LOCUS       NM_054016               7656 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens serine and arginine rich splicing factor 10 (SRSF10),
            transcript variant 2, mRNA.
ACCESSION   NM_054016 NM_021993 XM_003119081 XM_003119082 XM_003119083
            XM_003119084
VERSION     NM_054016.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7656)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7656)
  AUTHORS   An,W., Yang,Q., Xi,Y., Pan,H., Huang,H., Chen,Q., Wang,Y., Hua,D.,
            Shi,C., Wang,Q., Sun,C., Luo,W., Li,X., Yu,S. and Zhou,X.
  TITLE     Identification of SRSF10 as a promising prognostic biomarker with
            functional significance among SRSFs for glioma
  JOURNAL   Life Sci 338, 122392 (2024)
   PUBMED   38160788
  REMARK    GeneRIF: Identification of SRSF10 as a promising prognostic
            biomarker with functional significance among SRSFs for glioma.
REFERENCE   3  (bases 1 to 7656)
  AUTHORS   Fan,Y., Zhang,Y., Zhao,H., Liu,W., Xu,W., Jiang,L., Xu,R.,
            Zheng,Y., Tang,X., Li,X., Zhao,L., Liu,X., Hong,Y., Lin,Y., Chen,H.
            and Zhang,Y.
  TITLE     lncR-GAS5 upregulates the splicing factor SRSF10 to impair
            endothelial autophagy, leading to atherogenesis
  JOURNAL   Front Med 17 (2), 317-329 (2023)
   PUBMED   36645633
  REMARK    GeneRIF: lncR-GAS5 upregulates the splicing factor SRSF10 to impair
            endothelial autophagy, leading to atherogenesis.
REFERENCE   4  (bases 1 to 7656)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   5  (bases 1 to 7656)
  AUTHORS   Shin,C. and Manley,J.L.
  TITLE     The SR protein SRp38 represses splicing in M phase cells
  JOURNAL   Cell 111 (3), 407-417 (2002)
   PUBMED   12419250
  REMARK    GeneRIF: found to be dephosphorylated specifically in mitotic
            cells; show that dephosphorylated SRp38 is required for the
            observed splicing repression
REFERENCE   6  (bases 1 to 7656)
  AUTHORS   Clinton,J.M., Chansky,H.A., Odell,D.D., Zielinska-Kwiatkowska,A.,
            Hickstein,D.D. and Yang,L.
  TITLE     Characterization and expression of the human gene encoding two
            translocation liposarcoma protein-associated serine-arginine (TASR)
            proteins
  JOURNAL   Gene 284 (1-2), 141-147 (2002)
   PUBMED   11891055
REFERENCE   7  (bases 1 to 7656)
  AUTHORS   Cowper,A.E., Caceres,J.F., Mayeda,A. and Screaton,G.R.
  TITLE     Serine-arginine (SR) protein-like factors that antagonize authentic
            SR proteins and regulate alternative splicing
  JOURNAL   J Biol Chem 276 (52), 48908-48914 (2001)
   PUBMED   11684676
REFERENCE   8  (bases 1 to 7656)
  AUTHORS   Yang,L., Embree,L.J. and Hickstein,D.D.
  TITLE     TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by
            serine-arginine proteins
  JOURNAL   Mol Cell Biol 20 (10), 3345-3354 (2000)
   PUBMED   10779324
REFERENCE   9  (bases 1 to 7656)
  AUTHORS   Komatsu,M., Kominami,E., Arahata,K. and Tsukahara,T.
  TITLE     Cloning and characterization of two neural-salient
            serine/arginine-rich (NSSR) proteins involved in the regulation of
            alternative splicing in neurones
  JOURNAL   Genes Cells 4 (10), 593-606 (1999)
   PUBMED   10583508
REFERENCE   10 (bases 1 to 7656)
  AUTHORS   Yang,L., Embree,L.J., Tsai,S. and Hickstein,D.D.
  TITLE     Oncoprotein TLS interacts with serine-arginine proteins involved in
            RNA splicing
  JOURNAL   J Biol Chem 273 (43), 27761-27764 (1998)
   PUBMED   9774382
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK093226.1, BC005039.1 and
            AL590609.15.
