LOCUS       NM_003017               4228 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens serine and arginine rich splicing factor 3 (SRSF3),
            transcript variant 1, mRNA.
ACCESSION   NM_003017
VERSION     NM_003017.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4228)
  AUTHORS   Zhang,L., Zhang,H., Tang,Y., Dai,C. and Zheng,J.
  TITLE     SRSF3 suppresses RCC tumorigenesis and progression via regulating
            SP4 alternative splicing
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (8), 119841 (2024)
   PUBMED   39222664
  REMARK    GeneRIF: SRSF3 suppresses RCC tumorigenesis and progression via
            regulating SP4 alternative splicing.
REFERENCE   2  (bases 1 to 4228)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4228)
  AUTHORS   Gao,H., Rocha,K.C.E., Jin,Z., Kumar,D., Zhang,D., Wang,K., Das,M.,
            Farrell,A., Truong,T., Tekin,Y., Jung,H.S., Kempf,J.,
            Webster,N.J.G. and Ying,W.
  TITLE     Restoring SRSF3 in Kupffer cells attenuates obesity-related insulin
            resistance
  JOURNAL   Hepatology 80 (2), 363-375 (2024)
   PUBMED   38456794
  REMARK    GeneRIF: Restoring SRSF3 in Kupffer cells attenuates
            obesity-related insulin resistance.
REFERENCE   4  (bases 1 to 4228)
  AUTHORS   Sue,S.H., Liu,S.T. and Huang,S.M.
  TITLE     Factors affecting the expression and stability of full-length and
            truncated SRSF3 proteins in human cancer cells
  JOURNAL   Sci Rep 14 (1), 14397 (2024)
   PUBMED   38909100
  REMARK    GeneRIF: Factors affecting the expression and stability of
            full-length and truncated SRSF3 proteins in human cancer cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4228)
  AUTHORS   More,D.A., Singh,N., Mishra,R., Muralidharan,H.P., Gopinath,K.S.,
            Gopal,C. and Kumar,A.
  TITLE     Intronic miR-6741-3p targets the oncogene SRSF3: Implications for
            oral squamous cell carcinoma pathogenesis
  JOURNAL   PLoS One 19 (5), e0296565 (2024)
   PUBMED   38781195
  REMARK    GeneRIF: Intronic miR-6741-3p targets the oncogene SRSF3:
            Implications for oral squamous cell carcinoma pathogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4228)
  AUTHORS   Caceres,J.F., Screaton,G.R. and Krainer,A.R.
  TITLE     A specific subset of SR proteins shuttles continuously between the
            nucleus and the cytoplasm
  JOURNAL   Genes Dev 12 (1), 55-66 (1998)
   PUBMED   9420331
REFERENCE   7  (bases 1 to 4228)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   8  (bases 1 to 4228)
  AUTHORS   Gui,J.F., Lane,W.S. and Fu,X.D.
  TITLE     A serine kinase regulates intracellular localization of splicing
            factors in the cell cycle
  JOURNAL   Nature 369 (6482), 678-682 (1994)
   PUBMED   8208298
REFERENCE   9  (bases 1 to 4228)
  AUTHORS   Zahler,A.M., Lane,W.S., Stolk,J.A. and Roth,M.B.
  TITLE     SR proteins: a conserved family of pre-mRNA splicing factors
  JOURNAL   Genes Dev 6 (5), 837-847 (1992)
   PUBMED   1577277
REFERENCE   10 (bases 1 to 4228)
  AUTHORS   Ayane,M., Preuss,U., Kohler,G. and Nielsen,P.J.
  TITLE     A differentially expressed murine RNA encoding a protein with
            similarities to two types of nucleic acid binding motifs
  JOURNAL   Nucleic Acids Res 19 (6), 1273-1278 (1991)
   PUBMED   2030943
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z85986.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003017.4.
            
            Summary: The protein encoded by this gene is a member of the
            serine/arginine (SR)-rich family of pre-mRNA splicing factors,
            which constitute part of the spliceosome. Each of these factors
            contains an RNA recognition motif (RRM) for binding RNA and an RS
            domain for binding other proteins. The RS domain is rich in serine
            and arginine residues and facilitates interaction between different
            SR splicing factors. In addition to being critical for mRNA
            splicing, the SR proteins have also been shown to be involved in
            mRNA export from the nucleus and in translation. Two transcript
            variants, one protein-coding and the other non-coding, have been
            found for this gene. [provided by RefSeq, Sep 2010].
