LOCUS       NM_001195427            1888 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens serine and arginine rich splicing factor 2 (SRSF2),
            transcript variant 2, mRNA.
ACCESSION   NM_001195427
VERSION     NM_001195427.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1888)
  AUTHORS   Chen,X., Cao,Z. and Wang,Y.
  TITLE     Amyotrophic Lateral Sclerosis-Associated Mutants of SOD1 Perturb
            mRNA Splicing through Aberrant Interactions with SRSF2
  JOURNAL   Anal Chem 96 (23), 9713-9720 (2024)
   PUBMED   38795036
  REMARK    GeneRIF: Amyotrophic Lateral Sclerosis-Associated Mutants of SOD1
            Perturb mRNA Splicing through Aberrant Interactions with SRSF2.
REFERENCE   2  (bases 1 to 1888)
  AUTHORS   Hua,D., Zhou,X.X., Wang,Q., Sun,C.Y., Shi,C.J., Luo,W.J.,
            Jiang,Z.D. and Yu,S.Z.
  TITLE     [SRSF2 promotes glioblastoma cell proliferation by inducing
            alternative splicing of FSP1 and inhibiting ferroptosis]
  JOURNAL   Zhonghua Bing Li Xue Za Zhi 53 (5), 430-438 (2024)
   PUBMED   38678322
  REMARK    GeneRIF: [SRSF2 promotes glioblastoma cell proliferation by
            inducing alternative splicing of FSP1 and inhibiting ferroptosis].
REFERENCE   3  (bases 1 to 1888)
  AUTHORS   Liu,X., Devadiga,S.A., Stanley,R.F., Morrow,R.M., Janssen,K.A.,
            Quesnel-Vallieres,M., Pomp,O., Moverley,A.A., Li,C., Skuli,N.,
            Carroll,M., Huang,J., Wallace,D.C., Lynch,K.W., Abdel-Wahab,O. and
            Klein,P.S.
  TITLE     A mitochondrial surveillance mechanism activated by SRSF2 mutations
            in hematologic malignancies
  JOURNAL   J Clin Invest 134 (12), e175619 (2024)
   PUBMED   38713535
  REMARK    GeneRIF: A mitochondrial surveillance mechanism activated by SRSF2
            mutations in hematologic malignancies.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1888)
  AUTHORS   Ma,H.L., Bizet,M., Soares Da Costa,C., Murisier,F., de Bony,E.J.,
            Wang,M.K., Yoshimi,A., Lin,K.T., Riching,K.M., Wang,X.,
            Beckman,J.I., Arya,S., Droin,N., Calonne,E., Hassabi,B.,
            Zhang,Q.Y., Li,A., Putmans,P., Malbec,L., Hubert,C., Lan,J.,
            Mies,F., Yang,Y., Solary,E., Daniels,D.L., Gupta,Y.K., Deplus,R.,
            Abdel-Wahab,O., Yang,Y.G. and Fuks,F.
  TITLE     SRSF2 plays an unexpected role as reader of m5C on mRNA, linking
            epitranscriptomics to cancer
  JOURNAL   Mol Cell 83 (23), 4239-4254 (2023)
   PUBMED   38065062
  REMARK    GeneRIF: SRSF2 plays an unexpected role as reader of m[5]C on mRNA,
            linking epitranscriptomics to cancer.
REFERENCE   5  (bases 1 to 1888)
  AUTHORS   Lei,W.L., Du,Z., Meng,T.G., Su,R., Li,Y.Y., Liu,W., Sun,S.M.,
            Liu,M.Y., Hou,Y., Zhang,C.H., Gui,Y., Schatten,H., Han,Z., Liu,C.,
            Sun,F., Wang,Z.B., Qian,W.P. and Sun,Q.Y.
  TITLE     SRSF2 is required for mRNA splicing during spermatogenesis
  JOURNAL   BMC Biol 21 (1), 231 (2023)
   PUBMED   37867192
  REMARK    GeneRIF: SRSF2 is required for mRNA splicing during
            spermatogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1888)
  AUTHORS   Sureau,A., Soret,J., Vellard,M., Crochet,J. and Perbal,B.
  TITLE     The PR264/c-myb connection: expression of a splicing factor
            modulated by a nuclear protooncogene
  JOURNAL   Proc Natl Acad Sci U S A 89 (24), 11683-11687 (1992)
   PUBMED   1465383
REFERENCE   7  (bases 1 to 1888)
  AUTHORS   Zahler,A.M., Lane,W.S., Stolk,J.A. and Roth,M.B.
