ravera,S.
  TITLE     Impaired Mitochondrial Function and Marrow Failure in Patients
            Carrying a Variant of the SRSF4 Gene
  JOURNAL   Int J Mol Sci 25 (4), 2083 (2024)
   PUBMED   38396760
  REMARK    GeneRIF: Impaired Mitochondrial Function and Marrow Failure in
            Patients Carrying a Variant of the SRSF4 Gene.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2300)
  AUTHORS   Sun,Y., Liu,X., Wu,Z., Wang,X., Zhang,Y., Yan,W. and You,Y.
  TITLE     SRSF4 Confers Temozolomide Resistance of Glioma via Accelerating
            Double Strand Break Repair
  JOURNAL   J Mol Neurosci 73 (4-5), 259-268 (2023)
   PUBMED   37014544
  REMARK    GeneRIF: SRSF4 Confers Temozolomide Resistance of Glioma via
            Accelerating Double Strand Break Repair.
REFERENCE   3  (bases 1 to 2300)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2300)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2300)
  AUTHORS   Manley,J.L. and Krainer,A.R.
  TITLE     A rational nomenclature for serine/arginine-rich protein splicing
            factors (SR proteins)
  JOURNAL   Genes Dev 24 (11), 1073-1074 (2010)
   PUBMED   20516191
REFERENCE   6  (bases 1 to 2300)
  AUTHORS   Lareau,L.F., Inada,M., Green,R.E., Wengrod,J.C. and Brenner,S.E.
  TITLE     Unproductive splicing of SR genes associated with highly conserved
            and ultraconserved DNA elements
  JOURNAL   Nature 446 (7138), 926-929 (2007)
   PUBMED   17361132
REFERENCE   7  (bases 1 to 2300)
  AUTHORS   Zimowska,G., Shi,J., Munguba,G., Jackson,M.R., Alpatov,R.,
            Simmons,M.N., Shi,Y. and Sugrue,S.P.
  TITLE     Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal
            epithelial cells
  JOURNAL   Invest Ophthalmol Vis Sci 44 (11), 4715-4723 (2003)
   PUBMED   14578391
REFERENCE   8  (bases 1 to 2300)
  AUTHORS   Ramchatesingh,J., Zahler,A.M., Neugebauer,K.M., Roth,M.B. and
            Cooper,T.A.
  TITLE     A subset of SR proteins activates splicing of the cardiac troponin
            T alternative exon by direct interactions with an exonic enhancer
  JOURNAL   Mol Cell Biol 15 (9), 4898-4907 (1995)
   PUBMED   7651409
REFERENCE   9  (bases 1 to 2300)
  AUTHORS   Zahler,A.M., Neugebauer,K.M., Stolk,J.A. and Roth,M.B.
  TITLE     Human SR proteins and isolation of a cDNA encoding SRp75
  JOURNAL   Mol Cell Biol 13 (7), 4023-4028 (1993)
   PUBMED   8321209
REFERENCE   10 (bases 1 to 2300)
  AUTHORS   Zahler,A.M., Lane,W.S., Stolk,J.A. and Roth,M.B.
  TITLE     SR proteins: a conserved family of pre-mRNA splicing factors
  JOURNAL   Genes Dev 6 (5), 837-847 (1992)
   PUBMED   1577277
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590729.14, BC002781.2 and
            CV814357.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005626.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.805643.1,
                                           SRR1660803.180030.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2153307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373795.7/ ENSP00000362900.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AL590729.14        7258-7308           c
            52-2196             BC002781.2         1-2145
            2197-2300           CV814357.1         11-114              c
FEATURES             Location/Qualifiers
     source          1..2300
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.3"
     gene            1..2300
                     /gene="SRSF4"
                     /gene_synonym="SFRS4; SRP75"
                     /note="serine and arginine rich splicing factor 4"
                     /db_xref="GeneID:6429"
                     /db_xref="HGNC:HGNC:10786"
                     /db_xref="MIM:601940"
     exon            1..255
                     /gene="SRSF4"
                     /gene_synonym="SFRS4; SRP75"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1633
                     /gene="SRSF4"
                     /gene_synonym="SFRS4; SRP75"
                     /note="SR splicing factor 4; splicing factor,
                     arginine/serine-rich 4; SRP001LB; pre-mRNA-splicing factor
                     SRP75"
                     /codon_start=1
                     /product="serine/arginine-rich splicing factor 4"
                     /protein_id="NP_005617.2"
                     /db_xref="CCDS:CCDS333.1"
                     /db_xref="GeneID:6429"
                     /db_xref="HGNC:HGNC:10786"
                     /db_xref="MIM:601940"
                     /translation="MPRVYIGRLSYQARERDVERFFKGYGKILEVDLKNGYGFVEFDD
                     LRDADDAVYELNGKDLCGERVIVEHARGPRRDGSYGSGRSGYGYRRSGRDKYGPPTRT