            
            Transcript Variant: This variant (1) is the protein-coding variant.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.150012.1,
                                           SRR1803614.13020.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373715.11/ ENSP00000362820.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               Z85986.1           28858-28977         c
            121-328             Z85986.1           26371-26578         c
            329-463             Z85986.1           24356-24490         c
            464-502             Z85986.1           22149-22187         c
            503-589             Z85986.1           21545-21631         c
            590-3095            Z85986.1           18872-21377         c
            3096-4228           Z85986.1           17739-18871         c
FEATURES             Location/Qualifiers
     source          1..4228
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31-p21.2"
     gene            1..4228
                     /gene="SRSF3"
                     /gene_synonym="SFRS3; SRp20"
                     /note="serine and arginine rich splicing factor 3"
                     /db_xref="GeneID:6428"
                     /db_xref="HGNC:HGNC:10785"
                     /db_xref="MIM:603364"
     exon            1..120
                     /gene="SRSF3"
                     /gene_synonym="SFRS3; SRp20"
                     /inference="alignment:Splign:2.1.0"
     exon            121..328
                     /gene="SRSF3"
                     /gene_synonym="SFRS3; SRp20"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..617
                     /gene="SRSF3"
                     /gene_synonym="SFRS3; SRp20"
                     /note="splicing factor, arginine/serine-rich 3; splicing
                     factor, arginine/serine-rich, 20-kD; pre-mRNA-splicing
                     factor SRP20; pre-mRNA splicing factor SRp20; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="serine/arginine-rich splicing factor 3"
                     /protein_id="NP_003008.1"
                     /db_xref="CCDS:CCDS4823.1"
                     /db_xref="GeneID:6428"
                     /db_xref="HGNC:HGNC:10785"
                     /db_xref="MIM:603364"
                     /translation="MHRDSCPLDCKVYVGNLGNNGNKTELERAFGYYGPLRSVWVARN
                     PPGFAFVEFEDPRDAADAVRELDGRTLCGCRVRVELSNGEKRSRNRGPPPSWGRRPRD
                     DYRRRSPPPRRRSPRRRSFSRSRSRSLSRDRRRERSLSRERNHKPSRSFSRSRSRSRS
                     NERK"
     exon            329..463
                     /gene="SRSF3"
                     /gene_synonym="SFRS3; SRp20"
                     /inference="alignment:Splign:2.1.0"
     exon            464..502
                     /gene="SRSF3"
                     /gene_synonym="SFRS3; SRp20"
                     /inference="alignment:Splign:2.1.0"
     exon            503..589
                     /gene="SRSF3"
                     /gene_synonym="SFRS3; SRp20"
                     /inference="alignment:Splign:2.1.0"
     exon            590..4228
                     /gene="SRSF3"
                     /gene_synonym="SFRS3; SRp20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      900..905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF3"
                     /gene_synonym="SFRS3; SRp20"
                     /note="hexamer: AATAAA"
     polyA_site      921
                     /gene="SRSF3"
                     /gene_synonym="SFRS3; SRp20"
