LOCUS       NM_001350605            3959 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens serine and arginine rich splicing factor 11 (SRSF11),
            transcript variant 3, mRNA.
ACCESSION   NM_001350605 XM_011542427
VERSION     NM_001350605.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3959)
  AUTHORS   Oh,J., Oh,J.M. and Cho,S.Y.
  TITLE     METTL3-mediated downregulation of splicing factor SRSF11 is
            associated with carcinogenesis and poor survival of cancer patients
  JOURNAL   Eur Rev Med Pharmacol Sci 27 (6), 2561-2570 (2023)
   PUBMED   37013774
  REMARK    GeneRIF: METTL3-mediated downregulation of splicing factor SRSF11
            is associated with carcinogenesis and poor survival of cancer
            patients.
REFERENCE   2  (bases 1 to 3959)
  AUTHORS   Pan,Y.J., Huo,F.C., Kang,M.J., Liu,B.W., Wu,M.D. and Pei,D.S.
  TITLE     Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to
            metastasis potential of colorectal cancer
  JOURNAL   Clin Transl Med 12 (11), e1113 (2022)
   PUBMED   36394206
  REMARK    GeneRIF: Alternative splicing of HSPA12A pre-RNA by SRSF11
            contributes to metastasis potential of colorectal cancer.
REFERENCE   3  (bases 1 to 3959)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3959)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3959)
  AUTHORS   Anko,M.L.
  TITLE     Regulation of gene expression programmes by serine-arginine rich
            splicing factors
  JOURNAL   Semin Cell Dev Biol 32, 11-21 (2014)
   PUBMED   24657192
  REMARK    GeneRIF: Regulation of gene expression programmes by
            serine-arginine rich splicing factors.
            Review article
REFERENCE   6  (bases 1 to 3959)
  AUTHORS   Manley,J.L. and Krainer,A.R.
  TITLE     A rational nomenclature for serine/arginine-rich protein splicing
            factors (SR proteins)
  JOURNAL   Genes Dev 24 (11), 1073-1074 (2010)
   PUBMED   20516191
REFERENCE   7  (bases 1 to 3959)
  AUTHORS   Page-McCaw,P.S., Amonlirdviman,K. and Sharp,P.A.
  TITLE     PUF60: a novel U2AF65-related splicing activity
  JOURNAL   RNA 5 (12), 1548-1560 (1999)
   PUBMED   10606266
REFERENCE   8  (bases 1 to 3959)
  AUTHORS   Straub,T., Grue,P., Uhse,A., Lisby,M., Knudsen,B.R., Tange,T.O.,
            Westergaard,O. and Boege,F.
  TITLE     The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I
            activity by a direct interaction
  JOURNAL   J Biol Chem 273 (41), 26261-26264 (1998)
   PUBMED   9756848
REFERENCE   9  (bases 1 to 3959)
  AUTHORS   Zhang,W.J. and Wu,J.Y.
  TITLE     Functional properties of p54, a novel SR protein active in
            constitutive and alternative splicing
  JOURNAL   Mol Cell Biol 16 (10), 5400-5408 (1996)
   PUBMED   8816452
REFERENCE   10 (bases 1 to 3959)
  AUTHORS   Chaudhary,N., McMahon,C. and Blobel,G.
  TITLE     Primary structure of a human arginine-rich nuclear protein that
            colocalizes with spliceosome components
  JOURNAL   Proc Natl Acad Sci U S A 88 (18), 8189-8193 (1991)
   PUBMED   1896467
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC415520.1, DA157431.1,
            M74002.1, AL832279.1, BG494115.1, CN294419.1, BF680379.1 and
            AI002238.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001350605.1.