                     EYRLIVENLSSRCSWQDLKDYMRQAGEVTYADAHKGRKNEGVIEFVSYSDMKRALEKL
                     DGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKS
                     RSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEK
                     IQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRS
                     RSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSK
                     KKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKS
                     KPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRSHSRS"
     exon            256..398
                     /gene="SRSF4"
                     /gene_synonym="SFRS4; SRP75"
                     /inference="alignment:Splign:2.1.0"
     exon            399..511
                     /gene="SRSF4"
                     /gene_synonym="SFRS4; SRP75"
                     /inference="alignment:Splign:2.1.0"
     exon            512..726
                     /gene="SRSF4"
                     /gene_synonym="SFRS4; SRP75"
                     /inference="alignment:Splign:2.1.0"
     exon            727..816
                     /gene="SRSF4"
                     /gene_synonym="SFRS4; SRP75"
                     /inference="alignment:Splign:2.1.0"
     exon            817..2300
                     /gene="SRSF4"
                     /gene_synonym="SFRS4; SRP75"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2274..2279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF4"
                     /gene_synonym="SFRS4; SRP75"
                     /note="hexamer: AATAAA"
     polyA_site      2300
                     /gene="SRSF4"
                     /gene_synonym="SFRS4; SRP75"
                     /note="major polyA site"
ORIGIN      
        1 gcgtgctcgc gtacgtcgcc ggggttcggc tgcgtccgtc ccgccgcccg cccgttgccg
       61 ccgccgccgc tgccgccgtg ctctcgcttt gcccgccgcc gcctaagggg ggctggggcc
      121 ggggccagcc atcactgccg ttgccgggat gccgcgggtg tacatcggcc gcctgagcta
      181 ccaggcccgg gagcgcgatg tggagcgctt ctttaagggc tacgggaaga tcctggaggt
      241 ggatctgaag aacggatatg gttttgtgga gtttgatgat ctgcgtgatg cagatgatgc
      301 tgtttatgaa ctgaatggca aagacctttg tggtgagcga gtaattgttg agcatgcccg
      361 cggcccacgg cgagatggca gttacggttc tggacgcagt ggatatggtt atagaagaag
      421 tggccgagat aaatatggcc ctcctactcg cacagagtac agacttattg tggagaattt
      481 gtcaagtcgg tgcagctggc aagacctaaa ggattatatg cgtcaggcag gagaagtgac
      541 ttatgcagat gctcacaagg gacgcaaaaa tgaaggggtg attgaatttg tatcttattc
      601 tgatatgaaa agagctttgg aaaagttgga tggaactgaa gtcaatggga gaaaaatcag
      661 attagttgaa gacaagccag gttccagacg acgccggtcc tactccagaa gccggagtca
      721 ttcaaggtct cgctctcgaa gcagacattc ccgtaagagc agaagccgaa gtggcagcag
      781 caaaagcagt cattctaaga gtagatctcg gtccaggtcg ggctcccgct cccggagcaa
      841 gagccggagc cggagccaga gtcggagccg gagcaagaaa gagaaaagca ggagccccag
      901 caaggaaaag agccgcagcc gcagccatag cgctggcaag agccgcagca agagcaaaga
      961 ccaagctgaa gagaagatcc aaaacaatga caatgtcggg aaacccaaga gccggagtcc
     1021 tagcaggcat aaaagtaaga gcaaaagtcg gagcaggagt caggagagga gagtggagga
     1081 ggagaagcga gggagtgtga gcaggggcag gagccaggag aagagcctcc gccagagtcg
     1141 gagccggagc aggagcaaag ggggcagcag gagccggagc aggagccgca gcaagagcaa
     1201 ggacaagagg aagggcagga agagaagcag agaggagagc cgcagtcgca gtcgcagccg
     1261 cagcaagagt gagaggagca gaaagcgagg cagcaagcga gacagcaagg cgggcagcag
     1321 caagaagaag aagaaggaag acactgaccg ctcccagtcc agatctccat cccgctccgt
     1381 gtcaaaggag cgggaacatg ccaagtctga atccagccag agggaaggtc gaggagagag
     1441 tgagaatgct ggcaccaatc aggagacccg gtccaggtcg agatccaatt ccaaatcgaa
     1501 accaaacctt ccatcagaat cacgctccag atcaaagtca gcttcaaaaa cccgatctcg
     1561 gtccaagtct agatccaggt ctgcttccag atcgccctcc cgatctagat ctaggtccca
     1621 ctcaaggtcc taactggcta tggccacagc tggaactacc cgagaagtct tttgtacatg
     1681 tttggtagcc gtagcacaag tgattggagt agaacatgtc actgctgtac atttttaact
     1741 cccctaatgg tgtgtctata attgttaaat ctaagtgctt cctctcagta aagcctcctg
     1801 gcaccaggcc ttcctgctcg actgaaaaaa attttctctt tgaaaatccc cttttactca
     1861 tggcccacag tagaatatcc aaaacgcctt ggctttcagg cctggccttt cctacaggga
     1921 gctcagtaac ctggacggct ctaaggctgg aatgaccaca taggtaggta tggtgagttc
     1981 aaccattttt gctcttgaat tgatgccctt cgatgtatgc catttagtga aagtgctaag
     2041 tcttaagttt cctaccactt tggtttcata tttttggact taacaaagtt gtgaatagca
     2101 cagtcgagga aaattgatac ctgcagtaac ccataggaaa taaactgtag agttccatat
     2161 tctggtattg tgattatatt gttttatatt aaaaaagaaa agaaaagaat tttttttaat
     2221 tttatttttc cccgtcttgc aaagtatagt gacccctgtt tccattaaat ttgaataaag
     2281 actatttttg cttgacaaaa
//
