LOCUS       NM_001394403            3989 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens serine and arginine rich splicing factor 11 (SRSF11),
            transcript variant 17, mRNA.
ACCESSION   NM_001394403
VERSION     NM_001394403.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3989)
  AUTHORS   Oh,J., Oh,J.M. and Cho,S.Y.
  TITLE     METTL3-mediated downregulation of splicing factor SRSF11 is
            associated with carcinogenesis and poor survival of cancer patients
  JOURNAL   Eur Rev Med Pharmacol Sci 27 (6), 2561-2570 (2023)
   PUBMED   37013774
  REMARK    GeneRIF: METTL3-mediated downregulation of splicing factor SRSF11
            is associated with carcinogenesis and poor survival of cancer
            patients.
REFERENCE   2  (bases 1 to 3989)
  AUTHORS   Pan,Y.J., Huo,F.C., Kang,M.J., Liu,B.W., Wu,M.D. and Pei,D.S.
  TITLE     Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to
            metastasis potential of colorectal cancer
  JOURNAL   Clin Transl Med 12 (11), e1113 (2022)
   PUBMED   36394206
  REMARK    GeneRIF: Alternative splicing of HSPA12A pre-RNA by SRSF11
            contributes to metastasis potential of colorectal cancer.
REFERENCE   3  (bases 1 to 3989)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3989)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3989)
  AUTHORS   Anko,M.L.
  TITLE     Regulation of gene expression programmes by serine-arginine rich
            splicing factors
  JOURNAL   Semin Cell Dev Biol 32, 11-21 (2014)
   PUBMED   24657192
  REMARK    GeneRIF: Regulation of gene expression programmes by
            serine-arginine rich splicing factors.
            Review article
REFERENCE   6  (bases 1 to 3989)
  AUTHORS   Manley,J.L. and Krainer,A.R.
  TITLE     A rational nomenclature for serine/arginine-rich protein splicing
            factors (SR proteins)
  JOURNAL   Genes Dev 24 (11), 1073-1074 (2010)
   PUBMED   20516191
REFERENCE   7  (bases 1 to 3989)
  AUTHORS   Page-McCaw,P.S., Amonlirdviman,K. and Sharp,P.A.
  TITLE     PUF60: a novel U2AF65-related splicing activity
  JOURNAL   RNA 5 (12), 1548-1560 (1999)
   PUBMED   10606266
REFERENCE   8  (bases 1 to 3989)
  AUTHORS   Straub,T., Grue,P., Uhse,A., Lisby,M., Knudsen,B.R., Tange,T.O.,
            Westergaard,O. and Boege,F.
  TITLE     The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I
            activity by a direct interaction
  JOURNAL   J Biol Chem 273 (41), 26261-26264 (1998)
   PUBMED   9756848
REFERENCE   9  (bases 1 to 3989)
  AUTHORS   Zhang,W.J. and Wu,J.Y.
  TITLE     Functional properties of p54, a novel SR protein active in
            constitutive and alternative splicing
  JOURNAL   Mol Cell Biol 16 (10), 5400-5408 (1996)
   PUBMED   8816452
REFERENCE   10 (bases 1 to 3989)
  AUTHORS   Chaudhary,N., McMahon,C. and Blobel,G.
  TITLE     Primary structure of a human arginine-rich nuclear protein that
            colocalizes with spliceosome components
  JOURNAL   Proc Natl Acad Sci U S A 88 (18), 8189-8193 (1991)
   PUBMED   1896467
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL353771.8.