            
            Summary: This gene encodes 54-kD nuclear protein that contains an
            arginine/serine-rich region similar to segments found in pre-mRNA
            splicing factors. Although the function of this protein is not yet
            known, structure and immunolocalization data suggest that it may
            play a role in pre-mRNA processing. Alternative splicing results in
            multiple transcript variants encoding different proteins. In
            addition, a pseudogene of this gene has been found on chromosome
            12.[provided by RefSeq, Sep 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.54920.1,
                                           SRR1660807.100186.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370949.2/ ENSP00000359987.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                DC415520.1         30-114
            86-594              DA157431.1         1-509
            595-2378            M74002.1           421-2204
            2379-2901           AL832279.1         2505-3027
            2902-3394           BG494115.1         55-547
            3395-3498           CN294419.1         281-384
            3499-3500           BF680379.1         606-607
            3501-3642           CN294419.1         389-530
            3643-3959           AI002238.1         10-326              c
FEATURES             Location/Qualifiers
     source          1..3959
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..3959
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /note="serine and arginine rich splicing factor 11"
                     /db_xref="GeneID:9295"
                     /db_xref="HGNC:HGNC:10782"
                     /db_xref="MIM:602010"
     exon            1..460
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..1712
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /note="isoform 1 is encoded by transcript variant 3;
                     splicing factor, arginine/serine-rich 11; SR splicing
                     factor 11; arginine-rich 54 kDa nuclear protein; splicing
                     factor p54; serine/arginine-rich splicing factor 11"
                     /codon_start=1
                     /product="serine/arginine-rich splicing factor 11 isoform
                     1"
                     /protein_id="NP_001337534.1"
                     /db_xref="CCDS:CCDS647.1"
                     /db_xref="GeneID:9295"
                     /db_xref="HGNC:HGNC:10782"
                     /db_xref="MIM:602010"
                     /translation="MSNTTVVPSTAGPGPSGGPGGGGGGGGGGGGTEVIQVTNVSPSA
                     SSEQMRTLFGFLGKIDELRLFPPDDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVD
                     RALIVVPYAEGVIPDEAKALSLLAPANAVAGLLPGGGLLPTPNPLTQIGAVPLAALGA
                     PTLDPALAALGLPGANLNSQSLAADQLLKLMSTVDPKLNHVAAGLVSPSLKSDTSSKE
                     IEEAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRSRRR
                     SHSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKTRDKKKEDKEKKRSKTPPKSYSTAR
                     RSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERE
                     RSTSKKKKSKDKEKDRERKSESDKDVKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSP
                     KTKECSVEKGTGDSLRESKVNGDDHHEEDMDMSD"
     exon            461..594
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            595..704
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            705..797
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            798..847
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            848..975
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1057
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1189
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1279
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1375
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1514
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..3959
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2890..2895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /note="hexamer: AATAAA"
     polyA_site      2908
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /note="major polyA site"
     regulatory      3934..3939
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
                     /note="hexamer: AATAAA"
     polyA_site      3959
                     /gene="SRSF11"
                     /gene_synonym="dJ677H15.2; NET2; p54; SFRS11"
ORIGIN      
        1 agtgtcgtgg ttggaggcga ggtggggcgg ccgtttgttt tctcgtggtc tcgagctcgc
       61 gcgctctcat cccctccccc gcggcgtgcg gcggggcgga gaaacggcgg cggcggcggc
      121 ggcatcggca gcagtagcag aggctgtagc atcggacacc ctcctctctc ccgcaatccg