  TITLE     SR proteins: a conserved family of pre-mRNA splicing factors
  JOURNAL   Genes Dev 6 (5), 837-847 (1992)
   PUBMED   1577277
REFERENCE   8  (bases 1 to 1888)
  AUTHORS   Fu,X.D. and Maniatis,T.
  TITLE     Isolation of a complementary DNA that encodes the mammalian
            splicing factor SC35
  JOURNAL   Science 256 (5056), 535-538 (1992)
   PUBMED   1373910
REFERENCE   9  (bases 1 to 1888)
  AUTHORS   Vellard,M., Sureau,A., Soret,J., Martinerie,C. and Perbal,B.
  TITLE     A potential splicing factor is encoded by the opposite strand of
            the trans-spliced c-myb exon
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 2511-2515 (1992)
   PUBMED   1557353
REFERENCE   10 (bases 1 to 1888)
  AUTHORS   DuBridge,R.B., Tang,P., Hsia,H.C., Leong,P.M., Miller,J.H. and
            Calos,M.P.
  TITLE     Analysis of mutation in human cells by using an Epstein-Barr virus
            shuttle system
  JOURNAL   Mol Cell Biol 7 (1), 379-387 (1987)
   PUBMED   3031469
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005837.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001195427.1.
            
            Summary: The protein encoded by this gene is a member of the
            serine/arginine (SR)-rich family of pre-mRNA splicing factors,
            which constitute part of the spliceosome. Each of these factors
            contains an RNA recognition motif (RRM) for binding RNA and an RS
            domain for binding other proteins. The RS domain is rich in serine
            and arginine residues and facilitates interaction between different
            SR splicing factors. In addition to being critical for mRNA
            splicing, the SR proteins have also been shown to be involved in
            mRNA export from the nucleus and in translation. Two transcript
            variants encoding the same protein and one non-coding transcript
            variant have been found for this gene. In addition, a pseudogene of
            this gene has been found on chromosome 11. [provided by RefSeq, Sep
            2010].
            
            Transcript Variant: This variant (2) differs in the 3' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000339.2, AK124792.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2154405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359995.10/ ENSP00000353089.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-533               AC005837.1         26159-26691
            534-844             AC005837.1         27026-27336
            845-1888            AC005837.1         28332-29375
FEATURES             Location/Qualifiers
     source          1..1888
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..1888
                     /gene="SRSF2"
                     /gene_synonym="PR264; SC-35; SC35; SFRS2; SFRS2A; SRp30b"
                     /note="serine and arginine rich splicing factor 2"
                     /db_xref="GeneID:6427"
                     /db_xref="HGNC:HGNC:10783"
                     /db_xref="MIM:600813"
     exon            1..533
                     /gene="SRSF2"
                     /gene_synonym="PR264; SC-35; SC35; SFRS2; SFRS2A; SRp30b"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..837
                     /gene="SRSF2"
                     /gene_synonym="PR264; SC-35; SC35; SFRS2; SFRS2A; SRp30b"
                     /note="SR splicing factor 2; splicing factor,
                     arginine/serine-rich 2; splicing factor SC35; splicing
                     component, 35 kDa"
                     /codon_start=1
                     /product="serine/arginine-rich splicing factor 2"
                     /protein_id="NP_001182356.1"
                     /db_xref="CCDS:CCDS11749.1"
                     /db_xref="GeneID:6427"
                     /db_xref="HGNC:HGNC:10783"
                     /db_xref="MIM:600813"