            
            Summary: This gene encodes 54-kD nuclear protein that contains an
            arginine/serine-rich region similar to segments found in pre-mRNA
            splicing factors. Although the function of this protein is not yet
            known, structure and immunolocalization data suggest that it may
            play a role in pre-mRNA processing. Alternative splicing results in
            multiple transcript variants encoding different proteins. In
            addition, a pseudogene of this gene has been found on chromosome
            12.[provided by RefSeq, Sep 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.308457.1,
                                           SRR14038197.2470787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-460               AL353771.8         79737-80196
            461-493             AL353771.8         81123-81155
            494-627             AL353771.8         86779-86912
            628-737             AL353771.8         90625-90734
            738-830             AL353771.8         93053-93145
            831-880             AL353771.8         93858-93907
            881-1008            AL353771.8         95782-95909
            1009-1090           AL353771.8         97796-97877
            1091-1222           AL353771.8         103041-103172
            1223-1312           AL353771.8         105175-105264
            1313-1408           AL353771.8         108309-108404
            1409-1547           AL353771.8         108722-108860
            1548-3989           AL353771.8         108968-111409
FEATURES             Location/Qualifiers
     source          1..3989
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..3989
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /note="serine and arginine rich splicing factor 11"
                     /db_xref="GeneID:9295"
                     /db_xref="HGNC:HGNC:10782"
                     /db_xref="MIM:602010"
     exon            1..460
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..1742
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /note="isoform 9 is encoded by transcript variant 17;
                     splicing factor, arginine/serine-rich 11; SR splicing
                     factor 11; arginine-rich 54 kDa nuclear protein; splicing
                     factor p54; serine/arginine-rich splicing factor 11"
                     /codon_start=1
                     /product="serine/arginine-rich splicing factor 11 isoform
                     9"
                     /protein_id="NP_001381332.1"
                     /db_xref="GeneID:9295"
                     /db_xref="HGNC:HGNC:10782"
                     /db_xref="MIM:602010"
                     /translation="MSNTTVVPSTAGPGPSGGPGGGGGGGGGGGGTEVIQVTNVSPSA
                     SSEQMRTLFGFLGKIDELRLFPPEKLESSKNLLLCDSPLPVSSRVCFVKFHDPDSAVV
                     AQHLTNTVFVDRALIVVPYAEGVIPDEAKALSLLAPANAVAGLLPGGGLLPTPNPLTQ
                     IGAVPLAALGAPTLDPALAALGLPGANLNSQSLAADQLLKLMSTVDPKLNHVAAGLVS
                     PSLKSDTSSKEIEEAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSR
                     HRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKTRDKKKEDKEKKRS
                     KTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKD
                     KDKERSRDERERSTSKKKKSKDKEKDRERKSESDKDVKVTRDYDEEEQGYDSEKEKKE
                     EKKPIETGSPKTKECSVEKGTGDSLRESKVNGDDHHEEDMDMSD"
     exon            461..493
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            494..627
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            628..737
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            738..830
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            831..880
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1008
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1090
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1222
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1312
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1408
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1547
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..3989
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2920..2925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /note="hexamer: AATAAA"
     polyA_site      2938
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /note="major polyA site"
     regulatory      3964..3969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /note="hexamer: AATAAA"
     polyA_site      3989
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
ORIGIN      
        1 agtgtcgtgg ttggaggcga ggtggggcgg ccgtttgttt tctcgtggtc tcgagctcgc
       61 gcgctctcat cccctccccc gcggcgtgcg gcggggcgga gaaacggcgg cggcggcggc
      121 ggcatcggca gcagtagcag aggctgtagc atcggacacc ctcctctctc ccgcaatccg