            
            On May 17, 2019 this sequence version replaced NM_054016.3.
            
            Summary: This gene product is a member of the serine-arginine (SR)
            family of proteins, which are involved in constitutive and
            regulated RNA splicing. Members of this family are characterized by
            N-terminal RNP1 and RNP2 motifs, which are required for binding to
            RNA, and multiple C-terminal SR/RS repeats, which are important in
            mediating association with other cellular proteins. This protein
            interacts with the oncoprotein TLS, and abrogates the influence of
            TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes
            on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (2) represents the longest
            transcript and encodes the longest isoform (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.238330.1,
                                           SRR1660805.35925.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267755 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000492112.3/ ENSP00000420195.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AK093226.1         601-608
            9-1261              BC005039.1         1-1253
            1262-7656           AL590609.15        97369-103763        c
FEATURES             Location/Qualifiers
     source          1..7656
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..7656
                     /gene="SRSF10"
                     /gene_synonym="FUSIP1; FUSIP2; NSSR; PPP1R149; SFRS13;
                     SFRS13A; SRp38; SRrp40; TASR; TASR1; TASR2"
                     /note="serine and arginine rich splicing factor 10"
                     /db_xref="GeneID:10772"
                     /db_xref="HGNC:HGNC:16713"
                     /db_xref="MIM:605221"
     exon            1..137
                     /gene="SRSF10"
                     /gene_synonym="FUSIP1; FUSIP2; NSSR; PPP1R149; SFRS13;
                     SFRS13A; SRp38; SRrp40; TASR; TASR1; TASR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..861
                     /gene="SRSF10"
                     /gene_synonym="FUSIP1; FUSIP2; NSSR; PPP1R149; SFRS13;
                     SFRS13A; SRp38; SRrp40; TASR; TASR1; TASR2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     FUS-interacting protein (serine-arginine rich) 2; FUS
                     interacting protein (serine-arginine rich) 1; splicing
                     factor, arginine/serine-rich 13A; SR splicing factor 10;
                     neural-salient SR protein; TLS-associated serine-arginine
                     protein 1; serine-arginine repressor protein (40 kDa);
                     TLS-associated serine-arginine protein 2; protein
                     phosphatase 1, regulatory subunit 149; TLS-associated
                     protein TASR; splicing factor SRp38; TLS-associated SR
                     protein; 40 kDa SR-repressor protein; TLS-associated
                     protein with SR repeats; TLS-associated protein with
                     Ser-Arg repeats; serine/arginine-rich splicing factor 10"
                     /codon_start=1
                     /product="serine/arginine-rich splicing factor 10 isoform