                     /translation="MSYGRPPPDVEGMTSLKVDNLTYRTSPDTLRRVFEKYGRVGDVY
                     IPRDRYTKESRGFAFVRFHDKRDAEDAMDAMDGAVLDGRELRVQMARYGRPPDSHHSR
                     RGPPPRRYGGGGYGRRSRSPRRRRRSRSRSRSRSRSRSRSRYSRSKSRSRTRSRSRST
                     SKSRSARRSKSKSSSVSRSRSRSRSRSRSRSPPPVSKRESKSRSRSKSPPKSPEEEGA
                     VSS"
     exon            534..844
                     /gene="SRSF2"
                     /gene_synonym="PR264; SC-35; SC35; SFRS2; SFRS2A; SRp30b"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1888
                     /gene="SRSF2"
                     /gene_synonym="PR264; SC-35; SC35; SFRS2; SFRS2A; SRp30b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1145..1150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF2"
                     /gene_synonym="PR264; SC-35; SC35; SFRS2; SFRS2A; SRp30b"
                     /note="hexamer: ATTAAA"
     polyA_site      1166
                     /gene="SRSF2"
                     /gene_synonym="PR264; SC-35; SC35; SFRS2; SFRS2A; SRp30b"
     regulatory      1853..1858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF2"
                     /gene_synonym="PR264; SC-35; SC35; SFRS2; SFRS2A; SRp30b"
                     /note="hexamer: ATTAAA"
     polyA_site      1888
                     /gene="SRSF2"
                     /gene_synonym="PR264; SC-35; SC35; SFRS2; SFRS2A; SRp30b"
                     /note="major polyA site"
ORIGIN      
        1 agttgttact caggtgcgct agcctgcgga gcccgtccgt gctgttctgc ggcaaggcct
       61 ttcccagtgt ccccacgcgg aaggcaactg cctgagaggc gcggcgtcgc accgcccaga
      121 gctgaggaag ccggcgccag ttcgcggggc tccgggccgc cactcagagc tatgagctac
      181 ggccgccccc ctcccgatgt ggagggtatg acctccctca aggtggacaa cctgacctac
      241 cgcacctcgc ccgacacgct gaggcgcgtc ttcgagaagt acgggcgcgt cggcgacgtg
      301 tacatcccgc gggaccgcta caccaaggag tcccgcggct tcgccttcgt tcgctttcac
      361 gacaagcgcg acgctgagga cgctatggat gccatggacg gggccgtgct ggacggccgc
      421 gagctgcggg tgcaaatggc gcgctacggc cgccccccgg actcacacca cagccgccgg
      481 ggaccgccac cccgcaggta cgggggcggt ggctacggac gccggagccg cagccctagg
      541 cggcgtcgcc gcagccgatc ccggagtcgg agtcgttcca ggtctcgcag ccgatctcgc
      601 tacagccgct cgaagtctcg gtcccgcact cgttctcgat ctcggtcgac ctccaagtcc
      661 agatccgcac gaaggtccaa gtccaagtcc tcgtcggtct ccagatctcg ttcgcggtcc
      721 aggtcccggt ctcggtccag gagtcctccc ccagtgtcca agagggaatc caaatccagg
      781 tcgcgatcga agagtccccc caagtctcct gaagaggaag gagcggtgtc ctcttaagaa
      841 aatgatgtat cggcaagcag tgtaaacgga ggacttgggg aaaaaggacc acatagtcca
      901 tcgaagaaga gtccttggaa caagcaactg gctattgaaa aggttatttt gtaacatttg
      961 tctaactttt tacttgttta agctttgcct cagttggcaa acttcatttt atgtgccatt
     1021 ttgttgctgt tattcaaatt tcttgtaatt tagtgaggtg aacgacttca gatttcatta
     1081 ttggatttgg atatttgagg taaaatttca ttttgttata tagtgctgac tttttttgtt
     1141 tgaaattaaa cagattggta acctaatttg tggcctcctg acttttaagg aaaacgtgtg
     1201 cagccattac acacagccta aagctgtcaa gagattgact cagcattgcc ttcattcctt
     1261 aaaattaaaa acctacaaaa gttggtgtaa atttgtatat gttatttacc ttcagatcta
     1321 aatggtaatc tgaacccaaa tttgtataaa gacttttcag gtgaaaagac ttgatttttt
     1381 gaaaggattg tttatcaaac acaattctaa tctcttctct tatgtatttt tgtgcactag
     1441 gcgcagttgt gtagcagttg agtaatgctg gttagctgtt aaggtggcgt gttgcagtgc
     1501 agagtgcttg gctgtttcct gttttctccc gattgctcct gtgtaaagat gccttgtcgt
     1561 gcagaaacaa atggctgtcc agtttattaa aatgcctgac aactgcactt ccagtcaccc
     1621 gggccttgca tataaataac ggagcataca gtgagcacat ctagctgatg ataaatacac
     1681 ctttttttcc ctcttccccc taaaaatggt aaatctgatc atatctacat gtatgaactt
     1741 aacatggaaa atgttaagga agcaaatggt tgtaactttg taagtactta taacatggtg
     1801 tatctttttg cttatgaata ttctgtatta taaccattgt ttctgtagtt taattaaaac
     1861 attttcttgg tgttagcttt tctcagaa
//