      181 gttcctcttc cccctccttc tcactgtttg ttgtgtgttt gatgtgttaa agcaggagcg
      241 agaacccgag cagcgccatg agcaacacta ccgtcgtccc cagcactgca ggtccgggcc
      301 ccagcggcgg gcccggtggc ggaggtggtg gtggcggcgg aggcggcggc accgaggtaa
      361 tccaggtgac taatgtctcc ccgagcgcta gctctgagca gatgcggact ctcttcggtt
      421 tcctaggcaa gatcgacgaa ctgcgcctct tcccgccgga gaaattggaa tcctctaaga
      481 atctactgtt atgtgattcg cctttgccag tctcatctcg tgtctgcttt gttaagttcc
      541 atgatccaga ctcagcagtt gtggcacagc atctgacaaa cactgtattc gttgacagag
      601 ctttgatagt cgtaccatat gcagaaggag ttattcctga tgaagctaaa gctttgtctc
      661 tgttggcacc agctaatgca gtggcaggtc ttctgcctgg tggtggactc ctgcctactc
      721 ctaacccact tacccagatt ggcgctgttc cactggctgc tttgggggct cctactcttg
      781 atcctgccct tgctgcactt gggcttcctg gagcaaactt gaactctcag tctcttgctg
      841 cagatcagtt gctgaagctt atgagtactg ttgatcccaa gttgaatcat gtagctgctg
      901 gtctcgtttc accaagtctg aaatcggata cctctagtaa agaaatagag gaagctatga
      961 aaagagtacg agaagcacag tccctaattt ctgctgctat agaaccagat aagaaagaag
     1021 aaaaaagaag gcattcaaga tcaagatcac gttctaggag gaggaggact ccctcatctt
     1081 ctagacacag gcggtcaaga agcagatcga gacggcggtc acattctaag tctaggagtc
     1141 ggcgacgatc caaaagccca aggcggagaa gatctcattc cagagaaaga ggtagaaggt
     1201 caaggagcac atcaaaaaca agagacaaaa agaaagaaga caaagaaaag aaacgttcta
     1261 aaacaccacc aaaaagttac agcacagcca gacgttctag aagtgcaagc agagagagac
     1321 gacgacgaag aagcaggagt ggcacaagat ctcctaaaaa gcctcggtct cctaaaagaa
     1381 aattgtcccg ctcaccatcc cctaggagac ataaaaagga gaagaagaaa gataaagaca
     1441 aagaaagaag tagggatgaa agagaacgat caacaagcaa gaagaagaag agtaaagata
     1501 aggaaaagga ccgggaaaga aaatcagaga gtgataaaga tgtaaaagtt acacgggatt
     1561 atgatgaaga ggaacagggg tatgacagtg agaaagagaa aaaagaagag aagaaaccaa
     1621 tagaaacagg ttcccctaaa acaaaggaat gttctgtgga aaagggaact ggtgattcac
     1681 taagagaatc caaagtgaat ggggatgatc atcatgaaga agacatggat atgagtgact
     1741 gaatattgcc tctgagggag tccaactgta tacctgcatc agtgtcattc ctttgtgtga
     1801 tttcttaatg ctgtatttgt tcatctcaaa cctagatgta tacagctctg agttataaat
     1861 ggttataaag ctcctgttac tcatattagt tatttacatc aaaaagcttt tagaaaatgg
     1921 tacgaggtaa ccaattcttg tcatggtgaa atctgattga gtaaccaagc agttttacta
     1981 ttctggtgct gcttcataac aaaaatgaaa agctgcatgc atctacagca ggcatggatt
     2041 gtttatgtcg tatgatatcc tttattaagt aagttcactt atagtatttc tataatttga
     2101 ttcattgccg taatagagcc atgtaggaaa tgcactgatt gcatgttatt gtggcaagaa
     2161 tatcctaaat gtcattaaaa tcctccaaca tgatggatct acttatggtc ttgtttgttg
     2221 acatgacaaa ttaacattct tatagttaca tctggaaatg agcatttgaa atagataatc
     2281 ctttaagcct tgtggcaaaa tttttgtggc ttttgtttaa ctttgaaagg ttattatgca
     2341 ctaacctttt ttggtggcta attagggttt aaatacagaa acaagatttc aaataaaact
     2401 gtctttggca gtgagtaaat agcatatttt gaagtagagt tgtatacttt ttcataagat
     2461 gtttgggaat ttttttcctg aagtaataat ttattccaca tctacatcag tgaaagctat
     2521 ctacctatcc tgagtctatc ttaaaggaaa aaaagaaaaa aaccttatct cttgccctta
     2581 ttttgaattt tccactcttt cattaatttg ttttaagctc cgtgttggaa aaaaggggta
     2641 gtgcatttta aattgacctt catacgcttt taaaataaga caaatctact tgataatgta
     2701 cctttatttg atctcaagtt gtataaaacc aataaatttg tgttactgca gtagtaatct
     2761 tatgcacacg gtgatttcat gttatatatg caaagtaggc aactgttttc ttagttacag
     2821 aagtttcaag cttcactttt gtgcagtaga aacaaaagta ggctacagtc tgtgccatgt
     2881 tgatgtacag tttctgaaat tgttttacaa gactttgata ataaaaccct taaacttatg
     2941 ttcatgttcc tgtaaaaccg tatttgtatt tatttacgct actgaatgta tgacatttac
     3001 ctcattcatt ttacaaattc tttccctttc tgtccacata tttcagtata gtaaaaagag
     3061 gaagtctatc actgtagtga taattgccat caaaattgtc aaaaatgatt taatttctat
     3121 ccaaaatagt ccttttctta gcttagtatc attttattgc ttattttttg tgtgggaatg
     3181 gggttggata aagcaatgaa ctttagtata aacaaatccc acctatatct agcaaattta
     3241 tattttcggt gaaatacaga tatttgcctt tctggagtag tatagaagct gtcaatatgt
     3301 atctactgta cagtactaaa tagtattcat ttatgaaatg agtagtgttt gggtggctgg
     3361 ggttaaggga aaatgagact tggaattgta gcttttatcc aagttttgag tataaatagg
     3421 gttttgtttt gtttttttta acctaaaaac tgaaatgcca tatagaaaaa cagcattgtt
     3481 tttacagttt gtagtaagta actttttaaa gattttatca aaaagaattg tctatagtga
     3541 gtaaaagaag ttctaataat ggtcctaatc actgcatttt taaaaaacaa agttcaacac
     3601 aaatgacatt tgttttaaac tttagtagat aaaaggtgaa ccatgtgaca tgggcatttt
     3661 tgtaagtcaa aaacaaattt cacatatggt aaacctaata ttcacagtgt gttccctcac
     3721 ttgtaatctc tgaatacaaa tatactagct tttctaaagg gaatcatttt tttaaaagta
     3781 gtgccactga caagatgcta cagtgaagat tatccattct taggatattt attttcagtg
     3841 aacattttct gcacaaaggt agtgttgcac tgggacacaa gccttttaac agataaccag
     3901 ttgaaatcaa acactgcctc cacaccgagt tctgttgtgt atttgatagt aaattgattt
     3961 aaaaataaaa gtggtttttg ttagaaaaa
//