                     2"
                     /protein_id="NP_473357.1"
                     /db_xref="CCDS:CCDS30630.1"
                     /db_xref="GeneID:10772"
                     /db_xref="HGNC:HGNC:16713"
                     /db_xref="MIM:605221"
                     /translation="MSRYLRPPNTSLFVRNVADDTRSEDLRREFGRYGPIVDVYVPLD
                     FYTRRPRGFAYVQFEDVRDAEDALHNLDRKWICGRQIEIQFAQGDRKTPNQMKAKEGR
                     NVYSSSRYDDYDRYRRSRSRSYERRRSRSRSFDYNYRRSYSPRNSRPTGRPRRSRSHS
                     DNDRFKHRNRSFSRSKSNSRSRSKSQPKKEMKAKSRSRSASHTKTRGTSKTDSKTHYK
                     SGSRYEKESRKKEPPRSKSQSRSQSRSRSKSRSRSWTSPKSSGH"
     exon            138..242
                     /gene="SRSF10"
                     /gene_synonym="FUSIP1; FUSIP2; NSSR; PPP1R149; SFRS13;
                     SFRS13A; SRp38; SRrp40; TASR; TASR1; TASR2"
                     /inference="alignment:Splign:2.1.0"
     exon            243..346
                     /gene="SRSF10"
                     /gene_synonym="FUSIP1; FUSIP2; NSSR; PPP1R149; SFRS13;
                     SFRS13A; SRp38; SRrp40; TASR; TASR1; TASR2"
                     /inference="alignment:Splign:2.1.0"
     exon            347..509
                     /gene="SRSF10"
                     /gene_synonym="FUSIP1; FUSIP2; NSSR; PPP1R149; SFRS13;
                     SFRS13A; SRp38; SRrp40; TASR; TASR1; TASR2"
                     /inference="alignment:Splign:2.1.0"
     exon            510..563
                     /gene="SRSF10"
                     /gene_synonym="FUSIP1; FUSIP2; NSSR; PPP1R149; SFRS13;
                     SFRS13A; SRp38; SRrp40; TASR; TASR1; TASR2"
                     /inference="alignment:Splign:2.1.0"
     exon            564..7656
                     /gene="SRSF10"
                     /gene_synonym="FUSIP1; FUSIP2; NSSR; PPP1R149; SFRS13;
                     SFRS13A; SRp38; SRrp40; TASR; TASR1; TASR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5531..5536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF10"
                     /gene_synonym="FUSIP1; FUSIP2; NSSR; PPP1R149; SFRS13;
                     SFRS13A; SRp38; SRrp40; TASR; TASR1; TASR2"
                     /note="hexamer: AATAAA"
     polyA_site      5558
                     /gene="SRSF10"
                     /gene_synonym="FUSIP1; FUSIP2; NSSR; PPP1R149; SFRS13;
                     SFRS13A; SRp38; SRrp40; TASR; TASR1; TASR2"
                     /note="major polyA site"
     regulatory      7171..7176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF10"
                     /gene_synonym="FUSIP1; FUSIP2; NSSR; PPP1R149; SFRS13;
                     SFRS13A; SRp38; SRrp40; TASR; TASR1; TASR2"
                     /note="hexamer: AATAAA"
     regulatory      7194..7199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SRSF10"
                     /gene_synonym="FUSIP1; FUSIP2; NSSR; PPP1R149; SFRS13;
                     SFRS13A; SRp38; SRrp40; TASR; TASR1; TASR2"
                     /note="hexamer: AATAAA"
     polyA_site      7199
                     /gene="SRSF10"
                     /gene_synonym="FUSIP1; FUSIP2; NSSR; PPP1R149; SFRS13;
                     SFRS13A; SRp38; SRrp40; TASR; TASR1; TASR2"
     polyA_site      7215
                     /gene="SRSF10"
