LOCUS       NM_080743               3589 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens serine and arginine rich splicing factor 12 (SRSF12),
            transcript variant 1, mRNA.
ACCESSION   NM_080743
VERSION     NM_080743.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3589)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3589)
  AUTHORS   Varjosalo,M., Keskitalo,S., Van Drogen,A., Nurkkala,H.,
            Vichalkovski,A., Aebersold,R. and Gstaiger,M.
  TITLE     The protein interaction landscape of the human CMGC kinase group
  JOURNAL   Cell Rep 3 (4), 1306-1320 (2013)
   PUBMED   23602568
REFERENCE   3  (bases 1 to 3589)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 3589)
  AUTHORS   Manley,J.L. and Krainer,A.R.
  TITLE     A rational nomenclature for serine/arginine-rich protein splicing
            factors (SR proteins)
  JOURNAL   Genes Dev 24 (11), 1073-1074 (2010)
   PUBMED   20516191
REFERENCE   5  (bases 1 to 3589)
  AUTHORS   Cowper,A.E., Caceres,J.F., Mayeda,A. and Screaton,G.R.
  TITLE     Serine-arginine (SR) protein-like factors that antagonize authentic
            SR proteins and regulate alternative splicing
  JOURNAL   J Biol Chem 276 (52), 48908-48914 (2001)
   PUBMED   11684676
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP244338.1, AL353135.32, BC021715.1, AF449428.1 and AA889416.1.
            
            On Nov 23, 2018 this sequence version replaced NM_080743.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.268959.1,
                                           SRR1803616.37955.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000452027.3/ ENSP00000414302.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BP244338.1         11-28
            19-19               AL353135.32        46420-46420         c
            20-74               BP244338.1         30-84
            75-371              BC021715.1         22-318
            372-970             AF449428.1         188-786
            971-3280            AL353135.32        24635-26944         c
            3281-3589           AA889416.1         30-338              c
FEATURES             Location/Qualifiers
     source          1..3589
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q15"
     gene            1..3589
                     /gene="SRSF12"
                     /gene_synonym="SFRS13B; SFRS19; SRrp35"
                     /note="serine and arginine rich splicing factor 12"
                     /db_xref="GeneID:135295"
                     /db_xref="HGNC:HGNC:21220"
     exon            1..249
                     /gene="SRSF12"
                     /gene_synonym="SFRS13B; SFRS19; SRrp35"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..970
                     /gene="SRSF12"
                     /gene_synonym="SFRS13B; SFRS19; SRrp35"
                     /note="isoform a is encoded by transcript variant 1;
                     splicing factor, arginine/serine-rich 13B; splicing
                     factor, arginine/serine-rich 19; SR splicing factor 12; 35
                     kDa SR repressor protein; serine-arginine repressor
                     protein (35 kDa); serine/arginine-rich splicing factor 12"
                     /codon_start=1
                     /product="serine/arginine-rich splicing factor 12 isoform
                     a"
                     /protein_id="NP_542781.3"