                     /note="major polyA site"
     regulatory      1382..1387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF3"
                     /gene_synonym="SFRS3; SRp20"
                     /note="hexamer: ATTAAA"
     polyA_site      1412
                     /gene="SRSF3"
                     /gene_synonym="SFRS3; SRp20"
                     /note="major polyA site"
     regulatory      1527..1532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF3"
                     /gene_synonym="SFRS3; SRp20"
                     /note="hexamer: AATAAA"
     polyA_site      1563
                     /gene="SRSF3"
                     /gene_synonym="SFRS3; SRp20"
     regulatory      2039..2044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF3"
                     /gene_synonym="SFRS3; SRp20"
                     /note="hexamer: ATTAAA"
     polyA_site      2059
                     /gene="SRSF3"
                     /gene_synonym="SFRS3; SRp20"
     regulatory      3073..3078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF3"
                     /gene_synonym="SFRS3; SRp20"
                     /note="hexamer: ATTAAA"
     polyA_site      3095
                     /gene="SRSF3"
                     /gene_synonym="SFRS3; SRp20"
     regulatory      4208..4213
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF3"
                     /gene_synonym="SFRS3; SRp20"
                     /note="hexamer: AATACA"
     polyA_site      4228
                     /gene="SRSF3"
                     /gene_synonym="SFRS3; SRp20"
ORIGIN      
        1 ccgccatttc gtggacgccg ggtgagtgag agagttggtt ggtgttgggc cggaggaaag
       61 cgggaagact catcggagcg tgtggatttg agccgccgca ttttttaacc ctagatctcg
      121 aaatgcatcg tgattcctgt ccattggact gtaaggttta tgtaggcaat cttggaaaca
      181 atggcaacaa gacggaattg gaacgggctt ttggctacta tggaccactc cgaagtgtgt
      241 gggttgctag aaacccaccc ggctttgctt ttgttgaatt tgaagatccc cgagatgcag
      301 ctgatgcagt ccgagagcta gatggaagaa cactatgtgg ctgccgtgta agagtggaac
      361 tgtcgaatgg tgaaaaaaga agtagaaatc gtggcccacc tccctcttgg ggtcgtcgcc
      421 ctcgagatga ttatcgtagg aggagtcctc cacctcgtcg cagatctcca agaaggagaa
      481 gcttctctcg cagccggagc aggtcccttt ctagagatag gagaagagag agatcgctgt
      541 ctcgggagag aaatcacaag ccgtcccgat ccttctctag gtctcgtagt cgatctaggt
      601 caaatgaaag gaaatagaag acagtttgca agagaagtgg tgtacaggaa attacttcat
      661 ttgacaggag tatgtacaga aaattcaagt tttgtttgag acttcataag cttggtgcat
      721 ttttaagatg ttttagctgt tcaaatctgt ttgtctcttg aaacagtgac acaaaggtgt
      781 aattctctat ggtttgaaat ggatcatacg aggcatgtaa taccaagaat tgttacttta
      841 caatgttccc ttaagcaaaa ttgaatttgc tttgaacttt tagttatgca cagactgata
      901 ataaacctct aaacctgccc agcggaagtg tgtttttttt taaatttaaa tacagaaaca
      961 actggcaaaa attgaactaa gatttacttt tttttccata gctgggatat aggctgcagc
     1021 tatagttgaa caagcagtct ttaaaaactg ctgtgaaaca caggccatca gggaaaacga
     1081 aatgctgcac tattaaatta gaggtttttg aaaaatccaa ctctcatcct gggcagaggt
     1141 tgcctagttg gtatagaatg ttaagtttca agaaagttta cctttgcttt aggtcataag
     1201 ttccttattt gattgctgta tatggataca tggctgttcg tgacattctt tatgtgcaaa
     1261 tttgtgattt caaaaatgtc ctgccagttt aagggtacat tgtagagccg aactttgagt
     1321 tactgtgcaa gatttttttt tcatgctgtc atttgtaata tgttttgtga gaatccttgg
     1381 gattaaagtt ttggttacaa attgttcttt aacttgaaag cctgtttttc cttgcaaact
     1441 caaatctgtg agcttggtac caagtccagg tataacattc ctattggaag ccatacttat