                     /gene_synonym="FUSIP1; FUSIP2; NSSR; PPP1R149; SFRS13;
                     SFRS13A; SRp38; SRrp40; TASR; TASR1; TASR2"
ORIGIN      
        1 gaggctcggc cgcctgagcc gcggacggtt tgctgagccc gttagtgcgc ccggccgaga
       61 cacgccgccg ccatgtcccg ctacctgcgt ccccccaaca cgtctctgtt cgtcaggaac
      121 gtggccgacg acaccaggtc tgaagacttg cggcgtgaat ttggtcgtta tggtcctata
      181 gttgatgtgt atgttccact tgatttctac actcgccgtc caagaggatt tgcttatgtt
      241 caatttgagg atgttcgtga tgctgaagac gctttacata atttggacag aaagtggatt
      301 tgtggacggc agattgaaat acagtttgcc cagggggatc gaaagacacc aaatcagatg
      361 aaagccaagg aagggaggaa tgtgtacagt tcttcacgct atgatgatta tgacagatac
      421 agacgttcta gaagccgaag ttatgaaagg aggagatcaa gaagtcggtc ttttgattac
      481 aactatagaa gatcgtatag tcctagaaac agtagaccga ctggaagacc acggcgtagc
      541 agaagccatt ccgacaatga tagattcaaa caccgaaatc gatctttttc aagatctaaa
      601 tccaattcaa gatcacggtc caagtcccag cccaagaaag aaatgaaggc taaatcacgt
      661 tctaggtctg catctcacac caaaactaga ggcacctcta aaacagattc caaaacacat
      721 tataagtctg gctcaagata tgaaaaggaa tcaaggaaaa aagaaccacc tagatccaaa
      781 tctcagtcaa gatcacagtc taggtctagg tcaaaatcta gatcaaggtc ttggactagt
      841 cctaagtcca gtggccactg atagtataaa ccatggtcat ttttaggcat gtatcattca
      901 tttactcata gtttggttta cttaaattat caggaataca atgttgcaat gatgcttaaa
      961 aaacacttgt tagttttccc tgtaccaggc aatggttata attaaaatga tatgctgttg
     1021 agaagccact cttaagagtc cagtttgttt aatgttatgg gcagctacca atttgtggtg
     1081 tctctgtata tttttgtaaa gattctcatt ttttatgctt gaagtatttg gtgaaaagat
     1141 gttggttgac cataatttgc aacattgtct cattaaaaat aaactttcat attcatattt
     1201 ggtagaactg ttaacctaga aatgtagctt gctaataaga tagaatgata caaaagtgaa
     1261 gtagtagcca cagtacaaca ctgactgctc agacacattt aggttcaggg tggaccttta
     1321 tgtcttgtca agatgtctag gcccggctgg gcgtggtggc tcacacctgt aatcccagca
     1381 ctttgggagg ccgaggcggg cggatcacga ggtcaggagt tcgagaccag cctgaccaac
     1441 acggtgaaac cccgtctcta ctaaaaatac aaaaattatc cgggcatggt ggcacatgcc
     1501 tgtaatctca gctactcagg aggctgaggc aagagaatcg cttgaacctg ggaggtagaa
     1561 gttgcagtga gccaaaatca cgccactgca ctccagcctg ggcaacagag tgagactccg
     1621 tctcaaaaaa aaaaaaaaac cggatgtcta ggccaatgat aattattttt gatgcagtgt
     1681 ggattagttc ttttgttaac cccactgtct tggggaatga tgccagctgg gaaattgagt
     1741 ttttgactga aacatggagc cttcactgct ttttttctgg ttcctatgaa gatttggaac
     1801 atagaaaaca caaaaactca ccttaaaatt tgagcaggtc gttgatggca aaaataattt
     1861 taaggaaaaa ggaatattct tatgtagtta ttctaaagtt taaggagcgt tgttgaccat
     1921 aatattgctt agttttctta ctgctgttaa gtaagtaaat tgtttcaaag taggttttgt
     1981 gtgtgtgtgc ctagtgtaaa agaactgaaa ttttgatgct tacagcactt ggctcgtgca
     2041 tttgtatcaa aatttgcctg cctctttatg agggaggcct gcttttcaca cctcagttta
     2101 tttaatacga ggcaagttgt aagacaacac tcattctagg tgattctgtg gtgccatgaa
     2161 atttaaggta atttggggaa aaggattagt cagttttaag caagagtcac atcttttgag
     2221 ctttcgatta tcagtgtagt acctgactaa aaatgaagta atacccttaa accatttata
     2281 atttctagta tttctctgaa agatcgtttt ggggacaaaa gtgacttgac atgtccaatt
     2341 tcatttcaga ataaaaagct agcatcttta aaaatctcag attgcttgct tacagataca
     2401 agtacgaatt atggacaaac gattcctttt agaggattac ttttttcaat ttcggtttta