                     /db_xref="CCDS:CCDS47459.1"
                     /db_xref="GeneID:135295"
                     /db_xref="HGNC:HGNC:21220"
                     /translation="MSRYTRPPNTSLFIRNVADATRPEDLRREFGRYGPIVDVYIPLD
                     FYTRRPRGFAYVQFEDVRDAEDALYNLNRKWVCGRQIEIQFAQGDRKTPGQMKSKERH
                     PCSPSDHRRSRSPSQRRTRSRSSSWGRNRRRSDSLKESRHRRFSYSQSKSRSKSLPRR
                     STSARQSRTPRRNFGSRGRSRSKSLQKRSKSIGKSQSSSPQKQTSSGTKSRSHGRHSD
                     SIARSPCKSPKGYTNSETKVQTAKHSHFRSHSRSRSYRHKNSW"
     exon            250..354
                     /gene="SRSF12"
                     /gene_synonym="SFRS13B; SFRS19; SRrp35"
                     /inference="alignment:Splign:2.1.0"
     exon            355..458
                     /gene="SRSF12"
                     /gene_synonym="SFRS13B; SFRS19; SRrp35"
                     /inference="alignment:Splign:2.1.0"
     exon            459..600
                     /gene="SRSF12"
                     /gene_synonym="SFRS13B; SFRS19; SRrp35"
                     /inference="alignment:Splign:2.1.0"
     exon            601..3589
                     /gene="SRSF12"
                     /gene_synonym="SFRS13B; SFRS19; SRrp35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1032..1037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF12"
                     /gene_synonym="SFRS13B; SFRS19; SRrp35"
                     /note="hexamer: AATAAA"
     polyA_site      1060
                     /gene="SRSF12"
                     /gene_synonym="SFRS13B; SFRS19; SRrp35"
                     /note="major polyA site"
     regulatory      1098..1103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF12"
                     /gene_synonym="SFRS13B; SFRS19; SRrp35"
                     /note="hexamer: AATAAA"
     polyA_site      1128
                     /gene="SRSF12"
                     /gene_synonym="SFRS13B; SFRS19; SRrp35"
     regulatory      3566..3571
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF12"
                     /gene_synonym="SFRS13B; SFRS19; SRrp35"
                     /note="hexamer: AATAAA"
     polyA_site      3589
                     /gene="SRSF12"
                     /gene_synonym="SFRS13B; SFRS19; SRrp35"
                     /note="major polyA site"
ORIGIN      
        1 aggctggcgc cgcgctgcgc cccctctgcg ccggcctctg cggctgcgcg ctggcggggc
       61 tgaggccgag gggtgggggt cgcgccgggg gccggcggag ctcctgtggt ggtagcagcg
      121 gtagcgggag acggagcgag tccagcggcc gcgggcagac ccggagggaa cggaggaagc
      181 ggtcatgtct cgctacacga ggccccccaa cacctccctg ttcatcagga acgtcgcgga
      241 cgccaccagg cctgaggact tgcgccgtga gtttggtcga tatggcccta tagtagacgt
      301 ttacattcca cttgacttct acactcgccg cccaagagga tttgcttatg ttcaatttga
      361 agatgttcga gatgctgaag atgctcttta taacctcaat agaaagtggg tatgtggccg
      421 tcagattgaa atacagtttg cacaaggtga tcgcaaaaca ccaggccaaa tgaaatcaaa
      481 agaacgtcat ccttgttctc caagtgatca caggagatca agaagcccca gccaaagaag
      541 aactcgaagt agaagttctt catggggaag aaataggagg cggtcagaca gccttaaaga
      601 gtctcgacac aggcgatttt cttatagcca gtctaaatct cgttccaaat cattaccaag
      661 gcggtctacc tcagcaaggc agtcaagaac tccaagaagg aattttggct ctagaggacg
      721 gtcaaggtcc aagtccttac aaaagaggtc caagtcaata ggaaaatcac agtcaagttc
      781 acctcaaaag cagactagct caggaacaaa atcaagatca catggaagac attctgactc
      841 aatagcaaga tccccgtgta aatctcccaa agggtatacc aattctgaaa ctaaagtaca