     1501 attttcttgt aaagtgcttt tgaattaata aaatattagc ataattgtgt atagtcagtt
     1561 gaacccactg ttaccattgt tcttatccca tgggaagcag ttggttacac gattcttatt
     1621 ttataagaaa cagctgagag gcactatgga ttagtcttct gaagtgaagg aaatatagat
     1681 gtcacctaag tgatagttaa cccatttttt ttttttttag gcatagaagc cagttcaggg
     1741 tccataatat ttagtgacca acattttaaa gtatagcagc aacctggttc ttaaacacaa
     1801 agtaagttgc ccattaacaa atggctttta tctttagcat gaaaactttc cacaggtcta
     1861 aaaattgctt ccattttata atttgaggtg ttgcatggga attctaagct gatccatcat
     1921 gatgtaaaag ttcacaatat ggttcaaatg taacagtgca gaattgaata tggaggcatg
     1981 cataaccttc ctcttagaaa atggcaggtg ttgtaatttc aaatttttgt gcaattagat
     2041 taaatcataa tgcaacagtc ttgtggctta gtttccttaa atatgctctt aagatagttt
     2101 tggattatgc ggtattgact gtcttaaata tgaaagataa gtcattgcat taagagttca
     2161 agctaaatgg atacattaag atacagttcc taaacaaatt atttatttcc accttttaca
     2221 caaatcttgg gagaattggt gtcaggaagg ttcagcctta aagttaagca tgttcaagaa
     2281 agacactttt cagacagcct gtttatttac tgagagctct ggcattgggc attttgtctt
     2341 tagtattctc acatagccta caacctgttc ctgttaggaa caagccaaga tagctaagaa
     2401 gttacggaag ccatgcaata tgtcaattac attgcttttt ataaatggac aacttatgtg
     2461 ggcatttttg ggcagtatat gacttccttg caggctctta agttggaagg gtttctgtaa
     2521 aaaggacagt tacgggtata atatggctaa gagaaataat acagaacctg aaataaaagt
     2581 aacttcacca gggagttatc ctgacttagg tgacatacag tcccagttgg cagttacttt
     2641 aaccaggagc cctagcataa cctcaagact cttagaaact ttagaacatg gaaattgtta
     2701 aaagctttga attgcacatt tagattgtgg ctattaggaa tttttaaagt tgtaattcct
     2761 aaaataacag gtcacactaa ccggtcttgt ccatattcag ggttgagtgt aaaaatgaaa
     2821 ggaatcacaa aactgaactt agacctgtgg tttaaggatc aaggtgttca ctagaagtca
     2881 ctgttactaa tacttgatga caatgtaaag aaacattaag gattatattt gattgttttc
     2941 aaagacactg gctggatgtg gtggctcaca cttgtaattc ctagcacttt gggaggctag
     3001 ggcgggtggg aggatctctt gaagccagga gttggagacc agtctgccca acatggcaag
     3061 attcacattt ctattaaaag gaatatttag tttgatctct ggttcacagt tcattgtggg
     3121 ttgcttctga cctccatgtc ttaagcagaa agtagggaag ttgtagtttt accaagcaca
     3181 ggtaccctgt gtctaccatt tgagtatctt agagatcctt acaaacgtga tcccgtcagc
     3241 gtccatgaca ctcccaccct gttagactgc tgtcagtggc tttcacacaa acccatatgt
     3301 ggatggaaaa tccaggttat tactacattc attttagtac agtgctgcct aattagaaat
     3361 tttgttgaag aggtatttca gaatagatac agccagactc caggctcatt gacttagttt
     3421 ttcagggtga cctaaccctg tgtaattttg aggagttcta catgataaat acccttggtg
     3481 atgtgagaac cactagttta gtattttgtc caagtatgct ttttttcaga gttctgaatg
     3541 agatttagtt gtcataccta gttggtggta atttcttagt tgtatatttt tgtactacca
     3601 gattgttgcc ttctggtttt ccatcttttc gagaaagatt tctagttaaa gttactgaag
     3661 aaaaactggg ttggaagtac atttttctct aaataatcca gtagtgttga atttgatttt
     3721 atgtccactc taattttttt catcctgttt tattaggggg attcatcggg tacctgaaga
     3781 taattcagct gtagacccct taaggttctg agacaaggtc attgaaattt gttttggctg
     3841 ggtgtgatgg ctcatgcctg taatcccggt gcattgggag gttgaggcag gtggatcact
     3901 tgtggtcagg agttggagac cagcttggtc aacatggtga aaccccgtct ctactaacag
     3961 tacaaaaatt agctgggtgt ggtggcaggc gcctataatg ccagccactt gggaggctga
     4021 ggcaggagaa gtgcttaaac ctggtgggtg gaggttgcca tgagccgaga tgtagccact
     4081 tcactccagc ctgagtgaaa gcaaaacttc gtctccaaaa aaaaaaaaaa agtttgtttt
     4141 ggtaagccta gtataattga ttagttttgt ccatgcaact ttccccttgt tggactctgt
     4201 acttaataat acagtattta gattctca
//