     2461 gtaatctagg ctttgcctgt aaagaataca acgatggatt ttaaatactg tttgtggaat
     2521 gtgtttaaag gattgattct agaacctttg tatatttgat agtatttcta actttcattt
     2581 ctttactgtt tgcagttaat gttcatgttc tgctatgcaa tcgtttatat gcacgtttct
     2641 ttaatttttt tagattttcc tggatgtata gtttaaacaa caaaaagtct atttaaaact
     2701 gtagcagtag tttacagttc tagcaaagag gaaagttgtg gggttaaact ttgtattttc
     2761 tttcttatag aggcttctaa aaaggtattt ttatatgttc tttttaacaa atattgtgta
     2821 caacctttaa aacatcaatg tttggatcaa aacaagaccc agcttatttt ctgcttgctg
     2881 taaattaagc aaacatgcta taataaaaac aaaatgaagg aaataatgat taactggaat
     2941 tattacagta ttgaatatga ttctaaaata acaatggaaa cagtccttta tagatttagg
     3001 aatattttaa atcattgttg cactaggcac aactaacttt tactttggaa atgatagaac
     3061 ttgccagaaa ggtacatctt ttacacagta gttaaaaatt cattgtgtaa tatcaaagtt
     3121 gtttcatgat tgctcattaa gcctcttggg ttaactaact taagaggtta tttggtagtg
     3181 ttaagatgaa atttggatca gctaattcca agtttatatt ttcattattg gatggatcag
     3241 taattctgct ctccctctta taaacaagac gcattagggc ttaacgttta tgacatgatt
     3301 ttaaatcatt ttaaattgaa tgttgatgag caactaatat taagtgataa cctctttggg
     3361 gaagtaggtt aggtattttg tggtttgaat tctatctact ttatgacaat tatagctaat
     3421 ttattaagta ttcatgatgt gccagacact tgaaaaggct atgtgttaac tcactcttca
     3481 caaaacctta tgagaaagat acttttattt tccccatatc acagataagg aaactgaggc
     3541 acaaagaaaa gactgtaagg cagagccagg atttaagccc aggcctggtc ccttagtttt
     3601 gggggggttt tgtttgtttt acagactata atttgagaga agtagattga ggagatagct
     3661 cattgaaatt gttcattttc tgtatagaac tagaaggcct aatttcattt ttatttttac
     3721 ttgtgtcaac ttatttttag acttggacta ttgagaatct tatatgttgt tcctaaagcg
     3781 acacacctaa cagcttcaaa aggactatat tacagttgaa cccatggtag tttggatcct
     3841 actgatactt gatgaggatc tttacgtagt gttttatgtt agttttgggt gatgtagttg
     3901 agtcccccac ttactgagtt tacctactgt gtatgactgg gctcaatgat aaatagaatg
     3961 gttatatcaa cactcaaatg agggctgaca cacttcacct ctccttttac ttaagatctc
     4021 tctgcatttt tttttttttt ttgaagccaa gtaagcaaga agaaaaatga gagataatgc
     4081 ttcagtgaga gaggaaaggt gctacataga gtatgagctg ttaagttaca tcccagggga
     4141 aagacctggg aactattgta ttattctctt gaaaatttgg cccagtaagc tgctacatcc
     4201 agttcaacta acaaaatcct gtataccaca gagaagaata aaggaaacca aactgacaaa
     4261 catccttctt ttatttaaga ccaaactgca gctggaatac ccagtacagt tctgcttact
     4321 acacttcaag aaagatctga aagcggaaaa agaaccaaag aagggcagtt caagcgacca
     4381 aagggtgggt ggaaggtgct gcagtatgaa tactgtacga atattttgac tctggtctga
     4441 aaagataaaa gaatgttatc gaaaactaca tggaataatt gaagtccctt caagtttgaa
     4501 agtaagcatt ttaggacaaa taaaaggaaa ttcaactttg tacttgtgga aactaatccc
     4561 taaatatgaa taggtttata ttgattcatg ggtaacaggt ccataataaa ttattggaaa
     4621 ctaggatgtc tgaatatcaa ggaagacagc catagtctct tacagtgcct ctgttggtct
     4681 gtctcaaact gaattgggtg ggaaaaggta tggtccaata taaaagttcc atttttgcca
     4741 ttattggcaa atcttgcctt tgtttatttt ggtgccagtg ttttctgctt aatcatttgc
     4801 tttgttggca tctgtgttta tttacttgta caccacatgc agtttacatc tgtcttaact
     4861 actccttccc aggtaaattc caattatatt tgacatccag ctaagagggc ccatctcttc
     4921 tcacctcttt cctagtcagt atattcagca aatatttatt gagcccttac tgtgggcaaa
     4981 tcattgtact ggataattga gaaaaataga taattccctt attcagtaaa tgtctactga
     5041 gcacaatcta gtgaatcatt acagtatggc ctcattgttt tgtttgaggt gtgttattca