      901 aacagcaaag cattctcatt ttcggtcaca ttccagatct cgaagttatc gtcataaaaa
      961 cagttggtga acagcaacag aaagagcacc acgccgtctt taatataagt tattaaactc
     1021 tcattatgtt aaataaaaat tctttaaggc atacagaaaa tgcgagttga tattagttac
     1081 tttgggcata tggaagaaat aaaatctcta gctttggatt aataaaaatt tggtctccat
     1141 ttaaagggcc cacactacaa attatgattt gtctaatgtc accattttat ggaccatttt
     1201 ttatttacat tgtggcagaa gggtactttt caagggaaat gagtaaactg gaactaattt
     1261 ttaaaattct acttgcatag tattagtact attaataata ccttttacac aaatattttt
     1321 gactttaaag cactttcatg taaaaagtaa ctatgactgt ataattgcat agagcagact
     1381 taagctgttt gacacctatg tctcttttgt gtcttctgtt taaacttggg ccaattcctg
     1441 gtggatatta gttcatatta caaaattctg atgttccaaa aagtagaata tatatagaga
     1501 tcaaacattc aaaagataca ttctctccta agctcaaagg ttatattttt attgggtaga
     1561 acagtatagg taagttgaca tgaaattgca tcctgcacca tgaccacatt agtaatatca
     1621 gaacttttga gaaatactgg attttgaatg gtttgagact aattctttaa aaattaggct
     1681 gagcaacact cacaatccaa aaatattcat attaagactt acacatttga agaatggtac
     1741 attttgtata aaatcatatt tgataccatt atttccacat acctactttt catctgttgc
     1801 ttaatttttt ctttttagag ttcttgctca actttatatg gaacaagtct tattattttt
     1861 gaaagagtgt ttagtacctt gtattaagaa acttggccaa gcgtggtggt tcactcctgt
     1921 aatcccagca ctttgggagg tcgaggcggg cagattgctt gaggccagga gattgagacc
     1981 agcctgggca acatggtgaa atcctgtctc taaaatttaa aaaaaagaag aagaagaaac
     2041 tcgagactac atcttcaaaa aacaactttg cagtatttga attttacatt atactgccct
     2101 tcatttctga cagccaaata actttattga tatttattgc ttttgtagtt gttataacta
     2161 ataatttctt tgaaaatgtg ttgtagttta tgtttttcaa agggttttgg tagtgtttgt
     2221 gatagaatgg ttttgcatat gattattata ggggatatat ttatagagct ctacttgtat
     2281 actttgtgac ttacattatg aaaacttcaa agttctcaat ccatacagtt agtatttgta
     2341 tccagagtgt ttaagaaaaa aatctgtctt atatttttag tatataggag ccagtgttgc
     2401 ttctatttgt tttgaataca aattccagtt ttctttgcat attagatccc atatgtaaga
     2461 aacaacctta aacaataatt tgtatgctgg taatatttgg acaagtgcca taaattaatg
     2521 tatattgtac tttctgaata gattttctct aatcatagca aaatttattt caaaactaca
     2581 actctttgaa ttattccgct ataataaaat ttagttataa aattatgtgg cactactgaa
     2641 aatctaaagg ataatctgaa gaatgagtaa gacagatatt gatagaaatt tttagtattt
     2701 tcagaatgtt tgggttcata cacataagtg aaatcatttt aaaaactagg ggctgggcac
     2761 agtggctcac accagtaatc ctagcacttt gggaggccaa ggcaggagga ttgcttgagc
     2821 ccaggagttt gagaccagcc tgggcaacat agcaagaccc ctttatctat aaaaataata
     2881 ataactaggt accattgtga aaaataataa ctagggattg attatagtat ctttactctg
     2941 tattcacaaa tctctgtatt cctgaacata tttaatcctt tgatttacct ctgactaggt
     3001 ttgtcattgt aatccctggg ctgcttagga ggataccatt tggtttgatg aaaaagctgg
     3061 aatgataata gctcaaactc ttttgagcat ttagtacatg cttggcactg ttctatatgt
     3121 cttaagttat tcactcttgt atttaaccat caacactctt atgaggtaaa tatcccgcaa
     3181 ttacttttgc gccaacctag taccactaca gacaaggaaa cagatgcaga gaggctaagt
     3241 tacaagggca cacagccata aactttggat ctgtggagtg actgggcttc agagtcctct
     3301 tcctgactgc tgttcctatg tcttttgcaa agagaagtct ttgacaggta tatgctttat
     3361 taaaatcatg tttagaaaga aatgagagaa tagaattaga aaaaggaatg actgtaggct
     3421 tcgatgaaaa tgacttttgt gactaggtga aaattgtttg gctgggtatc ctggaaaatt
     3481 gtcttctggg aatatctata ttccagggtt cacttttgtc atagaattgt ttcttggccc
     3541 atttaagaga gatactttgt ttattaataa atcaaacgtt ttaatttta
//