      181 gttcctcttc cccctccttc tcactgtttg ttgtgtgttt gatgtgttaa agcaggagcg
      241 agaacccgag cagcgccatg agcaacacta ccgtcgtccc cagcactgca ggtccgggcc
      301 ccagcggcgg gcccggtggc ggaggtggtg gtggcggcgg aggcggcggc accgaggtaa
      361 tccaggtgac taatgtctcc ccgagcgcta gctctgagca gatgcggact ctcttcggtt
      421 tcctaggcaa gatcgacgaa ctgcgcctct tcccgccgga tgattcgcct ttgccagtct
      481 catctcgtgt ctgctttgtt aagttccatg atccagactc agcagttgtg gcacagcatc
      541 tgacaaacac tgtattcgtt gacagagctt tgatagtcgt accatatgca gaaggagtta
      601 ttcctgatga agctaaagct ttgtctctgt tggcaccagc taatgcagtg gcaggtcttc
      661 tgcctggtgg tggactcctg cctactccta acccacttac ccagattggc gctgttccac
      721 tggctgcttt gggggctcct actcttgatc ctgcccttgc tgcacttggg cttcctggag
      781 caaacttgaa ctctcagtct cttgctgcag atcagttgct gaagcttatg agtactgttg
      841 atcccaagtt gaatcatgta gctgctggtc tcgtttcacc aagtctgaaa tcggatacct
      901 ctagtaaaga aatagaggaa gctatgaaaa gagtacgaga agcacagtcc ctaatttctg
      961 ctgctataga accagataag aaagaagaaa aaagaaggca ttcaagatca agatcacgtt
     1021 ctaggaggag gaggactccc tcatcttcta gacacaggcg gtcaagaagc agatcgagac
     1081 ggcggtcaca ttctaagtct aggagtcggc gacgatccaa aagcccaagg cggagaagat
     1141 ctcattccag agaaagaggt agaaggtcaa ggagcacatc aaaaacaaga gacaaaaaga
     1201 aagaagacaa agaaaagaaa cgttctaaaa caccaccaaa aagttacagc acagccagac
     1261 gttctagaag tgcaagcaga gagagacgac gacgaagaag caggagtggc acaagatctc
     1321 ctaaaaagcc tcggtctcct aaaagaaaat tgtcccgctc accatcccct aggagacata
     1381 aaaaggagaa gaagaaagat aaagacaaag aaagaagtag ggatgaaaga gaacgatcaa
     1441 caagcaagaa gaagaagagt aaagataagg aaaaggaccg ggaaagaaaa tcagagagtg
     1501 ataaagatgt aaaacaggtt acacgggatt atgatgaaga ggaacagggg tatgacagtg
     1561 agaaagagaa aaaagaagag aagaaaccaa tagaaacagg ttcccctaaa acaaaggaat
     1621 gttctgtgga aaagggaact ggtgattcac taagagaatc caaagtgaat ggggatgatc
     1681 atcatgaaga agacatggat atgagtgact gaatattgcc tctgagggag tccaactgta
     1741 tacctgcatc agtgtcattc ctttgtgtga tttcttaatg ctgtatttgt tcatctcaaa
     1801 cctagatgta tacagctctg agttataaat ggttataaag ctcctgttac tcatattagt
     1861 tatttacatc aaaaagcttt tagaaaatgg tacgaggtaa ccaattcttg tcatggtgaa
     1921 atctgattga gtaaccaagc agttttacta ttctggtgct gcttcataac aaaaatgaaa
     1981 agctgcatgc atctacagca ggcatggatt gtttatgtcg tatgatatcc tttattaagt
     2041 aagttcactt atagtatttc tataatttga ttcattgccg taatagagcc atgtaggaaa
     2101 tgcactgatt gcatgttatt gtggcaagaa tatcctaaat gtcattaaaa tcctccaaca
     2161 tgatggatct acttatggtc ttgtttgttg acatgacaaa ttaacattct tatagttaca
     2221 tctggaaatg agcatttgaa atagataatc ctttaagcct tgtggcaaaa tttttgtggc
     2281 ttttgtttaa ctttgaaagg ttattatgca ctaacctttt ttggtggcta attagggttt
     2341 aaatacagaa acaagatttc aaataaaact gtctttggca gtgagtaaat agcatatttt
     2401 gaagtagagt tgtatacttt ttcataagat gtttgggaat ttttttcctg aagtaataat
     2461 ttattccaca tctacatcag tgaaagctat ctacctatcc tgagtctatc ttaaaggaaa
     2521 aaaagaaaaa aaccttatct cttgccctta ttttgaattt tccactcttt cattaatttg
     2581 ttttaagctc cgtgttggaa aaaaggggta gtgcatttta aattgacctt catacgcttt
     2641 taaaataaga caaatctact tgataatgta cctttatttg atctcaagtt gtataaaacc
     2701 aataaatttg tgttactgca gtagtaatct tatgcacacg gtgatttcat gttatatatg
     2761 caaagtaggc aactgttttc ttagttacag aagtttcaag cttcactttt gtgcagtaga
     2821 aacaaaagta ggctacagtc tgtgccatgt tgatgtacag tttctgaaat tgttttacaa
     2881 gactttgata ataaaaccct taaacttatg ttcatgttcc tgtaaaaccg tatttgtatt
     2941 tatttacgct actgaatgta tgacatttac ctcattcatt ttacaaattc tttccctttc
     3001 tgtccacata tttcagtata gtaaaaagag gaagtctatc actgtagtga taattgccat
     3061 caaaattgtc aaaaatgatt taatttctat ccaaaatagt ccttttctta gcttagtatc
     3121 attttattgc ttattttttg tgtgggaatg gggttggata aagcaatgaa ctttagtata
     3181 aacaaatccc acctatatct agcaaattta tattttcggt gaaatacaga tatttgcctt
     3241 tctggagtag tatagaagct gtcaatatgt atctactgta cagtactaaa tagtattcat
     3301 ttatgaaatg agtagtgttt gggtggctgg ggttaaggga aaatgagact tggaattgta
     3361 gcttttatcc aagttttgag tataaatagg gttttgtttt gtttttttta acctaaaaac
     3421 tgaaatgcca tatagaaaaa cagcattgtt tttacagttt gtagtaagta actttttaaa
     3481 gattttatca aaaagaattg tctatagtga gtaaaagaag ttctaataat ggtcctaatc
     3541 actgcatttt taaaaaacaa agttcaacac aaatgacatt tgttttaaac tttagtagat
     3601 aaaaggtgaa ccatgtgaca tgggcatttt tgtaagtcaa aaacaaattt cacatatggt
     3661 aaacctaata ttcacagtgt gttccctcac ttgtaatctc tgaatacaaa tatactagct
     3721 tttctaaagg gaatcatttt tttaaaagta gtgccactga caagatgcta cagtgaagat
     3781 tatccattct taggatattt attttcagtg aacattttct gcacaaaggt agtgttgcac
     3841 tgggacacaa gccttttaac agataaccag ttgaaatcaa acactgcctc cacaccgagt
     3901 tctgttgtgt atttgatagt aaattgattt aaaaataaaa gtggtttttg ttagaaaaa
//