     5101 taacaatatt ttacaccatt cgtatcaatg taattataga acacaatata cgatcaagga
     5161 taagtaattg tgtggttatc tgccatttaa aagtatccag tatttgatca cattattata
     5221 aataatgaaa aaatgattta atctgtaata aactggttta ttgtgcagtg actgtaatat
     5281 actagagtta taataaattg tttactctgc ctcaccaaac acatgctagg atataacccc
     5341 caaaataagt atttaacttt gcattaggta taaaggagac tgggtgctat aattagatta
     5401 ttttgaggca gacagagagc tgttatccta actgatttag tatgttctgt aattgagaaa
     5461 atgttcacca aattatactt tttagtgatt tacatgtaca ttttataggg gacatgttct
     5521 gtgtatagcg aataaataac ttttatagta tcacaaaatg ttttggattc cttagtttct
     5581 tattaggata tgatgtttct ttacctatac attgatttca tcacatttga tttttgtcat
     5641 cttttttgcc acatacttaa aattttccat ataaaattaa ctaaaaatct ggaagtggaa
     5701 tttaagcttt taatttgtag caattttgaa aatatagcag aggtatattt tcaagggagg
     5761 tgtgaaatgg aggtattatt gtttgtattt tattttagaa attttgtttg aacttgccca
     5821 agatcacaca gcaagtgtca gatcctaggt tacagcccat aatttttcac ttgtttcatc
     5881 ttttgttacc atgtttgttg tttaatccaa tggggaagtg tttttatagc tttattttca
     5941 tggagatagt aacattgata taatgggatc tagaatttac ttagagtcaa agtgactaga
     6001 tttaattaca aaaagtattt tgttgtatac cgttatacac tcattaacat aggggttctt
     6061 atggacagag gttctatgta tttttaaaag aatatgtaga ggctatagac ttttttgccc
     6121 tctacctccc ttctccattt ccttttgaag ttaagacatt taagggggag aattaaggtg
     6181 catattgagt tggggttttg tttaaaaaaa attaggtaaa tacatatata actacaataa
     6241 caacagttgg tagttctcta aaatatttaa ttatggtaaa tcagaaaagg ccctttaatt
     6301 tttgcatctg ttgaatgaat tgctttagga tctcttctgt ggttgtttct ctctatactg
     6361 aatgctgtca atattattga gcacttactg tgccgaacca tgtgcttttc aaatatttct
     6421 atttaatcct aaaaacactc ctgggaaatg ggtattattc ccattttaca gatgagaaaa
     6481 ttgtcctttg tagaataccc atcatgtgat agcttcttgc atattatgct attcatttct
     6541 cacaacctta caaggtaaat ggataatgtt cctggatgag agattaaacg tactcgaaga
     6601 tcttatggtt gtgtggctca gagactctaa gcatggcttt ccaaatctca ttctcttgta
     6661 gagattttcc attgtattgc attttgacca tgttcctgtt tacaaaacct aagattatat
     6721 tctgaagtat ctgtgacttg agtgatagct caggaataat ctgagggcat tctattagga
     6781 aggaggacta gcaaagccta tagttagcct atcctaggca tgaactattc tcattttaga
     6841 taggatgact tgataaatag gatgaagtga gcaacctgtt tgtcttcggt tattgctatc
     6901 tacaagacat tctgctagtc actgtggaaa agtttccttc tcttgggttt tttcctcttc
     6961 cccttcctct taacagtgtt ggttatcttt attatgtttc tgtgtatttg taacagctgt
     7021 ttcacccttg tattgcataa tggggatttt tcttggaata aaaagtgagg catgtaaatt
     7081 cattgagaac taaccgtagt ttgtaaagaa gtaaaaggcc tttgtatcta gttttttgca
     7141 gatcacattt ctttgaatgc tggaaagtga aataaactgg tctaggagcc aaaaataaat
     7201 cttgggtttt tttaagattt tgctcttaga tttgtaacca cctgggtaca actttttcct
     7261 aatttgtgta agaggtttta gagatgcact ctgtccctct tgctttacaa attgcctaca
     7321 agaatgcaac caaaatacta gaaactgaaa cttacacaaa acctttcagg ttttttcctg
     7381 tgttgtagtt ctagggaaga ggatagttta ttagtattta ttttaagctt aaggataggt
     7441 tttggacctg gattccatca tagtataact gccatcgaaa agaagacaaa ttgaaattac
     7501 agcatttacc taaggttcac agtatggctg acttcagcag ccttacatgg taagttctct
     7561 gtaccagcta tttttggttc tcgcaattgc atcgacttgg gaaattccta tcaccattct
     7621 ctatataggc taaccaaaac ttttatcagt accttt
//
